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Xian-Ming Chen

InstitutionRush University, Rush Medical College
DepartmentMicrobial Pathogens and Immunity
AddressChicago IL 60612
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    Xian-Ming Chen, MD, is a faculty member in the Department of Microbial Pathogens and Immunity. He received graduate training in China and conducted a Sasakawa Scholarship fellowship in Japan and a second research fellowship at Mayo Clinic. His research interests focus on the regulatory role for ncRNAs in mucosal innate defense and in host-pathogen interactions. Specifically, his research group studies the expression of ncRNA genes and their role in regulation of immune responses of innate immune cells and epithelial cells in the gastrointestinal tract; interactions between gastrointestinal epithelial cells and Cryptosporidium (a long-recognized cause of chronic and life-threatening enteric disease in HIV-AIDS patients and one of the most common pathogens responsible for moderate-to-severe diarrhea in young children worldwide); and the ncRNA signatures that may link mucosal inflammation to the tumorigenesis and other infectious diseases. He served on several NIH study sections and international grant review panels.

    My Scopus ID is 35271047800.

    Research Areas:
    Innate immunity and inflammation, host-pathogen interactions, infectious diseases.

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    MD, Xianning Medical College, China
    MS, Shanxi Medical University, China
    Research Fellow, Mayo Clinic College of Medicine
    Research Fellow, Kurume University School of Medicine, Japan
    BS, Xianning Medical College, Hubei Medical University (Wuhan University School of Basic Medical Sciences), China

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhang L, Yin JC, Yeh H, Ma NX, Lee G, Chen XA, Wang Y, Lin L, Chen L, Jin P, Wu GY, Chen G. Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons. Cell Stem Cell. 2015 Dec 03; 17(6):735-747. PMID: 26481520.
    2. Wang S, Chen XA, Hu J, Jiang JK, Li Y, Chan-Salis KY, Gu Y, Chen G, Thomas C, Pugh BF, Wang Y. ATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple-Negative Breast Cancer Cells. Mol Cancer Ther. 2015 Apr; 14(4):877-88. PMID: 25612620.
    3. Chang GS, Chen XA, Park B, Rhee HS, Li P, Han KH, Mishra T, Chan-Salis KY, Li Y, Hardison RC, Wang Y, Pugh BF. A comprehensive and high-resolution genome-wide response of p53 to stress. Cell Rep. 2014 Jul 24; 8(2):514-27. PMID: 25043190.
    4. Zhu H, Wang Y, Wang Y, Zhao S, Zhao M, Gui L, Xu W, Chen XA, Wang Y, Peng S. Folded Conformation, Cyclic Pentamer, Nano-Structure and PAD4 Binding Mode of YW3-56. J Phys Chem C Nanomater Interfaces. 2013 May 16; 117(19):10070-10078. PMID: 23795230.
    5. Leshner M, Wang S, Lewis C, Zheng H, Chen XA, Santy L, Wang Y. PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures. Front Immunol. 2012; 3:307. PMID: 23060885.
    6. Wang Y, Li P, Wang S, Hu J, Chen XA, Wu J, Fisher M, Oshaben K, Zhao N, Gu Y, Wang D, Chen G, Wang Y. Anticancer peptidylarginine deiminase (PAD) inhibitors regulate the autophagy flux and the mammalian target of rapamycin complex 1 activity. J Biol Chem. 2012 Jul 27; 287(31):25941-53. PMID: 22605338.
    7. Cichon J, Sun C, Chen B, Jiang M, Chen XA, Sun Y, Wang Y, Chen G. Cofilin aggregation blocks intracellular trafficking and induces synaptic loss in hippocampal neurons. J Biol Chem. 2012 Feb 03; 287(6):3919-29. PMID: 22184127.
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