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Xian-Ming Chen

TitleProfessor
InstitutionRush University, Rush Medical College
DepartmentMicrobial Pathogens and Immunity
AddressChicago IL 60612
ORCID ORCID Icon0000-0001-9848-2244 Additional info
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    Xian-Ming Chen, MD, is a faculty member in the Department of Microbial Pathogens and Immunity. He received graduate training in China and conducted a Sasakawa Scholarship fellowship in Japan and a second research fellowship at Mayo Clinic. His research interests focus on the regulatory role for ncRNAs in mucosal innate defense and in host-pathogen interactions. Specifically, his research group studies the expression of ncRNA genes and their role in regulation of immune responses of innate immune cells and epithelial cells in the gastrointestinal tract; interactions between gastrointestinal epithelial cells and Cryptosporidium (a long-recognized cause of chronic and life-threatening enteric disease in HIV-AIDS patients and one of the most common pathogens responsible for moderate-to-severe diarrhea in young children worldwide); and the ncRNA signatures that may link mucosal inflammation to the tumorigenesis and other infectious diseases. He served on several NIH study sections and international grant review panels.

    My Scopus ID is 35271047800.

    Research Areas:
    Innate immunity and inflammation, host-pathogen interactions, infectious diseases.

    My Faculty Profile at Rush University Medical Center:
    https://www.rushu.rush.edu/faculty/xian-ming-chen-md

    My Laboratory:
    https://www.rushu.rush.edu/research/departmental-research/microbial-pathogens-and-immunity-research/laboratory-xian-ming-chen-md

    My NCBI Bibliography:
    https://pubmed.ncbi.nlm.nih.gov/?term=Xian-Ming+Chen&sort=date

    My Scopus:
    https://www.scopus.com/authid/detail.uri?authorId=35271047800

    Education:
    MD, Xianning Medical College, China
    MS, Shanxi Medical University, China
    Research Fellow, Mayo Clinic College of Medicine
    Research Fellow, Kurume University School of Medicine, Japan
    BS, Xianning Medical College, Hubei Medical University (Wuhan University School of Basic Medical Sciences), China

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Graham ML, Chen XM. Use of ncRNAs to Study Host Cell-Parasite Interactions. Methods Mol Biol. 2026; 2978:157-171. PMID: 41144207.
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    2. Graham ML, Gong A-Y, Jin K, Pok C, Sharmin Z, Strauss-Soukup JK, Chen X-M. Long non-coding RNA U90926 modulates IFN-?-stimulated gene transcription and cell-intrinsic anti-Cryptosporidium defense in intestinal epithelial cells. Infect Immun. 2025 Oct 14; 93(10):e0032825. PMID: 40982010; PMCID: PMC12519777.
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    3. Jin K, Gong A-Y, Wang S, Martins GA, Strauss-Soukup JK, O'Connor RM, Chen X-M. Targeting the interaction between long noncoding RNA XR_001779380 and Prdm1 to enhance IFN-? immunity in murine neonatal intestinal epithelial cells. mBio. 2025 Jul 09; 16(7):e0077325. PMID: 40497734; PMCID: PMC12239576.
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    4. Gabriele F, Bogard JA, Palerma M, Ardini M, Byrne ME, Chen XM, Petukhov PA, Ippoliti R, Angelucci F, Williams DL. Targeting Apicomplexan Parasites: Structural and Functional Characterization of Cryptosporidium Thioredoxin Reductase as a Novel Drug Target. Biochemistry. 2025 05 20; 64(10):2212-2225. PMID: 40304242; PMCID: PMC12092171.
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    5. Sharmin Z, Jin K, Gong AY, Deng S, Pok C, Graham ML, Wang S, Mathy NW, Shibata A, Chen XM. LncRNA Nostrill promotes interferon-?-stimulated gene transcription and facilitates intestinal epithelial cell-intrinsic anti-Cryptosporidium defense. Front Immunol. 2024; 15:1397117. PMID: 39040107; PMCID: PMC11260782.
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    6. Graham ML, Li M, Gong AY, Deng S, Jin K, Wang S, Chen XM. Cryptosporidium parvum hijacks a host's long noncoding RNA U90926 to evade intestinal epithelial cell-autonomous antiparasitic defense. Front Immunol. 2023; 14:1205468. PMID: 37346046; PMCID: PMC10280636.
