"Endophenotypes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Measurable biological (physiological, biochemical, and anatomical features), behavioral (psychometric pattern) or cognitive markers that are found more often in individuals with a disease than in the general population. Because many endophenotypes are present before the disease onset and in individuals with heritable risk for disease such as unaffected family members, they can be used to help diagnose and search for causative genes.
| Descriptor ID |
D058068
|
| MeSH Number(s) |
G05.695.224
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Endophenotypes".
Below are MeSH descriptors whose meaning is more specific than "Endophenotypes".
This graph shows the total number of publications written about "Endophenotypes" by people in this website by year, and whether "Endophenotypes" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2013 | 1 | 2 | 3 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Endophenotypes" by people in Profiles.
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A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology. Ann Neurol. 2015 Mar; 77(3):469-77.
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ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology. Acta Neuropathol. 2014; 127(6):825-43.
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Heritability and linkage analysis of personality in bipolar disorder. J Affect Disord. 2013 Nov; 151(2):748-755.
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An inflection point in gene discovery efforts for neurodegenerative diseases: from syndromic diagnoses toward endophenotypes and the epigenome. JAMA Neurol. 2013 Jun; 70(6):719-26.
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GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science. 2013 Jun 21; 340(6139):1467-71.
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Heritability of different forms of memory in the Late Onset Alzheimer's Disease Family Study. J Alzheimers Dis. 2011; 23(2):249-55.