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Hazel Lum

TitleProfessor
InstitutionRush University, Rush Medical College
DepartmentCell and Molecular Medicine
AddressChicago IL 60612
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    Collapse Overview 
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    My Scopus ID is 7006024051.

    My Faculty Profile at Rush University Medical Center:
    https://www.rushu.rush.edu/faculty/hazel-lum-phd

    My NCBI Bibliography:
    https://www.ncbi.nlm.nih.gov/pubmed/?term=Hazel+Lum

    My Scopus:
    https://www.scopus.com/authid/detail.uri?authorId=7006024051


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Xu Z, Li W, Han J, Zou C, Huang W, Yu W, Shan X, Lum H, Li X, Liang G. Angiotensin II induces kidney inflammatory injury and fibrosis through binding to myeloid differentiation protein-2 (MD2). Sci Rep. 2017 Mar 21; 7:44911. PMID: 28322341.
      View in: PubMed
    2. Cowan C, Muraleedharan CK, O'Donnell JJ, Singh PK, Lum H, Kumar A, Xu S. MicroRNA-146 inhibits thrombin-induced NF-?B activation and subsequent inflammatory responses in human retinal endothelial cells. Invest Ophthalmol Vis Sci. 2014 Jul 01; 55(8):4944-51. PMID: 24985472.
      View in: PubMed
    3. Yoder M, Zhuge Y, Yuan Y, Holian O, Kuo S, van Breemen R, Thomas LL, Lum H. Bioactive lysophosphatidylcholine 16:0 and 18:0 are elevated in lungs of asthmatic subjects. Allergy Asthma Immunol Res. 2014 Jan; 6(1):61-5. PMID: 24404395; PMCID: PMC3881403.
    4. Zhuge Y, Yuan Y, van Breemen R, Degrand M, Holian O, Yoder M, Lum H. Stimulated bronchial epithelial cells release bioactive lysophosphatidylcholine 16:0, 18:0, and 18:1. Allergy Asthma Immunol Res. 2014 Jan; 6(1):66-74. PMID: 24404396; PMCID: PMC3881404.
    5. Si H, Yu J, Jiang H, Lum H, Liu D. Phytoestrogen genistein up-regulates endothelial nitric oxide synthase expression via activation of cAMP response element-binding protein in human aortic endothelial cells. Endocrinology. 2012 Jul; 153(7):3190-8. PMID: 22669896; PMCID: PMC3791435.
    6. O'Donnell JJ, Zhuge Y, Holian O, Cheng F, Thomas LL, Forsyth CB, Lum H. Loss of p120 catenin upregulates transcription of pro-inflammatory adhesion molecules in human endothelial cells. Microvasc Res. 2011 Sep; 82(2):105-12. PMID: 21554891; PMCID: PMC3149739.
    7. Rao G, Ding HG, Huang W, Le D, Maxhimer JB, Oosterhof A, van Kuppevelt T, Lum H, Lewis EJ, Reddy V, Prinz RA, Xu X. Reactive oxygen species mediate high glucose-induced heparanase-1 production and heparan sulphate proteoglycan degradation in human and rat endothelial cells: a potential role in the pathogenesis of atherosclerosis. Diabetologia. 2011 Jun; 54(6):1527-38. PMID: 21424539.
      View in: PubMed
    8. Fu Z, Zhang W, Zhen W, Lum H, Nadler J, Bassaganya-Riera J, Jia Z, Wang Y, Misra H, Liu D. Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice. Endocrinology. 2010 Jul; 151(7):3026-37. PMID: 20484465; PMCID: PMC2903942.
    9. Zhang J, O'Donnell JJ, Holian O, Vincent PA, Kim KS, Lum H. P120 catenin represses transcriptional activity through Kaiso in endothelial cells. Microvasc Res. 2010 Sep; 80(2):233-9. PMID: 20382170; PMCID: PMC2917640.
    10. Qiao J, Holian O, Lee BS, Huang F, Zhang J, Lum H. Phosphorylation of GTP dissociation inhibitor by PKA negatively regulates RhoA. Am J Physiol Cell Physiol. 2008 Nov; 295(5):C1161-8. PMID: 18768928; PMCID: PMC2584978.
    11. Ke Y, Lum H, Solaro RJ. Inhibition of endothelial barrier dysfunction by P21-activated kinase-1. Can J Physiol Pharmacol. 2007 Mar-Apr; 85(3-4):281-8. PMID: 17612635.
      View in: PubMed
    12. Huang F, Mehta D, Predescu S, Kim KS, Lum H. A novel lysophospholipid- and pH-sensitive receptor, GPR4, in brain endothelial cells regulates monocyte transmigration. Endothelium. 2007 Jan-Feb; 14(1):25-34. PMID: 17364894.
      View in: PubMed