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    7. Deng S, He W, Gong AY, Li M, Wang Y, Xia Z, Zhang XT, Huang Pacheco AS, Naqib A, Jenkins M, Swanson PC, Drescher KM, Strauss-Soukup JK, Belshan M, Chen XM. Cryptosporidium uses CSpV1 to activate host type I interferon and attenuate antiparasitic defenses. Nat Commun. 2023 03 16; 14(1):1456. PMID: 36928642; PMCID: PMC10020566.
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    8. Deng S, Graham ML, Chen XM. The Complexity of Interferon Signaling in Host Defense against Protozoan Parasite Infection. Pathogens. 2023 Feb 15; 12(2). PMID: 36839591; PMCID: PMC9962834.
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    9. Mathy NW, Deng S, Gong AY, Li M, Wang Y, Burleigh O, Kochvar A, Whiteford ER, Shibata A, Chen XM. The Long Non-Coding RNA Nostrill Regulates Transcription of Irf7 Through Interaction With NF-?B p65 to Enhance Intestinal Epithelial Defense Against Cryptosporidium parvum. Front Immunol. 2022; 13:863957. PMID: 35464447; PMCID: PMC9021721.
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    10. Gong AY, Wang Y, Li M, Zhang XT, Deng S, Chen JM, Lu E, Mathy NW, Martins GA, Strauss-Soukup JK, Chen XM. LncRNA XR_001779380 Primes Epithelial Cells for IFN-?-Mediated Gene Transcription and Facilitates Age-Dependent Intestinal Antimicrobial Defense. mBio. 2021 Oct 26; 12(5):e0212721. PMID: 34488445; PMCID: PMC8546593.
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    11. Xia Z, Xu J, Lu E, He W, Deng S, Gong AY, Strass-Soukup J, Martins GA, Lu G, Chen XM. m6A mRNA Methylation Regulates Epithelial Innate Antimicrobial Defense Against Cryptosporidial Infection. Front Immunol. 2021; 12:705232. PMID: 34295340; PMCID: PMC8291979.
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    12. Xie XY, Chen XM, Shi L, Liu JW. Increased expression of microRNA-26a-5p predicted a poor survival outcome in osteosarcoma patients: An observational study. Medicine (Baltimore). 2021 Mar 26; 100(12):e24765. PMID: 33761638; PMCID: PMC9281968.
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    13. Li J, Jin K, Li M, Mathy NW, Gong AY, Deng S, Martins GA, Sun M, Strauss-Soukup JK, Chen XM. A host cell long noncoding RNA NR_033736 regulates type I interferon-mediated gene transcription and modulates intestinal epithelial anti-Cryptosporidium defense. PLoS Pathog. 2021 Jan; 17(1):e1009241. PMID: 33481946; PMCID: PMC7857606.
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    14. He W, Li J, Gong AY, Deng S, Li M, Wang Y, Mathy NW, Feng Y, Xiao L, Chen XM. Cryptosporidial Infection Suppresses Intestinal Epithelial Cell MAPK Signaling Impairing Host Anti-Parasitic Defense. Microorganisms. 2021 Jan 12; 9(1). PMID: 33445463; PMCID: PMC7826584.
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    15. Mathy NW, Burleigh O, Kochvar A, Whiteford ER, Behrens M, Marta P, Tian C, Gong AY, Drescher KM, Steyger PS, Chen XM, Shibata A. A novel long intergenic non-coding RNA, Nostrill, regulates iNOS gene transcription and neurotoxicity in microglia. J Neuroinflammation. 2021 Jan 06; 18(1):16. PMID: 33407594; PMCID: PMC7789650.
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    16. Lorenzen K, Mathy NW, Whiteford ER, Eischeid A, Chen J, Behrens M, Chen XM, Shibata A. Microglia induce neurogenic protein expression in primary cortical cells by stimulating PI3K/AKT intracellular signaling in vitro. Mol Biol Rep. 2021 Jan; 48(1):563-584. PMID: 33387198; PMCID: PMC7884585.
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    17. Jiang L, Chen T, Xiong L, Xu JH, Gong AY, Dai B, Wu G, Zhu K, Lu E, Mathy NW, Chen XM. Knockdown of m6A methyltransferase METTL3 in gastric cancer cells results in suppression of cell proliferation. Oncol Lett. 2020 Sep; 20(3):2191-2198. PMID: 32782536; PMCID: PMC7400027.
