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Joshua J. Jacobs

TitleProfessor
InstitutionRush University, Rush Medical College
DepartmentOrthopedic Surgery
Phone312-942-5450
Fax312-942-2101
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    Collapse Overview 
    Collapse overview
    Other Appointments:
    The William A. Hark, MD/Susanne G. Swift Professor & Chairman
    Department of Orthopedic Surgery, Rush University Medical Center
    Associate Provost for Research, Rush University
    Vice Dean for Research, Rush Medical College

    My ORCID is 0000-0003-3902-7334.
    My Scopus ID is 56179325700.
    My NIH COMMONS name is TITANIUM.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Pourzal R, Hall DJ, Ehrich J, McCarthy SM, Mathew MT, Jacobs JJ, Urban RM. Alloy Microstructure Dictates Corrosion Modes in THA Modular Junctions. Clin Orthop Relat Res. 2017 Dec; 475(12):3026-3043. PMID: 28884275.
      View in: PubMed
    2. Hall DJ, Pourzal R, Lundberg HJ, Mathew MT, Jacobs JJ, Urban RM. Mechanical, chemical and biological damage modes within head-neck tapers of CoCrMo and Ti6Al4V contemporary hip replacements. J Biomed Mater Res B Appl Biomater. 2017 Aug 26. PMID: 28842959.
      View in: PubMed
    3. Fillingham YA, Della Valle CJ, Bohl DD, Kelly MP, Hall DJ, Pourzal R, Jacobs JJ. Serum Metal Levels for Diagnosis of Adverse Local Tissue Reactions Secondary to Corrosion in Metal-on-Polyethylene Total Hip Arthroplasty. J Arthroplasty. 2017 Sep; 32(9S):S272-S277. PMID: 28511949.
      View in: PubMed
    4. Caicedo MS, Solver E, Coleman L, Jacobs JJ, Hallab NJ. Females with Unexplained Joint Pain Following Total Joint Arthroplasty Exhibit a Higher Rate and Severity of Hypersensitivity to Implant Metals Compared with Males: Implications of Sex-Based Bioreactivity Differences. J Bone Joint Surg Am. 2017 Apr 19; 99(8):621-628. PMID: 28419029.
      View in: PubMed
    5. Longhurst H, Cicardi M, Craig T, Bork K, Grattan C, Baker J, Li HH, Reshef A, Bonner J, Bernstein JA, Anderson J, Lumry WR, Farkas H, Katelaris CH, Sussman GL, Jacobs J, Riedl M, Manning ME, Hebert J, Keith PK, Kivity S, Neri S, Levy DS, Baeza ML, Nathan R, Schwartz LB, Caballero T, Yang W, Crisan I, Hernandez MD, Hussain I, Tarzi M, Ritchie B, Králícková P, Guilarte M, Rehman SM, Banerji A, Gower RG, Bensen-Kennedy D, Edelman J, Feuersenger H, Lawo JP, Machnig T, Pawaskar D, Pragst I, Zuraw BL. Prevention of Hereditary Angioedema Attacks with a Subcutaneous C1 Inhibitor. N Engl J Med. 2017 03 23; 376(12):1131-1140. PMID: 28328347.
      View in: PubMed
    6. Gornet MF, Singh V, Schranck FW, Skipor AK, Jacobs JJ. Serum Metal Concentrations in Patients With Titanium Ceramic Composite Cervical Disc Replacements. Spine (Phila Pa 1976). 2017 Mar 15; 42(6):366-371. PMID: 27323223.
      View in: PubMed
    7. Banerji A, Busse P, Shennak M, Lumry W, Davis-Lorton M, Wedner HJ, Jacobs J, Baker J, Bernstein JA, Lockey R, Li HH, Craig T, Cicardi M, Riedl M, Al-Ghazawi A, Soo C, Iarrobino R, Sexton DJ, TenHoor C, Kenniston JA, Faucette R, Still JG, Kushner H, Mensah R, Stevens C, Biedenkapp JC, Chyung Y, Adelman B. Inhibiting Plasma Kallikrein for Hereditary Angioedema Prophylaxis. N Engl J Med. 2017 02 23; 376(8):717-728. PMID: 28225674.
      View in: PubMed
    8. Hallab NJ, Jacobs JJ. Chemokines Associated with Pathologic Responses to Orthopedic Implant Debris. Front Endocrinol (Lausanne). 2017; 8:5. PMID: 28154552.
      View in: PubMed
    9. Plummer DR, Yi PH, Jacobs JJ, Urban RM, Moric MM, Della Valle CJ. Aseptic Lymphocytic-Dominated Vasculitis-Associated Lesions Scores Do Not Correlate With Metal Ion Levels or Unreadable Synovial Fluid White Blood Cell Counts. J Arthroplasty. 2017 Apr; 32(4):1340-1343. PMID: 27979408.
      View in: PubMed
    10. Pourzal R, Hall DJ, Ha NQ, Urban RM, Levine BR, Jacobs JJ, Lundberg HJ. Does Surface Topography Play a Role in Taper Damage in Head-neck Modular Junctions? Clin Orthop Relat Res. 2016 Oct; 474(10):2232-42. PMID: 27339123.
      View in: PubMed
    11. Samelko L, Landgraeber S, McAllister K, Jacobs J, Hallab NJ. TLR4 (not TLR2) dominate cognate TLR activity associated with CoCrMo implant particles. J Orthop Res. 2017 05; 35(5):1007-1017. PMID: 27416075.
      View in: PubMed
    12. Royhman D, Patel M, Runa MJ, Wimmer MA, Jacobs JJ, Hallab NJ, Mathew MT. Fretting-corrosion behavior in hip implant modular junctions: The influence of friction energy and pH variation. J Mech Behav Biomed Mater. 2016 Sep; 62:570-587. PMID: 27310572.
      View in: PubMed
    13. Jacobs JJ. Corrosion of Modular Junctions: Why Is This Happening Now? J Arthroplasty. 2016 07; 31(7):1377. PMID: 27209332.
      View in: PubMed
    14. Jacobs JJ. Corrosion at the Head-Neck Junction: Why Is This Happening Now? J Arthroplasty. 2016 07; 31(7):1378-80. PMID: 27321963.
