Interleukin-12 Subunit p40
"Interleukin-12 Subunit p40" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cytokine subunit that is a component of both interleukin-12 and interleukin-23. It binds to the INTERLEUKIN-12 SUBUNIT P35 via a disulfide bond to form interleukin-12 and to INTERLEUKIN-23 SUBUNIT P19 to form interleukin-23.
| Descriptor ID |
D053762
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| MeSH Number(s) |
D12.644.276.374.465.512.500 D12.644.276.374.465.759.249 D12.776.467.374.465.512.500 D12.776.467.374.465.759.249 D23.529.374.465.512.500 D23.529.374.465.550.249
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| Concept/Terms |
Interleukin-12 Subunit p40- Interleukin-12 Subunit p40
- Interleukin 12 Subunit p40
- Interleukin-23 Subunit p40
- Interleukin 23 Subunit p40
- p40, Interleukin-23 Subunit
- Interleukin-12,23 p40 Subunit
- Interleukin 12,23 p40 Subunit
- p40 Subunit, Interleukin-12,23
- Interleukin-12b
- Interleukin 12b
- IL-12p40
- Interleukin-12 beta Chain
- Chain, Interleukin-12 beta
- Interleukin 12 beta Chain
- beta Chain, Interleukin-12
|
Below are MeSH descriptors whose meaning is more general than "Interleukin-12 Subunit p40".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-12 Subunit p40".
This graph shows the total number of publications written about "Interleukin-12 Subunit p40" by people in this website by year, and whether "Interleukin-12 Subunit p40" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2008 | 3 | 0 | 3 |
| 2009 | 3 | 0 | 3 |
| 2014 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Interleukin-12 Subunit p40" by people in Profiles.
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Regression of Triple-Negative Breast Cancer in a Patient-Derived Xenograft Mouse Model by Monoclonal Antibodies against IL-12 p40 Monomer. Cells. 2022 01 13; 11(2).
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IL-12 p40 monomer is different from other IL-12 family members to selectively inhibit IL-12R?1 internalization and suppress EAE. Proc Natl Acad Sci U S A. 2020 09 01; 117(35):21557-21567.
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Peroxisome Proliferator-Activated Receptor-d Acts within Peripheral Myeloid Cells to Limit Th Cell Priming during Experimental Autoimmune Encephalomyelitis. J Immunol. 2019 11 15; 203(10):2588-2601.
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Selective neutralization of IL-12 p40 monomer induces death in prostate cancer cells via IL-12-IFN-?. Proc Natl Acad Sci U S A. 2017 10 24; 114(43):11482-11487.
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Interleukin-12 (IL-12), but not IL-23, induces the expression of IL-7 in microglia and macrophages: implications for multiple sclerosis. Immunology. 2014 Apr; 141(4):549-63.
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IL-12 p40 homodimer, the so-called biologically inactive molecule, induces nitric oxide synthase in microglia via IL-12R beta 1. Glia. 2009 Nov 01; 57(14):1553-65.
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Suppression of regulatory T cells by IL-12p40 homodimer via nitric oxide. J Immunol. 2009 Aug 01; 183(3):2045-58.
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Functional blocking monoclonal antibodies against IL-12p40 homodimer inhibit adoptive transfer of experimental allergic encephalomyelitis. J Immunol. 2009 Apr 15; 182(8):5013-23.
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IL-12 p40 homodimer, but not IL-12 p70, induces the expression of IL-16 in microglia and macrophages. Mol Immunol. 2009 Feb; 46(5):773-83.
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Generation of functional blocking monoclonal antibodies against mouse interleukin-12 p40 homodimer and monomer. Hybridoma (Larchmt). 2008 Jun; 27(3):141-51.