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    18. Xu JH, Mathy NW, Chen XM. Use of miRNAs to Study Host Cell-Parasite Interactions. Methods Mol Biol. 2020; 2052:205-218. PMID: 31452164.
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    19. Wang Y, Shen Y, Liu H, Yin J, Zhang XT, Gong AY, Chen X, Chen S, Mathy NW, Cao J, Chen XM. Induction of Inflammatory Responses in Splenocytes by Exosomes Released from Intestinal Epithelial Cells following Cryptosporidium parvum Infection. Infect Immun. 2019 Apr; 87(4). PMID: 30642905; PMCID: PMC6434132.
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    20. Li M, Gong AY, Zhang XT, Wang Y, Mathy NW, Martins GA, Strauss-Soukup JK, Chen XM. Induction of a Long Noncoding RNA Transcript, NR_045064, Promotes Defense Gene Transcription and Facilitates Intestinal Epithelial Cell Responses against Cryptosporidium Infection. J Immunol. 2018 Dec 15; 201(12):3630-3640. PMID: 30446564; PMCID: PMC6289618.
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    21. Hu G, Liao K, Niu F, Yang L, Dallon BW, Callen S, Tian C, Shu J, Cui J, Sun Z, Lyubchenko YL, Ka M, Chen XM, Buch S. Astrocyte EV-Induced lincRNA-Cox2 Regulates Microglial Phagocytosis: Implications for Morphine-Mediated Neurodegeneration. Mol Ther Nucleic Acids. 2018 Dec 07; 13:450-463. PMID: 30388619; PMCID: PMC6202788.
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    22. Ming Z, Wang Y, Gong AY, Zhang XT, Li M, Chen T, Mathy NW, Strauss-Soukup JK, Chen XM. Attenuation of Intestinal Epithelial Cell Migration During Cryptosporidium parvum Infection Involves Parasite Cdg7_FLc_1030 RNA-Mediated Induction and Release of Dickkopf-1. J Infect Dis. 2018 Sep 08; 218(8):1336-1347. PMID: 30052999; PMCID: PMC6129111.
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    23. Riesberg LA, McDonald TL, Wang Y, Chen XM, Holzmer SW, Tracy SM, Drescher KM. Creatinine downregulates TNF-a in macrophage and T cell lines. Cytokine. 2018 Oct; 110:29-38. PMID: 29698843.
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    24. Ming Z, Gong AY, Wang Y, Zhang XT, Li M, Li Y, Pang J, Dong S, Strauss-Soukup JK, Chen XM. Trans-suppression of host CDH3 and LOXL4 genes during Cryptosporidium parvum infection involves nuclear delivery of parasite Cdg7_FLc_1000 RNA. Int J Parasitol. 2018 May; 48(6):423-431. PMID: 29438669; PMCID: PMC5930044.
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    25. Ming Z, Gong AY, Wang Y, Zhang XT, Li M, Dolata CE, Chen XM. Trans-suppression of defense DEFB1 gene in intestinal epithelial cells following Cryptosporidium parvum infection is associated with host delivery of parasite Cdg7_FLc_1000 RNA. Parasitol Res. 2018 Mar; 117(3):831-840. PMID: 29374323; PMCID: PMC6145129.
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    26. Ming Z, Gong AY, Wang Y, Zhang XT, Li M, Mathy NW, Strauss-Soukup JK, Chen XM. Involvement of Cryptosporidium parvum Cdg7_FLc_1000 RNA in the Attenuation of Intestinal Epithelial Cell Migration via Trans-Suppression of Host Cell SMPD3. J Infect Dis. 2017 Dec 27; 217(1):122-133. PMID: 28961856; PMCID: PMC5853865.
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    27. Zhao GH, Gong AY, Wang Y, Zhang XT, Li M, Mathy NW, Chen XM. Nuclear delivery of parasite Cdg2_FLc_0220 RNA transcript to epithelial cells during Cryptosporidium parvum infection modulates host gene transcription. Vet Parasitol. 2018 Feb 15; 251:27-33. PMID: 29426472; PMCID: PMC5808497.