      View in: PubMed
    15. Lachiewicz PF, Watters TS, Jacobs JJ. Metal Hypersensitivity and Total Knee Arthroplasty. J Am Acad Orthop Surg. 2016 Feb; 24(2):106-12. PMID: 26752739; PMCID: PMC4726476 [Available on 02/01/17].
    16. Bohl DD, Wetters NG, Del Gaizo DJ, Jacobs JJ, Rosenberg AG, Della Valle CJ. Repair of Intraoperative Injury to the Medial Collateral Ligament During Primary Total Knee Arthroplasty. J Bone Joint Surg Am. 2016 Jan 06; 98(1):35-9. PMID: 26738901.
      View in: PubMed
    17. Rockne RC, Trister AD, Jacobs J, Hawkins-Daarud AJ, Neal ML, Hendrickson K, Mrugala MM, Rockhill JK, Kinahan P, Krohn KA, Swanson KR. Addendum to 'A patient-specific computational model of hypoxia-modulated radiation resistance in glioblastoma using 18F-FMISO-PET'. J R Soc Interface. 2015 Nov 06; 12(112). PMID: 26577597; PMCID: PMC4685857.
    18. Hall DJ, Urban RM, Pourzal R, Turner TM, Skipor AK, Jacobs JJ. Nanoscale surface modification by anodic oxidation increased bone ingrowth and reduced fibrous tissue in the porous coating of titanium-alloy femoral hip arthroplasty implants. J Biomed Mater Res B Appl Biomater. 2017 Feb; 105(2):283-290. PMID: 26477322.
      View in: PubMed
    19. Haughom BD, Erickson BJ, Hellman MD, Jacobs JJ. Reply to letter to the editor: do complication rates differ by gender after metal-on-metal hip resurfacing arthroplasty? A systematic review. Clin Orthop Relat Res. 2015 Dec; 473(12):3983-4. PMID: 26400250; PMCID: PMC4626477 [Available on 12/01/16].
    20. Haughom BD, Erickson BJ, Hellman MD, Jacobs JJ. Do Complication Rates Differ by Gender After Metal-on-metal Hip Resurfacing Arthroplasty? A Systematic Review. Clin Orthop Relat Res. 2015 Aug; 473(8):2521-9. PMID: 25758375; PMCID: PMC4488218.
    21. Plummer DR, Berger RA, Paprosky WG, Sporer SM, Jacobs JJ, Della Valle CJ. Diagnosis and Management of Adverse Local Tissue Reactions Secondary to Corrosion at the Head-Neck Junction in Patients With Metal on Polyethylene Bearings. J Arthroplasty. 2016 Jan; 31(1):264-8. PMID: 26321628.
      View in: PubMed
    22. Rockne RC, Trister AD, Jacobs J, Hawkins-Daarud AJ, Neal ML, Hendrickson K, Mrugala MM, Rockhill JK, Kinahan P, Krohn KA, Swanson KR. A patient-specific computational model of hypoxia-modulated radiation resistance in glioblastoma using 18F-FMISO-PET. J R Soc Interface. 2015 Feb 06; 12(103). PMID: 25540239; PMCID: PMC4305419.
    23. Yi PH, Cross MB, Moric M, Levine BR, Sporer SM, Paprosky WG, Jacobs JJ, Della Valle CJ. Do serologic and synovial tests help diagnose infection in revision hip arthroplasty with metal-on-metal bearings or corrosion? Clin Orthop Relat Res. 2015 Feb; 473(2):498-505. PMID: 25171935; PMCID: PMC4294906.
    24. Campbell PA, Kung MS, Hsu AR, Jacobs JJ. Do retrieval analysis and blood metal measurements contribute to our understanding of adverse local tissue reactions? Clin Orthop Relat Res. 2014 Dec; 472(12):3718-27. PMID: 25160942; PMCID: PMC4397772.
    25. Novak CC, Hsu AR, Della Valle CJ, Skipor AK, Campbell P, Amstutz HC, Jiranek WA, Onyike A, Pombar XF, Jacobs JJ. Metal ion levels in maternal and placental blood after metal-on-metal total hip arthroplasty. Am J Orthop (Belle Mead NJ). 2014 Dec; 43(12):E304-8. PMID: 25490017.
      View in: PubMed
    26. Lega B, Burke J, Jacobs J, Kahana MJ. Slow-Theta-to-Gamma Phase-Amplitude Coupling in Human Hippocampus Supports the Formation of New Episodic Memories. Cereb Cortex. 2016 Jan; 26(1):268-278. PMID: 25316340.
      View in: PubMed
    27. Porter DA, Urban RM, Jacobs JJ, Gilbert JL, Rodriguez JA, Cooper HJ. Modern trunnions are more flexible: a mechanical analysis of THA taper designs. Clin Orthop Relat Res. 2014 Dec; 472(12):3963-70. PMID: 25267272; PMCID: PMC4397791.
    28. Kwon YM, Fehring TK, Lombardi AV, Barnes CL, Cabanela ME, Jacobs JJ. Risk stratification algorithm for management of patients with dual modular taper total hip arthroplasty: consensus statement of the American Association of Hip and Knee Surgeons, the American Academy of Orthopaedic Surgeons and the Hip Society. J Arthroplasty. 2014 Nov; 29(11):2060-4. PMID: 25189673.
      View in: PubMed
    29. Jacobs JJ, Jevsevar DS, Brown GA, Cummins DS. AAOS Osteoarthritis Guideline: transparency and credibility. Arthroscopy. 2014 Jun; 30(6):656-8. PMID: 24862694.
      View in: PubMed
    30. Landgraeber S, Jäger M, Jacobs JJ, Hallab NJ. The pathology of orthopedic implant failure is mediated by innate immune system cytokines. Mediators Inflamm. 2014; 2014:185150. PMID: 24891761; PMCID: PMC4033543.
    31. Silverton CD, Jacobs JJ, Devitt JW, Cooper HJ. Midterm results of a femoral stem with a modular neck design: clinical outcomes and metal ion analysis. J Arthroplasty. 2014 Sep; 29(9):1768-73. PMID: 24895065.
      View in: PubMed
    32. Reddy A, Caicedo MS, Samelko L, Jacobs JJ, Hallab NJ. Implant debris particle size affects serum protein adsorption which may contribute to particle size-based bioreactivity differences. J Long Term Eff Med Implants. 2014; 24(1):77-88. PMID: 24941408; PMCID: PMC4062925.
