 Apolipoprotein E4
"Apolipoprotein E4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.
| Descriptor ID |
D053327
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| MeSH Number(s) |
D10.532.091.500.750 D12.776.070.400.500.750 D12.776.521.120.500.750
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| Concept/Terms |
Apolipoprotein E4- Apolipoprotein E4
- Apolipoprotein E-4
- Apolipoprotein E 4
- Apo E4
- ApoE4
- Apo E epsilon 4
- Apo E-4
- Apo E 4
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Below are MeSH descriptors whose meaning is more general than "Apolipoprotein E4".
Below are MeSH descriptors whose meaning is more specific than "Apolipoprotein E4".
This graph shows the total number of publications written about "Apolipoprotein E4" by people in this website by year, and whether "Apolipoprotein E4" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2002 | 0 | 2 | 2 | | 2003 | 0 | 2 | 2 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 4 | 4 | | 2006 | 0 | 2 | 2 | | 2007 | 1 | 1 | 2 | | 2009 | 2 | 4 | 6 | | 2010 | 0 | 2 | 2 | | 2011 | 1 | 0 | 1 | | 2012 | 2 | 2 | 4 | | 2013 | 5 | 1 | 6 | | 2014 | 3 | 3 | 6 | | 2015 | 2 | 2 | 4 | | 2016 | 4 | 1 | 5 | | 2017 | 1 | 2 | 3 | | 2018 | 1 | 1 | 2 | | 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Apolipoprotein E4" by people in Profiles.
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Felsky D, Roostaei T, Nho K, Risacher SL, Bradshaw EM, Petyuk V, Schneider JA, Saykin A, Bennett DA, De Jager PL. Neuropathological correlates and genetic architecture of microglial activation in elderly human brain. Nat Commun. 2019 01 24; 10(1):409.
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Yang HS, Yu L, White CC, Chibnik LB, Chhatwal JP, Sperling RA, Bennett DA, Schneider JA, De Jager PL. Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE e4 haplotype status: a community-based cohort study. Lancet Neurol. 2018 09; 17(9):773-781.
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Weuve J, Barnes LL, Mendes de Leon CF, Rajan KB, Beck T, Aggarwal NT, Hebert LE, Bennett DA, Wilson RS, Evans DA. Cognitive Aging in Black and White Americans: Cognition, Cognitive Decline, and Incidence of Alzheimer Disease Dementia. Epidemiology. 2018 01; 29(1):151-159.
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Yu L, Lutz MW, Wilson RS, Burns DK, Roses AD, Saunders AM, Yang J, Gaiteri C, De Jager PL, Barnes LL, Bennett DA. APOE e4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African Americans. PLoS One. 2017; 12(7):e0180356.
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Jun GR, Chung J, Mez J, Barber R, Beecham GW, Bennett DA, Buxbaum JD, Byrd GS, Carrasquillo MM, Crane PK, Cruchaga C, De Jager P, Ertekin-Taner N, Evans D, Fallin MD, Foroud TM, Friedland RP, Goate AM, Graff-Radford NR, Hendrie H, Hall KS, Hamilton-Nelson KL, Inzelberg R, Kamboh MI, Kauwe JSK, Kukull WA, Kunkle BW, Kuwano R, Larson EB, Logue MW, Manly JJ, Martin ER, Montine TJ, Mukherjee S, Naj A, Reiman EM, Reitz C, Sherva R, St George-Hyslop PH, Thornton T, Younkin SG, Vardarajan BN, Wang LS, Wendlund JR, Winslow AR. Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimers Dement. 2017 Jul; 13(7):727-738.
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Yarchoan M, James BD, Shah RC, Arvanitakis Z, Wilson RS, Schneider J, Bennett DA, Arnold SE. Association of Cancer History with Alzheimer's Disease Dementia and Neuropathology. J Alzheimers Dis. 2017; 56(2):699-706.
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Rajan KB, Aggarwal NT, Schneider JA, Wilson RS, Everson-Rose SA, Evans DA. Role of APOE e4 Allele and Incident Stroke on Cognitive Decline and Mortality. Alzheimer Dis Assoc Disord. 2016 Oct-Dec; 30(4):318-323.
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Nation DA, Preis SR, Beiser A, Bangen KJ, Delano-Wood L, Lamar M, Libon DJ, Seshadri S, Wolf PA, Au R. Pulse Pressure Is Associated With Early Brain Atrophy and Cognitive Decline: Modifying Effects of APOE-e4. Alzheimer Dis Assoc Disord. 2016 Jul-Sep; 30(3):210-5.
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Chouraki V, Reitz C, Maury F, Bis JC, Bellenguez C, Yu L, Jakobsdottir J, Mukherjee S, Adams HH, Choi SH, Larson EB, Fitzpatrick A, Uitterlinden AG, de Jager PL, Hofman A, Gudnason V, Vardarajan B, Ibrahim-Verbaas C, van der Lee SJ, Lopez O, Dartigues JF, Berr C, Amouyel P, Bennett DA, van Duijn C, DeStefano AL, Launer LJ, Ikram MA, Crane PK, Lambert JC, Mayeux R, Seshadri S. Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer's Disease. J Alzheimers Dis. 2016 06 18; 53(3):921-32.
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van de Rest O, Wang Y, Barnes LL, Tangney C, Bennett DA, Morris MC. APOE e4 and the associations of seafood and long-chain omega-3 fatty acids with cognitive decline. Neurology. 2016 05 31; 86(22):2063-70.
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