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Joshua J. Jacobs

TitleProfessor
InstitutionRush University, Rush Medical College
DepartmentOrthopedic Surgery
Phone312-942-5450
Fax312-942-2101
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    Collapse Overview 
    Collapse overview
    Other Appointments:
    The William A. Hark, MD/Susanne G. Swift Professor & Chairman
    Department of Orthopedic Surgery, Rush University Medical Center
    Associate Provost for Research, Rush University
    Vice Dean for Research, Rush Medical College

    My ORCID is 0000-0003-3902-7334.
    My Scopus ID is 56179325700.
    My NIH COMMONS name is TITANIUM.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rahman TM, Hall DJ, Darrith B, Liu S, Jacobs JJ, Pourzal R, Silverton CD. Non-ischaemic cardiomyopathy associated with elevated serum cobalt and accelerated wear of a metal-on-metal hip resurfacing. BMJ Case Rep. 2022 Jun 27; 15(6). PMID: 35760505.
      View in: PubMed
    2. Berardi G, Frey-Law L, Sluka KA, Bayman EO, Coffey CS, Ecklund D, Vance CGT, Dailey DL, Burns J, Buvanendran A, McCarthy RJ, Jacobs J, Zhou XJ, Wixson R, Balach T, Brummett CM, Clauw D, Colquhoun D, Harte SE, Harris RE, Williams DA, Chang AC, Waljee J, Fisch KM, Jepsen K, Laurent LC, Olivier M, Langefeld CD, Howard TD, Fiehn O, Jacobs JM, Dakup P, Qian WJ, Swensen AC, Lokshin A, Lindquist M, Caffo BS, Crainiceanu C, Zeger S, Kahn A, Wager T, Taub M, Ford J, Sutherland SP, Wandner LD. Multi-Site Observational Study to Assess Biomarkers for Susceptibility or Resilience to Chronic Pain: The Acute to Chronic Pain Signatures (A2CPS) Study Protocol. Front Med (Lausanne). 2022; 9:849214. PMID: 35547202.
      View in: PubMed
    3. Mell SP, Wimmer MA, Jacobs JJ, Lundberg HJ. Optimal surgical component alignment minimizes TKR wear - An in silico study with nine alignment parameters. J Mech Behav Biomed Mater. 2022 01; 125:104939. PMID: 34740015.
      View in: PubMed
    4. McCarthy SM, Hall DJ, Mathew MT, Jacobs JJ, Lundberg HJ, Pourzal R. Are Damage Modes Related to Microstructure and Material Loss in Severely Damaged CoCrMo Femoral Heads? Clin Orthop Relat Res. 2021 09 01; 479(9):2083-2096. PMID: 34019490.
      View in: PubMed
    5. Rajani K, Olson I, Jacobs JJ, Riviere-Cazaux C, Burns K, Carlstrom L, Schroeder M, Oh J, Howe CL, Rahman M, Sarkaria JN, Elmquist WF, Burns TC. Methods for intratumoral microdialysis probe targeting and validation in murine brain tumor models. J Neurosci Methods. 2021 11 01; 363:109321. PMID: 34390758.
      View in: PubMed
    6. Manjunath V, Badhe RV, McCoy M, Rynne J, Bhatti A, Segu A, Oral E, Jacobs JJ, Chastain P, Bijukumar D, Mathew MT. The role of Vitamin E in hip implant-related corrosion and toxicity: Initial outcome. J Mech Behav Biomed Mater. 2021 11; 123:104769. PMID: 34412025.
      View in: PubMed
    7. Gustafson JA, Pourzal R, Levine BR, Jacobs JJ, Lundberg HJ. Corrigenda. Bone Joint J. 2021 Aug; 103-B(8):1438. PMID: 34334052.
      View in: PubMed
    8. Kunz L, Brandt A, Reinacher PC, Staresina BP, Reifenstein ET, Weidemann CT, Herweg NA, Patel A, Tsitsiklis M, Kempter R, Kahana MJ, Schulze-Bonhage A, Jacobs J. A neural code for egocentric spatial maps in the human medial temporal lobe. Neuron. 2021 09 01; 109(17):2781-2796.e10. PMID: 34265253.
      View in: PubMed
    9. Jacobs J, Neeno T. The importance of recognizing and managing a rare form of angioedema: hereditary angioedema due to C1-inhibitor deficiency. Postgrad Med. 2021 Aug; 133(6):639-650. PMID: 33993830.
      View in: PubMed
    10. Caicedo MS, Flores V, Padilla A, Lauryn S, Jacobs JJ, Hallab NJ. COVID-19 (SARS-CoV-2) lymphocyte responses are associated with inflammatory biomarkers in total joint replacement surgery candidates pre-operatively. J Orthop Surg Res. 2021 Jun 30; 16(1):415. PMID: 34193239.
      View in: PubMed
    11. Yang J, Heckmann ND, Nahhas CR, Salzano MB, Ruzich GP, Jacobs JJ, Paprosky WG, Rosenberg AG, Nam D. Early outcomes of a modern cemented total knee arthroplasty : is tibial loosening a concern? Bone Joint J. 2021 Jun; 103-B(6 Supple A):51-58. PMID: 34053274.
      View in: PubMed
    12. Samelko L, Caicedo M, McAllister K, Jacobs J, Hallab NJ. Metal-induced delayed type hypersensitivity responses potentiate particle induced osteolysis in a sex and age dependent manner. PLoS One. 2021; 16(5):e0251885. PMID: 34003868.
      View in: PubMed
    13. Gendo K, Orden T, Tevrizian A, Jacobs J, Mozelsio N, Gilbert K, Lodewick M. Food Sublingual Immunotherapy Using Consistent, Cheaper and Customizable Oral Immunotherapy Solutions. J Asthma Allergy. 2021; 14:467-470. PMID: 33981149.
      View in: PubMed
    14. Wilson BM, Ross RD, Jacobs JJ, Sumner DR. Comparison of Bone Turnover Biomarkers in Serum and Urine Measured on an Automated Analytical Platform. J Appl Lab Med. 2021 04 29; 6(3):750-755. PMID: 33249435.
      View in: PubMed
    15. Royhman D, Pourzal R, Hall D, Lundberg HJ, Wimmer MA, Jacobs J, Hallab NJ, Mathew MT. Fretting-corrosion in hip taper modular junctions: The influence of topography and pH levels - An in-vitro study. J Mech Behav Biomed Mater. 2021 06; 118:104443. PMID: 33752094.
      View in: PubMed
    16. Kwon YM, Della Valle CJ, Lombardi AV, Garbuz DS, Berry DJ, Jacobs JJ. Risk Stratification Algorithm for Management of Head-Neck Taper Tribocorrosion in Patients with Metal-on-Polyethylene Total Hip Arthroplasty: Consensus Statement of the American Association of Hip and Knee Surgeons, the American Academy of Orthopaedic Surgeons, and The Hip Society. J Bone Joint Surg Am. 2021 03 03; 103(5):e18. PMID: 33411461.
      View in: PubMed
    17. Liu S, Hall DJ, Della Valle CJ, Walsh MJ, Jacobs JJ, Pourzal R. Simultaneous Characterization of Implant Wear and Tribocorrosion Debris within Its Corresponding Tissue Response Using Infrared Chemical Imaging. Biotribology (Oxf). 2021 Jun; 26. PMID: 33829077.
      View in: PubMed
    18. Keating TC, Jacobs JJ. Augmented Reality in Orthopedic Practice and Education. Orthop Clin North Am. 2021 Jan; 52(1):15-26. PMID: 33222981.
      View in: PubMed
    19. Pickworth KK, Blais D, Bagnola A, Barcelona R, Boyd JM, Brink H, Chilbert M, Galipeau D, Gengler B, Gerlach AT, Hayes C, Jacobs J, Kazmi H, Lavelle R, Lindsley J, Macaulay TE, Militello MA, Orzel L, Patel S, Simone P, Tasca K, Varnado S, Zoubek S. COVID-19 pandemic: Challenges and solutions from the cardiology pharmacist's perspective. J Am Coll Clin Pharm. 2020 Sep; 3(6):1138-1146. PMID: 32838223.
      View in: PubMed
    20. Della Valle CJ, Jacobs JJ. The Hip Society Supplement 2020. Bone Joint J. 2020 07; 102-B(7_Supple_B):1-2. PMID: 32600198.
      View in: PubMed
    21. Gustafson JA, Pourzal R, Levine BR, Jacobs JJ, Lundberg HJ. Modelling changes in modular taper micromechanics due to surgeon assembly technique in total hip arthroplasty. Bone Joint J. 2020 Jul; 102-B(7_Supple_B):33-40. PMID: 32600210.
      View in: PubMed
    22. Darrith B, Rahman TM, Ananthasubramaniam K, Culvern C, Jacobs JJ, Silverton CD. Echocardiographic Changes in the Context of Metal-on-Metal Versus Nonmetal-on-Metal Total Hip Arthroplasty. J Arthroplasty. 2020 11; 35(11):3230-3236.e3. PMID: 32665157.
      View in: PubMed
    23. Knowlton CB, Lundberg HJ, Wimmer MA, Jacobs JJ. Can a gait-dependent model predict wear on retrieved total knee arthroplasty components? Bone Joint J. 2020 Jun; 102-B(6_Supple_A):129-137. PMID: 32475284.
