"Protein S Deficiency" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523)
| Descriptor ID |
D018455
|
| MeSH Number(s) |
C15.378.100.800 C15.378.147.890 C15.378.925.800
|
| Concept/Terms |
Protein S Deficiency- Protein S Deficiency
- Hereditary Thrombophilia Due To Protein S Deficiency
- Deficiency, Protein S
- Deficiencies, Protein S
- Protein S Deficiencies
|
Below are MeSH descriptors whose meaning is more general than "Protein S Deficiency".
Below are MeSH descriptors whose meaning is more specific than "Protein S Deficiency".
This graph shows the total number of publications written about "Protein S Deficiency" by people in this website by year, and whether "Protein S Deficiency" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein S Deficiency" by people in Profiles.
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Protein S deficiency in a living liver donor. Transpl Int. 2012 Feb; 25(2):e23-6.
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Severe acquired functional protein S deficiency and skin necrosis in a patient with ANCA-associated vasculitis. Thromb Haemost. 2000 Nov; 84(5):929-30.