Apolipoproteins E
"Apolipoproteins E" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.
Descriptor ID |
D001057
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MeSH Number(s) |
D10.532.091.500 D12.776.070.400.500 D12.776.521.120.500
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Apolipoproteins E".
Below are MeSH descriptors whose meaning is more specific than "Apolipoproteins E".
This graph shows the total number of publications written about "Apolipoproteins E" by people in this website by year, and whether "Apolipoproteins E" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1997 | 1 | 0 | 1 | 1999 | 0 | 1 | 1 | 2000 | 0 | 1 | 1 | 2001 | 1 | 0 | 1 | 2002 | 2 | 5 | 7 | 2003 | 2 | 1 | 3 | 2004 | 1 | 0 | 1 | 2005 | 3 | 3 | 6 | 2006 | 0 | 1 | 1 | 2007 | 0 | 2 | 2 | 2008 | 0 | 1 | 1 | 2009 | 1 | 0 | 1 | 2010 | 1 | 4 | 5 | 2011 | 3 | 1 | 4 | 2012 | 0 | 3 | 3 | 2013 | 3 | 3 | 6 | 2014 | 1 | 1 | 2 | 2015 | 2 | 3 | 5 | 2016 | 0 | 4 | 4 | 2017 | 2 | 3 | 5 | 2018 | 5 | 4 | 9 | 2019 | 0 | 4 | 4 | 2020 | 1 | 4 | 5 | 2021 | 3 | 4 | 7 | 2022 | 1 | 1 | 2 |
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Below are the most recent publications written about "Apolipoproteins E" by people in Profiles.
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Wang S, Li B, Solomon V, Fonteh A, Rapoport SI, Bennett DA, Arvanitakis Z, Chui HC, Sullivan PM, Yassine HN. Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4. Mol Neurodegener. 2022 06 15; 17(1):42.
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Panitch R, Hu J, Xia W, Bennett DA, Stein TD, Farrer LA, Jun GR. Blood and brain transcriptome analysis reveals APOE genotype-mediated and immune-related pathways involved in Alzheimer disease. Alzheimers Res Ther. 2022 02 09; 14(1):30.
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Dugan AJ, Nelson PT, Katsumata Y, Shade LMP, Boehme KL, Teylan MA, Cykowski MD, Mukherjee S, Kauwe JSK, Hohman TJ, Schneider JA. Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study. Acta Neuropathol Commun. 2021 09 15; 9(1):152.
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Ma Y, Yu L, Olah M, Smith R, Oatman SR, Allen M, Pishva E, Zhang B, Menon V, Ertekin-Taner N, Lunnon K, Bennett DA, Klein HU, De Jager PL. Epigenomic features related to microglia are associated with attenuated effect of APOE e4 on Alzheimer's disease risk in humans. Alzheimers Dement. 2022 04; 18(4):688-699.
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Dhana K, Barnes LL, Liu X, Agarwal P, Desai P, Krueger KR, Holland TM, Halloway S, Aggarwal NT, Evans DA, Rajan KB. Genetic risk, adherence to a healthy lifestyle, and cognitive decline in African Americans and European Americans. Alzheimers Dement. 2022 04; 18(4):572-580.
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Zalocusky KA, Najm R, Taubes AL, Hao Y, Yoon SY, Koutsodendris N, Nelson MR, Rao A, Bennett DA, Bant J, Amornkul DJ, Xu Q, An A, Cisne-Thomson O, Huang Y. Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer's disease. Nat Neurosci. 2021 06; 24(6):786-798.
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Deters KD, Mormino EC, Yu L, Lutz MW, Bennett DA, Barnes LL. TOMM40-APOE haplotypes are associated with cognitive decline in non-demented Blacks. Alzheimers Dement. 2021 08; 17(8):1287-1296.
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Wingo AP, Liu Y, Gerasimov ES, Gockley J, Logsdon BA, Duong DM, Dammer EB, Robins C, Beach TG, Reiman EM, Epstein MP, De Jager PL, Lah JJ, Bennett DA, Seyfried NT, Levey AI, Wingo TS. Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer's disease pathogenesis. Nat Genet. 2021 02; 53(2):143-146.
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Ayton S, Portbury S, Kalinowski P, Agarwal P, Diouf I, Schneider JA, Morris MC, Bush AI. Regional brain iron associated with deterioration in Alzheimer's disease: A large cohort study and theoretical significance. Alzheimers Dement. 2021 07; 17(7):1244-1256.
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Fransquet PD, Lacaze P, Saffery R, Phung J, Parker E, Shah RC, Murray A, Woods RL, Ryan J. DNA methylation analysis of candidate genes associated with dementia in peripheral blood. Epigenomics. 2020 12; 12(23):2109-2123.
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