"Insulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Descriptor ID |
D007328
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MeSH Number(s) |
D06.472.699.587.200.500.625 D12.644.548.586.200.500.625
|
Concept/Terms |
Insulin- Insulin
- Insulin, Regular
- Regular Insulin
- Soluble Insulin
- Insulin, Soluble
|
Below are MeSH descriptors whose meaning is more general than "Insulin".
Below are MeSH descriptors whose meaning is more specific than "Insulin".
This graph shows the total number of publications written about "Insulin" by people in this website by year, and whether "Insulin" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2007 | 1 | 0 | 1 |
2013 | 0 | 1 | 1 |
2014 | 0 | 1 | 1 |
2015 | 2 | 0 | 2 |
2016 | 0 | 1 | 1 |
2017 | 1 | 0 | 1 |
2020 | 0 | 1 | 1 |
2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Insulin" by people in Profiles.
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The D2D3 form of uPAR acts as an immunotoxin and may cause diabetes and kidney disease. Sci Transl Med. 2023 09 20; 15(714):eabq6492.
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Raptor levels are critical for ?-cell adaptation to a high-fat diet in male mice. Mol Metab. 2023 09; 75:101769.
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Liberal versus conservative intravenous fluid administration in pediatric diabetic ketoacidosis. Acad Emerg Med. 2022 Nov; 29(11):1399-1400.
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Novel roles of mTORC2 in regulation of insulin secretion by actin filament remodeling. Am J Physiol Endocrinol Metab. 2022 08 01; 323(2):E133-E144.
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Evaluation and Management of the Critically Ill Adult With Diabetic Ketoacidosis. J Emerg Med. 2020 Sep; 59(3):371-383.
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Pancreatic and duodenal homeobox-1 (PDX1) contributes to ?-cell mass expansion and proliferation induced by Akt/PKB pathway. Islets. 2020 03 03; 12(2):32-40.
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A Comparison of Insulin Doses for the Treatment of Hyperkalemia in Patients with Renal Insufficiency. Pharmacotherapy. 2017 12; 37(12):1516-1522.
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Loss of mTORC1 signalling impairs ?-cell homeostasis and insulin processing. Nat Commun. 2017 07 12; 8:16014.
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Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function. Blood. 2017 09 21; 130(12):1445-1455.
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?-Cell deletion of Nr4a1 and Nr4a3 nuclear receptors impedes mitochondrial respiration and insulin secretion. Am J Physiol Endocrinol Metab. 2016 07 01; 311(1):E186-201.