"Integrin alpha2beta1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.
| Descriptor ID |
D038982
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| MeSH Number(s) |
D12.776.395.550.625.298 D12.776.543.550.625.298 D12.776.543.750.685.200 D12.776.543.750.705.408.530.249 D12.776.543.750.705.408.850.199 D12.776.543.750.705.675.352 D12.776.543.750.705.876.280
|
| Concept/Terms |
Integrin alpha2beta1- Integrin alpha2beta1
- alpha2beta1, Integrin
- VLA-2
- VLA 2
- Glycoprotein Ia-IIa
- Glycoprotein Ia IIa
- alpha2beta1Integrin
- Very Late Antigen-2
- Late Antigen-2, Very
- Very Late Antigen 2
- CD49b-CD29
- CD49b CD29
- Platelet Membrane Glycoprotein Heterodimer Ia-IIa
- Platelet Membrane Glycoprotein Heterodimer Ia IIa
|
Below are MeSH descriptors whose meaning is more general than "Integrin alpha2beta1".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha2beta1".
This graph shows the total number of publications written about "Integrin alpha2beta1" by people in this website by year, and whether "Integrin alpha2beta1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
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Below are the most recent publications written about "Integrin alpha2beta1" by people in Profiles.
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Fibronectin fragments and blocking antibodies to alpha2beta1 and alpha5beta1 integrins stimulate mitogen-activated protein kinase signaling and increase collagenase 3 (matrix metalloproteinase 13) production by human articular chondrocytes. Arthritis Rheum. 2002 Sep; 46(9):2368-76.