      View in: PubMed
    24. Wright RW, Armstrong AD, Azar FM, Bednar MS, Carpenter JE, Evans JB, Flynn JM, Garvin KL, Jacobs JJ, Kang JD, Lundy DW, Mencio GA, Murray PM, Nelson CL, Peabody T, Porter SE, Roberson JR, Saltzman CL, Sebastianelli WJ, Taitsman LA, Van Heest AE, Martin DF. The American Board of Orthopaedic Surgery Response to COVID-19. J Am Acad Orthop Surg. 2020 Jun 01; 28(11):e465-e468. PMID: 32324709.
      View in: PubMed
    25. Pourzal R, Cip J, Rad E, Laurent MP, Berger RA, Jacobs JJ, Wimmer MA. Joint line elevation and tibial slope are associated with increased polyethylene wear in cruciate-retaining total knee replacement. J Orthop Res. 2020 07; 38(7):1596-1606. PMID: 32374428.
      View in: PubMed
    26. Ngai V, Kunze J, Cip J, Laurent MP, Jacobs JJ, Wimmer MA. Backside wear of tibial polyethylene components is affected by gait pattern: A knee simulator study using rare earth tracer technology. J Orthop Res. 2020 07; 38(7):1607-1616. PMID: 32410286.
      View in: PubMed
    27. Goyal A, Miller J, Qasim SE, Watrous AJ, Zhang H, Stein JM, Inman CS, Gross RE, Willie JT, Lega B, Lin JJ, Sharan A, Wu C, Sperling MR, Sheth SA, McKhann GM, Smith EH, Schevon C, Jacobs J. Functionally distinct high and low theta oscillations in the human hippocampus. Nat Commun. 2020 05 18; 11(1):2469. PMID: 32424312.
      View in: PubMed
    28. Gupta K, Vuckovic I, Zhang S, Xiong Y, Carlson BL, Jacobs J, Olson I, Petterson XM, Macura SI, Sarkaria J, Burns TC. Radiation Induced Metabolic Alterations Associate With Tumor Aggressiveness and Poor Outcome in Glioblastoma. Front Oncol. 2020; 10:535. PMID: 32432031.
      View in: PubMed
    29. Hannon CP, Cotter EJ, Cooper HJ, Deirmengian CA, Rodriguez JA, Urban RM, Paprosky WG, Jacobs JJ. Adverse Local Tissue Reaction due to Mechanically Assisted Crevice Corrosion Presenting as Late Instability Following Metal-on-Polyethylene Total Hip Arthroplasty. J Arthroplasty. 2020 09; 35(9):2666-2670. PMID: 32389403.
      View in: PubMed
    30. Samelko L, Petfield J, McAllister K, Hsu J, Hawkinson M, Jacobs JJ, Hallab NJ. Do Battlefield Injury-acquired Indwelling Metal Fragments Induce Metal Immunogenicity? Clin Orthop Relat Res. 2020 04; 478(4):752-766. PMID: 32229747.
      View in: PubMed
    31. McGrory BJ, Jacobs JJ, Kwon YM, Fillingham Y. Standardizing terms for tribocorrosion-associated adverse local tissue reaction in total hip arthroplasty. Arthroplast Today. 2020 Jun; 6(2):196-200. PMID: 32577461.
      View in: PubMed
    32. Bernstein JA, Virchow JC, Murphy K, Maspero JF, Jacobs J, Adir Y, Humbert M, Castro M, Marsteller DA, McElhattan J, Hickey L, Garin M, Vanlandingham R, Brusselle G. Effect of fixed-dose subcutaneous reslizumab on asthma exacerbations in patients with severe uncontrolled asthma and corticosteroid sparing in patients with oral corticosteroid-dependent asthma: results from two phase 3, randomised, double-blind, placebo-controlled trials. Lancet Respir Med. 2020 05; 8(5):461-474. PMID: 32066536.
      View in: PubMed
    33. Hall DJ, Pourzal R, Jacobs JJ. What Surgeons Need to Know About Adverse Local Tissue Reaction in Total Hip Arthroplasty. J Arthroplasty. 2020 06; 35(6S):S55-S59. PMID: 32005621.
      View in: PubMed
    34. Schwartz A, Iorio R, Jacobs J. Study Of Orthopedic Surgery Times. Health Aff (Millwood). 2019 12; 38(12):2114. PMID: 31794299.
      View in: PubMed
    35. Ansell DA, Jacobs JJ. Addressing Disparities in Total Hip Replacement Outcomes: Commentary on an article by Kanu Okike, MD, MPH, et al.: "Association of Race and Ethnicity with Total Hip Arthroplasty Outcomes in a Universally Insured Population". J Bone Joint Surg Am. 2019 07 03; 101(13):e66. PMID: 31274731.
      View in: PubMed
    36. Liu S, Hall DJ, McCarthy SM, Jacobs JJ, Urban RM, Pourzal R. Fourier transform infrared spectroscopic imaging of wear and corrosion products within joint capsule tissue from total hip replacements patients. J Biomed Mater Res B Appl Biomater. 2020 02; 108(2):513-526. PMID: 31099981.
      View in: PubMed
    37. Jacobs J, Rockne RC, Hawkins-Daarud AJ, Jackson PR, Johnston SK, Kinahan P, Swanson KR. Improved model prediction of glioma growth utilizing tissue-specific boundary effects. Math Biosci. 2019 06; 312:59-66. PMID: 31009624.
      View in: PubMed
    38. Nahhas CR, Yi PH, Moric M, Puri R, Jacobs JJ, Sporer SM. High Failure at a Minimum 5-Year Follow-Up in Primary Total Hip Arthroplasty Using a Modular Femoral Trunnion. J Arthroplasty. 2019 07; 34(7):1395-1399. PMID: 30982763.
      View in: PubMed
    39. Solensky R, Jacobs J, Lester M, Lieberman P, McCafferty F, Nilsson T, Park M, Schwarz G, Soong W, Wagelie-Steffen A, Wedner HJ, Weiss M, Windom H, Tonascia J, Yates KP, Mendelson LM, Wolfe J, Adkinson NF. Penicillin Allergy Evaluation: A Prospective, Multicenter, Open-Label Evaluation of a Comprehensive Penicillin Skin Test Kit. J Allergy Clin Immunol Pract. 2019 Jul - Aug; 7(6):1876-1885.e3. PMID: 30878711.
      View in: PubMed
    40. Tornetta P, Jacobs JJ, Sterling RS, Kogan M, Fletcher KA, Friedman AM. Personality Assessment in Orthopaedic Surgery: AOA Critical Issues. J Bone Joint Surg Am. 2019 Feb 20; 101(4):e13. PMID: 30801381.
      View in: PubMed
    41. Craig T, Zuraw B, Longhurst H, Cicardi M, Bork K, Grattan C, Katelaris C, Sussman G, Keith PK, Yang W, Hébert J, Hanzlikova J, Staubach-Renz P, Martinez-Saguer I, Magerl M, Aygören-Pürsün E, Farkas H, Reshef A, Kivity S, Neri S, Crisan I, Caballero T, Baeza ML, Hernandez MD, Li H, Lumry W, Bernstein JA, Hussain I, Anderson J, Schwartz LB, Jacobs J, Manning M, Levy D, Riedl M, Christiansen S, Feuersenger H, Pragst I, Mycroft S, Pawaskar D, Jacobs I. Long-Term Outcomes with Subcutaneous C1-Inhibitor Replacement Therapy for Prevention of Hereditary Angioedema Attacks. J Allergy Clin Immunol Pract. 2019 Jul - Aug; 7(6):1793-1802.e2. PMID: 30772477.
      View in: PubMed
    42. Lumry WR, Martinez-Saguer I, Yang WH, Bernstein JA, Jacobs J, Moldovan D, Riedl MA, Johnston DT, Li HH, Tang Y, Schranz J, Lu P, Vardi M, Farkas H. Fixed-Dose Subcutaneous C1-Inhibitor Liquid for Prophylactic Treatment of C1-INH-HAE: SAHARA Randomized Study. J Allergy Clin Immunol Pract. 2019 May - Jun; 7(5):1610-1618.e4. PMID: 30682573.
      View in: PubMed
    43. Samelko L, Caicedo MS, Jacobs J, Hallab NJ. Transition from metal-DTH resistance to susceptibility is facilitated by NLRP3 inflammasome signaling induced Th17 reactivity: Implications for orthopedic implants. PLoS One. 2019; 14(1):e0210336. PMID: 30653583.
      View in: PubMed
    44. Craig T, Lumry W, Cicardi M, Zuraw B, Bernstein JA, Anderson J, Jacobs J, Riedl MA, Manning ME, Banerji A, Gower RG, Caballero T, Farkas H, Feuersenger H, Jacobs I, Machnig T, Longhurst H. Treatment effect of switching from intravenous to subcutaneous C1-inhibitor for prevention of hereditary angioedema attacks: COMPACT subgroup findings. J Allergy Clin Immunol Pract. 2019 Jul - Aug; 7(6):2035-2038. PMID: 30660873.
      View in: PubMed
    45. Hall DJ, Pourzal R, Jacobs JJ, Urban RM. Metal wear particles in hematopoietic marrow of the axial skeleton in patients with prior revision for mechanical failure of a hip or knee arthroplasty. J Biomed Mater Res B Appl Biomater. 2019 08; 107(6):1930-1936. PMID: 30501001.
