 Depressive Disorder, Treatment-Resistant
"Depressive Disorder, Treatment-Resistant" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Failure to respond to two or more trials of antidepressant monotherapy or failure to respond to four or more trials of different antidepressant therapies. (Campbell's Psychiatric Dictionary, 9th ed.)
| Descriptor ID |
D061218
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| MeSH Number(s) |
F03.600.300.387
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| Concept/Terms |
Depressive Disorder, Treatment-Resistant- Depressive Disorder, Treatment-Resistant
- Depressive Disorder, Treatment Resistant
- Depressive Disorders, Treatment-Resistant
- Disorder, Treatment-Resistant Depressive
- Disorders, Treatment-Resistant Depressive
- Treatment-Resistant Depressive Disorder
- Treatment-Resistant Depressive Disorders
- Therapy-Resistant Depression
- Depression, Therapy-Resistant
- Depressions, Therapy-Resistant
- Therapy Resistant Depression
- Therapy-Resistant Depressions
- Treatment Resistant Depression
- Depression, Treatment Resistant
- Depressions, Treatment Resistant
- Resistant Depression, Treatment
- Resistant Depressions, Treatment
- Treatment Resistant Depressions
- Refractory Depression
- Depression, Refractory
- Depressions, Refractory
- Refractory Depressions
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Below are MeSH descriptors whose meaning is more general than "Depressive Disorder, Treatment-Resistant".
Below are MeSH descriptors whose meaning is more specific than "Depressive Disorder, Treatment-Resistant".
This graph shows the total number of publications written about "Depressive Disorder, Treatment-Resistant" by people in this website by year, and whether "Depressive Disorder, Treatment-Resistant" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 2 | 2 | | 2014 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 | | 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Depressive Disorder, Treatment-Resistant" by people in Profiles.
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Fava M, Mazzone E, Freeman M, Flynn M, Judge H, Hoeppner B, Hock RS, Shui A, Macaluso M, Morrison MF, Carpenter LL, Shelton R, Zajecka J, Papakostas GI. Double-blind, placebo-controlled, proof-of-concept trial of a kappa-selective opioid receptor antagonist augmentation in treatment-resistant depression. Ann Clin Psychiatry. 2020 02; 32(4):18-26.
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Daly EJ, Trivedi MH, Janik A, Li H, Zhang Y, Li X, Lane R, Lim P, Duca AR, Hough D, Thase ME, Zajecka J, Winokur A, Divacka I, Fagiolini A, Cubala WJ, Bitter I, Blier P, Shelton RC, Molero P, Manji H, Drevets WC, Singh JB. Efficacy of Esketamine Nasal Spray Plus Oral Antidepressant Treatment for Relapse Prevention in Patients With Treatment-Resistant Depression: A Randomized Clinical Trial. JAMA Psychiatry. 2019 09 01; 76(9):893-903.
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Aaronson ST, Sears P, Ruvuna F, Bunker M, Conway CR, Dougherty DD, Reimherr FW, Schwartz TL, Zajecka JM. A 5-Year Observational Study of Patients With Treatment-Resistant Depression Treated With Vagus Nerve Stimulation or Treatment as Usual: Comparison of Response, Remission, and Suicidality. Am J Psychiatry. 2017 07 01; 174(7):640-648.
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Sanacora G, Johnson MR, Khan A, Atkinson SD, Riesenberg RR, Schronen JP, Burke MA, Zajecka JM, Barra L, Su HL, Posener JA, Bui KH, Quirk MC, Piser TM, Mathew SJ, Pathak S. Adjunctive Lanicemine (AZD6765) in Patients with Major Depressive Disorder and History of Inadequate Response to Antidepressants: A Randomized, Placebo-Controlled Study. Neuropsychopharmacology. 2017 Mar; 42(4):844-853.
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Philip NS, Dunner DL, Dowd SM, Aaronson ST, Brock DG, Carpenter LL, Demitrack MA, Hovav S, Janicak PG, George MS. Can Medication Free, Treatment-Resistant, Depressed Patients Who Initially Respond to TMS Be Maintained Off Medications? A Prospective, 12-Month Multisite Randomized Pilot Study. Brain Stimul. 2016 Mar-Apr; 9(2):251-7.
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Papakostas GI, Shelton RC, Zajecka JM, Bottiglieri T, Roffman J, Cassiello C, Stahl SM, Fava M. Effect of adjunctive L-methylfolate 15 mg among inadequate responders to SSRIs in depressed patients who were stratified by biomarker levels and genotype: results from a randomized clinical trial. J Clin Psychiatry. 2014 Aug; 75(8):855-63.
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Powers C, Hart VA, Shattell M, MacCulloch T. The concept of "the will to thrive" in mental health. Issues Ment Health Nurs. 2012 Nov; 33(11):805-7.
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Fava M, Mischoulon D, Iosifescu D, Witte J, Pencina M, Flynn M, Harper L, Levy M, Rickels K, Pollack M. A double-blind, placebo-controlled study of aripiprazole adjunctive to antidepressant therapy among depressed outpatients with inadequate response to prior antidepressant therapy (ADAPT-A Study). Psychother Psychosom. 2012; 81(2):87-97.
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