 Bombesin
"Bombesin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tetradecapeptide originally obtained from the skins of toads Bombina bombina and B. variegata. It is also an endogenous neurotransmitter in many animals including mammals. Bombesin affects vascular and other smooth muscle, gastric secretion, and renal circulation and function.
| Descriptor ID |
D001839
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| MeSH Number(s) |
D06.472.699.100 D12.644.400.085 D12.644.548.100 D12.776.641.650.085 D20.888.033.137 D23.946.833.033.137
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Bombesin".
Below are MeSH descriptors whose meaning is more specific than "Bombesin".
This graph shows the total number of publications written about "Bombesin" by people in this website by year, and whether "Bombesin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1983 | 0 | 1 | 1 | | 1984 | 0 | 1 | 1 | | 1985 | 1 | 1 | 2 | | 1988 | 2 | 1 | 3 | | 1989 | 0 | 1 | 1 | | 1991 | 2 | 0 | 2 | | 1993 | 0 | 1 | 1 | | 1997 | 1 | 0 | 1 |
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Below are the most recent publications written about "Bombesin" by people in Profiles.
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Kelley MJ, Linnoila RI, Avis IL, Georgiadis MS, Cuttitta F, Mulshine JL, Johnson BE. Antitumor activity of a monoclonal antibody directed against gastrin-releasing peptide in patients with small cell lung cancer. Chest. 1997 Jul; 112(1):256-61.
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Avis I, Jett M, Kasprzyk PG, Cuttitta F, Treston AM, Maneckjee R, Mulshine JL. Effect of gastrin-releasing peptide on the pancreatic tumor cell line (Capan). Mol Carcinog. 1993; 8(4):214-20.
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Avis IL, Kovacs TO, Kasprzyk PG, Treston AM, Bartholomew R, Walsh JH, Cuttitta F, Mulshine JL. Preclinical evaluation of an anti-autocrine growth factor monoclonal antibody for treatment of patients with small-cell lung cancer. J Natl Cancer Inst. 1991 Oct 16; 83(20):1470-6.
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Mahmoud S, Staley J, Taylor J, Bogden A, Moreau JP, Coy D, Avis I, Cuttitta F, Mulshine JL, Moody TW. [Psi 13,14] bombesin analogues inhibit growth of small cell lung cancerin vitro and in vivo. Cancer Res. 1991 Apr 01; 51(7):1798-802.
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Mulshine JL, Treston AM, Natale RB, Kasprzyk PG, Avis I, Nakanishi Y, Cuttitta F. Autocrine growth factors as therapeutic targets in lung cancer. Chest. 1989 Jul; 96(1 Suppl):31S-34S.
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Trepel JB, Moyer JD, Cuttitta F, Frucht H, Coy DH, Natale RB, Mulshine JL, Jensen RT, Sausville EA. A novel bombesin receptor antagonist inhibits autocrine signals in a small cell lung carcinoma cell line. Biochem Biophys Res Commun. 1988 Nov 15; 156(3):1383-9.
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Mulshine JL, Avis I, Treston AM, Mobley C, Kaspryzyk P, Carrasquillo JA, Larson SM, Nakanishi Y, Merchant B, Minna JD, et al. Clinical use of a monoclonal antibody to bombesin-like peptide in patients with lung cancer. Ann N Y Acad Sci. 1988; 547:360-72.
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Kasprzyk PG, Cuttitta F, Treston AM, Avis I, Nakanishi Y, Wong H, Walsh JH, Mulshine JL. Consideration of the chemistry of solid-phase matrix interaction leads to improved quantitation of neuropeptides. Ann N Y Acad Sci. 1988; 547:41-53.
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Cuttitta F, Carney DN, Mulshine J, Moody TW, Fedorko J, Fischler A, Minna JD. Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer. Nature. 1985 Aug 29-Sep 4; 316(6031):823-6.
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Cuttitta F, Carney DN, Mulshine J, Moody TW, Fedorko J, Fischler A, Minna JD. Autocrine growth factors in human small cell lung cancer. Cancer Surv. 1985; 4(4):707-27.
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