      View in: PubMed
    46. Banerji A, Riedl MA, Bernstein JA, Cicardi M, Longhurst HJ, Zuraw BL, Busse PJ, Anderson J, Magerl M, Martinez-Saguer I, Davis-Lorton M, Zanichelli A, Li HH, Craig T, Jacobs J, Johnston DT, Shapiro R, Yang WH, Lumry WR, Manning ME, Schwartz LB, Shennak M, Soteres D, Zaragoza-Urdaz RH, Gierer S, Smith AM, Tachdjian R, Wedner HJ, Hebert J, Rehman SM, Staubach P, Schranz J, Baptista J, Nothaft W, Maurer M. Effect of Lanadelumab Compared With Placebo on Prevention of Hereditary Angioedema Attacks: A Randomized Clinical Trial. JAMA. 2018 11 27; 320(20):2108-2121. PMID: 30480729.
      View in: PubMed
    47. Staudigl T, Leszczynski M, Jacobs J, Sheth SA, Schroeder CE, Jensen O, Doeller CF. Hexadirectional Modulation of High-Frequency Electrophysiological Activity in the Human Anterior Medial Temporal Lobe Maps Visual Space. Curr Biol. 2018 10 22; 28(20):3325-3329.e4. PMID: 30318353.
      View in: PubMed
    48. Singh V, Skipor AK, Selim AA, Jacobs JJ. Chromium and Nickel Concentrations in Subjects with a Stainless Steel Metal-on-Metal Cervical Disc Arthroplasty: Results from a Prospective Longitudinal Study with 7 Years Follow-Up. Int J Spine Surg. 2018 Aug; 12(4):460-468. PMID: 30276106.
      View in: PubMed
    49. Pawaskar D, Tortorici MA, Zuraw B, Craig T, Cicardi M, Longhurst H, Li HH, Lumry WR, Martinez-Saguer I, Jacobs J, Bernstein JA, Riedl MA, Katelaris CH, Keith PK, Feussner A, Sidhu J. Population pharmacokinetics of subcutaneous C1-inhibitor for prevention of attacks in patients with hereditary angioedema. Clin Exp Allergy. 2018 10; 48(10):1325-1332. PMID: 29998524.
      View in: PubMed
    50. Edwards CA, Rusheen AE, Oh Y, Paek SB, Jacobs J, Lee KH, Dennis KD, Bennet KE, Kouzani AZ, Lee KH, Goerss SJ. A novel re-attachable stereotactic frame for MRI-guided neuronavigation and its validation in a large animal and human cadaver model. J Neural Eng. 2018 12; 15(6):066003. PMID: 30124202.
      View in: PubMed
    51. Ross RD, Deng Y, Fang R, Frisch NB, Jacobs JJ, Sumner DR. Discovery of biomarkers to identify peri-implant osteolysis before radiographic diagnosis. J Orthop Res. 2018 10; 36(10):2754-2761. PMID: 29873110.
      View in: PubMed
    52. Johnstone B, Jacobs JJ, Sandell LJ, Wilkinson JM. Regenerative medicine will make orthopaedic implants obsolete in our time Orthopaedic Research Society first annual meeting debate, San Diego, March 21st, 2017. J Orthop Res. 2018 10; 36(10):2579-2585. PMID: 29744929.
      View in: PubMed
    53. Landgraeber S, Samelko L, McAllister K, Putz S, Jacobs JJ, Hallab NJ. CoCrMo alloy vs. UHMWPE Particulate Implant Debris Induces Sex Dependent Aseptic Osteolysis Responses In Vivo using a Murine Model. Open Orthop J. 2018; 12:115-124. PMID: 29785221.
      View in: PubMed
    54. Pourzal R, Lundberg HJ, Hall DJ, Jacobs JJ. What Factors Drive Taper Corrosion? J Arthroplasty. 2018 09; 33(9):2707-2711. PMID: 29705684.
      View in: PubMed
    55. Courtney PM, Bohl DD, Lau EC, Ong KL, Jacobs JJ, Della Valle CJ. Risk Adjustment Is Necessary in Medicare Bundled Payment Models for Total Hip and Knee Arthroplasty. J Arthroplasty. 2018 08; 33(8):2368-2375. PMID: 29691171.
      View in: PubMed
    56. Della Valle CJ, Calkins TE, Jacobs JJ. Diagnosing Taper Corrosion: When Is It the Taper and When Is It Something Else? J Arthroplasty. 2018 09; 33(9):2712-2715. PMID: 29502964.
      View in: PubMed
    57. Royhman D, Patel M, Jacobs JJ, Wimmer MA, Hallab NJ, Mathew MT. In vitro simulation of fretting-corrosion in hip implant modular junctions: The influence of pH. Med Eng Phys. 2018 02; 52:1-9. PMID: 29290499.
      View in: PubMed
    58. Jacobs JJ, Capek S, Spinner RJ, Swanson KR. Mathematical model of perineural tumor spread: a pilot study. Acta Neurochir (Wien). 2018 03; 160(3):655-661. PMID: 29264779.
      View in: PubMed
    59. Tetreault MW, Jacobs JJ, Mahmud W, Nam D. Adverse Local Tissue Reaction After a Metal-on-Metal Total Hip Prosthesis Without Elevated Serum Metal Ion Levels. Orthopedics. 2018 May 01; 41(3):e438-e441. PMID: 29257191.
      View in: PubMed
    60. Murphy K, Jacobs J, Bjermer L, Fahrenholz JM, Shalit Y, Garin M, Zangrilli J, Castro M. Long-term Safety and Efficacy of Reslizumab in Patients with Eosinophilic Asthma. J Allergy Clin Immunol Pract. 2017 Nov - Dec; 5(6):1572-1581.e3. PMID: 29122156.
      View in: PubMed
    61. Pourzal R, Hall DJ, Ehrich J, McCarthy SM, Mathew MT, Jacobs JJ, Urban RM. Alloy Microstructure Dictates Corrosion Modes in THA Modular Junctions. Clin Orthop Relat Res. 2017 Dec; 475(12):3026-3043. PMID: 28884275.
      View in: PubMed
    62. Hall DJ, Pourzal R, Lundberg HJ, Mathew MT, Jacobs JJ, Urban RM. Mechanical, chemical and biological damage modes within head-neck tapers of CoCrMo and Ti6Al4V contemporary hip replacements. J Biomed Mater Res B Appl Biomater. 2018 07; 106(5):1672-1685. PMID: 28842959.
      View in: PubMed
    63. Fillingham YA, Della Valle CJ, Bohl DD, Kelly MP, Hall DJ, Pourzal R, Jacobs JJ. Serum Metal Levels for Diagnosis of Adverse Local Tissue Reactions Secondary to Corrosion in Metal-on-Polyethylene Total Hip Arthroplasty. J Arthroplasty. 2017 09; 32(9S):S272-S277. PMID: 28511949.
      View in: PubMed
    64. Caicedo MS, Solver E, Coleman L, Jacobs JJ, Hallab NJ. Females with Unexplained Joint Pain Following Total Joint Arthroplasty Exhibit a Higher Rate and Severity of Hypersensitivity to Implant Metals Compared with Males: Implications of Sex-Based Bioreactivity Differences. J Bone Joint Surg Am. 2017 Apr 19; 99(8):621-628. PMID: 28419029.
      View in: PubMed
    65. Longhurst H, Cicardi M, Craig T, Bork K, Grattan C, Baker J, Li HH, Reshef A, Bonner J, Bernstein JA, Anderson J, Lumry WR, Farkas H, Katelaris CH, Sussman GL, Jacobs J, Riedl M, Manning ME, Hebert J, Keith PK, Kivity S, Neri S, Levy DS, Baeza ML, Nathan R, Schwartz LB, Caballero T, Yang W, Crisan I, Hernandez MD, Hussain I, Tarzi M, Ritchie B, Králícková P, Guilarte M, Rehman SM, Banerji A, Gower RG, Bensen-Kennedy D, Edelman J, Feuersenger H, Lawo JP, Machnig T, Pawaskar D, Pragst I, Zuraw BL. Prevention of Hereditary Angioedema Attacks with a Subcutaneous C1 Inhibitor. N Engl J Med. 2017 03 23; 376(12):1131-1140. PMID: 28328347.
      View in: PubMed
    66. Gornet MF, Singh V, Schranck FW, Skipor AK, Jacobs JJ. Serum Metal Concentrations in Patients With Titanium Ceramic Composite Cervical Disc Replacements. Spine (Phila Pa 1976). 2017 Mar 15; 42(6):366-371. PMID: 27323223.
      View in: PubMed
    67. Banerji A, Busse P, Shennak M, Lumry W, Davis-Lorton M, Wedner HJ, Jacobs J, Baker J, Bernstein JA, Lockey R, Li HH, Craig T, Cicardi M, Riedl M, Al-Ghazawi A, Soo C, Iarrobino R, Sexton DJ, TenHoor C, Kenniston JA, Faucette R, Still JG, Kushner H, Mensah R, Stevens C, Biedenkapp JC, Chyung Y, Adelman B. Inhibiting Plasma Kallikrein for Hereditary Angioedema Prophylaxis. N Engl J Med. 2017 02 23; 376(8):717-728. PMID: 28225674.
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    68. Hallab NJ, Jacobs JJ. Chemokines Associated with Pathologic Responses to Orthopedic Implant Debris. Front Endocrinol (Lausanne). 2017; 8:5. PMID: 28154552.
