SOX9 Transcription Factor
"SOX9 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A SOXE transcription factor that plays a critical role in regulating CHONDROGENESIS; OSTEOGENESIS; and male sex determination. Loss of function of the SOX9 transcription factor due to genetic mutations is a cause of CAMPOMELIC DYSPLASIA.
| Descriptor ID |
D055758
|
| MeSH Number(s) |
D12.776.260.719.500.500 D12.776.660.235.400.750.500.500 D12.776.664.235.400.750.500.500 D12.776.930.823.500.500
|
| Concept/Terms |
SOX9 Transcription Factor- SOX9 Transcription Factor
- Transcription Factor, SOX9
- SOX-9 Transcription Factor
- SOX 9 Transcription Factor
- Transcription Factor, SOX-9
|
Below are MeSH descriptors whose meaning is more general than "SOX9 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "SOX9 Transcription Factor".
This graph shows the total number of publications written about "SOX9 Transcription Factor" by people in this website by year, and whether "SOX9 Transcription Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 2 | 2 |
| 2010 | 2 | 0 | 2 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 3 | 0 | 3 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "SOX9 Transcription Factor" by people in Profiles.
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CRISPR-mediated Sox9 activation and RelA inhibition enhance cell therapy for osteoarthritis. Mol Ther. 2024 Aug 07; 32(8):2549-2562.
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SOX9 keeps growth plates and articular cartilage healthy by inhibiting chondrocyte dedifferentiation/osteoblastic redifferentiation. Proc Natl Acad Sci U S A. 2021 02 23; 118(8).
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A Novel Regulatory Mechanism of Type II Collagen Expression via a SOX9-dependent Enhancer in Intron 6. J Biol Chem. 2017 Jan 13; 292(2):528-538.
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Smpd3 Expression in both Chondrocytes and Osteoblasts Is Required for Normal Endochondral Bone Development. Mol Cell Biol. 2016 09 01; 36(17):2282-99.
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SOX9 directly Regulates CTGF/CCN2 Transcription in Growth Plate Chondrocytes and in Nucleus Pulposus Cells of Intervertebral Disc. Sci Rep. 2016 07 20; 6:29916.
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SOX9 regulates multiple genes in chondrocytes, including genes encoding ECM proteins, ECM modification enzymes, receptors, and transporters. PLoS One. 2014; 9(9):e107577.
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Lactoferricin enhances BMP7-stimulated anabolic pathways in intervertebral disc cells. Gene. 2013 07 25; 524(2):282-91.
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The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template. Nucleic Acids Res. 2010 Oct; 38(18):6018-28.
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Identification of SOX9 interaction sites in the genome of chondrocytes. PLoS One. 2010 Apr 09; 5(4):e10113.
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Primary bovine intervertebral disc cells transduced with adenovirus overexpressing 12 BMPs and Sox9 maintain appropriate phenotype. Am J Phys Med Rehabil. 2009 Jun; 88(6):455-63.