Trinucleotide Repeat Expansion
"Trinucleotide Repeat Expansion" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An increased number of contiguous trinucleotide repeats in the DNA sequence from one generation to the next. The presence of these regions is associated with diseases such as FRAGILE X SYNDROME and MYOTONIC DYSTROPHY. Some CHROMOSOME FRAGILE SITES are composed of sequences where trinucleotide repeat expansion occurs.
| Descriptor ID |
D019680
|
| MeSH Number(s) |
G02.111.570.080.708.800.140.865 G02.111.570.080.708.800.500.850.200 G05.360.080.708.800.074.865 G05.360.080.708.800.500.850.200 G05.360.340.024.189.220.865 G05.360.340.024.850.500.850.200 G05.365.590.220.865 G05.558.220.865
|
| Concept/Terms |
Trinucleotide Repeat Expansion- Trinucleotide Repeat Expansion
- Expansion, Trinucleotide Repeat
- Expansions, Trinucleotide Repeat
- Repeat Expansion, Trinucleotide
- Repeat Expansions, Trinucleotide
- Trinucleotide Repeat Expansions
- Expanded Trinucleotide Repeat
- Expanded Trinucleotide Repeats
- Repeat, Expanded Trinucleotide
- Repeats, Expanded Trinucleotide
- Trinucleotide Repeat, Expanded
- Trinucleotide Repeats, Expanded
|
Below are MeSH descriptors whose meaning is more general than "Trinucleotide Repeat Expansion".
Below are MeSH descriptors whose meaning is more specific than "Trinucleotide Repeat Expansion".
This graph shows the total number of publications written about "Trinucleotide Repeat Expansion" by people in this website by year, and whether "Trinucleotide Repeat Expansion" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 2 | 1 | 3 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2013 | 2 | 0 | 2 |
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 2 | 2 |
| 2016 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Trinucleotide Repeat Expansion" by people in Profiles.
-
Fragile X Gray Zone Alleles Are Associated With Signs of Parkinsonism and Earlier Death. Mov Disord. 2020 08; 35(8):1448-1456.
-
Clinical Phenotype of Adult Fragile X Gray Zone Allele Carriers: a Case Series. Cerebellum. 2016 10; 15(5):623-31.
-
Clinical-Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS): Implications for Clinical Trials. JAMA Neurol. 2016 Jan; 73(1):102-10.
-
Characterization and Early Detection of Balance Deficits in Fragile X Premutation Carriers With and Without Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS). Cerebellum. 2015 Dec; 14(6):650-62.
-
Neurological and endocrine phenotypes of fragile X carrier women. Clin Genet. 2016 Jan; 89(1):60-7.
-
Fragile X gene expansions are not associated with dementia. Neurobiol Aging. 2014 Nov; 35(11):2637-2638.
-
Development of a genomic DNA reference material panel for myotonic dystrophy type 1 (DM1) genetic testing. J Mol Diagn. 2013 Jul; 15(4):518-25.
-
Fragile X AGG analysis provides new risk predictions for 45-69 repeat alleles. Am J Med Genet A. 2013 Apr; 161A(4):771-8.
-
FMR1 gray-zone alleles: association with Parkinson's disease in women? Mov Disord. 2011 Aug 15; 26(10):1900-6.
-
Huntington's disease - clinical signs, symptoms, presymptomatic diagnosis, and diagnosis. Handb Clin Neurol. 2011; 100:3-13.