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    28. Lu Y, Liu X, Xie M, Liu M, Ye M, Li M, Chen XM, Li X, Zhou R. The NF-?B-Responsive Long Noncoding RNA FIRRE Regulates Posttranscriptional Regulation of Inflammatory Gene Expression through Interacting with hnRNPU. J Immunol. 2017 Nov 15; 199(10):3571-3582. PMID: 28993514; PMCID: PMC5672816.
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    29. Wang Y, Gong AY, Ma S, Chen X, Strauss-Soukup JK, Chen XM. Delivery of parasite Cdg7_Flc_0990 RNA transcript into intestinal epithelial cells during Cryptosporidium parvum infection suppresses host cell gene transcription through epigenetic mechanisms. Cell Microbiol. 2017 Nov; 19(11). PMID: 28655069; PMCID: PMC5638686.
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    30. Mathy NW, Chen XM. Long non-coding RNAs (lncRNAs) and their transcriptional control of inflammatory responses. J Biol Chem. 2017 Jul 28; 292(30):12375-12382. PMID: 28615453; PMCID: PMC5535013.
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    31. Wang Y, Gong AY, Ma S, Chen X, Li Y, Su CJ, Norall D, Chen J, Strauss-Soukup JK, Chen XM. Delivery of Parasite RNA Transcripts Into Infected Epithelial Cells During Cryptosporidium Infection and Its Potential Impact on Host Gene Transcription. J Infect Dis. 2017 Feb 15; 215(4):636-643. PMID: 28007919; PMCID: PMC5388288.
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    32. Ma S, Ming Z, Gong AY, Wang Y, Chen X, Hu G, Zhou R, Shibata A, Swanson PC, Chen XM. A long noncoding RNA, lincRNA-Tnfaip3, acts as a coregulator of NF-?B to modulate inflammatory gene transcription in mouse macrophages. FASEB J. 2017 Mar; 31(3):1215-1225. PMID: 27979905; PMCID: PMC6191062.
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    33. Zhang XT, Gong AY, Wang Y, Chen X, Lim SS, Dolata CE, Chen XM. Cryptosporidium parvum infection attenuates the ex vivo propagation of murine intestinal enteroids. Physiol Rep. 2016 Dec; 4(24). PMID: 28039407; PMCID: PMC5210379.
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    34. Hu G, Gong AY, Wang Y, Ma S, Chen X, Chen J, Su CJ, Shibata A, Strauss-Soukup JK, Drescher KM, Chen XM. LincRNA-Cox2 Promotes Late Inflammatory Gene Transcription in Macrophages through Modulating SWI/SNF-Mediated Chromatin Remodeling. J Immunol. 2016 Mar 15; 196(6):2799-2808. PMID: 26880762; PMCID: PMC4779692.
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    35. Xia Z, Lu Y, Li X, Mao T, Chen XM, Zhou R. Upregulation of KSRP by miR-27b provides IFN-?-induced post-transcriptional regulation of CX3CL1 in liver epithelial cells. Sci Rep. 2015 Dec 03; 5:17590. PMID: 26631623; PMCID: PMC5009954.
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    36. Tong Q, Gong AY, Zhang XT, Lin C, Ma S, Chen J, Hu G, Chen XM. LincRNA-Cox2 modulates TNF-a-induced transcription of Il12b gene in intestinal epithelial cells through regulation of Mi-2/NuRD-mediated epigenetic histone modifications. FASEB J. 2016 Mar; 30(3):1187-97. PMID: 26578685; PMCID: PMC4750408.
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    37. Checkley W, White AC, Jaganath D, Arrowood MJ, Chalmers RM, Chen XM, Fayer R, Griffiths JK, Guerrant RL, Hedstrom L, Huston CD, Kotloff KL, Kang G, Mead JR, Miller M, Petri WA, Priest JW, Roos DS, Striepen B, Thompson RC, Ward HD, Van Voorhis WA, Xiao L, Zhu G, Houpt ER. A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium. Lancet Infect Dis. 2015 Jan; 15(1):85-94. PMID: 25278220; PMCID: PMC4401121.
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    38. Xie H, Lei N, Gong AY, Chen XM, Hu G. Cryptosporidium parvum induces SIRT1 expression in host epithelial cells through downregulating let-7i. Hum Immunol. 2014 Aug; 75(8):760-5. PMID: 24862934; PMCID: PMC4327856.
