 Apolipoproteins E
"Apolipoproteins E" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.
| Descriptor ID |
D001057
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| MeSH Number(s) |
D10.532.091.500 D12.776.070.400.500 D12.776.521.120.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Apolipoproteins E".
Below are MeSH descriptors whose meaning is more specific than "Apolipoproteins E".
This graph shows the total number of publications written about "Apolipoproteins E" by people in this website by year, and whether "Apolipoproteins E" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1997 | 1 | 0 | 1 | | 1999 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2001 | 1 | 0 | 1 | | 2002 | 2 | 5 | 7 | | 2003 | 2 | 1 | 3 | | 2004 | 1 | 0 | 1 | | 2005 | 3 | 3 | 6 | | 2006 | 0 | 1 | 1 | | 2007 | 0 | 2 | 2 | | 2008 | 0 | 1 | 1 | | 2009 | 1 | 0 | 1 | | 2010 | 1 | 4 | 5 | | 2011 | 3 | 1 | 4 | | 2012 | 0 | 3 | 3 | | 2013 | 3 | 3 | 6 | | 2014 | 1 | 1 | 2 | | 2015 | 2 | 3 | 5 | | 2016 | 0 | 4 | 4 | | 2017 | 2 | 3 | 5 | | 2018 | 5 | 4 | 9 | | 2019 | 0 | 4 | 4 | | 2020 | 1 | 3 | 4 | | 2021 | 1 | 1 | 2 |
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Below are the most recent publications written about "Apolipoproteins E" by people in Profiles.
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Zalocusky KA, Najm R, Taubes AL, Hao Y, Yoon SY, Koutsodendris N, Nelson MR, Rao A, Bennett DA, Bant J, Amornkul DJ, Xu Q, An A, Cisne-Thomson O, Huang Y. Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer's disease. Nat Neurosci. 2021 06; 24(6):786-798.
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Wingo AP, Liu Y, Gerasimov ES, Gockley J, Logsdon BA, Duong DM, Dammer EB, Robins C, Beach TG, Reiman EM, Epstein MP, De Jager PL, Lah JJ, Bennett DA, Seyfried NT, Levey AI, Wingo TS. Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer's disease pathogenesis. Nat Genet. 2021 02; 53(2):143-146.
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Bennett DA, Knopman DS. Extending Alzheimer disease biomarker studies into the Hispanic community. Neurology. 2020 10 13; 95(15):665-666.
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Oveisgharan S, Hachinski V. No difference in dementia prediction between apolipoprotein E4 and the ischemic score. Alzheimers Dement. 2020 11; 16(11):1596-1599.
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Yang HS, White CC, Klein HU, Yu L, Gaiteri C, Ma Y, Felsky D, Mostafavi S, Petyuk VA, Sperling RA, Ertekin-Taner N, Schneider JA, Bennett DA, De Jager PL. Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology. Neuron. 2020 08 05; 107(3):496-508.e6.
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Arnold M, Nho K, Kueider-Paisley A, Massaro T, Huynh K, Brauner B, MahmoudianDehkordi S, Louie G, Moseley MA, Thompson JW, John-Williams LS, Tenenbaum JD, Blach C, Chang R, Brinton RD, Baillie R, Han X, Trojanowski JQ, Shaw LM, Martins R, Weiner MW, Trushina E, Toledo JB, Meikle PJ, Bennett DA, Krumsiek J, Doraiswamy PM, Saykin AJ, Kaddurah-Daouk R, Kastenmüller G. Sex and APOE e4 genotype modify the Alzheimer's disease serum metabolome. Nat Commun. 2020 03 02; 11(1):1148.
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Clark DO, Xu H, Moser L, Adeoye P, Lin AW, Tangney CC, Risacher SL, Saykin AJ, Considine RV, Unverzagt FW. MIND food and speed of processing training in older adults with low education, the MINDSpeed Alzheimer's disease prevention pilot trial. Contemp Clin Trials. 2019 09; 84:105814.
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Bourassa P, Tremblay C, Schneider JA, Bennett DA, Calon F. Beta-amyloid pathology in human brain microvessel extracts from the parietal cortex: relation with cerebral amyloid angiopathy and Alzheimer's disease. Acta Neuropathol. 2019 05; 137(5):801-823.
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Felsky D, Roostaei T, Nho K, Risacher SL, Bradshaw EM, Petyuk V, Schneider JA, Saykin A, Bennett DA, De Jager PL. Neuropathological correlates and genetic architecture of microglial activation in elderly human brain. Nat Commun. 2019 01 24; 10(1):409.
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Zammit AR, Muniz-Terrera G, Katz MJ, Hall CB, Ezzati A, Bennett DA, Lipton RB. Subtypes Based on Neuropsychological Performance Predict Incident Dementia: Findings from the Rush Memory and Aging Project. J Alzheimers Dis. 2019; 67(1):125-135.
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