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    69. Plummer DR, Yi PH, Jacobs JJ, Urban RM, Moric MM, Della Valle CJ. Aseptic Lymphocytic-Dominated Vasculitis-Associated Lesions Scores Do Not Correlate With Metal Ion Levels or Unreadable Synovial Fluid White Blood Cell Counts. J Arthroplasty. 2017 04; 32(4):1340-1343. PMID: 27979408.
      View in: PubMed
    70. Pourzal R, Hall DJ, Ha NQ, Urban RM, Levine BR, Jacobs JJ, Lundberg HJ. Does Surface Topography Play a Role in Taper Damage in Head-neck Modular Junctions? Clin Orthop Relat Res. 2016 Oct; 474(10):2232-42. PMID: 27339123.
      View in: PubMed
    71. Wilson J, Riff AJ, Hellman MD, Sethi S, Jacobs JJ, Gitelis S. A Novel Complication of the Dall-Miles Cable Grip System Mimicking Recurrent Synovial Chondromatosis: A Case Report and Review of the Literature. JBJS Case Connect. 2016 Oct-Dec; 6(4):e87. PMID: 29252741.
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    72. Samelko L, Landgraeber S, McAllister K, Jacobs J, Hallab NJ. Cobalt Alloy Implant Debris Induces Inflammation and Bone Loss Primarily through Danger Signaling, Not TLR4 Activation: Implications for DAMP-ening Implant Related Inflammation. PLoS One. 2016; 11(7):e0160141. PMID: 27467577.
      View in: PubMed
    73. Samelko L, Landgraeber S, McAllister K, Jacobs J, Hallab NJ. TLR4 (not TLR2) dominate cognate TLR activity associated with CoCrMo implant particles. J Orthop Res. 2017 05; 35(5):1007-1017. PMID: 27416075.
      View in: PubMed
    74. Royhman D, Patel M, Runa MJ, Wimmer MA, Jacobs JJ, Hallab NJ, Mathew MT. Fretting-corrosion behavior in hip implant modular junctions: The influence of friction energy and pH variation. J Mech Behav Biomed Mater. 2016 09; 62:570-587. PMID: 27310572.
      View in: PubMed
    75. Jacobs JJ. Corrosion of Modular Junctions: Why Is This Happening Now? J Arthroplasty. 2016 07; 31(7):1377. PMID: 27209332.
      View in: PubMed
    76. Jacobs JJ. Corrosion at the Head-Neck Junction: Why Is This Happening Now? J Arthroplasty. 2016 07; 31(7):1378-80. PMID: 27321963.
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    77. Lachiewicz PF, Watters TS, Jacobs JJ. Metal Hypersensitivity and Total Knee Arthroplasty. J Am Acad Orthop Surg. 2016 Feb; 24(2):106-12. PMID: 26752739.
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    78. Bohl DD, Wetters NG, Del Gaizo DJ, Jacobs JJ, Rosenberg AG, Della Valle CJ. Repair of Intraoperative Injury to the Medial Collateral Ligament During Primary Total Knee Arthroplasty. J Bone Joint Surg Am. 2016 Jan 06; 98(1):35-9. PMID: 26738901.
      View in: PubMed
    79. Rockne RC, Trister AD, Jacobs J, Hawkins-Daarud AJ, Neal ML, Hendrickson K, Mrugala MM, Rockhill JK, Kinahan P, Krohn KA, Swanson KR. Addendum to 'A patient-specific computational model of hypoxia-modulated radiation resistance in glioblastoma using 18F-FMISO-PET'. J R Soc Interface. 2015 Nov 06; 12(112). PMID: 26577597.
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    80. Hall DJ, Urban RM, Pourzal R, Turner TM, Skipor AK, Jacobs JJ. Nanoscale surface modification by anodic oxidation increased bone ingrowth and reduced fibrous tissue in the porous coating of titanium-alloy femoral hip arthroplasty implants. J Biomed Mater Res B Appl Biomater. 2017 02; 105(2):283-290. PMID: 26477322.
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    81. Haughom BD, Erickson BJ, Hellman MD, Jacobs JJ. Reply to letter to the editor: do complication rates differ by gender after metal-on-metal hip resurfacing arthroplasty? A systematic review. Clin Orthop Relat Res. 2015 Dec; 473(12):3983-4. PMID: 26400250.
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    82. Zhang H, Jacobs J. Traveling Theta Waves in the Human Hippocampus. J Neurosci. 2015 Sep 09; 35(36):12477-87. PMID: 26354915.
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    83. Haughom BD, Erickson BJ, Hellman MD, Jacobs JJ. Do Complication Rates Differ by Gender After Metal-on-metal Hip Resurfacing Arthroplasty? A Systematic Review. Clin Orthop Relat Res. 2015 Aug; 473(8):2521-9. PMID: 25758375.
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    84. Plummer DR, Berger RA, Paprosky WG, Sporer SM, Jacobs JJ, Della Valle CJ. Diagnosis and Management of Adverse Local Tissue Reactions Secondary to Corrosion at the Head-Neck Junction in Patients With Metal on Polyethylene Bearings. J Arthroplasty. 2016 Jan; 31(1):264-8. PMID: 26321628.
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    85. Miller JF, Fried I, Suthana N, Jacobs J. Repeating spatial activations in human entorhinal cortex. Curr Biol. 2015 Apr 20; 25(8):1080-5. PMID: 25843029.
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    86. Rockne RC, Trister AD, Jacobs J, Hawkins-Daarud AJ, Neal ML, Hendrickson K, Mrugala MM, Rockhill JK, Kinahan P, Krohn KA, Swanson KR. A patient-specific computational model of hypoxia-modulated radiation resistance in glioblastoma using 18F-FMISO-PET. J R Soc Interface. 2015 Feb 06; 12(103). PMID: 25540239.
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    87. Yi PH, Cross MB, Moric M, Levine BR, Sporer SM, Paprosky WG, Jacobs JJ, Della Valle CJ. Do serologic and synovial tests help diagnose infection in revision hip arthroplasty with metal-on-metal bearings or corrosion? Clin Orthop Relat Res. 2015 Feb; 473(2):498-505. PMID: 25171935.
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    88. Campbell PA, Kung MS, Hsu AR, Jacobs JJ. Do retrieval analysis and blood metal measurements contribute to our understanding of adverse local tissue reactions? Clin Orthop Relat Res. 2014 Dec; 472(12):3718-27. PMID: 25160942.
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    89. Novak CC, Hsu AR, Della Valle CJ, Skipor AK, Campbell P, Amstutz HC, Jiranek WA, Onyike A, Pombar XF, Jacobs JJ. Metal ion levels in maternal and placental blood after metal-on-metal total hip arthroplasty. Am J Orthop (Belle Mead NJ). 2014 Dec; 43(12):E304-8. PMID: 25490017.
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    90. Lega B, Burke J, Jacobs J, Kahana MJ. Slow-Theta-to-Gamma Phase-Amplitude Coupling in Human Hippocampus Supports the Formation of New Episodic Memories. Cereb Cortex. 2016 Jan; 26(1):268-278. PMID: 25316340.
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    91. Porter DA, Urban RM, Jacobs JJ, Gilbert JL, Rodriguez JA, Cooper HJ. Modern trunnions are more flexible: a mechanical analysis of THA taper designs. Clin Orthop Relat Res. 2014 Dec; 472(12):3963-70. PMID: 25267272.
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    92. Kwon YM, Fehring TK, Lombardi AV, Barnes CL, Cabanela ME, Jacobs JJ. Risk stratification algorithm for management of patients with dual modular taper total hip arthroplasty: consensus statement of the American Association of Hip and Knee Surgeons, the American Academy of Orthopaedic Surgeons and the Hip Society. J Arthroplasty. 2014 Nov; 29(11):2060-4. PMID: 25189673.
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    93. Jacobs JJ, Jevsevar DS, Brown GA, Cummins DS. AAOS Osteoarthritis Guideline: transparency and credibility. Arthroscopy. 2014 Jun; 30(6):656-8. PMID: 24862694.
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    94. Landgraeber S, Jäger M, Jacobs JJ, Hallab NJ. The pathology of orthopedic implant failure is mediated by innate immune system cytokines. Mediators Inflamm. 2014; 2014:185150. PMID: 24891761.
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    95. Silverton CD, Jacobs JJ, Devitt JW, Cooper HJ. Midterm results of a femoral stem with a modular neck design: clinical outcomes and metal ion analysis. J Arthroplasty. 2014 Sep; 29(9):1768-73. PMID: 24895065.
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    96. Reddy A, Caicedo MS, Samelko L, Jacobs JJ, Hallab NJ. Implant debris particle size affects serum protein adsorption which may contribute to particle size-based bioreactivity differences. J Long Term Eff Med Implants. 2014; 24(1):77-88. PMID: 24941408.
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    97. Kwon YM, Lombardi AV, Jacobs JJ, Fehring TK, Lewis CG, Cabanela ME. Risk stratification algorithm for management of patients with metal-on-metal hip arthroplasty: consensus statement of the American Association of Hip and Knee Surgeons, the American Academy of Orthopaedic Surgeons, and the Hip Society. J Bone Joint Surg Am. 2014 Jan 01; 96(1):e4. PMID: 24382732.