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    39. Zhou R, Feng Y, Chen XM. Non-coding RNAs in epithelial immunity to Cryptosporidium infection. Parasitology. 2014 Sep; 141(10):1233-43. PMID: 24828969; PMCID: PMC4327859.
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    40. Zhou R, Gong AY, Chen D, Miller RE, Eischeid AN, Chen XM. Histone deacetylases and NF-kB signaling coordinate expression of CX3CL1 in epithelial cells in response to microbial challenge by suppressing miR-424 and miR-503. PLoS One. 2013; 8(5):e65153. PMID: 23724129; PMCID: PMC3665534.
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    41. Yu C, Gong AY, Chen D, Solelo Leon D, Young CY, Chen XM. Phenethyl isothiocyanate inhibits androgen receptor-regulated transcriptional activity in prostate cancer cells through suppressing PCAF. Mol Nutr Food Res. 2013 Oct; 57(10):1825-33. PMID: 23661605.
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    42. Hu G, Gong AY, Roth AL, Huang BQ, Ward HD, Zhu G, Larusso NF, Hanson ND, Chen XM. Release of luminal exosomes contributes to TLR4-mediated epithelial antimicrobial defense. PLoS Pathog. 2013; 9(4):e1003261. PMID: 23592986; PMCID: PMC3617097.
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    43. Duan M, Yao H, Hu G, Chen X, Lund AK, Buch S. HIV Tat induces expression of ICAM-1 in HUVECs: implications for miR-221/-222 in HIV-associated cardiomyopathy. PLoS One. 2013; 8(3):e60170. PMID: 23555914; PMCID: PMC3610892.
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    44. Liu J, Eischeid AN, Chen XM. Col1A1 production and apoptotic resistance in TGF-ß1-induced epithelial-to-mesenchymal transition-like phenotype of 603B cells. PLoS One. 2012; 7(12):e51371. PMID: 23236489; PMCID: PMC3517566.
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    45. Gong AY, Eischeid AN, Xiao J, Zhao J, Chen D, Wang ZY, Young CY, Chen XM. miR-17-5p targets the p300/CBP-associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells. BMC Cancer. 2012 Oct 24; 12:492. PMID: 23095762; PMCID: PMC3519561.
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    46. Leshner M, Wang S, Lewis C, Zheng H, Chen XA, Santy L, Wang Y. PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures. Front Immunol. 2012; 3:307. PMID: 23060885.
      Citations:    
    47. Zhou R, Gong AY, Eischeid AN, Chen XM. miR-27b targets KSRP to coordinate TLR4-mediated epithelial defense against Cryptosporidium parvum infection. PLoS Pathog. 2012; 8(5):e1002702. PMID: 22615562; PMCID: PMC3355088.
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    48. Hu G, Drescher KM, Chen XM. Exosomal miRNAs: Biological Properties and Therapeutic Potential. Front Genet. 2012; 3:56. PMID: 22529849; PMCID: PMC3330238.
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    49. Xiao J, Gong AY, Eischeid AN, Chen D, Deng C, Young CY, Chen XM. miR-141 modulates androgen receptor transcriptional activity in human prostate cancer cells through targeting the small heterodimer partner protein. Prostate. 2012 Oct 01; 72(14):1514-22. PMID: 22314666.
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    50. Zhou R, Li X, Hu G, Gong AY, Drescher KM, Chen XM. miR-16 targets transcriptional corepressor SMRT and modulates NF-kappaB-regulated transactivation of interleukin-8 gene. PLoS One. 2012; 7(1):e30772. PMID: 22292036; PMCID: PMC3265513.
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    51. Zhao J, Gong AY, Zhou R, Liu J, Eischeid AN, Chen XM. Downregulation of PCAF by miR-181a/b provides feedback regulation to TNF-a-induced transcription of proinflammatory genes in liver epithelial cells. J Immunol. 2012 Feb 01; 188(3):1266-74. PMID: 22219331; PMCID: PMC3262895.
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    52. Zhou R, O'Hara SP, Chen XM. MicroRNA regulation of innate immune responses in epithelial cells. Cell Mol Immunol. 2011 Sep; 8(5):371-9. PMID: 21725335; PMCID: PMC4012889.