    33. Kwon YM, Lombardi AV, Jacobs JJ, Fehring TK, Lewis CG, Cabanela ME. Risk stratification algorithm for management of patients with metal-on-metal hip arthroplasty: consensus statement of the American Association of Hip and Knee Surgeons, the American Academy of Orthopaedic Surgeons, and the Hip Society. J Bone Joint Surg Am. 2014 Jan 01; 96(1):e4. PMID: 24382732.
      View in: PubMed
    34. Panigrahi P, Liao Y, Mathew MT, Fischer A, Wimmer MA, Jacobs JJ, Marks LD. Intergranular pitting corrosion of CoCrMo biomedical implant alloy. J Biomed Mater Res B Appl Biomater. 2014 May; 102(4):850-9. PMID: 24376124.
      View in: PubMed
    35. Hsu AR, Levine BR, Skipor AK, Hallab NJ, Paprosky WG, Jacobs JJ. Effect of a second joint arthroplasty on metal ion levels after primary total hip arthroplasty. Am J Orthop (Belle Mead NJ). 2013 Oct; 42(10):E84-7. PMID: 24278909.
      View in: PubMed
    36. Jacobs JJ, King TR, Klippel JH, Berven SH, Burr DB, Caskey PM, Elderkin AL, Esposito PW, Gall EP, Goldring SR, Pollak AN, Sandborg CI, Templeton KJ. Beyond the decade: strategic priorities to reduce the burden of musculoskeletal disease. J Bone Joint Surg Am. 2013 Sep 04; 95(17):e1251-6. PMID: 24005209; PMCID: PMC3748998.
    37. Caicedo MS, Samelko L, McAllister K, Jacobs JJ, Hallab NJ. Increasing both CoCrMo-alloy particle size and surface irregularity induces increased macrophage inflammasome activation in vitro potentially through lysosomal destabilization mechanisms. J Orthop Res. 2013 Oct; 31(10):1633-42. PMID: 23794526; PMCID: PMC4028039.
    38. Samelko L, Caicedo MS, Lim SJ, Della-Valle C, Jacobs J, Hallab NJ. Cobalt-alloy implant debris induce HIF-1a hypoxia associated responses: a mechanism for metal-specific orthopedic implant failure. PLoS One. 2013; 8(6):e67127. PMID: 23840602; PMCID: PMC3688623.
    39. Cooper HJ, Urban RM, Wixson RL, Meneghini RM, Jacobs JJ. Adverse local tissue reaction arising from corrosion at the femoral neck-body junction in a dual-taper stem with a cobalt-chromium modular neck. J Bone Joint Surg Am. 2013 May 15; 95(10):865-72. PMID: 23677352; PMCID: PMC3748981.
    40. Jacobs JJ. Moving forward: from curses to blessings. J Am Acad Orthop Surg. 2013 May; 21(5):261-5. PMID: 23637143.
      View in: PubMed
    41. Jacobs JJ, Wimmer MA. An important contribution to our understanding of the performance of the current generation of metal-on-metal hip replacements. J Bone Joint Surg Am. 2013 Apr 17; 95(8):e53. PMID: 23595079; PMCID: PMC3748978.
    42. Levine BR, Hsu AR, Skipor AK, Hallab NJ, Paprosky WG, Galante JO, Jacobs JJ. Ten-year outcome of serum metal ion levels after primary total hip arthroplasty: a concise follow-up of a previous report*. J Bone Joint Surg Am. 2013 Mar 20; 95(6):512-8. PMID: 23515985; PMCID: PMC3748974.
    43. Liao Y, Hoffman E, Wimmer M, Fischer A, Jacobs J, Marks L. CoCrMo metal-on-metal hip replacements. Phys Chem Chem Phys. 2013 Jan 21; 15(3):746-56. PMID: 23196425; PMCID: PMC3530782.
    44. Ma Y, Ren Y, Han EQ, Li H, Chen D, Jacobs JJ, Gitelis S, O'Keefe RJ, Konttinen YT, Yin G, Li TF. Inhibition of the Wnt-ß-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy. Biochem Biophys Res Commun. 2013 Feb 08; 431(2):274-9. PMID: 23291185; PMCID: PMC3710725.
    45. Jacobs JJ. Large (36 or 40-mm) femoral heads decreased the rate of dislocation after revision total hip arthroplasty. J Bone Joint Surg Am. 2012 Nov 21; 94(22):2095. PMID: 23172329; PMCID: PMC3497903.
    46. Amstutz HC, Campbell PA, Dorey FJ, Johnson AJ, Skipor AK, Jacobs JJ. Do ion concentrations after metal-on-metal hip resurfacing increase over time? A prospective study. J Arthroplasty. 2013 Apr; 28(4):695-700. PMID: 23123040.
      View in: PubMed
    47. Mathew MT, Jacobs JJ, Wimmer MA. Wear-corrosion synergism in a CoCrMo hip bearing alloy is influenced by proteins. Clin Orthop Relat Res. 2012 Nov; 470(11):3109-17. PMID: 22956237; PMCID: PMC3462838.
    48. Urban RM, Hall DJ, Della Valle C, Wimmer MA, Jacobs JJ, Galante JO. Successful long-term fixation and progression of osteolysis associated with first-generation cementless acetabular components retrieved post mortem. J Bone Joint Surg Am. 2012 Oct 17; 94(20):1877-85. PMID: 23079880; PMCID: PMC3489071.
    49. Cooper HJ, Della Valle CJ, Berger RA, Tetreault M, Paprosky WG, Sporer SM, Jacobs JJ. Corrosion at the head-neck taper as a cause for adverse local tissue reactions after total hip arthroplasty. J Bone Joint Surg Am. 2012 Sep 19; 94(18):1655-61. PMID: 23289127; PMCID: PMC3444948.
    50. Hallab NJ, Caicedo M, McAllister K, Skipor A, Amstutz H, Jacobs JJ. Asymptomatic prospective and retrospective cohorts with metal-on-metal hip arthroplasty indicate acquired lymphocyte reactivity varies with metal ion levels on a group basis. J Orthop Res. 2013 Feb; 31(2):173-82. PMID: 22941579; PMCID: PMC3534831.
