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Yanling Wang

TitleAssociate Professor
InstitutionRush University, Rush Medical College
DepartmentNeurological Sciences
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    Collapse Biography 
    Collapse awards and honors
    2001Award for Scientific Communication , Shandong University, Shandong, China
    2003Excellent Graduate Student Scholarship, Shandong University, Shandong, China
    2010Best Poster Award, UCSF Stem Cell Conference
    2007Donalty-Coggins Memorial Award , Citizens United for Research in Epilepsy, USA
    2004Excellent Research Award , Provincial Natural Science Foundation, Shandong, China
    2013 - 2014Allen Exceptional Employee

    Collapse Overview 
    Collapse overview
    Dr. Wang leads the Human Cell Modeling Group (HCMG) at Rush Alzheimer’s Disease Center. HCMG is a team of exceptionally talented scientists whose goal is to develop novel treatments to slow, stop or even prevent Alzheimer's disease. To this end, Dr. Wang’s team uses induced pluripotent stem cells (iPSCs) and direct lineage conversion to generate disease-relevant brain cells from RADC cohort participants. This “disease-in-a-dish” approach allows them to investigate disease phenotypes at molecular, cellular and functional levels. To identify causal driver genes and genetic variants of AD, Dr. Wang’s team employs CRISPR/Cas9 genetic screening and iPSC genome engineering along with a battery of assays to measure AD phenotype in vitro. Her team is implementing those technologies in iPSC-derived neurons, astrocytes and microglia to systematically dissect the function of disease-associated genes and risk variants in AD pathogenesis.

    Dr. Wang also oversee the Rush Omics Core. The Core laboratory is equipped with state-of-art instruments including the Illumina NovaSeq 6000, Chemagic 360, Zephyr NGS Workstation, Fragment Analyzer, iSeq and a 10x Genomics Chromium System. Dr. Wang’s team have developed an automated next-generation sequencing platform to carry out RNAseq on postmortem brain tissue and cultured cells at both population and single-cell levels. Her team is currently developing novel sequencing approaches to identify biomarkers and molecular signatures of AD and related disorders.

    Prior to Rush, Dr. Wang led a Stem Cell Biology team at Allen Institute for Brain Science. She carried out her Postdoc research on developmental biology and Neuroscience at University of California, San Francisco and earned her MD, PhD in Pediatric Neurology at Shandong University, China.

    Dr. Wang’s team is recruiting highly motivated postdocs, staff scientists and research associates, ideally with experience in next generation sequencing, or genome engineering or iPSC technology. Please contact her for more information

