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Vineet Gupta

TitleAssociate Professor
InstitutionRush University, Rush Medical College
DepartmentInternal Medicine, Division of Nephrology
Address1735 W. Harrison St.
Chicago IL 60612
Phone312-942-0102
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    Collapse Overview 
    Collapse overview
    Other Appointments:
    Vice Chair for Research and Innovation
    Director, Drug Discovery Center

    My ORCID is 0000-0001-6987-2550.
    My Scopus ID is 14064902400.
    My NIH COMMONS name is GUPTAV.

    Education:
    PhD, University of Rochester


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Mukherjee K, Gu C, Collins A, Mettlen M, Samelko B, Altintas MM, Sudhini YR, Wang X, Bouley R, Brown D, Pedro BP, Bane SL, Gupta V, Brinkkoetter PT, Hagmann H, Reiser J, Sever S. Simultaneous stabilization of actin cytoskeleton in multiple nephron-specific cells protects the kidney from diverse injury. Nat Commun. 2022 05 03; 13(1):2422. PMID: 35504916.
      View in: PubMed
    2. Modi S, Giri B, Gupta VK, Lavania S, Sethi V, Sharma NS, Pandey S, Vickers S, Dudeja V, Saluja AK. Minnelide synergizes with conventional chemotherapy by targeting both cancer and associated stroma components in pancreatic cancer. Cancer Lett. 2022 07 01; 537:215591. PMID: 35398530.
      View in: PubMed
    3. Villanueva V, Li X, Jimenez V, Faridi HM, Gupta V. CD11b agonists offer a novel approach for treating lupus nephritis. Transl Res. 2022 Jul; 245:41-54. PMID: 35288363.
      View in: PubMed
    4. Lavania S, Gupta VK, Saluja A. The Rise of Aptamers: Promising Avenues in the Treatment of Solid Tumors. Gastroenterology. 2021 09; 161(3):804-806. PMID: 34174244.
      View in: PubMed
    5. Rajagopalan A, Venkatesh I, Aslam R, Kirchenbuechler D, Khanna S, Cimbaluk D, Kordower JH, Gupta V. SeqStain is an efficient method for multiplexed, spatialomic profiling of human and murine tissues. Cell Rep Methods. 2021 Jun 21; 1(2). PMID: 34766102.
      View in: PubMed
    6. Gupta VK, Sharma NS, Durden B, Garrido VT, Kesh K, Edwards D, Wang D, Myer C, Mateo-Victoriano B, Kollala SS, Ban Y, Gao Z, Bhattacharya SK, Saluja A, Singh PK, Banerjee S. Hypoxia-Driven Oncometabolite L-2HG Maintains Stemness-Differentiation Balance and Facilitates Immune Evasion in Pancreatic Cancer. Cancer Res. 2021 08 01; 81(15):4001-4013. PMID: 33990397.
      View in: PubMed
    7. Reddy SN, Nair NP, Tate JE, Thiyagarajan V, Giri S, Praharaj I, Mohan VR, Babji S, Gupte MD, Arora R, Bidari S, Senthamizh S, Mekala S, Goru KB, Reddy B, Pamu P, Gorthi RP, Badur M, Mohan V, Sathpathy S, Mohanty H, Dash M, Mohakud NK, Ray RK, Mohanty P, Gathwala G, Chawla S, Gupta M, Gupta R, Goyal S, Sharma P, Mathew MA, Jacob TJK, Sundaram B, Purushothaman GKC, Dorairaj P, Jagannatham M, Murugiah K, Boopathy H, Maniam R, Gurusamy R, Kumaravel S, Shenoy A, Jain H, Goswami JK, Wakhlu A, Gupta V, Vinayagamurthy G, Parashar UD, Kang G. Intussusception after Rotavirus Vaccine Introduction in India. N Engl J Med. 2020 11 12; 383(20):1932-1940. PMID: 33176083.
      View in: PubMed
    8. Kesh K, Garrido VT, Dosch A, Durden B, Gupta VK, Sharma NS, Lyle M, Nagathihalli N, Merchant N, Saluja A, Banerjee S. Stroma secreted IL6 selects for "stem-like" population and alters pancreatic tumor microenvironment by reprogramming metabolic pathways. Cell Death Dis. 2020 11 11; 11(11):967. PMID: 33177492.
      View in: PubMed
    9. Kesh K, Gupta VK, Durden B, Garrido V, Mateo-Victoriano B, Lavania SP, Banerjee S. Therapy Resistance, Cancer Stem Cells and ECM in Cancer: The Matrix Reloaded. Cancers (Basel). 2020 Oct 21; 12(10). PMID: 33096662.
