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Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation.
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Transcriptional activation of bovine mimecan by p53 through an intronic DNA-binding site.
Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2.
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Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2.
Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2. J Biol Chem. 1999 Jun 04; 274(23):16531-5.
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PubMed
subject areas
Humans
Nuclear Proteins
Point Mutation
Protein Conformation
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-mdm2
Tumor Cells, Cultured
Tumor Suppressor Protein p53
Ubiquitins
Ultraviolet Rays
Zinc Fingers
authors with profiles
Carl G Maki