 Trinucleotide Repeat Expansion
"Trinucleotide Repeat Expansion" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An increased number of contiguous trinucleotide repeats in the DNA sequence from one generation to the next. The presence of these regions is associated with diseases such as FRAGILE X SYNDROME and MYOTONIC DYSTROPHY. Some CHROMOSOME FRAGILE SITES are composed of sequences where trinucleotide repeat expansion occurs.
| Descriptor ID |
D019680
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| MeSH Number(s) |
G02.111.570.080.708.800.140.865 G02.111.570.080.708.800.500.850.200 G05.355.600.220.865 G05.360.080.708.800.074.865 G05.360.080.708.800.500.850.200 G05.360.340.024.189.220.865 G05.360.340.024.850.500.850.200 G05.365.590.220.865
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| Concept/Terms |
Trinucleotide Repeat Expansion- Trinucleotide Repeat Expansion
- Expansion, Trinucleotide Repeat
- Expansions, Trinucleotide Repeat
- Repeat Expansion, Trinucleotide
- Repeat Expansions, Trinucleotide
- Trinucleotide Repeat Expansions
- Expanded Trinucleotide Repeat
- Expanded Trinucleotide Repeats
- Repeat, Expanded Trinucleotide
- Repeats, Expanded Trinucleotide
- Trinucleotide Repeat, Expanded
- Trinucleotide Repeats, Expanded
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Below are MeSH descriptors whose meaning is more general than "Trinucleotide Repeat Expansion".
Below are MeSH descriptors whose meaning is more specific than "Trinucleotide Repeat Expansion".
This graph shows the total number of publications written about "Trinucleotide Repeat Expansion" by people in this website by year, and whether "Trinucleotide Repeat Expansion" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2003 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2007 | 2 | 1 | 3 | | 2008 | 0 | 1 | 1 | | 2010 | 1 | 1 | 2 | | 2011 | 1 | 0 | 1 | | 2013 | 2 | 0 | 2 | | 2014 | 1 | 0 | 1 | | 2015 | 0 | 2 | 2 | | 2016 | 2 | 0 | 2 | | 2019 | 1 | 1 | 2 | | 2020 | 0 | 1 | 1 | | 2021 | 0 | 2 | 2 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Trinucleotide Repeat Expansion" by people in Profiles.
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Maltman N, Klusek J, DaWalt L, Hong J, Sterling A, Berry-Kravis E, Mailick MR. Verbal inhibition declines among older women with high FMR1 premutation expansions: A prospective study. Brain Cogn. 2022 06; 159:105851.
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Mailick MR, Hong J, Movaghar A, DaWalt L, Berry-Kravis EM, Brilliant MH, Boero J, Todd PK, Hall D. Mild Neurological Signs in FMR1 Premutation Women in an Unselected Community-Based Cohort. Mov Disord. 2021 10; 36(10):2378-2386.
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Abbasi DA, Nguyen TTA, Hall DA, Robertson-Dick E, Berry-Kravis E, Cologna SM. Characterization of the Cerebrospinal Fluid Proteome in Patients with Fragile X-Associated Tremor/Ataxia Syndrome. Cerebellum. 2022 Feb; 21(1):86-98.
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Hall DA, Nag S, Ouyang B, Bennett DA, Liu Y, Ali A, Zhou L, Berry-Kravis E. Fragile X Gray Zone Alleles Are Associated With Signs of Parkinsonism and Earlier Death. Mov Disord. 2020 08; 35(8):1448-1456.
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Klusek J, Hong J, Sterling A, Berry-Kravis E, Mailick MR. Inhibition deficits are modulated by age and CGG repeat length in carriers of the FMR1 premutation allele who are mothers of children with fragile X syndrome. Brain Cogn. 2020 03; 139:105511.
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Nayar K, McKinney W, Hogan AL, Martin GE, La Valle C, Sharp K, Berry-Kravis E, Norton ES, Gordon PC, Losh M. Language processing skills linked to FMR1 variation: A study of gaze-language coordination during rapid automatized naming among women with the FMR1 premutation. PLoS One. 2019; 14(7):e0219924.
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Debrey SM, Leehey MA, Klepitskaya O, Filley CM, Shah RC, Kluger B, Berry-Kravis E, Spector E, Tassone F, Hall DA. Clinical Phenotype of Adult Fragile X Gray Zone Allele Carriers: a Case Series. Cerebellum. 2016 10; 15(5):623-31.
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Clinical-Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS): Implications for Clinical Trials. JAMA Neurol. 2016 Jan; 73(1):102-10.
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O'Keefe JA, Robertson-Dick E, Dunn EJ, Li Y, Deng Y, Fiutko AN, Berry-Kravis E, Hall DA. Characterization and Early Detection of Balance Deficits in Fragile X Premutation Carriers With and Without Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS). Cerebellum. 2015 Dec; 14(6):650-62.
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Hall D, Todorova-Koteva K, Pandya S, Bernard B, Ouyang B, Walsh M, Pounardjian T, Deburghraeve C, Zhou L, Losh M, Leehey M, Berry-Kravis E. Neurological and endocrine phenotypes of fragile X carrier women. Clin Genet. 2016 Jan; 89(1):60-7.
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