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    98. Panigrahi P, Liao Y, Mathew MT, Fischer A, Wimmer MA, Jacobs JJ, Marks LD. Intergranular pitting corrosion of CoCrMo biomedical implant alloy. J Biomed Mater Res B Appl Biomater. 2014 May; 102(4):850-9. PMID: 24376124.
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    99. Jacobs J. Hippocampal theta oscillations are slower in humans than in rodents: implications for models of spatial navigation and memory. Philos Trans R Soc Lond B Biol Sci. 2014 Feb 05; 369(1635):20130304. PMID: 24366145.
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    100. Ikegaki N, Hicks SL, Regan PL, Jacobs J, Jumbo AS, Leonhardt P, Rappaport EF, Tang XX. S(+)-ibuprofen destabilizes MYC/MYCN and AKT, increases p53 expression, and induces unfolded protein response and favorable phenotype in neuroblastoma cell lines. Int J Oncol. 2014 Jan; 44(1):35-43. PMID: 24173829.
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    101. Hsu AR, Levine BR, Skipor AK, Hallab NJ, Paprosky WG, Jacobs JJ. Effect of a second joint arthroplasty on metal ion levels after primary total hip arthroplasty. Am J Orthop (Belle Mead NJ). 2013 Oct; 42(10):E84-7. PMID: 24278909.
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    102. Jacobs JJ, King TR, Klippel JH, Berven SH, Burr DB, Caskey PM, Elderkin AL, Esposito PW, Gall EP, Goldring SR, Pollak AN, Sandborg CI, Templeton KJ. Beyond the decade: strategic priorities to reduce the burden of musculoskeletal disease. J Bone Joint Surg Am. 2013 Sep 04; 95(17):e1251-6. PMID: 24005209.
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    103. Jacobs J, Weidemann CT, Miller JF, Solway A, Burke JF, Wei XX, Suthana N, Sperling MR, Sharan AD, Fried I, Kahana MJ. Direct recordings of grid-like neuronal activity in human spatial navigation. Nat Neurosci. 2013 Sep; 16(9):1188-90. PMID: 23912946.
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    104. Rodriguez Merzagora A, Coffey TJ, Sperling MR, Sharan A, Litt B, Baltuch G, Jacobs J. Repeated stimuli elicit diminished high-gamma electrocorticographic responses. Neuroimage. 2014 Jan 15; 85 Pt 2:844-52. PMID: 23867555.
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    105. Caicedo MS, Samelko L, McAllister K, Jacobs JJ, Hallab NJ. Increasing both CoCrMo-alloy particle size and surface irregularity induces increased macrophage inflammasome activation in vitro potentially through lysosomal destabilization mechanisms. J Orthop Res. 2013 Oct; 31(10):1633-42. PMID: 23794526.
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    106. Samelko L, Caicedo MS, Lim SJ, Della-Valle C, Jacobs J, Hallab NJ. Cobalt-alloy implant debris induce HIF-1a hypoxia associated responses: a mechanism for metal-specific orthopedic implant failure. PLoS One. 2013; 8(6):e67127. PMID: 23840602.
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    107. Cooper HJ, Urban RM, Wixson RL, Meneghini RM, Jacobs JJ. Adverse local tissue reaction arising from corrosion at the femoral neck-body junction in a dual-taper stem with a cobalt-chromium modular neck. J Bone Joint Surg Am. 2013 May 15; 95(10):865-72. PMID: 23677352.
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    108. Jacobs JJ. Moving forward: from curses to blessings. J Am Acad Orthop Surg. 2013 May; 21(5):261-5. PMID: 23637143.
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    109. Jacobs JJ, Wimmer MA. An important contribution to our understanding of the performance of the current generation of metal-on-metal hip replacements. J Bone Joint Surg Am. 2013 Apr 17; 95(8):e53. PMID: 23595079.
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    110. Levine BR, Hsu AR, Skipor AK, Hallab NJ, Paprosky WG, Galante JO, Jacobs JJ. Ten-year outcome of serum metal ion levels after primary total hip arthroplasty: a concise follow-up of a previous report*. J Bone Joint Surg Am. 2013 Mar 20; 95(6):512-8. PMID: 23515985.
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    111. Liao Y, Hoffman E, Wimmer M, Fischer A, Jacobs J, Marks L. CoCrMo metal-on-metal hip replacements. Phys Chem Chem Phys. 2013 Jan 21; 15(3):746-56. PMID: 23196425.
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    112. Ma Y, Ren Y, Han EQ, Li H, Chen D, Jacobs JJ, Gitelis S, O'Keefe RJ, Konttinen YT, Yin G, Li TF. Inhibition of the Wnt-ß-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy. Biochem Biophys Res Commun. 2013 Feb 08; 431(2):274-9. PMID: 23291185.
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    113. Cooper HJ, Jacobs JJ, Leikin JB, Barden RM, Rosenberg AG. Elevated Serum Metal Levels from Vitamin Supplementation: A Case Report. JBJS Case Connect. 2013 Jan-Mar; 3(1):e18. PMID: 29252323.
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    114. Jacobs JJ. Large (36 or 40-mm) femoral heads decreased the rate of dislocation after revision total hip arthroplasty. J Bone Joint Surg Am. 2012 Nov 21; 94(22):2095. PMID: 23172329.
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    115. Amstutz HC, Campbell PA, Dorey FJ, Johnson AJ, Skipor AK, Jacobs JJ. Do ion concentrations after metal-on-metal hip resurfacing increase over time? A prospective study. J Arthroplasty. 2013 Apr; 28(4):695-700. PMID: 23123040.
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    116. Mathew MT, Jacobs JJ, Wimmer MA. Wear-corrosion synergism in a CoCrMo hip bearing alloy is influenced by proteins. Clin Orthop Relat Res. 2012 Nov; 470(11):3109-17. PMID: 22956237.
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    117. Urban RM, Hall DJ, Della Valle C, Wimmer MA, Jacobs JJ, Galante JO. Successful long-term fixation and progression of osteolysis associated with first-generation cementless acetabular components retrieved post mortem. J Bone Joint Surg Am. 2012 Oct 17; 94(20):1877-85. PMID: 23079880.
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    118. Cooper HJ, Della Valle CJ, Berger RA, Tetreault M, Paprosky WG, Sporer SM, Jacobs JJ. Corrosion at the head-neck taper as a cause for adverse local tissue reactions after total hip arthroplasty. J Bone Joint Surg Am. 2012 Sep 19; 94(18):1655-61. PMID: 23289127.
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    119. Hallab NJ, Caicedo M, McAllister K, Skipor A, Amstutz H, Jacobs JJ. Asymptomatic prospective and retrospective cohorts with metal-on-metal hip arthroplasty indicate acquired lymphocyte reactivity varies with metal ion levels on a group basis. J Orthop Res. 2013 Feb; 31(2):173-82. PMID: 22941579.
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    120. Jacobs JJ, An HS. Commentary: Total disc arthroplasty and the bearing surface debate. Spine J. 2012 Aug; 12(8):702-4. PMID: 23021032.
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    121. Wimmer MA, Laurent MP, Haman JD, Jacobs JJ, Galante JO. Surface damage versus tibial polyethylene insert conformity: a retrieval study. Clin Orthop Relat Res. 2012 Jul; 470(7):1814-25. PMID: 22395868.
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    122. Kwon YM, Jacobs JJ, MacDonald SJ, Potter HG, Fehring TK, Lombardi AV. Evidence-based understanding of management perils for metal-on-metal hip arthroplasty patients. J Arthroplasty. 2012 Sep; 27(8 Suppl):20-5. PMID: 22608691.
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    123. Meneghini RM, Hallab NJ, Jacobs JJ. Evaluation and treatment of painful total hip arthroplasties with modular metal taper junctions. Orthopedics. 2012 May; 35(5):386-91. PMID: 22588392.
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    124. Jacobs JJ, Mont MA, Bozic KJ, Della Valle CJ, Goodman SB, Lewis CG, Yates AC, Boggio LN, Watters WC, Turkelson CM, Wies JL, Sluka P, Hitchcock K. American Academy of Orthopaedic Surgeons clinical practice guideline on: preventing venous thromboembolic disease in patients undergoing elective hip and knee arthroplasty. J Bone Joint Surg Am. 2012 Apr 18; 94(8):746-7. PMID: 22517391.
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    125. Preventing venous thromboembolic disease in patients undergoing elective total hip and knee arthroplasty. J Bone Joint Surg Am. 2012 Apr 18; 94(8):673-4. PMID: 22517384.
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    126. Jacobs JJ. The utility of MARS MRI in patients with metal-on-metal bearings: commentary on an article by Alister J. Hart, MA, MD, FRCSG(Orth), et al.: "Pseudotumors in association with well-functioning metal-on-metal hip prostheses. a case-control study using three-dimensional computed tomography and magnetic resonance imaging". J Bone Joint Surg Am. 2012 Feb 15; 94(4):e26. PMID: 22336984.
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    127. Graves SE, Rothwell A, Tucker K, Jacobs JJ, Sedrakyan A. A multinational assessment of metal-on-metal bearings in hip replacement. J Bone Joint Surg Am. 2011 Dec 21; 93 Suppl 3:43-7. PMID: 22262422.