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    53. Chen X, Song CH, Feng BS, Li TL, Li P, Zheng PY, Chen XM, Xing Z, Yang PC. Intestinal epithelial cell-derived integrin aß6 plays an important role in the induction of regulatory T cells and inhibits an antigen-specific Th2 response. J Leukoc Biol. 2011 Oct; 90(4):751-9. PMID: 21724807.
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    54. O'Hara SP, Chen XM. The cell biology of cryptosporidium infection. Microbes Infect. 2011 Aug; 13(8-9):721-30. PMID: 21458585; PMCID: PMC3130844.
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    55. Gong AY, Hu G, Zhou R, Liu J, Feng Y, Soukup GA, Chen XM. MicroRNA-221 controls expression of intercellular adhesion molecule-1 in epithelial cells in response to Cryptosporidium parvum infection. Int J Parasitol. 2011 Mar; 41(3-4):397-403. PMID: 21236259; PMCID: PMC3046242.
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    56. Hu G, Zhou R, Liu J, Gong AY, Chen XM. MicroRNA-98 and let-7 regulate expression of suppressor of cytokine signaling 4 in biliary epithelial cells in response to Cryptosporidium parvum infection. J Infect Dis. 2010 Jul 01; 202(1):125-35. PMID: 20486857; PMCID: PMC2880649.
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    57. Zhou R, Hu G, Gong AY, Chen XM. Binding of NF-kappaB p65 subunit to the promoter elements is involved in LPS-induced transactivation of miRNA genes in human biliary epithelial cells. Nucleic Acids Res. 2010 Jun; 38(10):3222-32. PMID: 20144951; PMCID: PMC2879527.
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    58. Hu G, Gong AY, Liu J, Zhou R, Deng C, Chen XM. miR-221 suppresses ICAM-1 translation and regulates interferon-gamma-induced ICAM-1 expression in human cholangiocytes. Am J Physiol Gastrointest Liver Physiol. 2010 Apr; 298(4):G542-50. PMID: 20110463; PMCID: PMC2853302.
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    59. Gong AY, Zhou R, Hu G, Liu J, Sosnowska D, Drescher KM, Dong H, Chen XM. Cryptosporidium parvum induces B7-H1 expression in cholangiocytes by down-regulating microRNA-513. J Infect Dis. 2010 Jan 01; 201(1):160-9. PMID: 19916867; PMCID: PMC2791176.
      Citations:    
    60. Zhou R, Hu G, Liu J, Gong AY, Drescher KM, Chen XM. NF-kappaB p65-dependent transactivation of miRNA genes following Cryptosporidium parvum infection stimulates epithelial cell immune responses. PLoS Pathog. 2009 Dec; 5(12):e1000681. PMID: 19997496; PMCID: PMC2778997.
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    61. O'Hara SP, Splinter PL, Gajdos GB, Trussoni CE, Fernandez-Zapico ME, Chen XM, LaRusso NF. NFkappaB p50-CCAAT/enhancer-binding protein beta (C/EBPbeta)-mediated transcriptional repression of microRNA let-7i following microbial infection. J Biol Chem. 2010 Jan 01; 285(1):216-25. PMID: 19903813; PMCID: PMC2804168.
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    62. Li X, Liu J, Zhou R, Huang S, Huang S, Chen XM. Gene silencing of MIR22 in acute lymphoblastic leukaemia involves histone modifications independent of promoter DNA methylation. Br J Haematol. 2010 Jan; 148(1):69-79. PMID: 19807731.
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    63. Hu G, Zhou R, Liu J, Gong AY, Eischeid AN, Dittman JW, Chen XM. MicroRNA-98 and let-7 confer cholangiocyte expression of cytokine-inducible Src homology 2-containing protein in response to microbial challenge. J Immunol. 2009 Aug 01; 183(3):1617-24. PMID: 19592657; PMCID: PMC2906382.
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    64. Chen XM. MicroRNA signatures in liver diseases. World J Gastroenterol. 2009 Apr 14; 15(14):1665-72. PMID: 19360909; PMCID: PMC2668771.
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    65. Liu J, Drescher KM, Chen XM. MicroRNAs and Epithelial Immunity. Int Rev Immunol. 2009; 28(3-4):139-54. PMID: 19811319; PMCID: PMC2764336.
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