      View in: PubMed
    10. Gupta VK, Banerjee S, Saluja AK. Learning From Gender Disparity: Role of Estrogen Receptor Activation in Coping With Pancreatic Cancer. Cell Mol Gastroenterol Hepatol. 2020; 10(4):862-863. PMID: 32798451.
      View in: PubMed
    11. Geraghty T, Rajagopalan A, Aslam R, Pohlman A, Venkatesh I, Zloza A, Cimbaluk D, DeNardo DG, Gupta V. Positive Allosteric Modulation of CD11b as a Novel Therapeutic Strategy Against Lung Cancer. Front Oncol. 2020; 10:748. PMID: 32528880.
      View in: PubMed
    12. Sharma NS, Gupta VK, Garrido VT, Hadad R, Durden BC, Kesh K, Giri B, Ferrantella A, Dudeja V, Saluja A, Banerjee S. Targeting tumor-intrinsic hexosamine biosynthesis sensitizes pancreatic cancer to anti-PD1 therapy. J Clin Invest. 2020 01 02; 130(1):451-465. PMID: 31613799.
      View in: PubMed
    13. Sharma K, Singh U, Rai M, Shukla J, Gupta V, Narayan G, Kumar S. Interleukin 6 and disease transformation in chronic myeloid leukemia: A Northeast Indian population study. J Cancer Res Ther. 2020 Jan-Mar; 16(1):30-33. PMID: 32362606.
      View in: PubMed
    14. Sharma NS, Gnamlin P, Durden B, Gupta VK, Kesh K, Garrido VT, Dudeja V, Saluja A, Banerjee S. Long non-coding RNA GAS5 acts as proliferation "brakes" in CD133+ cells responsible for tumor recurrence. Oncogenesis. 2019 Nov 18; 8(12):68. PMID: 31740660.
      View in: PubMed
    15. Giri B, Gupta VK, Yaffe B, Modi S, Roy P, Sethi V, Lavania SP, Vickers SM, Dudeja V, Banerjee S, Watts J, Saluja A. Correction to: Pre-clinical evaluation of Minnelide as a therapy for acute myeloid leukemia. J Transl Med. 2019 Sep 04; 17(1):301. PMID: 31484534.
      View in: PubMed
    16. Giri B, Gupta VK, Yaffe B, Modi S, Roy P, Sethi V, Lavania SP, Vickers SM, Dudeja V, Banerjee S, Watts J, Saluja A. Pre-clinical evaluation of Minnelide as a therapy for acute myeloid leukemia. J Transl Med. 2019 05 20; 17(1):163. PMID: 31109340.
      View in: PubMed
    17. Dauer P, Sharma NS, Gupta VK, Durden B, Hadad R, Banerjee S, Dudeja V, Saluja A, Banerjee S. ER stress sensor, glucose regulatory protein 78 (GRP78) regulates redox status in pancreatic cancer thereby maintaining "stemness". Cell Death Dis. 2019 02 12; 10(2):132. PMID: 30755605.
      View in: PubMed
    18. Kaminski A, Gupta KH, Goldufsky JW, Lee HW, Gupta V, Shafikhani SH. Pseudomonas aeruginosa ExoS Induces Intrinsic Apoptosis in Target Host Cells in a Manner That is Dependent on its GAP Domain Activity. Sci Rep. 2018 09 19; 8(1):14047. PMID: 30232373.
      View in: PubMed
    19. Dauer P, Sharma NS, Gupta VK, Nomura A, Dudeja V, Saluja A, Banerjee S. GRP78-mediated antioxidant response and ABC transporter activity confers chemoresistance to pancreatic cancer cells. Mol Oncol. 2018 09; 12(9):1498-1512. PMID: 29738634.
      View in: PubMed
    20. Dauer P, Zhao X, Gupta VK, Sharma N, Kesh K, Gnamlin P, Dudeja V, Vickers SM, Banerjee S, Saluja A. Inactivation of Cancer-Associated-Fibroblasts Disrupts Oncogenic Signaling in Pancreatic Cancer Cells and Promotes Its Regression. Cancer Res. 2018 03 01; 78(5):1321-1333. PMID: 29259015.
      View in: PubMed
    21. Lee HW, Arif E, Altintas MM, Quick K, Maheshwari S, Plezia A, Mahmood A, Reiser J, Nihalani D, Gupta V. High-content screening assay-based discovery of paullones as novel podocyte-protective agents. Am J Physiol Renal Physiol. 2018 02 01; 314(2):F280-F292. PMID: 29046299.