    51. Jacobs JJ, An HS. Commentary: Total disc arthroplasty and the bearing surface debate. Spine J. 2012 Aug; 12(8):702-4. PMID: 23021032.
      View in: PubMed
    52. Wimmer MA, Laurent MP, Haman JD, Jacobs JJ, Galante JO. Surface damage versus tibial polyethylene insert conformity: a retrieval study. Clin Orthop Relat Res. 2012 Jul; 470(7):1814-25. PMID: 22395868; PMCID: PMC3369095.
    53. Kwon YM, Jacobs JJ, MacDonald SJ, Potter HG, Fehring TK, Lombardi AV. Evidence-based understanding of management perils for metal-on-metal hip arthroplasty patients. J Arthroplasty. 2012 Sep; 27(8 Suppl):20-5. PMID: 22608691.
      View in: PubMed
    54. Meneghini RM, Hallab NJ, Jacobs JJ. Evaluation and treatment of painful total hip arthroplasties with modular metal taper junctions. Orthopedics. 2012 May; 35(5):386-91. PMID: 22588392.
      View in: PubMed
    55. Jacobs JJ, Mont MA, Bozic KJ, Della Valle CJ, Goodman SB, Lewis CG, Yates AC, Boggio LN, Watters WC, Turkelson CM, Wies JL, Sluka P, Hitchcock K. American Academy of Orthopaedic Surgeons clinical practice guideline on: preventing venous thromboembolic disease in patients undergoing elective hip and knee arthroplasty. J Bone Joint Surg Am. 2012 Apr 18; 94(8):746-7. PMID: 22517391; PMCID: PMC3326685.
    56. Preventing venous thromboembolic disease in patients undergoing elective total hip and knee arthroplasty. J Bone Joint Surg Am. 2012 Apr 18; 94(8):673-4. PMID: 22517384; PMCID: PMC3326687.
    57. Jacobs JJ. The utility of MARS MRI in patients with metal-on-metal bearings: commentary on an article by Alister J. Hart, MA, MD, FRCSG(Orth), et al.: "Pseudotumors in association with well-functioning metal-on-metal hip prostheses. a case-control study using three-dimensional computed tomography and magnetic resonance imaging". J Bone Joint Surg Am. 2012 Feb 15; 94(4):e26. PMID: 22336984.
      View in: PubMed
    58. Graves SE, Rothwell A, Tucker K, Jacobs JJ, Sedrakyan A. A multinational assessment of metal-on-metal bearings in hip replacement. J Bone Joint Surg Am. 2011 Dec 21; 93 Suppl 3:43-7. PMID: 22262422.
      View in: PubMed
    59. Mont MA, Jacobs JJ, Boggio LN, Bozic KJ, Della Valle CJ, Goodman SB, Lewis CG, Yates AJ, Watters WC, Turkelson CM, Wies JL, Donnelly P, Patel N, Sluka P. Preventing venous thromboembolic disease in patients undergoing elective hip and knee arthroplasty. J Am Acad Orthop Surg. 2011 Dec; 19(12):768-76. PMID: 22134209.
      View in: PubMed
    60. Mont MA, Jacobs JJ. AAOS clinical practice guideline: preventing venous thromboembolic disease in patients undergoing elective hip and knee arthroplasty. J Am Acad Orthop Surg. 2011 Dec; 19(12):777-8. PMID: 22134210.
      View in: PubMed
    61. Gilbert JL, Mali S, Urban RM, Silverton CD, Jacobs JJ. In vivo oxide-induced stress corrosion cracking of Ti-6Al-4V in a neck-stem modular taper: Emergent behavior in a new mechanism of in vivo corrosion. J Biomed Mater Res B Appl Biomater. 2012 Feb; 100(2):584-94. PMID: 22113876.
      View in: PubMed
    62. Jacobs J. Recurrent attacks of hereditary angioedema: a case of delayed diagnosis. Allergy Asthma Proc. 2011 Sep-Oct; 32 Suppl 1:S23-6. PMID: 22195758.
      View in: PubMed
    63. Laurent MP, Pourzal R, Fischer A, Bertin KC, Jacobs JJ, Wimmer MA. In vivo wear of a squeaky alumina-on-alumina hip prosthesis: a case report. J Bone Joint Surg Am. 2011 Apr 06; 93(7):e27. PMID: 21471407.
      View in: PubMed
    64. Guyer RD, Shellock J, MacLennan B, Hanscom D, Knight RQ, McCombe P, Jacobs JJ, Urban RM, Bradford D, Ohnmeiss DD. Early failure of metal-on-metal artificial disc prostheses associated with lymphocytic reaction: diagnosis and treatment experience in four cases. Spine (Phila Pa 1976). 2011 Apr 01; 36(7):E492-7. PMID: 21252827.
      View in: PubMed
    65. Bedair H, Berli M, Gezer S, Jacobs JJ, Della Valle CJ. Hematologic genetic testing in high-risk patients before knee arthroplasty: a pilot study. Clin Orthop Relat Res. 2011 Jan; 469(1):131-7. PMID: 20824408; PMCID: PMC3008871.
    66. Regan PL, Jacobs J, Wang G, Torres J, Edo R, Friedmann J, Tang XX. Hsp90 inhibition increases p53 expression and destabilizes MYCN and MYC in neuroblastoma. Int J Oncol. 2011 Jan; 38(1):105-12. PMID: 21109931; PMCID: PMC3212671.
    67. Jacobs JJ. Commentary on an article by Stephen S. Tower, MD: "Arthroprosthetic cobaltism: neurological and cardiac manifestations in two patients with metal-on-metal arthroplasty. a case report". J Bone Joint Surg Am. 2010 Dec 01; 92(17):e35. PMID: 21123606; PMCID: PMC3346177.
    68. Gallardo LA, Knowlton CB, Kunze J, Jacobs JJ, Wimmer MA, Laurent MP. Effect of europium(II) stearate on the mechanical properties and the oxidation resistance of UHMWPE. J Mech Behav Biomed Mater. 2011 Jul; 4(5):821-6. PMID: 21565729.