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    128. Mont MA, Jacobs JJ, Boggio LN, Bozic KJ, Della Valle CJ, Goodman SB, Lewis CG, Yates AJ, Watters WC, Turkelson CM, Wies JL, Donnelly P, Patel N, Sluka P. Preventing venous thromboembolic disease in patients undergoing elective hip and knee arthroplasty. J Am Acad Orthop Surg. 2011 Dec; 19(12):768-76. PMID: 22134209.
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    129. Mont MA, Jacobs JJ. AAOS clinical practice guideline: preventing venous thromboembolic disease in patients undergoing elective hip and knee arthroplasty. J Am Acad Orthop Surg. 2011 Dec; 19(12):777-8. PMID: 22134210.
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    130. Gilbert JL, Mali S, Urban RM, Silverton CD, Jacobs JJ. In vivo oxide-induced stress corrosion cracking of Ti-6Al-4V in a neck-stem modular taper: Emergent behavior in a new mechanism of in vivo corrosion. J Biomed Mater Res B Appl Biomater. 2012 Feb; 100(2):584-94. PMID: 22113876.
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    131. Jacobs J. Recurrent attacks of hereditary angioedema: a case of delayed diagnosis. Allergy Asthma Proc. 2011 Sep-Oct; 32 Suppl 1:23-26. PMID: 22195758.
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    132. Laurent MP, Pourzal R, Fischer A, Bertin KC, Jacobs JJ, Wimmer MA. In vivo wear of a squeaky alumina-on-alumina hip prosthesis: a case report. J Bone Joint Surg Am. 2011 Apr 06; 93(7):e27. PMID: 21471407.
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    133. Guyer RD, Shellock J, MacLennan B, Hanscom D, Knight RQ, McCombe P, Jacobs JJ, Urban RM, Bradford D, Ohnmeiss DD. Early failure of metal-on-metal artificial disc prostheses associated with lymphocytic reaction: diagnosis and treatment experience in four cases. Spine (Phila Pa 1976). 2011 Apr 01; 36(7):E492-7. PMID: 21252827.
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    134. Bedair H, Berli M, Gezer S, Jacobs JJ, Della Valle CJ. Hematologic genetic testing in high-risk patients before knee arthroplasty: a pilot study. Clin Orthop Relat Res. 2011 Jan; 469(1):131-7. PMID: 20824408.
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    135. Regan PL, Jacobs J, Wang G, Torres J, Edo R, Friedmann J, Tang XX. Hsp90 inhibition increases p53 expression and destabilizes MYCN and MYC in neuroblastoma. Int J Oncol. 2011 Jan; 38(1):105-12. PMID: 21109931.
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    136. Jacobs JJ. Commentary on an article by Stephen S. Tower, MD: "Arthroprosthetic cobaltism: neurological and cardiac manifestations in two patients with metal-on-metal arthroplasty. a case report". J Bone Joint Surg Am. 2010 Dec 01; 92(17):e35. PMID: 21123606.
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    137. Gallardo LA, Knowlton CB, Kunze J, Jacobs JJ, Wimmer MA, Laurent MP. Effect of europium(II) stearate on the mechanical properties and the oxidation resistance of UHMWPE. J Mech Behav Biomed Mater. 2011 Jul; 4(5):821-6. PMID: 21565729.
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    138. Zuraw BL, Busse PJ, White M, Jacobs J, Lumry W, Baker J, Craig T, Grant JA, Hurewitz D, Bielory L, Cartwright WE, Koleilat M, Ryan W, Schaefer O, Manning M, Patel P, Bernstein JA, Friedman RA, Wilkinson R, Tanner D, Kohler G, Gunther G, Levy R, McClellan J, Redhead J, Guss D, Heyman E, Blumenstein BA, Kalfus I, Frank MM. Nanofiltered C1 inhibitor concentrate for treatment of hereditary angioedema. N Engl J Med. 2010 Aug 05; 363(6):513-22. PMID: 20818886.
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    139. Deirmengian C, Hallab N, Tarabishy A, Della Valle C, Jacobs JJ, Lonner J, Booth RE. Synovial fluid biomarkers for periprosthetic infection. Clin Orthop Relat Res. 2010 Aug; 468(8):2017-23. PMID: 20300901.
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    140. Caicedo MS, Pennekamp PH, McAllister K, Jacobs JJ, Hallab NJ. Soluble ions more than particulate cobalt-alloy implant debris induce monocyte costimulatory molecule expression and release of proinflammatory cytokines critical to metal-induced lymphocyte reactivity. J Biomed Mater Res A. 2010 Jun 15; 93(4):1312-21. PMID: 19844976.
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    141. Wright G, Sporer S, Urban R, Jacobs J. Fracture of a modular femoral neck after total hip arthroplasty: a case report. J Bone Joint Surg Am. 2010 Jun; 92(6):1518-21. PMID: 20516329.
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    142. Schwartz AJ, Della Valle CJ, Rosenberg AG, Jacobs JJ, Berger RA, Galante JO. Cruciate-retaining TKA using a third-generation system with a four-pegged tibial component: a minimum 10-year followup note. Clin Orthop Relat Res. 2010 Aug; 468(8):2160-7. PMID: 20440662.
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    143. Jacobs J, Korolev IO, Caplan JB, Ekstrom AD, Litt B, Baltuch G, Fried I, Schulze-Bonhage A, Madsen JR, Kahana MJ. Right-lateralized brain oscillations in human spatial navigation. J Cogn Neurosci. 2010 May; 22(5):824-36. PMID: 19400683.
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    144. Wimmer MA, Fischer A, Büscher R, Pourzal R, Sprecher C, Hauert R, Jacobs JJ. Wear mechanisms in metal-on-metal bearings: the importance of tribochemical reaction layers. J Orthop Res. 2010 Apr; 28(4):436-43. PMID: 19877285.
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    145. Schemitsch EH, Bhandari M, Boden SD, Bourne RB, Bozic KJ, Jacobs JJ, Zdero R. The evidence-based approach in bringing new orthopaedic devices to market. J Bone Joint Surg Am. 2010 Apr; 92(4):1030-7. PMID: 20360530.
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    146. Hallab NJ, Caicedo M, Epstein R, McAllister K, Jacobs JJ. In vitro reactivity to implant metals demonstrates a person-dependent association with both T-cell and B-cell activation. J Biomed Mater Res A. 2010 Feb; 92(2):667-82. PMID: 19235773.
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    147. Catelas I, Jacobs JJ. Biologic activity of wear particles. Instr Course Lect. 2010; 59:3-16. PMID: 20415362.
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    148. Jacobs JJ, King T. US bone and joint decade prepares for the future. Arthritis Rheum. 2009 Nov 15; 61(11):1470-1. PMID: 19877083.
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    149. Caicedo MS, Desai R, McAllister K, Reddy A, Jacobs JJ, Hallab NJ. Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: a novel mechanism for implant debris reactivity. J Orthop Res. 2009 Jul; 27(7):847-54. PMID: 19105226.
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    150. Della Valle CJ, Mesko NW, Quigley L, Rosenberg AG, Jacobs JJ, Galante JO. Primary total hip arthroplasty with a porous-coated acetabular component. A concise follow-up, at a minimum of twenty years, of previous reports. J Bone Joint Surg Am. 2009 May; 91(5):1130-5. PMID: 19411461.
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    151. Craig T, Riedl M, Dykewicz MS, Gower RG, Baker J, Edelman FJ, Hurewitz D, Jacobs J, Kalfus I. When is prophylaxis for hereditary angioedema necessary? Ann Allergy Asthma Immunol. 2009 May; 102(5):366-72. PMID: 19492656.
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    152. Turkelson C, Jacobs JJ. Role of technology assessment in orthopaedics. Clin Orthop Relat Res. 2009 Oct; 467(10):2570-6. PMID: 19404712.
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    153. Jacobs JJ, Urban RM, Hallab NJ, Skipor AK, Fischer A, Wimmer MA. Metal-on-metal bearing surfaces. J Am Acad Orthop Surg. 2009 Feb; 17(2):69-76. PMID: 19202120.
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    154. Hallab NJ, Jacobs JJ. Biologic effects of implant debris. Bull NYU Hosp Jt Dis. 2009; 67(2):182-8. PMID: 19583551.
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    155. Rodrigues DC, Urban RM, Jacobs JJ, Gilbert JL. In vivo severe corrosion and hydrogen embrittlement of retrieved modular body titanium alloy hip-implants. J Biomed Mater Res B Appl Biomater. 2009 Jan; 88(1):206-19. PMID: 18683224.
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    156. Henley MB, Turkelson C, Jacobs JJ, Haralson RH. AOA symposium. Evidence-based medicine, the quality initiative, and P4P: performance or paperwork? J Bone Joint Surg Am. 2008 Dec; 90(12):2781-90. PMID: 19047724.
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    157. Caicedo M, Jacobs JJ, Reddy A, Hallab NJ. Analysis of metal ion-induced DNA damage, apoptosis, and necrosis in human (Jurkat) T-cells demonstrates Ni2+ and V3+ are more toxic than other metals: Al3+, Be2+, Co2+, Cr3+, Cu2+, Fe3+, Mo5+, Nb5+, Zr2+. J Biomed Mater Res A. 2008 Sep 15; 86(4):905-13. PMID: 18050301.
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    158. Tunyogi-Csapo M, Kis-Toth K, Radacs M, Farkas B, Jacobs JJ, Finnegan A, Mikecz K, Glant TT. Cytokine-controlled RANKL and osteoprotegerin expression by human and mouse synovial fibroblasts: fibroblast-mediated pathologic bone resorption. Arthritis Rheum. 2008 Aug; 58(8):2397-408. PMID: 18668542.
