"Osteocalcin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
| Descriptor ID |
D015675
|
| MeSH Number(s) |
D12.776.157.125.700
|
| Concept/Terms |
Osteocalcin- Osteocalcin
- Bone gamma-Carboxyglutamic Acid Protein
- Bone gamma Carboxyglutamic Acid Protein
- Vitamin K-Dependent Bone Protein
- Vitamin K Dependent Bone Protein
- Calcium-Binding Protein, Vitamin K-Dependent
- Calcium Binding Protein, Vitamin K Dependent
- Gla Protein, Bone
- 4-Carboxyglutamic Protein, Bone
- 4 Carboxyglutamic Protein, Bone
- Bone 4-Carboxyglutamic Protein
- Protein, Bone 4-Carboxyglutamic
- Bone Gla Protein
- Protein, Bone Gla
|
Below are MeSH descriptors whose meaning is more general than "Osteocalcin".
Below are MeSH descriptors whose meaning is more specific than "Osteocalcin".
This graph shows the total number of publications written about "Osteocalcin" by people in this website by year, and whether "Osteocalcin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 1 | 1 | 2 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Osteocalcin" by people in Profiles.
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Brief Report: Undercarboxylated Osteocalcin Is Associated With Cognition in Women With and Without HIV. J Acquir Immune Defic Syndr. 2022 10 01; 91(2):162-167.
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Comparison of Bone Turnover Biomarkers in Serum and Urine Measured on an Automated Analytical Platform. J Appl Lab Med. 2021 04 29; 6(3):750-755.
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Change in Circulating Undercarboxylated Osteocalcin (ucOCN) Is Associated With Fat Accumulation in HIV-Seropositive Women. J Acquir Immune Defic Syndr. 2021 04 15; 86(5):e139-e145.
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Early changes in serum osteocalcin and body weight are predictive of implant fixation in a rat model of implant loosening. J Orthop Res. 2020 06; 38(6):1216-1227.
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Chemically modified RNA activated matrices enhance bone regeneration. J Control Release. 2015 Nov 28; 218:22-8.
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Expression levels of insulin receptor substrate-1 modulate the osteoblastic differentiation of mesenchymal stem cells and osteosarcoma cells. Growth Factors. 2014 Feb; 32(1):41-52.
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Excessive bone formation in a mouse model of ankylosing spondylitis is associated with decreases in Wnt pathway inhibitors. Arthritis Res Ther. 2012 Nov 22; 14(6):R253.
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Deiodinase-mediated thyroid hormone inactivation minimizes thyroid hormone signaling in the early development of fetal skeleton. Bone. 2008 Nov; 43(5):921-30.
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Short-term reduction in bone markers with high-dose simvastatin. Osteoporos Int. 2005 Oct; 16(10):1272-6.
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Nuclear microenvironments support physiological control of gene expression. Chromosome Res. 2003; 11(5):527-36.