 Apolipoproteins E
"Apolipoproteins E" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.
| Descriptor ID |
D001057
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| MeSH Number(s) |
D10.532.091.500 D12.776.070.400.500 D12.776.521.120.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Apolipoproteins E".
Below are MeSH descriptors whose meaning is more specific than "Apolipoproteins E".
This graph shows the total number of publications written about "Apolipoproteins E" by people in this website by year, and whether "Apolipoproteins E" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1997 | 1 | 0 | 1 | | 1999 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2001 | 1 | 0 | 1 | | 2002 | 2 | 5 | 7 | | 2003 | 2 | 1 | 3 | | 2004 | 1 | 0 | 1 | | 2005 | 3 | 3 | 6 | | 2006 | 0 | 1 | 1 | | 2007 | 0 | 2 | 2 | | 2009 | 1 | 0 | 1 | | 2010 | 1 | 2 | 3 | | 2011 | 3 | 1 | 4 | | 2012 | 0 | 3 | 3 | | 2013 | 3 | 3 | 6 | | 2014 | 1 | 1 | 2 | | 2015 | 2 | 3 | 5 | | 2016 | 0 | 4 | 4 | | 2017 | 2 | 3 | 5 | | 2018 | 5 | 3 | 8 | | 2019 | 0 | 3 | 3 | | 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Apolipoproteins E" by people in Profiles.
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Arnold M, Nho K, Kueider-Paisley A, Massaro T, Huynh K, Brauner B, MahmoudianDehkordi S, Louie G, Moseley MA, Thompson JW, John-Williams LS, Tenenbaum JD, Blach C, Chang R, Brinton RD, Baillie R, Han X, Trojanowski JQ, Shaw LM, Martins R, Weiner MW, Trushina E, Toledo JB, Meikle PJ, Bennett DA, Krumsiek J, Doraiswamy PM, Saykin AJ, Kaddurah-Daouk R, Kastenmüller G. Sex and APOE e4 genotype modify the Alzheimer's disease serum metabolome. Nat Commun. 2020 03 02; 11(1):1148.
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Bourassa P, Tremblay C, Schneider JA, Bennett DA, Calon F. Beta-amyloid pathology in human brain microvessel extracts from the parietal cortex: relation with cerebral amyloid angiopathy and Alzheimer's disease. Acta Neuropathol. 2019 05; 137(5):801-823.
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Felsky D, Roostaei T, Nho K, Risacher SL, Bradshaw EM, Petyuk V, Schneider JA, Saykin A, Bennett DA, De Jager PL. Neuropathological correlates and genetic architecture of microglial activation in elderly human brain. Nat Commun. 2019 01 24; 10(1):409.
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Zammit AR, Muniz-Terrera G, Katz MJ, Hall CB, Ezzati A, Bennett DA, Lipton RB. Subtypes Based on Neuropsychological Performance Predict Incident Dementia: Findings from the Rush Memory and Aging Project. J Alzheimers Dis. 2019; 67(1):125-135.
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Rajan KB, Barnes LL, Wilson RS, Weuve J, McAninch EA, Evans DA. Apolipoprotein E Genotypes, Age, Race, and Cognitive Decline in a Population Sample. J Am Geriatr Soc. 2019 04; 67(4):734-740.
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González HM, Tarraf W, Jian X, Vásquez PM, Kaplan R, Thyagarajan B, Daviglus M, Lamar M, Gallo LC, Zeng D, Fornage M. Apolipoprotein E genotypes among diverse middle-aged and older Latinos: Study of Latinos-Investigation of Neurocognitive Aging results (HCHS/SOL). Sci Rep. 2018 12 13; 8(1):17578.
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Lee S, Zhou X, Gao Y, Vardarajan B, Reyes-Dumeyer D, Rajan KB, Wilson RS, Evans DA, Besser LM, Kukull WA, Bennett DA, Brickman AM, Schupf N, Mayeux R, Barral S. Episodic memory performance in a multi-ethnic longitudinal study of 13,037 elderly. PLoS One. 2018; 13(11):e0206803.
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Broce IJ, Tan CH, Fan CC, Jansen I, Savage JE, Witoelar A, Wen N, Hess CP, Dillon WP, Glastonbury CM, Glymour M, Yokoyama JS, Elahi FM, Rabinovici GD, Miller BL, Mormino EC, Sperling RA, Bennett DA, McEvoy LK, Brewer JB, Feldman HH, Hyman BT, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Schellenberg GD, Yaffe K, Sugrue LP, Dale AM, Posthuma D, Andreassen OA, Karch CM, Desikan RS. Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease. Acta Neuropathol. 2019 02; 137(2):209-226.
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Lamar M, Yu L, Rubin LH, James BD, Barnes LL, Farfel JM, Gaiteri C, Buchman AS, Bennett DA, Schneider JA. APOE genotypes as a risk factor for age-dependent accumulation of cerebrovascular disease in older adults. Alzheimers Dement. 2019 02; 15(2):258-266.
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Hohman TJ, Dumitrescu L, Barnes LL, Thambisetty M, Beecham G, Kunkle B, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, Bennett DA, Schneider JA, Jefferson AL. Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau. JAMA Neurol. 2018 08 01; 75(8):989-998.
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