 Chlorpromazine
"Chlorpromazine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
| Descriptor ID |
D002746
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| MeSH Number(s) |
D02.886.369.198 D03.494.741.198
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Chlorpromazine".
Below are MeSH descriptors whose meaning is more specific than "Chlorpromazine".
This graph shows the total number of publications written about "Chlorpromazine" by people in this website by year, and whether "Chlorpromazine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1980 | 1 | 0 | 1 | | 1983 | 0 | 1 | 1 | | 1985 | 0 | 1 | 1 | | 1990 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 |
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Below are the most recent publications written about "Chlorpromazine" by people in Profiles.
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Melikyan GB, Markosyan RM, Roth MG, Cohen FS. A point mutation in the transmembrane domain of the hemagglutinin of influenza virus stabilizes a hemifusion intermediate that can transit to fusion. Mol Biol Cell. 2000 Nov; 11(11):3765-75.
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Qiao H, Armstrong RT, Melikyan GB, Cohen FS, White JM. A specific point mutant at position 1 of the influenza hemagglutinin fusion peptide displays a hemifusion phenotype. Mol Biol Cell. 1999 Aug; 10(8):2759-69.
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Jacobs ER, DeCoursey TE. Mechanisms of potassium channel block in rat alveolar epithelial cells. J Pharmacol Exp Ther. 1990 Nov; 255(2):459-72.
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Klawans HL, Carvey P, Tanner CM, Goetz CG. The pathophysiology of tardive dyskinesia. J Clin Psychiatry. 1985 Apr; 46(4 Pt 2):38-41.
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Klawans HL, Goetz CG, Carvey P. Animal models of tardive dyskinesias. Clin Neuropharmacol. 1983 Jun; 6(2):129-35.
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Klawans HL, Carvey P, Hitri A, Nausieda PA, Weiner WJ. Correlation between daily dosage of chlorpromazine and subsequent supersensitivity. Adv Biochem Psychopharmacol. 1980; 24:569-72.
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Klawans HL, Bergen D, Bruyn GW, Paulson GW. Neuroleptic-induced tardiave dyskinesias in nonpsychotic patients. Arch Neurol. 1974 Apr; 30(4):338-9.
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Klawans HL, Goetz C, Weiner WJ. 5-Hydroxytryptophan-induced myoclonus in guinea pigs and the possible role of serotonin in infantile myoclonus. Neurology. 1973 Nov; 23(11):1234-40.
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BLUMBERG AG, KLEIN DF, POLLACK M. EFFECTS OF CHLORPROMAZINE AND IMIPRAMINE ON SYSTOLIC BLOOD PRESSURE IN PSYCHIATRIC PATIENTS: RELATIONSHIPS TO AGE, DIAGNOSIS AND INITIAL BLOOD PRESSURE. J Psychiatr Res. 1964 Jan; 2:51-60.
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