 Motor Neuron Disease
"Motor Neuron Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)
| Descriptor ID |
D016472
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| MeSH Number(s) |
C10.574.562 C10.668.467
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| Concept/Terms |
Motor Neuron Disease- Motor Neuron Disease
- Motor Neuron Diseases
- Neuron Disease, Motor
- Neuron Diseases, Motor
- Motor System Disease
- Motor System Diseases
Lateral Sclerosis- Lateral Sclerosis
- Lateral Scleroses
- Scleroses, Lateral
- Sclerosis, Lateral
- Primary Lateral Sclerosis
- Lateral Scleroses, Primary
- Lateral Sclerosis, Primary
- Primary Lateral Scleroses
- Scleroses, Primary Lateral
- Sclerosis, Primary Lateral
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Below are MeSH descriptors whose meaning is more general than "Motor Neuron Disease".
Below are MeSH descriptors whose meaning is more specific than "Motor Neuron Disease".
This graph shows the total number of publications written about "Motor Neuron Disease" by people in this website by year, and whether "Motor Neuron Disease" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 1 | 0 | 1 | | 1994 | 1 | 0 | 1 | | 2002 | 0 | 1 | 1 | | 2007 | 1 | 1 | 2 |
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Below are the most recent publications written about "Motor Neuron Disease" by people in Profiles.
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Duffy JR, Peach RK, Strand EA. Progressive apraxia of speech as a sign of motor neuron disease. Am J Speech Lang Pathol. 2007 Aug; 16(3):198-208.
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Cairns NJ, Neumann M, Bigio EH, Holm IE, Troost D, Hatanpaa KJ, Foong C, White CL, Schneider JA, Kretzschmar HA, Carter D, Taylor-Reinwald L, Paulsmeyer K, Strider J, Gitcho M, Goate AM, Morris JC, Mishra M, Kwong LK, Stieber A, Xu Y, Forman MS, Trojanowski JQ, Lee VM, Mackenzie IR. TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions. Am J Pathol. 2007 Jul; 171(1):227-40.
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Gordon AJ, Meriggioli MN. Clinical immunopharmacology of autoimmune neuropathies and myopathies. Clin Neuropharmacol. 2002 May-Jun; 25(3):174-81.
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Banerjee P, Boyers MJ, Berry-Kravis E, Dawson G. Preferential beta-hexosaminidase (Hex) A (alpha beta) formation in the absence of beta-Hex B (beta beta) due to heterozygous point mutations present in beta-Hex beta-chain alleles of a motor neuron disease patient. J Biol Chem. 1994 Feb 18; 269(7):4819-26.
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Appelbaum JS, Roos RP, Salazar-Grueso EF, Buchman A, Iannaccone S, Glantz R, Siddique T, Maselli R. Intrafamilial heterogeneity in hereditary motor neuron disease. Neurology. 1992 Aug; 42(8):1488-92.
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