Thyroxine
"Thyroxine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
Descriptor ID |
D013974
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MeSH Number(s) |
D06.472.931.812 D12.125.072.050.767
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Concept/Terms |
Thyroxine- Thyroxine
- L-3,5,3',5'-Tetraiodothyronine
- L-Thyroxine
- L Thyroxine
- Thyroxin
- O-(4-Hydroxy-3,5-diiodophenyl) 3,5-diiodo-L-tyrosine
- O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine
- T4 Thyroid Hormone
- Thyroid Hormone, T4
- 3,5,3',5'-Tetraiodothyronine
- Levothyroxine
Levothroid- Levothroid
- Aventis Brand of Levothyroxine Sodium
- Forest Brand of Levothyroxine Sodium
Levoxyl- Levoxyl
- Monarch Brand of Levothyroxine Sodium
Lévothyrox- Lévothyrox
- Merck Lipha Santé Brand of Levothyroxine Sodium
Novothyrox- Novothyrox
- Genpharm Brand of Levothyroxine Sodium
Oroxine- Oroxine
- Sigma Brand of Levothyroxine Sodium
Synthroid- Synthroid
- Abbot Brand of Levothyroxine Sodium
Synthrox- Synthrox
- Vortex Brand of Levothyroxine Sodium
Thyrax- Thyrax
- Nourypharma Brand of Levothyroxine Sodium
Tiroidine- Tiroidine
- Rudefsa Brand of Levothyroxine Sodium
Tiroxina Leo- Tiroxina Leo
- Leo, Tiroxina
- Byk Brand of Levothyroxine Sodium
Unithroid- Unithroid
- Watson Brand of Levothyroxine Sodium
Berlthyrox- Berlthyrox
- Berlin-Chemie Brand of Levothyroxine Sodium
- Berlin Chemie Brand of Levothyroxine Sodium
Dexnon- Dexnon
- Kern Brand of Levothyroxine Sodium
Eferox- Eferox
- Hexal Brand 1 of Levothyroxine Sodium
Eltroxin- Eltroxin
- GlaxoSmithKline Brand of Levothyroxine Sodium
- Goldshield Brand of Levothyroxine Sodium
- Thevier
- Allphar Brand of Levothyroxine Sodium
- GlaxoWellcome Brand of Levothyroxine Sodium
Euthyrox- Euthyrox
- Merck Brand of Levothyroxine Sodium
- Eutirox
L-Thyrox- L-Thyrox
- L Thyrox
- Hexal Brand 2 of Levothyroxine Sodium
L-Thyroxin beta- L-Thyroxin beta
- L Thyroxin beta
- LThyroxin beta
- betapharm Brand of Levothyroxine Sodium
L-Thyroxin Henning- L-Thyroxin Henning
- L Thyroxin Henning
- LThyroxin Henning
- Sanofi Synthelabo Brand of Levothyroxine Sodium
- Henning Berlin Brand of Levothyroxine Sodium
L-Thyroxine Roche- L-Thyroxine Roche
- L Thyroxine Roche
- Roche Brand of Levothyroxine Sodium
Levo-T- Levo-T
- Levo T
- LevoT
- Mova Brand of Levothyroxine Sodium
Levothyroxin Deladande- Levothyroxin Deladande
- Deladande, Levothyroxin
- Levothyroxin Delalande
- Delalande, Levothyroxin
- Delalande Brand of Levothyroxine Sodium
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Below are MeSH descriptors whose meaning is more general than "Thyroxine".
Below are MeSH descriptors whose meaning is more specific than "Thyroxine".
