"Complement C1q" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subcomponent of complement C1, composed of six copies of three polypeptide chains (A, B, and C), each encoded by a separate gene (C1QA; C1QB; C1QC). This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY.
| Descriptor ID |
D015922
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| MeSH Number(s) |
D12.776.124.486.274.050.270
|
| Concept/Terms |
Complement C1q- Complement C1q
- C1q, Complement
- Complement Component 1q
- Component 1q, Complement
- C1q Complement
- Complement, C1q
- Complement 1q
|
Below are MeSH descriptors whose meaning is more general than "Complement C1q".
Below are MeSH descriptors whose meaning is more specific than "Complement C1q".
This graph shows the total number of publications written about "Complement C1q" by people in this website by year, and whether "Complement C1q" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2018 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Complement C1q" by people in Profiles.
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Refining colorectal cancer classification and clinical stratification through a single-cell atlas. Genome Biol. 2022 05 11; 23(1):113.
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Serologic features of cohorts with variable genetic risk for systemic lupus erythematosus. Mol Med. 2018 06 01; 24(1):24.
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Predictive value of serum anti-C1q antibody levels in experimental autoimmune myasthenia gravis. Neuromuscul Disord. 2006 Feb; 16(2):137-43.
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Direct binding of complement component C1q to human immunodeficiency virus (HIV) and human T lymphotrophic virus-I (HTLV-I) coinfected cells. AIDS Res Hum Retroviruses. 1991 Jul; 7(7):579-85.