Receptor, Metabotropic Glutamate 5
"Receptor, Metabotropic Glutamate 5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A type I G protein-coupled receptor mostly expressed post-synaptic pyramidal cells of the cortex and CENTRAL NERVOUS SYSTEM.
| Descriptor ID |
D064529
|
| MeSH Number(s) |
D12.776.543.750.695.450.500 D12.776.543.750.720.200.450.500.500
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Receptor, Metabotropic Glutamate 5".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, G-Protein-Coupled [D12.776.543.750.695]
- Receptors, Metabotropic Glutamate [D12.776.543.750.695.450]
- Receptor, Metabotropic Glutamate 5 [D12.776.543.750.695.450.500]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Amino Acid [D12.776.543.750.720.200]
- Receptors, Glutamate [D12.776.543.750.720.200.450]
- Receptors, Metabotropic Glutamate [D12.776.543.750.720.200.450.500]
- Receptor, Metabotropic Glutamate 5 [D12.776.543.750.720.200.450.500.500]
Below are MeSH descriptors whose meaning is more specific than "Receptor, Metabotropic Glutamate 5".
This graph shows the total number of publications written about "Receptor, Metabotropic Glutamate 5" by people in this website by year, and whether "Receptor, Metabotropic Glutamate 5" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 4 | 4 |
| 2012 | 1 | 1 | 2 |
| 2013 | 1 | 1 | 2 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Receptor, Metabotropic Glutamate 5" by people in Profiles.
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Effects of mavoglurant on visual attention and pupil reactivity while viewing photographs of faces in Fragile X Syndrome. PLoS One. 2019; 14(1):e0209984.
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Mavoglurant in Fragile X Syndrome: Results of two open-label, extension trials in adults and adolescents. Sci Rep. 2018 11 19; 8(1):16970.
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Effect of the mGluR5-NAM Basimglurant on Behavior in Adolescents and Adults with Fragile X Syndrome in a Randomized, Double-Blind, Placebo-Controlled Trial: FragXis Phase 2 Results. Neuropsychopharmacology. 2018 02; 43(3):503-512.
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A Phase 2A Trial of the Novel mGluR5-Negative Allosteric Modulator Dipraglurant for Levodopa-Induced Dyskinesia in Parkinson's Disease. Mov Disord. 2016 09; 31(9):1373-80.
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Development of mavoglurant and its potential for the treatment of fragile X syndrome. Expert Opin Investig Drugs. 2014 Jan; 23(1):125-34.
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Cellular distribution of AMPA receptor subunits and mGlu5 following acute and repeated administration of morphine or methamphetamine. J Neurochem. 2013 Aug; 126(4):503-17.
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mGluR5 is necessary for maintenance of methamphetamine-induced associative learning. Eur Neuropsychopharmacol. 2013 Jul; 23(7):691-6.
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Fragile X syndrome and targeted treatment trials. Results Probl Cell Differ. 2012; 54:297-335.
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Developmental regulation of group I metabotropic glutamate receptors in the premature brain and their protective role in a rodent model of periventricular leukomalacia. Neuron Glia Biol. 2010 Nov; 6(4):277-88.
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Brain region-selective cellular redistribution of mGlu5 but not GABA(B) receptors following methamphetamine-induced associative learning. Synapse. 2011 Dec; 65(12):1333-43.