This graph shows the total number of publications written about "Thyroxine" by people in this website by year, and whether "Thyroxine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1981 | 0 | 1 | 1 | 1984 | 1 | 0 | 1 | 1985 | 2 | 0 | 2 | 1986 | 1 | 0 | 1 | 1987 | 1 | 2 | 3 | 1989 | 0 | 1 | 1 | 1991 | 1 | 0 | 1 | 1992 | 1 | 0 | 1 | 1993 | 1 | 0 | 1 | 1997 | 1 | 0 | 1 | 1999 | 0 | 1 | 1 | 2000 | 1 | 2 | 3 | 2002 | 0 | 3 | 3 | 2003 | 0 | 3 | 3 | 2004 | 0 | 1 | 1 | 2005 | 2 | 2 | 4 | 2006 | 2 | 0 | 2 | 2007 | 0 | 2 | 2 | 2008 | 1 | 1 | 2 | 2009 | 2 | 0 | 2 | 2010 | 0 | 1 | 1 | 2011 | 2 | 0 | 2 | 2013 | 2 | 1 | 3 | 2014 | 1 | 2 | 3 | 2015 | 5 | 1 | 6 | 2016 | 2 | 0 | 2 | 2017 | 2 | 0 | 2 | 2018 | 0 | 3 | 3 | 2020 | 3 | 1 | 4 | 2021 | 2 | 0 | 2 |
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Below are the most recent publications written about "Thyroxine" by people in Profiles.
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Shakir MKM, Brooks DI, McAninch EA, Fonseca TL, Mai VQ, Bianco AC, Hoang TD. Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism. J Clin Endocrinol Metab. 2021 10 21; 106(11):e4400-e4413.
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Jonklaas J, Bianco AC, Cappola AR, Celi FS, Fliers E, Heuer H, McAninch EA, Moeller LC, Nygaard B, Sawka AM, Watt T, Dayan CM. Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document. Thyroid. 2021 02; 31(2):156-182.
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Bocco BMLC, Fernandes GW, Fonseca TL, Bianco AC. Iodine Deficiency Increases Fat Contribution to Energy Expenditure in Male Mice. Endocrinology. 2020 12 01; 161(12).
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Ettleson MD, Bianco AC. Individualized Therapy for Hypothyroidism: Is T4 Enough for Everyone? J Clin Endocrinol Metab. 2020 09 01; 105(9).
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Bianco AC, Taylor P. Levothyroxine treatment and cholesterol in hypothyroidism. Nat Rev Endocrinol. 2020 04; 16(4):193-194.
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McKeever L, Peterson SJ, Lateef O, Freels S, Fonseca TL, Bocco BMLC, Fernandes GW, Roehl K, Nowak K, Mozer M, Bianco AC, Braunschweig CA. Higher Caloric Exposure in Critically Ill Patients Transiently Accelerates Thyroid Hormone Activation. J Clin Endocrinol Metab. 2020 02 01; 105(2).
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Jo S, Fonseca TL, Bocco BMLC, Fernandes GW, McAninch EA, Bolin AP, Da Conceição RR, Werneck-de-Castro JP, Ignacio DL, Egri P, Németh D, Fekete C, Bernardi MM, Leitch VD, Mannan NS, Curry KF, Butterfield NC, Bassett JHD, Williams GR, Gereben B, Ribeiro MO, Bianco AC. Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain. J Clin Invest. 2019 01 02; 129(1):230-245.
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Bianco AC, Kim BS. Pathophysiological relevance of deiodinase polymorphism. Curr Opin Endocrinol Diabetes Obes. 2018 10; 25(5):341-346.
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Peterson SJ, Cappola AR, Castro MR, Dayan CM, Farwell AP, Hennessey JV, Kopp PA, Ross DS, Samuels MH, Sawka AM, Taylor PN, Jonklaas J, Bianco AC. An Online Survey of Hypothyroid Patients Demonstrates Prominent Dissatisfaction. Thyroid. 2018 06; 28(6):707-721.
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Shaoba A, Basu S, Mantis S, Minutti C. Serum Thyroid-Stimulating Hormone Levels and Body Mass Index Percentiles in Children with Primary Hypothyroidism on Levothyroxine Replacement. J Clin Res Pediatr Endocrinol. 2017 Dec 15; 9(4):337-343.
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