"Caspase 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 9. Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
| Descriptor ID |
D053148
|
| MeSH Number(s) |
D08.811.277.656.262.500.126.350.300 D08.811.277.656.300.200.126.350.300 D12.644.360.075.405.350.300 D12.776.476.075.405.350.300
|
| Concept/Terms |
Procaspase-3- Procaspase-3
- Procaspase 3
- Pro-Caspase-3
- Pro Caspase 3
|
Below are MeSH descriptors whose meaning is more general than "Caspase 3".
Below are MeSH descriptors whose meaning is more specific than "Caspase 3".
This graph shows the total number of publications written about "Caspase 3" by people in this website by year, and whether "Caspase 3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 2 | 2 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
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Below are the most recent publications written about "Caspase 3" by people in Profiles.
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Signaling mechanisms leading to the regulation of differentiation and apoptosis of articular chondrocytes by insulin-like growth factor-1. J Biol Chem. 2003 Sep 19; 278(38):36563-71.
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p38 kinase-dependent and -independent Inhibition of protein kinase C zeta and -alpha regulates nitric oxide-induced apoptosis and dedifferentiation of articular chondrocytes. J Biol Chem. 2002 Aug 16; 277(33):30375-81.
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ERK-1/2 and p38 kinase oppositely regulate nitric oxide-induced apoptosis of chondrocytes in association with p53, caspase-3, and differentiation status. J Biol Chem. 2002 Jan 11; 277(2):1332-9.
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Modulation of nitric oxide-induced apoptotic death of HL-60 cells by protein kinase C and protein kinase A through mitogen-activated protein kinases and CPP32-like protease pathways. Cell Immunol. 1999 May 25; 194(1):36-46.
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Overexpression of protein kinase C isoforms protects RAW 264.7 macrophages from nitric oxide-induced apoptosis: involvement of c-Jun N-terminal kinase/stress-activated protein kinase, p38 kinase, and CPP-32 protease pathways. J Immunol. 1999 Mar 15; 162(6):3395-401.