"Apolipoproteins E" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.
| Descriptor ID |
D001057
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| MeSH Number(s) |
D10.532.091.500 D12.776.070.400.500 D12.776.521.120.500
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Apolipoproteins E".
Below are MeSH descriptors whose meaning is more specific than "Apolipoproteins E".
This graph shows the total number of publications written about "Apolipoproteins E" by people in this website by year, and whether "Apolipoproteins E" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 1 | 0 | 1 |
| 2002 | 2 | 4 | 6 |
| 2003 | 2 | 1 | 3 |
| 2005 | 3 | 3 | 6 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 2 | 3 |
| 2011 | 3 | 1 | 4 |
| 2012 | 0 | 3 | 3 |
| 2013 | 3 | 3 | 6 |
| 2014 | 1 | 1 | 2 |
| 2015 | 2 | 3 | 5 |
| 2016 | 0 | 4 | 4 |
| 2017 | 2 | 3 | 5 |
| 2018 | 5 | 4 | 9 |
| 2019 | 0 | 3 | 3 |
| 2020 | 1 | 4 | 5 |
| 2021 | 3 | 5 | 8 |
| 2022 | 1 | 10 | 11 |
| 2023 | 1 | 6 | 7 |
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Below are the most recent publications written about "Apolipoproteins E" by people in Profiles.
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Association Between Triglycerides and Risk of Dementia in Community-Dwelling Older Adults: A Prospective Cohort Study. Neurology. 2023 Nov 27; 101(22):e2288-e2299.
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Associations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older Adults. JAMA Neurol. 2023 09 01; 80(9):929-939.
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A polygenic risk score for Alzheimer's disease constructed using APOE-region variants has stronger association than APOE alleles with mild cognitive impairment in Hispanic/Latino adults in the U.S. Alzheimers Res Ther. 2023 08 30; 15(1):146.
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Validation of newly derived polygenic risk scores for dementia in a prospective study of older individuals. Alzheimers Dement. 2023 Dec; 19(12):5333-5342.
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Sex differences in associations between APOE e2 and longitudinal cognitive decline. Alzheimers Dement. 2023 10; 19(10):4651-4661.
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Association of Mediterranean-DASH Intervention for Neurodegenerative Delay and Mediterranean Diets With Alzheimer Disease Pathology. Neurology. 2023 05 30; 100(22):e2259-e2268.
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Race and Apolipoprotein E-e4 Allele Status Differences in the Association Between Loneliness and Cognitive Decline. Psychosom Med. 2023 04 01; 85(3):231-237.
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Amyloid-Related Imaging Abnormalities in the DIAN-TU-001 Trial of Gantenerumab and Solanezumab: Lessons from a Trial in Dominantly Inherited Alzheimer Disease. Ann Neurol. 2022 11; 92(5):729-744.
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Eicosanoid lipidome activation in post-mortem brain tissues of individuals with APOE4 and Alzheimer's dementia. Alzheimers Res Ther. 2022 10 11; 14(1):152.
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A healthy plant-based diet was associated with slower cognitive decline in African American older adults: a biracial community-based cohort. Am J Clin Nutr. 2022 10 06; 116(4):875-886.