      View in: PubMed
    69. Zuraw BL, Busse PJ, White M, Jacobs J, Lumry W, Baker J, Craig T, Grant JA, Hurewitz D, Bielory L, Cartwright WE, Koleilat M, Ryan W, Schaefer O, Manning M, Patel P, Bernstein JA, Friedman RA, Wilkinson R, Tanner D, Kohler G, Gunther G, Levy R, McClellan J, Redhead J, Guss D, Heyman E, Blumenstein BA, Kalfus I, Frank MM. Nanofiltered C1 inhibitor concentrate for treatment of hereditary angioedema. N Engl J Med. 2010 Aug 05; 363(6):513-22. PMID: 20818886.
      View in: PubMed
    70. Deirmengian C, Hallab N, Tarabishy A, Della Valle C, Jacobs JJ, Lonner J, Booth RE. Synovial fluid biomarkers for periprosthetic infection. Clin Orthop Relat Res. 2010 Aug; 468(8):2017-23. PMID: 20300901; PMCID: PMC2895851.
    71. Caicedo MS, Pennekamp PH, McAllister K, Jacobs JJ, Hallab NJ. Soluble ions more than particulate cobalt-alloy implant debris induce monocyte costimulatory molecule expression and release of proinflammatory cytokines critical to metal-induced lymphocyte reactivity. J Biomed Mater Res A. 2010 Jun 15; 93(4):1312-21. PMID: 19844976.
      View in: PubMed
    72. Wright G, Sporer S, Urban R, Jacobs J. Fracture of a modular femoral neck after total hip arthroplasty: a case report. J Bone Joint Surg Am. 2010 Jun; 92(6):1518-21. PMID: 20516329; PMCID: PMC2874667.
    73. Schwartz AJ, Della Valle CJ, Rosenberg AG, Jacobs JJ, Berger RA, Galante JO. Cruciate-retaining TKA using a third-generation system with a four-pegged tibial component: a minimum 10-year followup note. Clin Orthop Relat Res. 2010 Aug; 468(8):2160-7. PMID: 20440662; PMCID: PMC2895838.
    74. Wimmer MA, Fischer A, Büscher R, Pourzal R, Sprecher C, Hauert R, Jacobs JJ. Wear mechanisms in metal-on-metal bearings: the importance of tribochemical reaction layers. J Orthop Res. 2010 Apr; 28(4):436-43. PMID: 19877285.
      View in: PubMed
    75. Schemitsch EH, Bhandari M, Boden SD, Bourne RB, Bozic KJ, Jacobs JJ, Zdero R. The evidence-based approach in bringing new orthopaedic devices to market. J Bone Joint Surg Am. 2010 Apr; 92(4):1030-7. PMID: 20360530.
      View in: PubMed
    76. Hallab NJ, Caicedo M, Epstein R, McAllister K, Jacobs JJ. In vitro reactivity to implant metals demonstrates a person-dependent association with both T-cell and B-cell activation. J Biomed Mater Res A. 2010 Feb; 92(2):667-82. PMID: 19235773; PMCID: PMC2797558.
    77. Catelas I, Jacobs JJ. Biologic activity of wear particles. Instr Course Lect. 2010; 59:3-16. PMID: 20415362.
      View in: PubMed
    78. Jacobs JJ, King T. US bone and joint decade prepares for the future. Arthritis Rheum. 2009 Nov 15; 61(11):1470-1. PMID: 19877083.
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    79. Caicedo MS, Desai R, McAllister K, Reddy A, Jacobs JJ, Hallab NJ. Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: a novel mechanism for implant debris reactivity. J Orthop Res. 2009 Jul; 27(7):847-54. PMID: 19105226.
      View in: PubMed
    80. Della Valle CJ, Mesko NW, Quigley L, Rosenberg AG, Jacobs JJ, Galante JO. Primary total hip arthroplasty with a porous-coated acetabular component. A concise follow-up, at a minimum of twenty years, of previous reports. J Bone Joint Surg Am. 2009 May; 91(5):1130-5. PMID: 19411461.
      View in: PubMed
    81. Craig T, Riedl M, Dykewicz MS, Gower RG, Baker J, Edelman FJ, Hurewitz D, Jacobs J, Kalfus I. When is prophylaxis for hereditary angioedema necessary? Ann Allergy Asthma Immunol. 2009 May; 102(5):366-72. PMID: 19492656.
      View in: PubMed
    82. Turkelson C, Jacobs JJ. Role of technology assessment in orthopaedics. Clin Orthop Relat Res. 2009 Oct; 467(10):2570-6. PMID: 19404712; PMCID: PMC2745459.
    83. Jacobs JJ, Urban RM, Hallab NJ, Skipor AK, Fischer A, Wimmer MA. Metal-on-metal bearing surfaces. J Am Acad Orthop Surg. 2009 Feb; 17(2):69-76. PMID: 19202120.
      View in: PubMed
    84. Hallab NJ, Jacobs JJ. Biologic effects of implant debris. Bull NYU Hosp Jt Dis. 2009; 67(2):182-8. PMID: 19583551.
      View in: PubMed
    85. Rodrigues DC, Urban RM, Jacobs JJ, Gilbert JL. In vivo severe corrosion and hydrogen embrittlement of retrieved modular body titanium alloy hip-implants. J Biomed Mater Res B Appl Biomater. 2009 Jan; 88(1):206-19. PMID: 18683224; PMCID: PMC2667129.
    86. Henley MB, Turkelson C, Jacobs JJ, Haralson RH. AOA symposium. Evidence-based medicine, the quality initiative, and P4P: performance or paperwork? J Bone Joint Surg Am. 2008 Dec; 90(12):2781-90. PMID: 19047724.
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    87. Caicedo M, Jacobs JJ, Reddy A, Hallab NJ. Analysis of metal ion-induced DNA damage, apoptosis, and necrosis in human (Jurkat) T-cells demonstrates Ni2+ and V3+ are more toxic than other metals: Al3+, Be2+, Co2+, Cr3+, Cu2+, Fe3+, Mo5+, Nb5+, Zr2+. J Biomed Mater Res A. 2008 Sep 15; 86(4):905-13. PMID: 18050301.
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    88. Tunyogi-Csapo M, Kis-Toth K, Radacs M, Farkas B, Jacobs JJ, Finnegan A, Mikecz K, Glant TT. Cytokine-controlled RANKL and osteoprotegerin expression by human and mouse synovial fibroblasts: fibroblast-mediated pathologic bone resorption. Arthritis Rheum. 2008 Aug; 58(8):2397-408. PMID: 18668542.
