 Aggrecans
"Aggrecans" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Large HYALURONAN-containing proteoglycans found in articular cartilage (CARTILAGE, ARTICULAR). They form into aggregates that provide tissues with the capacity to resist high compressive and tensile forces.
| Descriptor ID |
D053674
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| MeSH Number(s) |
D09.698.735.200.500 D12.776.395.650.750.687.100 D12.776.503.280.437.100 D12.776.860.300.140
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| Concept/Terms |
Aggrecans- Aggrecans
- Cartilage-Specific Proteoglycan Core Proteins
- Cartilage Specific Proteoglycan Core Proteins
- Aggrecan
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Below are MeSH descriptors whose meaning is more general than "Aggrecans".
Below are MeSH descriptors whose meaning is more specific than "Aggrecans".
This graph shows the total number of publications written about "Aggrecans" by people in this website by year, and whether "Aggrecans" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1990 | 0 | 2 | 2 | | 1991 | 0 | 2 | 2 | | 1992 | 0 | 5 | 5 | | 1993 | 0 | 5 | 5 | | 1994 | 0 | 5 | 5 | | 1995 | 0 | 9 | 9 | | 1996 | 0 | 3 | 3 | | 1997 | 0 | 3 | 3 | | 1998 | 0 | 3 | 3 | | 1999 | 0 | 3 | 3 | | 2000 | 0 | 4 | 4 | | 2001 | 0 | 6 | 6 | | 2002 | 0 | 7 | 7 | | 2003 | 0 | 5 | 5 | | 2004 | 0 | 6 | 6 | | 2005 | 0 | 8 | 8 | | 2006 | 1 | 8 | 9 | | 2007 | 4 | 0 | 4 | | 2008 | 3 | 1 | 4 | | 2009 | 2 | 3 | 5 | | 2010 | 5 | 2 | 7 | | 2011 | 4 | 0 | 4 | | 2012 | 0 | 4 | 4 | | 2013 | 2 | 4 | 6 | | 2014 | 1 | 0 | 1 | | 2015 | 1 | 2 | 3 | | 2016 | 2 | 1 | 3 | | 2017 | 1 | 2 | 3 | | 2018 | 1 | 0 | 1 | | 2019 | 1 | 3 | 4 | | 2020 | 0 | 1 | 1 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Aggrecans" by people in Profiles.
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Lai Y, Zheng W, Qu M, Xiao CC, Chen S, Yao Q, Gong W, Tao C, Yan Q, Zhang P, Wu X, Xiao G. Kindlin-2 loss in condylar chondrocytes causes spontaneous osteoarthritic lesions in the temporomandibular joint in mice. Int J Oral Sci. 2022 Jul 04; 14(1):33.
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Xue J, Chen J, Shen Q, Chan D, Li J, Tanguay AP, Schmidt TA, Niazi F, Plaas A. Addition of High Molecular Weight Hyaluronic Acid to Fibroblast-Like Stromal Cells Modulates Endogenous Hyaluronic Acid Metabolism and Enhances Proteolytic Processing and Secretion of Versican. Cells. 2020 07 13; 9(7).
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Malfait AM, Tortorella MD. The "elusive DMOAD": Aggrecanase inhibition from laboratory to clinic. Clin Exp Rheumatol. 2019 Sep-Oct; 37 Suppl 120(5):130-134.
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Kugyelka R, Prenek L, Olasz K, Kohl Z, Botz B, Glant TT, Berki T, Boldizsár F. ZAP-70 Regulates Autoimmune Arthritis via Alterations in T Cell Activation and Apoptosis. Cells. 2019 05 24; 8(5).
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Chubinskaya S, Cotter EJ, Frank RM, Hakimiyan AA, Yanke AB, Cole BJ. Biologic Characteristics of Shoulder Articular Cartilage in Comparison to Knee and Ankle Articular Cartilage From Individual Donors. Cartilage. 2021 10; 12(4):456-467.
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Rims C, Uchtenhagen H, Kaplan MJ, Carmona-Rivera C, Carlucci P, Mikecz K, Markovics A, Carlin J, Buckner JH, James EA. Citrullinated Aggrecan Epitopes as Targets of Autoreactive CD4+ T Cells in Patients With Rheumatoid Arthritis. Arthritis Rheumatol. 2019 04; 71(4):518-528.
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Miller RE, Ishihara S, Tran PB, Golub SB, Last K, Miller RJ, Fosang AJ, Malfait AM. An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2. JCI Insight. 2018 03 22; 3(6).
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Mikecz K, Glant TT, Markovics A, Rosenthal KS, Kurko J, Carambula RE, Cress S, Steiner HL, Zimmerman DH. An epitope-specific DerG-PG70 LEAPS vaccine modulates T cell responses and suppresses arthritis progression in two related murine models of rheumatoid arthritis. Vaccine. 2017 07 13; 35(32):4048-4056.
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Huang G, Chubinskaya S, Liao W, Loeser RF. Wnt5a induces catabolic signaling and matrix metalloproteinase production in human articular chondrocytes. Osteoarthritis Cartilage. 2017 09; 25(9):1505-1515.
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Liao L, Zhang S, Gu J, Takarada T, Yoneda Y, Huang J, Zhao L, Oh CD, Li J, Wang B, Wang M, Chen D. Deletion of Runx2 in Articular Chondrocytes Decelerates the Progression of DMM-Induced Osteoarthritis in Adult Mice. Sci Rep. 2017 05 24; 7(1):2371.
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