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    159. Jacobs JJ. Translational research: Whither the ORS? J Orthop Res. 2008 May; 26(5):737-40. PMID: 18383313.
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    160. Bozic KJ, Jacobs JJ. Technology assessment and adoption in orthopaedics: lessons learned. J Bone Joint Surg Am. 2008 Apr; 90(4):689-90. PMID: 18381303.
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    161. Goldberg SH, Urban RM, Jacobs JJ, King GJ, O'Driscoll SW, Cohen MS. Modes of wear after semiconstrained total elbow arthroplasty. J Bone Joint Surg Am. 2008 Mar; 90(3):609-19. PMID: 18310712.
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    162. Hallab NJ, Caicedo M, Finnegan A, Jacobs JJ. Th1 type lymphocyte reactivity to metals in patients with total hip arthroplasty. J Orthop Surg Res. 2008 Feb 13; 3:6. PMID: 18271968.
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    163. Beaty J, Jacobs JJ, Berry D. Osteoarthritis of the hip. N Engl J Med. 2008 Jan 31; 358(5):534; author reply 534-5. PMID: 18240429.
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    164. Jacobs JJ, Campbell PA, T Konttinen Y. How has the biologic reaction to wear particles changed with newer bearing surfaces? J Am Acad Orthop Surg. 2008; 16 Suppl 1:S49-55. PMID: 18612014.
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    165. Bitsch RG, Zamorano M, Loidolt T, Heisel C, Jacobs JJ, Schmalzried TP. Ion production and excretion in a patient with a metal-on-metal bearing hip prosthesis. A case report. J Bone Joint Surg Am. 2007 Dec; 89(12):2758-63. PMID: 18056510.
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    166. Salineros MJ, Crowninshield RD, Laurent M, Wimmer MA, Jacobs JJ. Analysis of retrieved acetabular components of three polyethylene types. Clin Orthop Relat Res. 2007 Dec; 465:140-9. PMID: 17632415.
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    167. Wimmer MA, Schmid TM, Jacobs JJ. Tribology: a portal to understand joint failure? Arthritis Rheum. 2007 Nov; 56(11):3511-3. PMID: 17968920.
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    168. Tunyogi-Csapo M, Koreny T, Vermes C, Galante JO, Jacobs JJ, Glant TT. Role of fibroblasts and fibroblast-derived growth factors in periprosthetic angiogenesis. J Orthop Res. 2007 Oct; 25(10):1378-88. PMID: 17557346.
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    169. Baer TM, Mulshine JL, Jacobs JJ. Biomedical imaging archive network. Skeletal Radiol. 2007 Sep; 36(9):799-801. PMID: 17410352.
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    170. Della Valle CJ, Sporer SM, Jacobs JJ, Berger RA, Rosenberg AG, Paprosky WG. Preoperative testing for sepsis before revision total knee arthroplasty. J Arthroplasty. 2007 Sep; 22(6 Suppl 2):90-3. PMID: 17823024.
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    171. Levine B, Sporer S, Della Valle CJ, Jacobs JJ, Paprosky W. Porous tantalum in reconstructive surgery of the knee: a review. J Knee Surg. 2007 Jul; 20(3):185-94. PMID: 17665779.
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    172. Deirmengian CA, Jacobs JJ. Trends in joint arthroplasty: minimally invasive surgery, wear-resistant materials, and biologics. J Clin Rheumatol. 2007 Jun; 13(3):153-8. PMID: 17551384.
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    173. Farley FA, Weinstein JN, Aamoth GM, Shapiro MS, Jacobs J, McCarthy JC, Kramer J. Workforce analysis in orthopaedic surgery: how can we improve the accuracy of our predictions? J Am Acad Orthop Surg. 2007 May; 15(5):268-73. PMID: 17478749.
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    174. Jacobs JJ. Closing the gap: Orthopaedic research in clinical practice. J Am Acad Orthop Surg. 2007 Jan; 15(1):1-2. PMID: 17213377.
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    175. Levine B, Della Valle CJ, Jacobs JJ. Applications of porous tantalum in total hip arthroplasty. J Am Acad Orthop Surg. 2006 Nov; 14(12):646-55. PMID: 17077337.
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    176. Berger R, Della Valle C, Jacobs JJ, Sheinkop MB, Rosenberg AG, Galante JO. The progression of patellofemoral arthrosis after medial unicompartmental replacement: results at 11 to 15 years. Clin Orthop Relat Res. 2006 Nov; 452:285-6. PMID: 16980894.
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    177. Brand RA, Jacobs JJ, Heckman JD. Professionalism in publishing. J Bone Joint Surg Am. 2006 Nov; 88(11):2323-5. PMID: 17079386.
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    178. Meneghini RM, Hallab NJ, Berger RA, Jacobs JJ, Paprosky WG, Rosenberg AG. Stem diameter and rotational stability in revision total hip arthroplasty: a biomechanical analysis. J Orthop Surg Res. 2006 Oct 02; 1:5. PMID: 17150125.
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    179. Koreny T, Tunyogi-Csapó M, Gál I, Vermes C, Jacobs JJ, Glant TT. The role of fibroblasts and fibroblast-derived factors in periprosthetic osteolysis. Arthritis Rheum. 2006 Oct; 54(10):3221-32. PMID: 17009257.
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    180. Sporer SM, DellaValle C, Jacobs J, Wimmer M. A case of disassociation of a modular femoral neck trunion after total hip arthroplasty. J Arthroplasty. 2006 Sep; 21(6):918-21. PMID: 16950051.
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    181. Rasquinha VJ, Ranawat CS, Weiskopf J, Rodriguez JA, Skipor AK, Jacobs JJ. Serum metal levels and bearing surfaces in total hip arthroplasty. J Arthroplasty. 2006 Sep; 21(6 Suppl 2):47-52. PMID: 16950061.
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    182. Crowninshield RD, Wimmer MA, Jacobs JJ, Rosenberg AG. Clinical performance of contemporary tibial polyethylene components. J Arthroplasty. 2006 Aug; 21(5):754-61. PMID: 16877165.
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    183. Jacobs JJ, Galante JO, Mirza SK, Zdeblick T. Relationships with industry: critical for new technology or an unnecessary evil? J Bone Joint Surg Am. 2006 Jul; 88(7):1650-63. PMID: 16818992.
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    184. Weinstein SL, Jacobs JJ, Goldberg MJ. Osteoarthritis of the knee. N Engl J Med. 2006 Jun 08; 354(23):2508-9; author reply 2508-9. PMID: 16760456.
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    185. Levine BR, Sporer S, Poggie RA, Della Valle CJ, Jacobs JJ. Experimental and clinical performance of porous tantalum in orthopedic surgery. Biomaterials. 2006 Sep; 27(27):4671-81. PMID: 16737737.
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    186. Jacobs JJ, Hallab NJ. Loosening and osteolysis associated with metal-on-metal bearings: A local effect of metal hypersensitivity? J Bone Joint Surg Am. 2006 Jun; 88(6):1171-2. PMID: 16757747.
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    187. Jacobs JJ, Hallab NJ, Urban RM, Wimmer MA. Wear particles. J Bone Joint Surg Am. 2006 Apr; 88 Suppl 2:99-102. PMID: 16595453.
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    188. Fritz EA, Glant TT, Vermes C, Jacobs JJ, Roebuck KA. Chemokine gene activation in human bone marrow-derived osteoblasts following exposure to particulate wear debris. J Biomed Mater Res A. 2006 Apr; 77(1):192-201. PMID: 16392133.
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    189. Berger RA, Deirmengian CA, Della Valle CJ, Paprosky WG, Jacobs JJ, Rosenberg AG. A technique for minimally invasive, quadriceps-sparing total knee arthroplasty. J Knee Surg. 2006 Jan; 19(1):63-70. PMID: 16468498.
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    190. McGrory B, Callaghan J, Kraay M, Jacobs J, Robb W, Wasielewski R, Brand RA. Editorial: minimally invasive and small-incision joint replacement surgery: what surgeons should consider. Clin Orthop Relat Res. 2005 Nov; 440:251-4. PMID: 16239815.
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    191. Berger RA, Sanders S, Gerlinger T, Della Valle C, Jacobs JJ, Rosenberg AG. Outpatient total knee arthroplasty with a minimally invasive technique. J Arthroplasty. 2005 Oct; 20(7 Suppl 3):33-8. PMID: 16214000.
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    192. Wasielewski RC, Jacobs JJ, Arthurs B, Rubash HE. The acetabular insert-metal backing interface: an additional source of polyethylene wear debris. J Arthroplasty. 2005 Oct; 20(7):914-22. PMID: 16230245.
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    193. Burnett RS, Berger RA, Della Valle CJ, Sporer SM, Jacobs JJ, Paprosky WG, Rosenberg AG. Extensor mechanism allograft reconstruction after total knee arthroplasty. J Bone Joint Surg Am. 2005 Sep; 87 Suppl 1(Pt 2):175-94. PMID: 16140793.
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    194. Della Valle CJ, Shuaipaj T, Berger RA, Rosenberg AG, Shott S, Jacobs JJ, Galante JO. Revision of the acetabular component without cement after total hip arthroplasty. A concise follow-up, at fifteen to nineteen years, of a previous report. J Bone Joint Surg Am. 2005 Aug; 87(8):1795-800. PMID: 16085621.