    13. Qiao J, Huang F, Naikawadi RP, Kim KS, Said T, Lum H. Lysophosphatidylcholine impairs endothelial barrier function through the G protein-coupled receptor GPR4. Am J Physiol Lung Cell Mol Physiol. 2006 Jul; 291(1):L91-101. PMID: 16461426.
      View in: PubMed
    14. Carvey PM, Zhao CH, Hendey B, Lum H, Trachtenberg J, Desai BS, Snyder J, Zhu YG, Ling ZD. 6-Hydroxydopamine-induced alterations in blood-brain barrier permeability. Eur J Neurosci. 2005 Sep; 22(5):1158-68. PMID: 16176358.
      View in: PubMed
    15. Huang F, Subbaiah PV, Holian O, Zhang J, Johnson A, Gertzberg N, Lum H. Lysophosphatidylcholine increases endothelial permeability: role of PKCalpha and RhoA cross talk. Am J Physiol Lung Cell Mol Physiol. 2005 Aug; 289(2):L176-85. PMID: 15764646.
      View in: PubMed
    16. Kim KS, Ren J, Jiang Y, Ebrahem Q, Tipps R, Cristina K, Xiao YJ, Qiao J, Taylor KL, Lum H, Anand-Apte B, Xu Y. GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine. FASEB J. 2005 May; 19(7):819-21. PMID: 15857892.
      View in: PubMed
    17. Mutlu GM, Ahkmedov AT, Lum H, Factor P. Potential genetic therapies for acute lung injury. Curr Gene Ther. 2004 Dec; 4(4):487-95. PMID: 15578996.
      View in: PubMed
    18. Rochais F, Vandecasteele G, Lefebvre F, Lugnier C, Lum H, Mazet JL, Cooper DM, Fischmeister R. Negative feedback exerted by cAMP-dependent protein kinase and cAMP phosphodiesterase on subsarcolemmal cAMP signals in intact cardiac myocytes: an in vivo study using adenovirus-mediated expression of CNG channels. J Biol Chem. 2004 Dec 10; 279(50):52095-105. PMID: 15466415.
      View in: PubMed
    19. Meja KK, Catley MC, Cambridge LM, Barnes PJ, Lum H, Newton R, Giembycz MA. Adenovirus-mediated delivery and expression of a cAMP-dependent protein kinase inhibitor gene to BEAS-2B epithelial cells abolishes the anti-inflammatory effects of rolipram, salbutamol, and prostaglandin E2: a comparison with H-89. J Pharmacol Exp Ther. 2004 May; 309(2):833-44. PMID: 14747610.
      View in: PubMed
    20. Lum H, Qiao J, Walter RJ, Huang F, Subbaiah PV, Kim KS, Holian O. Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells. Am J Physiol Heart Circ Physiol. 2003 Oct; 285(4):H1786-9. PMID: 12805023.
      View in: PubMed
    21. Qiao J, Huang F, Lum H. PKA inhibits RhoA activation: a protection mechanism against endothelial barrier dysfunction. Am J Physiol Lung Cell Mol Physiol. 2003 Jun; 284(6):L972-80. PMID: 12588708.
      View in: PubMed
    22. Boo YC, Hwang J, Sykes M, Michell BJ, Kemp BE, Lum H, Jo H. Shear stress stimulates phosphorylation of eNOS at Ser(635) by a protein kinase A-dependent mechanism. Am J Physiol Heart Circ Physiol. 2002 Nov; 283(5):H1819-28. PMID: 12384459.
      View in: PubMed
    23. Lum H, Hao Z, Gayle D, Kumar P, Patterson CE, Uhler MD. Vascular endothelial cells express isoforms of protein kinase A inhibitor. Am J Physiol Cell Physiol. 2002 Jan; 282(1):C59-66. PMID: 11742798.
      View in: PubMed
    24. Lum H, Podolski JL, Gurnack ME, Schulz IT, Huang F, Holian O. Protein phosphatase 2B inhibitor potentiates endothelial PKC activity and barrier dysfunction. Am J Physiol Lung Cell Mol Physiol. 2001 Sep; 281(3):L546-55. PMID: 11504680.
      View in: PubMed
    25. Lum HK, Lee KL. The human HMGB1 promoter is modulated by a silencer and an enhancer-containing intron. Biochim Biophys Acta. 2001 Jul 30; 1520(1):79-84. PMID: 11470162.
      View in: PubMed
    26. Lum H, Roebuck KA. Oxidant stress and endothelial cell dysfunction. Am J Physiol Cell Physiol. 2001 Apr; 280(4):C719-41. PMID: 11245588.
      View in: PubMed
    27. Lum H, Jaffe HA, Schulz IT, Masood A, RayChaudhury A, Green RD. Expression of PKA inhibitor (PKI) gene abolishes cAMP-mediated protection to endothelial barrier dysfunction. Am J Physiol. 1999 Sep; 277(3 Pt 1):C580-8. PMID: 10484345.
      View in: PubMed
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