      View in: PubMed
    22. Nomura A, Gupta VK, Dauer P, Sharma NS, Dudeja V, Merchant N, Saluja AK, Banerjee S. NF?B-Mediated Invasiveness in CD133+ Pancreatic TICs Is Regulated by Autocrine and Paracrine Activation of IL1 Signaling. Mol Cancer Res. 2018 01; 16(1):162-172. PMID: 28970361.
      View in: PubMed
    23. McGinn O, Gupta VK, Dauer P, Arora N, Sharma N, Nomura A, Dudeja V, Saluja A, Banerjee S. Inhibition of hypoxic response decreases stemness and reduces tumorigenic signaling due to impaired assembly of HIF1 transcription complex in pancreatic cancer. Sci Rep. 2017 08 11; 7(1):7872. PMID: 28801636.
      View in: PubMed
    24. Hayek SS, Koh KH, Grams ME, Wei C, Ko YA, Li J, Samelko B, Lee H, Dande RR, Lee HW, Hahm E, Peev V, Tracy M, Tardi NJ, Gupta V, Altintas MM, Garborcauskas G, Stojanovic N, Winkler CA, Lipkowitz MS, Tin A, Inker LA, Levey AS, Zeier M, Freedman BI, Kopp JB, Skorecki K, Coresh J, Quyyumi AA, Sever S, Reiser J. A tripartite complex of suPAR, APOL1 risk variants and avß3 integrin on podocytes mediates chronic kidney disease. Nat Med. 2017 Aug; 23(8):945-953. PMID: 28650456.
      View in: PubMed
    25. Dauer P, Gupta VK, McGinn O, Nomura A, Sharma NS, Arora N, Giri B, Dudeja V, Saluja AK, Banerjee S. Inhibition of Sp1 prevents ER homeostasis and causes cell death by lysosomal membrane permeabilization in pancreatic cancer. Sci Rep. 2017 05 08; 7(1):1564. PMID: 28484232.
      View in: PubMed
    26. Reiser J, Lee HW, Gupta V, Altintas MM. A High-Content Screening Technology for Quantitatively Studying Podocyte Dynamics. Adv Chronic Kidney Dis. 2017 05; 24(3):183-188. PMID: 28501082.
      View in: PubMed
    27. Gupta VK, Banerjee S. Isolation of Lipid Raft Proteins from CD133+ Cancer Stem Cells. Methods Mol Biol. 2017; 1609:25-31. PMID: 28660570.
      View in: PubMed
    28. Hahm E, Wei C, Fernandez I, Li J, Tardi NJ, Tracy M, Wadhwani S, Cao Y, Peev V, Zloza A, Lusciks J, Hayek SS, O'Connor C, Bitzer M, Gupta V, Sever S, Sykes DB, Scadden DT, Reiser J. Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease. Nat Med. 2017 01; 23(1):100-106. PMID: 27941791.
      View in: PubMed
    29. Lee HW, Khan SQ, Khaliqdina S, Altintas MM, Grahammer F, Zhao JL, Koh KH, Tardi NJ, Faridi MH, Geraghty T, Cimbaluk DJ, Susztak K, Moita LF, Baltimore D, Tharaux PL, Huber TB, Kretzler M, Bitzer M, Reiser J, Gupta V. Absence of miR-146a in Podocytes Increases Risk of Diabetic Glomerulopathy via Up-regulation of ErbB4 and Notch-1. J Biol Chem. 2017 Jan 13; 292(2):732-747. PMID: 27913625.
      View in: PubMed
    30. Johnson CM, O'Brien XM, Byrd AS, Parisi VE, Loosely AJ, Li W, Witt H, Faridi MH, LeFort CT, Gupta V, Kim M, Reichner JS. Integrin Cross-Talk Regulates the Human Neutrophil Response to Fungal ß-Glucan in the Context of the Extracellular Matrix: A Prominent Role for VLA3 in the Antifungal Response. J Immunol. 2017 01 01; 198(1):318-334. PMID: 27852744.
      View in: PubMed
    31. Gupta V, Reiser J. Stop that podocyte! Am J Physiol Renal Physiol. 2017 02 01; 312(2):F373-F374. PMID: 27760773.
      View in: PubMed
    32. Gu C, Lee HW, Garborcauskas G, Reiser J, Gupta V, Sever S. Dynamin Autonomously Regulates Podocyte Focal Adhesion Maturation. J Am Soc Nephrol. 2017 02; 28(2):446-451. PMID: 27432739.
      View in: PubMed
    33. Jagarapu J, Kelchtermans J, Rong M, Chen S, Hehre D, Hummler S, Faridi MH, Gupta V, Wu S. Efficacy of Leukadherin-1 in the Prevention of Hyperoxia-Induced Lung Injury in Neonatal Rats. Am J Respir Cell Mol Biol. 2015 Dec; 53(6):793-801. PMID: 25909334.
