"src-Family Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A PROTEIN-TYROSINE KINASE family that was originally identified by homology to the Rous sarcoma virus ONCOGENE PROTEIN PP60(V-SRC). They interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways. Oncogenic forms of src-family kinases can occur through altered regulation or expression of the endogenous protein and by virally encoded src (v-src) genes.
| Descriptor ID |
D019061
|
| MeSH Number(s) |
D08.811.913.696.620.682.725.800
|
| Concept/Terms |
src-Family Kinases- src-Family Kinases
- src Family Kinases
- src-Family Tyrosine Kinases
- Tyrosine Kinases, src-Family
- src Family Tyrosine Kinases
- src Tyrosine Kinases
- Kinases, src Tyrosine
- Tyrosine Kinases, src
- Protein-Tyrosine Kinases, src
- Kinases, src Protein-Tyrosine
- src Protein-Tyrosine Kinases
- src Kinases
- Kinases, src
|
Below are MeSH descriptors whose meaning is more general than "src-Family Kinases".
Below are MeSH descriptors whose meaning is more specific than "src-Family Kinases".
This graph shows the total number of publications written about "src-Family Kinases" by people in this website by year, and whether "src-Family Kinases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 3 | 3 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
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Below are the most recent publications written about "src-Family Kinases" by people in Profiles.
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Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells. Mol Cancer. 2013 Jul 16; 12:76.
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Rituximab is a safe and effective long-term treatment for children with steroid and calcineurin inhibitor-dependent idiopathic nephrotic syndrome. Kidney Int. 2013 Nov; 84(5):1025-33.
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PTPIP51, a positive modulator of the MAPK/Erk pathway, is upregulated in glioblastoma and interacts with 14-3-3? and PTP1B in situ. Histol Histopathol. 2011 12; 26(12):1531-43.
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Temporal perturbation of tyrosine phosphoproteome dynamics reveals the system-wide regulatory networks. Mol Cell Proteomics. 2009 Feb; 8(2):226-31.
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Modeling breast cancer-associated c-Src and EGFR overexpression in human MECs: c-Src and EGFR cooperatively promote aberrant three-dimensional acinar structure and invasive behavior. Cancer Res. 2007 May 01; 67(9):4164-72.
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Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease. J Neurosci. 2004 Sep 08; 24(36):7895-902.
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The Cbl family and other ubiquitin ligases: destructive forces in control of antigen receptor signaling. Immunity. 2004 Jul; 21(1):7-17.
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Biochemical basis for the requirement of kinase activity for Cbl-dependent ubiquitinylation and degradation of a target tyrosine kinase. J Biol Chem. 2004 Aug 20; 279(34):36132-41.
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Eosinophil major basic protein stimulates neutrophil superoxide production by a class IA phosphoinositide 3-kinase and protein kinase C-zeta-dependent pathway. J Immunol. 2003 Oct 01; 171(7):3734-41.