 Leukoencephalopathy, Progressive Multifocal
"Leukoencephalopathy, Progressive Multifocal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)
| Descriptor ID |
D007968
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| MeSH Number(s) |
C02.182.500.300.500 C02.256.721.500 C02.290.575 C02.839.550 C10.228.140.695.750 C10.228.228.210.150.300.500 C10.228.228.245.340.575 C10.314.450
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| Concept/Terms |
Leukoencephalopathy, Progressive Multifocal- Leukoencephalopathy, Progressive Multifocal
- Leukoencephalopathies, Progressive Multifocal
- Multifocal Leukoencephalopathies, Progressive
- Multifocal Leukoencephalopathy, Progressive
- Progressive Multifocal Leukoencephalopathies
- JC Polyomavirus Encephalopathy
- Encephalopathies, JC Polyomavirus
- Encephalopathy, JC Polyomavirus
- Progressive Multifocal Leukoencephalopathy
- Encephalitis, JC Polyomavirus
- JC Polyomavirus Encephalitis
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Below are MeSH descriptors whose meaning is more general than "Leukoencephalopathy, Progressive Multifocal".
- Diseases [C]
- Virus Diseases [C02]
- Central Nervous System Viral Diseases [C02.182]
- Encephalitis [C02.182.500]
- Encephalitis, Viral [C02.182.500.300]
- Leukoencephalopathy, Progressive Multifocal [C02.182.500.300.500]
- DNA Virus Infections [C02.256]
- Polyomavirus Infections [C02.256.721]
- Leukoencephalopathy, Progressive Multifocal [C02.256.721.500]
- Encephalitis, Viral [C02.290]
- Leukoencephalopathy, Progressive Multifocal [C02.290.575]
- Slow Virus Diseases [C02.839]
- Leukoencephalopathy, Progressive Multifocal [C02.839.550]
- Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
- Brain Diseases [C10.228.140]
- Leukoencephalopathies [C10.228.140.695]
- Leukoencephalopathy, Progressive Multifocal [C10.228.140.695.750]
- Central Nervous System Infections [C10.228.228]
- Central Nervous System Viral Diseases [C10.228.228.210]
- Encephalitis [C10.228.228.210.150]
- Encephalitis, Viral [C10.228.228.210.150.300]
- Leukoencephalopathy, Progressive Multifocal [C10.228.228.210.150.300.500]
- Encephalitis [C10.228.228.245]
- Encephalitis, Viral [C10.228.228.245.340]
- Leukoencephalopathy, Progressive Multifocal [C10.228.228.245.340.575]
- Demyelinating Diseases [C10.314]
- Leukoencephalopathy, Progressive Multifocal [C10.314.450]
Below are MeSH descriptors whose meaning is more specific than "Leukoencephalopathy, Progressive Multifocal".
This graph shows the total number of publications written about "Leukoencephalopathy, Progressive Multifocal" by people in this website by year, and whether "Leukoencephalopathy, Progressive Multifocal" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 0 | 1 | 1 | | 1999 | 2 | 0 | 2 | | 2001 | 3 | 0 | 3 | | 2002 | 2 | 0 | 2 | | 2003 | 4 | 0 | 4 | | 2004 | 4 | 2 | 6 | | 2005 | 6 | 1 | 7 | | 2006 | 4 | 1 | 5 | | 2007 | 6 | 0 | 6 | | 2008 | 5 | 0 | 5 | | 2009 | 6 | 0 | 6 | | 2010 | 3 | 0 | 3 | | 2011 | 7 | 0 | 7 | | 2012 | 8 | 0 | 8 | | 2013 | 8 | 0 | 8 | | 2014 | 5 | 0 | 5 | | 2015 | 4 | 0 | 4 | | 2016 | 2 | 0 | 2 | | 2017 | 2 | 0 | 2 | | 2018 | 1 | 0 | 1 | | 2019 | 5 | 0 | 5 | | 2020 | 1 | 0 | 1 | | 2021 | 4 | 0 | 4 |
To return to the timeline, click here.
Below are the most recent publications written about "Leukoencephalopathy, Progressive Multifocal" by people in Profiles.
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O'Hara BA, Gee GV, Haley SA, Morris-Love J, Nyblade C, Nieves C, Hanson BA, Dang X, Turner TJ, Chavin JM, Lublin A, Koralnik IJ, Atwood WJ. Teriflunomide Inhibits JCPyV Infection and Spread in Glial Cells and Choroid Plexus Epithelial Cells. Int J Mol Sci. 2021 Sep 10; 22(18).
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Bernard-Valnet R, Koralnik IJ, Du Pasquier R. Advances in Treatment of Progressive Multifocal Leukoencephalopathy. Ann Neurol. 2021 12; 90(6):865-873.
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Patel A, Sul J, Gordon ML, Steinklein J, Sanguinetti S, Pramanik B, Purohit D, Haroutunian V, Williamson A, Koralnik I, Harel A. Progressive Multifocal Leukoencephalopathy in a Patient With Progressive Multiple Sclerosis Treated With Ocrelizumab Monotherapy. JAMA Neurol. 2021 06 01; 78(6):736-740.
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Mian A, Andrapalliyal N, Weathers AL, Pohlman B, Hill BT. Late occurrence of progressive multifocal leukoencephalopathy after anti-CD19 chimeric antigen receptor T-cell therapy. Eur J Haematol. 2021 Apr; 106(4):584-588.
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Breville G, Koralnik IJ, Lalive PH. Brainstem progressive multifocal leukoencephalopathy. Eur J Neurol. 2021 03; 28(3):1016-1021.
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Tan CS, Ghofrani J, Geiger E, Koralnik IJ, Jost S. Brief Report: Decreased JC Virus-Specific Antibody-Dependent Cellular Cytotoxicity in HIV-Seropositive PML Survivors. J Acquir Immune Defic Syndr. 2019 10 01; 82(2):220-224.
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Mubanga E, Patel A, Siddiqi OK, Hanson BA, Dang X, Lakhi S, Mulundu G, Bender N, Koralnik IJ. Progressive multifocal leukoencephalopathy in Zambia is caused by JC virus with prototype regulatory region. J Neurovirol. 2019 08; 25(4):475-479.
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Corbridge SM, Rice RC, Bean LA, Wüthrich C, Dang X, Nicholson DA, Koralnik IJ. JC virus infection of meningeal and choroid plexus cells in patients with progressive multifocal leukoencephalopathy. J Neurovirol. 2019 08; 25(4):520-524.
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Koralnik IJ. Can Immune Checkpoint Inhibitors Keep JC Virus in Check? N Engl J Med. 2019 04 25; 380(17):1667-1668.
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Stefoski D, Balabanov R, Waheed R, Ko M, Koralnik IJ, Sierra Morales F. Treatment of natalizumab-associated PML with filgrastim. Ann Clin Transl Neurol. 2019 May; 6(5):923-931.
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