 Amiloride
"Amiloride" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
| Descriptor ID |
D000584
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| MeSH Number(s) |
D03.383.679.149
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| Concept/Terms |
Amiduret Trom- Amiduret Trom
- Trom, Amiduret
- Trommsdorff Brand of Amiloride Hydrochloride
Amiloberag- Amiloberag
- Berolina Brand of Amiloride Hydrochloride
Midoride- Midoride
- Amrad Brand of Amiloride Hydrochloride
Kaluril- Kaluril
- Alphapharm Brand of Amiloride Hydrochloride
Midamor- Midamor
- Modamide
- Merck Sharp & Dohme Brand of Amiloride Hydrochloride
- Cahill May Roberts Brand of Amiloride Hydrochloride
- Merck Brand of Amiloride Hydrochloride
Amidal- Amidal
- Douglas Brand of Amiloride Hydrochloride
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Below are MeSH descriptors whose meaning is more general than "Amiloride".
Below are MeSH descriptors whose meaning is more specific than "Amiloride".
This graph shows the total number of publications written about "Amiloride" by people in this website by year, and whether "Amiloride" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1983 | 0 | 2 | 2 | | 1991 | 0 | 1 | 1 | | 1994 | 0 | 1 | 1 | | 1997 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 |
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Below are the most recent publications written about "Amiloride" by people in Profiles.
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Assadi FK, Kimura RE, Subramanian U, Patel S. Liddle syndrome in a newborn infant. Pediatr Nephrol. 2002 Aug; 17(8):609-11.
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Buyn T, Dudeja P, Harris JE, Ou D, Seed T, Sawlani D, Meng J, Bonomi P, Anderson KM. A 5-lipoxygenase inhibitor at micromolar concentration raises intracellular calcium in U937 cells prior to their physiologic cell death. Prostaglandins Leukot Essent Fatty Acids. 1997 Jan; 56(1):69-77.
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DeCoursey TE, Cherny VV. Na(+)-H+ antiport detected through hydrogen ion currents in rat alveolar epithelial cells and human neutrophils. J Gen Physiol. 1994 May; 103(5):755-85.
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Hendey B, Mamrack MD. WS-1 human fibroblasts contain distinct calcium and protein kinase C-mediated pathways for activation of Na+/H+ exchange: contrasting effects of thrombin and PMA. J Cell Physiol. 1991 Feb; 146(2):290-7.
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Blatter LA, McGuigan JA. Intracellular pH regulation in ferret ventricular muscle. The role of Na-H exchange and the influence of metabolic substrates. Circ Res. 1991 Jan; 68(1):150-61.
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Leven RM, Gonnella PA, Reeber MJ, Nachmias VT. Platelet shape change and cytoskeletal assembly: effects of pH and monovalent cation ionophores. Thromb Haemost. 1983 Jun 28; 49(3):230-4.
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Leven RM, Mullikin WH, Nachmias VT. Role of sodium in ADP- and thrombin-induced megakaryocyte spreading. J Cell Biol. 1983 May; 96(5):1234-40.
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