 Metalloendopeptidases
"Metalloendopeptidases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
ENDOPEPTIDASES which use a metal such as ZINC in the catalytic mechanism.
| Descriptor ID |
D008666
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| MeSH Number(s) |
D08.811.277.656.300.480 D08.811.277.656.675.374
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Metalloendopeptidases".
Below are MeSH descriptors whose meaning is more specific than "Metalloendopeptidases".
This graph shows the total number of publications written about "Metalloendopeptidases" by people in this website by year, and whether "Metalloendopeptidases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1983 | 1 | 0 | 1 | | 1986 | 1 | 0 | 1 | | 1992 | 1 | 0 | 1 | | 1994 | 1 | 0 | 1 | | 1995 | 1 | 2 | 3 | | 1996 | 1 | 1 | 2 | | 1997 | 1 | 2 | 3 | | 1998 | 1 | 0 | 1 | | 1999 | 0 | 1 | 1 | | 2001 | 3 | 1 | 4 | | 2002 | 2 | 0 | 2 | | 2003 | 2 | 0 | 2 | | 2004 | 2 | 1 | 3 | | 2005 | 1 | 1 | 2 | | 2010 | 1 | 0 | 1 |
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Below are the most recent publications written about "Metalloendopeptidases" by people in Profiles.
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Wang S, Wang R, Chen L, Bennett DA, Dickson DW, Wang DS. Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer's brain. J Neurochem. 2010 Oct; 115(1):47-57.
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Manadan AM, Harris C, Block JA. Thrombotic thrombocytopenic purpura in the setting of systemic sclerosis. Semin Arthritis Rheum. 2005 Feb; 34(4):683-8.
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Richards JS, Hernandez-Gonzalez I, Gonzalez-Robayna I, Teuling E, Lo Y, Boerboom D, Falender AE, Doyle KH, LeBaron RG, Thompson V, Sandy JD. Regulated expression of ADAMTS family members in follicles and cumulus oocyte complexes: evidence for specific and redundant patterns during ovulation. Biol Reprod. 2005 May; 72(5):1241-55.
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Westling J, Gottschall PE, Thompson VP, Cockburn A, Perides G, Zimmermann DR, Sandy JD. ADAMTS4 (aggrecanase-1) cleaves human brain versican V2 at Glu405-Gln406 to generate glial hyaluronate binding protein. Biochem J. 2004 Feb 01; 377(Pt 3):787-95.
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Tortorella MD, Arner EC, Hills R, Easton A, Korte-Sarfaty J, Fok K, Wittwer AJ, Liu RQ, Malfait AM. Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes. J Biol Chem. 2004 Apr 23; 279(17):17554-61.
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Fan Z, Chubinskaya S, Rueger DC, Bau B, Haag J, Aigner T. Regulation of anabolic and catabolic gene expression in normal and osteoarthritic adult human articular chondrocytes by osteogenic protein-1. Clin Exp Rheumatol. 2004 Jan-Feb; 22(1):103-6.
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Gao G, Plaas A, Thompson VP, Jin S, Zuo F, Sandy JD. ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1. J Biol Chem. 2004 Mar 12; 279(11):10042-51.
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Russell DL, Doyle KM, Ochsner SA, Sandy JD, Richards JS. Processing and localization of ADAMTS-1 and proteolytic cleavage of versican during cumulus matrix expansion and ovulation. J Biol Chem. 2003 Oct 24; 278(43):42330-9.
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Westling J, Fosang AJ, Last K, Thompson VP, Tomkinson KN, Hebert T, McDonagh T, Collins-Racie LA, LaVallie ER, Morris EA, Sandy JD. ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain. J Biol Chem. 2002 May 03; 277(18):16059-66.
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Gao G, Westling J, Thompson VP, Howell TD, Gottschall PE, Sandy JD. Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by C-terminal truncation. J Biol Chem. 2002 Mar 29; 277(13):11034-41.
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