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    195. Hallab NJ, Anderson S, Caicedo M, Brasher A, Mikecz K, Jacobs JJ. Effects of soluble metals on human peri-implant cells. J Biomed Mater Res A. 2005 Jul 01; 74(1):124-40. PMID: 15937919.
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    196. Fritz EA, Jacobs JJ, Glant TT, Roebuck KA. Chemokine IL-8 induction by particulate wear debris in osteoblasts is mediated by NF-kappaB. J Orthop Res. 2005 Nov; 23(6):1249-57. PMID: 15950427.
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    197. Berger RA, Meneghini RM, Jacobs JJ, Sheinkop MB, Della Valle CJ, Rosenberg AG, Galante JO. Results of unicompartmental knee arthroplasty at a minimum of ten years of follow-up. J Bone Joint Surg Am. 2005 May; 87(5):999-1006. PMID: 15866962.
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    198. Heisel C, Silva M, Skipor AK, Jacobs JJ, Schmalzried TP. The relationship between activity and ions in patients with metal-on-metal bearing hip prostheses. J Bone Joint Surg Am. 2005 Apr; 87(4):781-7. PMID: 15805207.
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    199. Hallab NJ, Anderson S, Stafford T, Glant T, Jacobs JJ. Lymphocyte responses in patients with total hip arthroplasty. J Orthop Res. 2005 Mar; 23(2):384-91. PMID: 15734252.
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    200. Meneghini RM, Hallab NJ, Jacobs JJ. The biology of alternative bearing surfaces in total joint arthroplasty. Instr Course Lect. 2005; 54:481-93. PMID: 15948473.
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    201. Berger RA, Jacobs JJ, Meneghini RM, Della Valle C, Paprosky W, Rosenberg AG. Rapid rehabilitation and recovery with minimally invasive total hip arthroplasty. Clin Orthop Relat Res. 2004 Dec; (429):239-47. PMID: 15577494.
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    202. Jacobs JJ, Skipor AK, Campbell PA, Hallab NJ, Urban RM, Amstutz HC. Can metal levels be used to monitor metal-on-metal hip arthroplasties? J Arthroplasty. 2004 Dec; 19(8 Suppl 3):59-65. PMID: 15578555.
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    203. Burnett RS, Berger RA, Paprosky WG, Della Valle CJ, Jacobs JJ, Rosenberg AG. Extensor mechanism allograft reconstruction after total knee arthroplasty. A comparison of two techniques. J Bone Joint Surg Am. 2004 Dec; 86(12):2694-9. PMID: 15590855.
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    204. Urban RM, Tomlinson MJ, Hall DJ, Jacobs JJ. Accumulation in liver and spleen of metal particles generated at nonbearing surfaces in hip arthroplasty. J Arthroplasty. 2004 Dec; 19(8 Suppl 3):94-101. PMID: 15578561.
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    205. MacDonald SJ, Brodner W, Jacobs JJ. A consensus paper on metal ions in metal-on-metal hip arthroplasties. J Arthroplasty. 2004 Dec; 19(8 Suppl 3):12-6. PMID: 15578546.
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    206. Hallab NJ, Anderson S, Caicedo M, Skipor A, Campbell P, Jacobs JJ. Immune responses correlate with serum-metal in metal-on-metal hip arthroplasty. J Arthroplasty. 2004 Dec; 19(8 Suppl 3):88-93. PMID: 15578560.
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    207. Berger RA, Meneghini RM, Sheinkop MB, Della Valle CJ, Jacobs JJ, Rosenberg AG, Galante JO. The progression of patellofemoral arthrosis after medial unicompartmental replacement: results at 11 to 15 years. Clin Orthop Relat Res. 2004 Nov; (428):92-9. PMID: 15534526.
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    208. Della Valle CJ, Berger RA, Shott S, Rosenberg AG, Jacobs JJ, Quigley L, Galante JO. Primary total hip arthroplasty with a porous-coated acetabular component. A concise follow-up of a previous report. J Bone Joint Surg Am. 2004 Jun; 86(6):1217-22. PMID: 15173295.
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    209. Hallab NJ, Messina C, Skipor A, Jacobs JJ. Differences in the fretting corrosion of metal-metal and ceramic-metal modular junctions of total hip replacements. J Orthop Res. 2004 Mar; 22(2):250-9. PMID: 15013082.
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    210. Hirakawa K, Jacobs JJ, Urban R, Saito T. Mechanisms of failure of total hip replacements: lessons learned from retrieval studies. Clin Orthop Relat Res. 2004 Mar; (420):10-7. PMID: 15057073.
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    211. Della Valle CJ, Berger RA, Rosenberg AG, Jacobs JJ, Sheinkop MB, Paprosky WG. Extended trochanteric osteotomy in complex primary total hip arthroplasty. A brief note. J Bone Joint Surg Am. 2003 Dec; 85(12):2385-90. PMID: 14668509.
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    212. Jacobs JJ, Hallab NJ, Skipor AK, Urban RM. Metal degradation products: a cause for concern in metal-metal bearings? Clin Orthop Relat Res. 2003 Dec; (417):139-47. PMID: 14646711.
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    213. Hallab NJ, Cunningham BW, Jacobs JJ. Spinal implant debris-induced osteolysis. Spine (Phila Pa 1976). 2003 Oct 15; 28(20):S125-38. PMID: 14560184.
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    214. Martell JM, Berkson E, Berger R, Jacobs J. Comparison of two and three-dimensional computerized polyethylene wear analysis after total hip arthroplasty. J Bone Joint Surg Am. 2003 Jun; 85(6):1111-7. PMID: 12784011.
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    215. Hallab NJ, Skipor A, Jacobs JJ. Interfacial kinetics of titanium- and cobalt-based implant alloys in human serum: metal release and biofilm formation. J Biomed Mater Res A. 2003 Jun 01; 65(3):311-8. PMID: 12746877.
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    216. Rosenberg AG, Jacobs JJ, Saleh KJ, Kassim RA, Christie MJ, Lewallen DG, Rand JA, Rubash HE. The patella in revision total knee arthroplasty. J Bone Joint Surg Am. 2003; 85-A Suppl 1:S63-70. PMID: 12540672.
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    217. Skipor AK, Campbell PA, Patterson LM, Anstutz HC, Schmalzried TP, Jacobs JJ. Serum and urine metal levels in patients with metal-on-metal surface arthroplasty. J Mater Sci Mater Med. 2002 Dec; 13(12):1227-34. PMID: 15348670.
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    218. Surace MF, Berzins A, Urban RM, Jacobs JJ, Berger RA, Natarajan RN, Andriacchi TP, Galante JO. Coventry Award paper. Backsurface wear and deformation in polyethylene tibial inserts retrieved postmortem. Clin Orthop Relat Res. 2002 Nov; (404):14-23. PMID: 12439232.
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    219. Berzins A, Jacobs JJ, Berger R, Ed C, Natarajan R, Andriacchi T, Galante JO. Surface damage in machined ram-extruded and net-shape molded retrieved polyethylene tibial inserts of total knee replacements. J Bone Joint Surg Am. 2002 Sep; 84(9):1534-40. PMID: 12208909.
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    220. Goldberg JR, Gilbert JL, Jacobs JJ, Bauer TW, Paprosky W, Leurgans S. A multicenter retrieval study of the taper interfaces of modular hip prostheses. Clin Orthop Relat Res. 2002 Aug; (401):149-61. PMID: 12151892.
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    221. Hallab NJ, Vermes C, Messina C, Roebuck KA, Glant TT, Jacobs JJ. Concentration- and composition-dependent effects of metal ions on human MG-63 osteoblasts. J Biomed Mater Res. 2002 Jun 05; 60(3):420-33. PMID: 11920666.
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    222. Qureshi AA, Virdi AS, Didonna ML, Jacobs JJ, Masuda K, Paprosky WP, Thonar EJ, Sumner DR. Implant design affects markers of bone resorption and formation in total hip replacement. J Bone Miner Res. 2002 May; 17(5):800-7. PMID: 12009010.
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    223. Fritz EA, Glant TT, Vermes C, Jacobs JJ, Roebuck KA. Titanium particles induce the immediate early stress responsive chemokines IL-8 and MCP-1 in osteoblasts. J Orthop Res. 2002 May; 20(3):490-8. PMID: 12038622.
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    224. Vermes C, Jacobs JJ, Zhang J, Firneisz G, Roebuck KA, Glant TT. Shedding of the interleukin-6 (IL-6) receptor (gp80) determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts. J Biol Chem. 2002 May 10; 277(19):16879-87. PMID: 11884403.
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    225. Jacobs JJ, Rosenberg AG, Galante JO, Berger R, Quigley L, Gitelis S, Sheinkop M. A question of prevalence: liner dislodgment in Harris-Galante acetabular components. J Bone Joint Surg Am. 2002 Jan; 84(1):143-4. PMID: 11792793.
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    226. Glant TT, Jacobs JJ, Mikecz K, Yao J, Chubinskaja S, Williams JM, Urban RL, Shanbhag AS, Lee SH, Sumner DR. Particulate-Induced, Prostaglandin- and Cytokine-Mediated Bone Resorption in an Experimental System and in Failed Joint Replacements. Am J Ther. 1996 Jan; 3(1):27-41. PMID: 11856995.
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