 Clonazepam
"Clonazepam" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
| Descriptor ID |
D002998
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| MeSH Number(s) |
D03.438.079.080.070.150
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Clonazepam".
Below are MeSH descriptors whose meaning is more specific than "Clonazepam".
This graph shows the total number of publications written about "Clonazepam" by people in this website by year, and whether "Clonazepam" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1983 | 0 | 1 | 1 | | 1986 | 1 | 1 | 2 | | 1987 | 3 | 0 | 3 | | 1989 | 0 | 1 | 1 | | 1990 | 1 | 2 | 3 | | 1991 | 1 | 0 | 1 | | 1992 | 1 | 0 | 1 | | 1993 | 1 | 2 | 3 | | 1994 | 1 | 1 | 2 | | 1998 | 1 | 0 | 1 | | 2000 | 1 | 1 | 2 | | 2003 | 2 | 0 | 2 | | 2004 | 1 | 0 | 1 | | 2009 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2014 | 2 | 0 | 2 |
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Below are the most recent publications written about "Clonazepam" by people in Profiles.
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Pollack MH, Stein M, Simon N, Van Ameringen M. Response to Silberman. Am J Psychiatry. 2014 Jul; 171(7):795-6.
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Pollack MH, Van Ameringen M, Simon NM, Worthington JW, Hoge EA, Keshaviah A, Stein MB. A double-blind randomized controlled trial of augmentation and switch strategies for refractory social anxiety disorder. Am J Psychiatry. 2014 Jan; 171(1):44-53.
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Otto MW, McHugh RK, Simon NM, Farach FJ, Worthington JJ, Pollack MH. Efficacy of CBT for benzodiazepine discontinuation in patients with panic disorder: Further evaluation. Behav Res Ther. 2010 Aug; 48(8):720-7.
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Simon NM, Otto MW, Worthington JJ, Hoge EA, Thompson EH, Lebeau RT, Moshier SJ, Zalta AK, Pollack MH. Next-step strategies for panic disorder refractory to initial pharmacotherapy: a 3-phase randomized clinical trial. J Clin Psychiatry. 2009 Nov; 70(11):1563-70.
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Simon NM, Otto MW, Smits JA, Nicolaou DC, Reese HE, Pollack MH. Changes in anxiety sensitivity with pharmacotherapy for panic disorder. J Psychiatr Res. 2004 Sep-Oct; 38(5):491-5.
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Pollack MH, Simon NM, Worthington JJ, Doyle AL, Peters P, Toshkov F, Otto MW. Combined paroxetine and clonazepam treatment strategies compared to paroxetine monotherapy for panic disorder. J Psychopharmacol. 2003 Sep; 17(3):276-82.
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Negrusz A, Bowen AM, Moore CM, Dowd SM, Strong MJ, Janicak PG. Elimination of 7-aminoclonazepam in urine after a single dose of clonazepam. Anal Bioanal Chem. 2003 Aug; 376(8):1198-204.
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Sedova M, Blatter LA. Intracellular sodium modulates mitochondrial calcium signaling in vascular endothelial cells. J Biol Chem. 2000 Nov 10; 275(45):35402-7.
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Otto MW, Pollack MH, Gould RA, Worthington JJ, McArdle ET, Rosenbaum JF. A comparison of the efficacy of clonazepam and cognitive-behavioral group therapy for the treatment of social phobia. J Anxiety Disord. 2000 Jul-Aug; 14(4):345-58.
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Worthington JJ, Pollack MH, Otto MW, McLean RY, Moroz G, Rosenbaum JF. Long-term experience with clonazepam in patients with a primary diagnosis of panic disorder. Psychopharmacol Bull. 1998; 34(2):199-205.
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