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MDM2 can promote the ubiquitination, nuclear export, and degradation of p53 in the absence of direct binding.
The MDM2 RING-finger domain is required to promote p53 nuclear export.
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The MDM2 RING-finger domain is required to promote p53 nuclear export.
The MDM2 RING-finger domain is required to promote p53 nuclear export. Nat Cell Biol. 2000 Sep; 2(9):569-73.
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PubMed
subject areas
Active Transport, Cell Nucleus
Cell Nucleus
Humans
Nuclear Proteins
Protein Structure, Tertiary
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-mdm2
Tumor Cells, Cultured
Tumor Suppressor Protein p53
Ubiquitins
Zinc Fingers
authors with profiles
Carl G Maki