      View in: PubMed
    89. Jacobs JJ. Translational research: Whither the ORS? J Orthop Res. 2008 May; 26(5):737-40. PMID: 18383313.
      View in: PubMed
    90. Bozic KJ, Jacobs JJ. Technology assessment and adoption in orthopaedics: lessons learned. J Bone Joint Surg Am. 2008 Apr; 90(4):689-90. PMID: 18381303.
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    91. Goldberg SH, Urban RM, Jacobs JJ, King GJ, O'Driscoll SW, Cohen MS. Modes of wear after semiconstrained total elbow arthroplasty. J Bone Joint Surg Am. 2008 Mar; 90(3):609-19. PMID: 18310712.
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    92. Hallab NJ, Caicedo M, Finnegan A, Jacobs JJ. Th1 type lymphocyte reactivity to metals in patients with total hip arthroplasty. J Orthop Surg Res. 2008 Feb 13; 3:6. PMID: 18271968; PMCID: PMC2275232.
    93. Beaty J, Jacobs JJ, Berry D. Osteoarthritis of the hip. N Engl J Med. 2008 Jan 31; 358(5):534; author reply 534-5. PMID: 18240429.
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    94. Jacobs JJ, Campbell PA, T Konttinen Y. How has the biologic reaction to wear particles changed with newer bearing surfaces? J Am Acad Orthop Surg. 2008; 16 Suppl 1:S49-55. PMID: 18612014.
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    95. Salineros MJ, Crowninshield RD, Laurent M, Wimmer MA, Jacobs JJ. Analysis of retrieved acetabular components of three polyethylene types. Clin Orthop Relat Res. 2007 Dec; 465:140-9. PMID: 17632415.
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    96. Bitsch RG, Zamorano M, Loidolt T, Heisel C, Jacobs JJ, Schmalzried TP. Ion production and excretion in a patient with a metal-on-metal bearing hip prosthesis. A case report. J Bone Joint Surg Am. 2007 Dec; 89(12):2758-63. PMID: 18056510.
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    97. Wimmer MA, Schmid TM, Jacobs JJ. Tribology: a portal to understand joint failure? Arthritis Rheum. 2007 Nov; 56(11):3511-3. PMID: 17968920.
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    98. Tunyogi-Csapo M, Koreny T, Vermes C, Galante JO, Jacobs JJ, Glant TT. Role of fibroblasts and fibroblast-derived growth factors in periprosthetic angiogenesis. J Orthop Res. 2007 Oct; 25(10):1378-88. PMID: 17557346.
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    99. Baer TM, Mulshine JL, Jacobs JJ. Biomedical imaging archive network. Skeletal Radiol. 2007 Sep; 36(9):799-801. PMID: 17410352.
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    100. Della Valle CJ, Sporer SM, Jacobs JJ, Berger RA, Rosenberg AG, Paprosky WG. Preoperative testing for sepsis before revision total knee arthroplasty. J Arthroplasty. 2007 Sep; 22(6 Suppl 2):90-3. PMID: 17823024.
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    101. Levine B, Sporer S, Della Valle CJ, Jacobs JJ, Paprosky W. Porous tantalum in reconstructive surgery of the knee: a review. J Knee Surg. 2007 Jul; 20(3):185-94. PMID: 17665779.
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    102. Deirmengian CA, Jacobs JJ. Trends in joint arthroplasty: minimally invasive surgery, wear-resistant materials, and biologics. J Clin Rheumatol. 2007 Jun; 13(3):153-8. PMID: 17551384.
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    103. Farley FA, Weinstein JN, Aamoth GM, Shapiro MS, Jacobs J, McCarthy JC, Kramer J. Workforce analysis in orthopaedic surgery: how can we improve the accuracy of our predictions? J Am Acad Orthop Surg. 2007 May; 15(5):268-73. PMID: 17478749.
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    104. Jacobs JJ. Closing the gap: Orthopaedic research in clinical practice. J Am Acad Orthop Surg. 2007 Jan; 15(1):1-2. PMID: 17213377.
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    105. Levine B, Della Valle CJ, Jacobs JJ. Applications of porous tantalum in total hip arthroplasty. J Am Acad Orthop Surg. 2006 Nov; 14(12):646-55. PMID: 17077337.
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    106. Berger R, Della Valle C, Jacobs JJ, Sheinkop MB, Rosenberg AG, Galante JO. The progression of patellofemoral arthrosis after medial unicompartmental replacement: results at 11 to 15 years. Clin Orthop Relat Res. 2006 Nov; 452:285-6. PMID: 16980894.
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    107. Brand RA, Jacobs JJ, Heckman JD. Professionalism in publishing. J Bone Joint Surg Am. 2006 Nov; 88(11):2323-5. PMID: 17079386.
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    108. Meneghini RM, Hallab NJ, Berger RA, Jacobs JJ, Paprosky WG, Rosenberg AG. Stem diameter and rotational stability in revision total hip arthroplasty: a biomechanical analysis. J Orthop Surg Res. 2006 Oct 02; 1:5. PMID: 17150125; PMCID: PMC1635007.
    109. Koreny T, Tunyogi-Csapó M, Gál I, Vermes C, Jacobs JJ, Glant TT. The role of fibroblasts and fibroblast-derived factors in periprosthetic osteolysis. Arthritis Rheum. 2006 Oct; 54(10):3221-32. PMID: 17009257.
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    110. Sporer SM, DellaValle C, Jacobs J, Wimmer M. A case of disassociation of a modular femoral neck trunion after total hip arthroplasty. J Arthroplasty. 2006 Sep; 21(6):918-21. PMID: 16950051.
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    111. Rasquinha VJ, Ranawat CS, Weiskopf J, Rodriguez JA, Skipor AK, Jacobs JJ. Serum metal levels and bearing surfaces in total hip arthroplasty. J Arthroplasty. 2006 Sep; 21(6 Suppl 2):47-52. PMID: 16950061.
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    112. Crowninshield RD, Wimmer MA, Jacobs JJ, Rosenberg AG. Clinical performance of contemporary tibial polyethylene components. J Arthroplasty. 2006 Aug; 21(5):754-61. PMID: 16877165.
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    113. Jacobs JJ, Galante JO, Mirza SK, Zdeblick T. Relationships with industry: critical for new technology or an unnecessary evil? J Bone Joint Surg Am. 2006 Jul; 88(7):1650-63. PMID: 16818992.