    My Scopus ID is 12776188660.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Martinez R, Mulholland H, Gregor B, Yao Z, Bakken TE, Menon V, Nelson A, Fuqua M, Ngo K, Grimley JS, Gaiteri C and Wang Y . Ex Vivo ANd In Vitro Comparison to Benchmark Functional Development of Human ESC-derived Neurons. Under Revision. Neuron. 2018.
    2. Tasaki S, Gaiteri C, Dawe R, Mostafavi S, Su L, Wang Y, De Jager PL, Bennett DA. Multi-omic integration decribes features of gene regulation in older adults and expands the set of genes driving cognitive decline. Frontiers Genetics. 2018.
    3. Liu Z, Zhang Z, Limdtner S, Li Z, Liang Q, Wen Y, Tao G, You Y, Chen B, Wang Y, Rubenstein JL, Yang Z. Sp9 promotes medial ganglionic eminence-derived cortical interneuron tangential migration through regulating Lhx6, Lhx8 and Nkx2-1 expression. Cerebral Cortex. 2018.
    4. Gaiteri C, Dawe R, Mosafavi S, Blizinsky KD, Tasaki S, komashko V, Yu L, Wang Y, Schneider JA, Arfanakis K, De Jager PL, Bennett DA. Relation of gene expression and epigenetic molecular systems and MRI-based brain microstructural characteristics . Brain imaging and Behaviour. 2018.
    5. Yao Z, Mich J, Ku S, Menon V, Krostag AR, Martinez R, Furchtgott L, Mulholland H, Bort S, Fuqua M, Gregor B, Thompson CL, Phillips JW, Grimley JS, Levi BP*, Wang Y* and Ramanathan S*. A single cell roadmap of lineage bifurcation in human ESC models of embryonic brain development. Cell Stem Cell. Featured on the cover. *Corresponding authors. 2017.
    6. Wang Y, Dolmetch R. In vitro human corticogenesis. Neuron. 2013.
    7. Chen YJ, Vogt D, Wang Y, Visel A, Silberberg SN, Nicholas CR, Danjo T, Pollack JL, Pennacchio LA, Anderson S, Sasai Y, Baraban SC, Kriegstein AR, Alvarez-Buylla A, Rubenstein Jl. Use of "MGE enhancers" for labeling and selection of embryonic stem cell-derived medial ganglioniceminence (MGE) progenitors and neurons. PLOS ONE. 2013.
    8. Wang Y, Li G, Stanco A, Long GE, Crawford D, Potter GB, Pleasure SJ, Behrens T, Rubenstein JL*. CXCR4 and CXCR7 have distinct function in regulating interneuron migration. Neuron. Featured on the cover. *Corresponding author. 2011.
    9. Wang Y*, Dye CA, Sohal V, Long JE, Estrada RC, Roztocil T, Lufkin T, Deisseroth K, Baraban SC, Rubenstein JL*. Dlx5 and Dlz6 regulate the development of Parvalbumin-expressing cortical interneurons. J Neurosci. *Corresponding authors. 2010.
    10. Greenwood JS. F, Wang Y, Estrada RC, Ackerman L, Ohara PT, Baraban SC. Seizures, enhanced excitation and increased vesicle number in Lis 1 mutant mice. Ann Neurol. 2009.
    11. Yee CL, Wang Y and Rubenstein JL. Arcuate nucleus expression of NKX2.1, and DLX, and lineages expressing these transcription factors in NPY†, POMC† and TH† beurons in neonatal and adult Mice. J Comp Neurol. 2009.
    12. Wang Y, Baraban SC. Aberrant dentate gyrus cytoarchitecture and fiber lamination in Lis1 mutant mice. Hippocampus. 2008; Featured on the cover.
    13. Wang Y, Greenwood JS. F, Calcagnotto MEds, Kirsch HE, Barbaro NM, Baraban SC. Ann Neurol. Neocortical hyperexcitability in the absence of cortical tuber formation. 2007.
    14. Wang Y, Baraban SC. Abnormal neurogenesis of the adult hippocampus in a murine model of human lissencephaly. Developmental Neuroscience. 2006.
    15. Wang Y, Baraban SC. Mammalian target of rapamycin pathway is involved in activity-dependent expression of AMPA receptors. Neurosci Letter. 2006.
    16. Wang Y, Sun R, Lei G, Li B, Wang J. Neurogenesis of dentate granule cells following kainic acid induced seizures in immature rats. Chinese Journal of Pediatrics. 2004.
    17. Wang Y, Sun R, Wang J. Malnutrition increases hippocampal neurogenesis in the immature rat after status epilepticus. Chinese Journal of Pediatrics. 2003.
    18. Wang Y, Sun R, Wang J. A comparative study of clinical characteristics in child and adult patients with moyamoya disease. Journal of Shandong University. 2002.
    19. Wang Y, Wang YW, Xia W. Clinical investigation of changes of neuropeptide Y an dckacitonin gene-related peptide in pulmonary hypertension secondary to congenital heart defects. Shanghai Medical Journal. 2002.
    20. Wang Y, Sun R, Lei G. Neuroprotective effects of nimodipine on kainate-induced hipppocampal neurons. Journal of Shandong University. 2001.
    21. Bratt-leal A, Zhang A, Wang Y and Loring J. Elsevier. In press. Induced Pluripotent Stem Cells. In: Principles of Regenerative Medicine.
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