"Amiloride" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
| Descriptor ID |
D000584
|
| MeSH Number(s) |
D03.383.679.149
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Amiloride".
Below are MeSH descriptors whose meaning is more specific than "Amiloride".
This graph shows the total number of publications written about "Amiloride" by people in this website by year, and whether "Amiloride" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
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Below are the most recent publications written about "Amiloride" by people in Profiles.
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Liddle syndrome in a newborn infant. Pediatr Nephrol. 2002 Aug; 17(8):609-11.
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A 5-lipoxygenase inhibitor at micromolar concentration raises intracellular calcium in U937 cells prior to their physiologic cell death. Prostaglandins Leukot Essent Fatty Acids. 1997 Jan; 56(1):69-77.
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Na(+)-H+ antiport detected through hydrogen ion currents in rat alveolar epithelial cells and human neutrophils. J Gen Physiol. 1994 May; 103(5):755-85.
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WS-1 human fibroblasts contain distinct calcium and protein kinase C-mediated pathways for activation of Na+/H+ exchange: contrasting effects of thrombin and PMA. J Cell Physiol. 1991 Feb; 146(2):290-7.
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Intracellular pH regulation in ferret ventricular muscle. The role of Na-H exchange and the influence of metabolic substrates. Circ Res. 1991 Jan; 68(1):150-61.
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Platelet shape change and cytoskeletal assembly: effects of pH and monovalent cation ionophores. Thromb Haemost. 1983 Jun 28; 49(3):230-4.
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Role of sodium in ADP- and thrombin-induced megakaryocyte spreading. J Cell Biol. 1983 May; 96(5):1234-40.