"Microbial Collagenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 3.4.24.3.
| Descriptor ID |
D003012
|
| MeSH Number(s) |
D08.811.277.656.300.480.205.500 D08.811.277.656.675.374.205.500
|
| Concept/Terms |
Microbial Collagenase- Microbial Collagenase
- Clostridium histolyticum Collagenase
- Collagenase, Clostridium histolyticum
- Nucleolysin
- Collagenase, Microbial
- Collalysine
- Clostridiopeptidase A
- Collagenase Clostridium histolyticum
- Clostridium histolyticum, Collagenase
- histolyticum, Collagenase Clostridium
|
Below are MeSH descriptors whose meaning is more general than "Microbial Collagenase".
Below are MeSH descriptors whose meaning is more specific than "Microbial Collagenase".
This graph shows the total number of publications written about "Microbial Collagenase" by people in this website by year, and whether "Microbial Collagenase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 2 | 0 | 2 |
| 2015 | 0 | 1 | 1 |
| 2018 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Microbial Collagenase" by people in Profiles.
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Characteristics of Men With Peyronie's Disease and Collagenase Clostridium Histolyticum Treatment Failure: Predictors of Surgical Intervention and Outcomes. J Sex Med. 2020 05; 17(5):1005-1011.
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Re: Re: Limited success with clostridium collagenase histolyticum following FDA approval for the treatment of Peyronie's disease. Int J Impot Res. 2020 03; 32(2):257-258.
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Limited success with clostridium collagenase histolyticum following FDA approval for the treatment of Peyronie's disease. Int J Impot Res. 2019 Jan; 31(1):15-19.
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Contemporary Review of Peyronie's Disease Treatment. Curr Urol Rep. 2018 May 17; 19(7):51.
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Pharmacologic therapy for Peyronie's disease: what should we prescribe? Expert Opin Pharmacother. 2015 Jun; 16(9):1299-311.
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Clinical safety and effectiveness of collagenase clostridium histolyticum injection in patients with Peyronie's disease: a phase 3 open-label study. J Sex Med. 2015 Jan; 12(1):248-58.
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Surgical correction of persistent Peyronie's disease following collagenase clostridium histolyticum treatment. J Sex Med. 2015 Jan; 12(1):259-64.
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Baseline characteristics from an ongoing phase 3 study of collagenase clostridium histolyticum in patients with Peyronie's disease. J Sex Med. 2013 Nov; 10(11):2822-31.
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Phase 2b study of the clinical efficacy and safety of collagenase Clostridium histolyticum in patients with Peyronie disease. J Urol. 2012 Jun; 187(6):2268-74.
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Strain-controlled enzymatic cleavage of collagen in loaded matrix. Biochem Biophys Res Commun. 2005 Oct 21; 336(2):483-9.