      View in: PubMed
    34. Gupta V, Kerry VB, Goosby E, Yates R. Politics and Universal Health Coverage--The Post-2015 Global Health Agenda. N Engl J Med. 2015 Sep 24; 373(13):1189-92. PMID: 26376044.
      View in: PubMed
    35. Lee HW, Khan SQ, Faridi MH, Wei C, Tardi NJ, Altintas MM, Elshabrawy HA, Mangos S, Quick KL, Sever S, Reiser J, Gupta V. A Podocyte-Based Automated Screening Assay Identifies Protective Small Molecules. J Am Soc Nephrol. 2015 Nov; 26(11):2741-52. PMID: 25858967.
      View in: PubMed
    36. Khan SQ, Guo L, Cimbaluk DJ, Elshabrawy H, Faridi MH, Jolly M, George JF, Agarwal A, Gupta V. A Small Molecule ß2 Integrin Agonist Improves Chronic Kidney Allograft Survival by Reducing Leukocyte Recruitment and Accompanying Vasculopathy. Front Med (Lausanne). 2014; 1:45. PMID: 25593918.
      View in: PubMed
    37. Gupta V, Reiser J. MicroRNAs: a macroview into focal segmental glomerulosclerosis. Am J Kidney Dis. 2015 Feb; 65(2):206-8. PMID: 25616630.
      View in: PubMed
    38. Cascão R, Vidal B, Raquel H, Neves-Costa A, Figueiredo N, Gupta V, Fonseca JE, Moita LF. Potent anti-inflammatory and antiproliferative effects of gambogic acid in a rat model of antigen-induced arthritis. Mediators Inflamm. 2014; 2014:195327. PMID: 24623960.
      View in: PubMed
    39. Yu CC, Fornoni A, Weins A, Hakroush S, Maiguel D, Sageshima J, Chen L, Ciancio G, Faridi MH, Behr D, Campbell KN, Chang JM, Chen HC, Oh J, Faul C, Arnaout MA, Fiorina P, Gupta V, Greka A, Burke GW, Mundel P. Abatacept in B7-1-positive proteinuric kidney disease. N Engl J Med. 2013 Dec 19; 369(25):2416-23. PMID: 24206430.
      View in: PubMed
    40. Mills RW, McCrudden K, Gupta VK, Britton A, Al Qahtani M, Hasan RA. Intussusception caused by heterotopic pancreatic tissue in a child. Fetal Pediatr Pathol. 2011; 30(2):106-10. PMID: 21391750.
      View in: PubMed
    41. Qureshi AH, Chaoji V, Maiguel D, Faridi MH, Barth CJ, Salem SM, Singhal M, Stoub D, Krastins B, Ogihara M, Zaki MJ, Gupta V. Proteomic and phospho-proteomic profile of human platelets in basal, resting state: insights into integrin signaling. PLoS One. 2009 Oct 27; 4(10):e7627. PMID: 19859549.
      View in: PubMed
    42. Gupta V, Alonso JL, Sugimori T, Essafi M, Issafi M, Xiong JP, Arnaout MA. Role of the beta-subunit arginine/lysine finger in integrin heterodimer formation and function. J Immunol. 2008 Feb 01; 180(3):1713-8. PMID: 18209068.
      View in: PubMed
    43. Wei C, Möller CC, Altintas MM, Li J, Schwarz K, Zacchigna S, Xie L, Henger A, Schmid H, Rastaldi MP, Cowan P, Kretzler M, Parrilla R, Bendayan M, Gupta V, Nikolic B, Kalluri R, Carmeliet P, Mundel P, Reiser J. Modification of kidney barrier function by the urokinase receptor. Nat Med. 2008 Jan; 14(1):55-63. PMID: 18084301.
      View in: PubMed
    44. Park JY, Arnaout MA, Gupta V. A simple, no-wash cell adhesion-based high-throughput assay for the discovery of small-molecule regulators of the integrin CD11b/CD18. J Biomol Screen. 2007 Apr; 12(3):406-17. PMID: 17438069.
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    45. Gupta V, Gylling A, Alonso JL, Sugimori T, Ianakiev P, Xiong JP, Arnaout MA. The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18. Blood. 2007 Apr 15; 109(8):3513-20. PMID: 17170130.
      View in: PubMed
    46. Gupta VK, Cheifetz IM. Heliox administration in the pediatric intensive care unit: an evidence-based review. Pediatr Crit Care Med. 2005 Mar; 6(2):204-11. PMID: 15730610.
      View in: PubMed
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