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    114. Weinstein SL, Jacobs JJ, Goldberg MJ. Osteoarthritis of the knee. N Engl J Med. 2006 Jun 08; 354(23):2508-9; author reply 2508-9. PMID: 16760456.
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    115. Levine BR, Sporer S, Poggie RA, Della Valle CJ, Jacobs JJ. Experimental and clinical performance of porous tantalum in orthopedic surgery. Biomaterials. 2006 Sep; 27(27):4671-81. PMID: 16737737.
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    116. Jacobs JJ, Hallab NJ. Loosening and osteolysis associated with metal-on-metal bearings: A local effect of metal hypersensitivity? J Bone Joint Surg Am. 2006 Jun; 88(6):1171-2. PMID: 16757747.
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    117. Jacobs JJ, Hallab NJ, Urban RM, Wimmer MA. Wear particles. J Bone Joint Surg Am. 2006 Apr; 88 Suppl 2:99-102. PMID: 16595453.
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    118. Fritz EA, Glant TT, Vermes C, Jacobs JJ, Roebuck KA. Chemokine gene activation in human bone marrow-derived osteoblasts following exposure to particulate wear debris. J Biomed Mater Res A. 2006 Apr; 77(1):192-201. PMID: 16392133.
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    119. Berger RA, Deirmengian CA, Della Valle CJ, Paprosky WG, Jacobs JJ, Rosenberg AG. A technique for minimally invasive, quadriceps-sparing total knee arthroplasty. J Knee Surg. 2006 Jan; 19(1):63-70. PMID: 16468498.
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    120. McGrory B, Callaghan J, Kraay M, Jacobs J, Robb W, Wasielewski R, Brand RA. Editorial: minimally invasive and small-incision joint replacement surgery: what surgeons should consider. Clin Orthop Relat Res. 2005 Nov; 440:251-4. PMID: 16239815.
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    121. Berger RA, Sanders S, Gerlinger T, Della Valle C, Jacobs JJ, Rosenberg AG. Outpatient total knee arthroplasty with a minimally invasive technique. J Arthroplasty. 2005 Oct; 20(7 Suppl 3):33-8. PMID: 16214000.
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    122. Wasielewski RC, Jacobs JJ, Arthurs B, Rubash HE. The acetabular insert-metal backing interface: an additional source of polyethylene wear debris. J Arthroplasty. 2005 Oct; 20(7):914-22. PMID: 16230245.
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    123. Burnett RS, Berger RA, Della Valle CJ, Sporer SM, Jacobs JJ, Paprosky WG, Rosenberg AG. Extensor mechanism allograft reconstruction after total knee arthroplasty. J Bone Joint Surg Am. 2005 Sep; 87 Suppl 1(Pt 2):175-94. PMID: 16140793.
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    124. Della Valle CJ, Shuaipaj T, Berger RA, Rosenberg AG, Shott S, Jacobs JJ, Galante JO. Revision of the acetabular component without cement after total hip arthroplasty. A concise follow-up, at fifteen to nineteen years, of a previous report. J Bone Joint Surg Am. 2005 Aug; 87(8):1795-800. PMID: 16085621.
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    125. Hallab NJ, Anderson S, Caicedo M, Brasher A, Mikecz K, Jacobs JJ. Effects of soluble metals on human peri-implant cells. J Biomed Mater Res A. 2005 Jul 01; 74(1):124-40. PMID: 15937919.
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    126. Fritz EA, Jacobs JJ, Glant TT, Roebuck KA. Chemokine IL-8 induction by particulate wear debris in osteoblasts is mediated by NF-kappaB. J Orthop Res. 2005 Nov; 23(6):1249-57. PMID: 15950427.
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    127. Berger RA, Meneghini RM, Jacobs JJ, Sheinkop MB, Della Valle CJ, Rosenberg AG, Galante JO. Results of unicompartmental knee arthroplasty at a minimum of ten years of follow-up. J Bone Joint Surg Am. 2005 May; 87(5):999-1006. PMID: 15866962.
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    128. Heisel C, Silva M, Skipor AK, Jacobs JJ, Schmalzried TP. The relationship between activity and ions in patients with metal-on-metal bearing hip prostheses. J Bone Joint Surg Am. 2005 Apr; 87(4):781-7. PMID: 15805207.
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    129. Hallab NJ, Anderson S, Stafford T, Glant T, Jacobs JJ. Lymphocyte responses in patients with total hip arthroplasty. J Orthop Res. 2005 Mar; 23(2):384-91. PMID: 15734252.
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    130. Meneghini RM, Hallab NJ, Jacobs JJ. The biology of alternative bearing surfaces in total joint arthroplasty. Instr Course Lect. 2005; 54:481-93. PMID: 15948473.
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    131. Berger RA, Jacobs JJ, Meneghini RM, Della Valle C, Paprosky W, Rosenberg AG. Rapid rehabilitation and recovery with minimally invasive total hip arthroplasty. Clin Orthop Relat Res. 2004 Dec; (429):239-47. PMID: 15577494.
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    132. Jacobs JJ, Skipor AK, Campbell PA, Hallab NJ, Urban RM, Amstutz HC. Can metal levels be used to monitor metal-on-metal hip arthroplasties? J Arthroplasty. 2004 Dec; 19(8 Suppl 3):59-65. PMID: 15578555.
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    133. Burnett RS, Berger RA, Paprosky WG, Della Valle CJ, Jacobs JJ, Rosenberg AG. Extensor mechanism allograft reconstruction after total knee arthroplasty. A comparison of two techniques. J Bone Joint Surg Am. 2004 Dec; 86-A(12):2694-9. PMID: 15590855.
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    134. Urban RM, Tomlinson MJ, Hall DJ, Jacobs JJ. Accumulation in liver and spleen of metal particles generated at nonbearing surfaces in hip arthroplasty. J Arthroplasty. 2004 Dec; 19(8 Suppl 3):94-101. PMID: 15578561.
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    135. MacDonald SJ, Brodner W, Jacobs JJ. A consensus paper on metal ions in metal-on-metal hip arthroplasties. J Arthroplasty. 2004 Dec; 19(8 Suppl 3):12-6. PMID: 15578546.
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    136. Hallab NJ, Anderson S, Caicedo M, Skipor A, Campbell P, Jacobs JJ. Immune responses correlate with serum-metal in metal-on-metal hip arthroplasty. J Arthroplasty. 2004 Dec; 19(8 Suppl 3):88-93. PMID: 15578560.
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    137. Berger RA, Meneghini RM, Sheinkop MB, Della Valle CJ, Jacobs JJ, Rosenberg AG, Galante JO. The progression of patellofemoral arthrosis after medial unicompartmental replacement: results at 11 to 15 years. Clin Orthop Relat Res. 2004 Nov; (428):92-9. PMID: 15534526.
      View in: PubMed
    138. Della Valle CJ, Berger RA, Shott S, Rosenberg AG, Jacobs JJ, Quigley L, Galante JO. Primary total hip arthroplasty with a porous-coated acetabular component. A concise follow-up of a previous report. J Bone Joint Surg Am. 2004 Jun; 86-A(6):1217-22. PMID: 15173295.
      View in: PubMed
    139. Hallab NJ, Messina C, Skipor A, Jacobs JJ. Differences in the fretting corrosion of metal-metal and ceramic-metal modular junctions of total hip replacements. J Orthop Res. 2004 Mar; 22(2):250-9. PMID: 15013082.
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    140. Hirakawa K, Jacobs JJ, Urban R, Saito T. Mechanisms of failure of total hip replacements: lessons learned from retrieval studies. Clin Orthop Relat Res. 2004 Mar; (420):10-7. PMID: 15057073.
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    141. Della Valle CJ, Berger RA, Rosenberg AG, Jacobs JJ, Sheinkop MB, Paprosky WG. Extended trochanteric osteotomy in complex primary total hip arthroplasty. A brief note. J Bone Joint Surg Am. 2003 Dec; 85-A(12):2385-90. PMID: 14668509.
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    142. Jacobs JJ, Hallab NJ, Skipor AK, Urban RM. Metal degradation products: a cause for concern in metal-metal bearings? Clin Orthop Relat Res. 2003 Dec; (417):139-47. PMID: 14646711.
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    143. Hallab NJ, Cunningham BW, Jacobs JJ. Spinal implant debris-induced osteolysis. Spine (Phila Pa 1976). 2003 Oct 15; 28(20):S125-38. PMID: 14560184.
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    144. Martell JM, Berkson E, Berger R, Jacobs J. Comparison of two and three-dimensional computerized polyethylene wear analysis after total hip arthroplasty. J Bone Joint Surg Am. 2003 Jun; 85-A(6):1111-7. PMID: 12784011.
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    145. Hallab NJ, Skipor A, Jacobs JJ. Interfacial kinetics of titanium- and cobalt-based implant alloys in human serum: metal release and biofilm formation. J Biomed Mater Res A. 2003 Jun 01; 65(3):311-8. PMID: 12746877.
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    146. Rosenberg AG, Jacobs JJ, Saleh KJ, Kassim RA, Christie MJ, Lewallen DG, Rand JA, Rubash HE. The patella in revision total knee arthroplasty. J Bone Joint Surg Am. 2003; 85-A Suppl 1:S63-70. PMID: 12540672.
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    147. Skipor AK, Campbell PA, Patterson LM, Anstutz HC, Schmalzried TP, Jacobs JJ. Serum and urine metal levels in patients with metal-on-metal surface arthroplasty. J Mater Sci Mater Med. 2002 Dec; 13(12):1227-34. PMID: 15348670.
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    148. Surace MF, Berzins A, Urban RM, Jacobs JJ, Berger RA, Natarajan RN, Andriacchi TP, Galante JO. Coventry Award paper. Backsurface wear and deformation in polyethylene tibial inserts retrieved postmortem. Clin Orthop Relat Res. 2002 Nov; (404):14-23. PMID: 12439232.
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    149. Berzins A, Jacobs JJ, Berger R, Ed C, Natarajan R, Andriacchi T, Galante JO. Surface damage in machined ram-extruded and net-shape molded retrieved polyethylene tibial inserts of total knee replacements. J Bone Joint Surg Am. 2002 Sep; 84-A(9):1534-40. PMID: 12208909.
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    150. Goldberg JR, Gilbert JL, Jacobs JJ, Bauer TW, Paprosky W, Leurgans S. A multicenter retrieval study of the taper interfaces of modular hip prostheses. Clin Orthop Relat Res. 2002 Aug; (401):149-61. PMID: 12151892.
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    151. Hallab NJ, Vermes C, Messina C, Roebuck KA, Glant TT, Jacobs JJ. Concentration- and composition-dependent effects of metal ions on human MG-63 osteoblasts. J Biomed Mater Res. 2002 Jun 05; 60(3):420-33. PMID: 11920666.
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    152. Qureshi AA, Virdi AS, Didonna ML, Jacobs JJ, Masuda K, Paprosky WP, Thonar EJ, Sumner DR. Implant design affects markers of bone resorption and formation in total hip replacement. J Bone Miner Res. 2002 May; 17(5):800-7. PMID: 12009010.
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    153. Fritz EA, Glant TT, Vermes C, Jacobs JJ, Roebuck KA. Titanium particles induce the immediate early stress responsive chemokines IL-8 and MCP-1 in osteoblasts. J Orthop Res. 2002 May; 20(3):490-8. PMID: 12038622.
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    154. Vermes C, Jacobs JJ, Zhang J, Firneisz G, Roebuck KA, Glant TT. Shedding of the interleukin-6 (IL-6) receptor (gp80) determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts. J Biol Chem. 2002 May 10; 277(19):16879-87. PMID: 11884403.
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    155. Jacobs JJ, Rosenberg AG, Galante JO, Berger R, Quigley L, Gitelis S, Sheinkop M. A question of prevalence: liner dislodgment in Harris-Galante acetabular components. J Bone Joint Surg Am. 2002 Jan; 84-A(1):143-4. PMID: 11792793.
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    156. Glant TT, Jacobs JJ, Mikecz K, Yao J, Chubinskaja S, Williams JM, Urban RL, Shanbhag AS, Lee SH, Sumner DR. Particulate-Induced, Prostaglandin- and Cytokine-Mediated Bone Resorption in an Experimental System and in Failed Joint Replacements. Am J Ther. 1996 Jan; 3(1):27-41. PMID: 11856995.
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