Item Type | Name |
Concept
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Disease Models, Animal
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Concept
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Animals
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Concept
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Behavior, Animal
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Concept
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Animals, Genetically Modified
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Academic Article
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CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis.
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Academic Article
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Structure analysis reveals the flexibility of the ADAMTS-5 active site.
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Academic Article
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Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes.
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Academic Article
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Damage-associated molecular patterns generated in osteoarthritis directly excite murine nociceptive neurons through Toll-like receptor 4.
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Academic Article
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Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network.
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Academic Article
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A commentary on modelling osteoarthritis pain in small animals.
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Academic Article
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Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models.
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Academic Article
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Modelling pain in post-traumatic osteoarthritis of the knee.
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Academic Article
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Towards a mechanism-based approach to pain management in osteoarthritis.
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Academic Article
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Substrate-dependent inhibition kinetics of an active site-directed inhibitor of ADAMTS-4 (Aggrecanase 1).
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Academic Article
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Osteoarthritis joint pain: the cytokine connection.
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Academic Article
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Nanoparticles for improved local retention after intra-articular injection into the knee joint.
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Academic Article
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A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype.
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Academic Article
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Genetically Engineered Mouse Models Reveal the Importance of Proteases as Osteoarthritis Drug Targets.
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Academic Article
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Transport and equilibrium uptake of a peptide inhibitor of PACE4 into articular cartilage is dominated by electrostatic interactions.
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Academic Article
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The usual suspects: verdict not guilty?
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Academic Article
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ADAMTS-4 (aggrecanase-1): N-terminal activation mechanisms.
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Academic Article
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On the predictive utility of animal models of osteoarthritis.
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Academic Article
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ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization.
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Academic Article
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PCSK6-mediated corin activation is essential for normal blood pressure.
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Academic Article
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Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors.
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Academic Article
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Standardization of nutrient media for isolated human articular chondrocytes in gelified agarose suspension culture.
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Academic Article
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Blockade of IL-12 during the induction of collagen-induced arthritis (CIA) markedly attenuates the severity of the arthritis.
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Academic Article
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The beta2-adrenergic agonist salbutamol is a potent suppressor of established collagen-induced arthritis: mechanisms of action.
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Academic Article
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The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis.
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Academic Article
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Chronic relapsing homologous collagen-induced arthritis in DBA/1 mice as a model for testing disease-modifying and remission-inducing therapies.
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Academic Article
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P-selectin glycoprotein ligand 1 therapy ameliorates established collagen-induced arthritis in DBA/1 mice partly through the suppression of tumour necrosis factor.
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Academic Article
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Will the real aggrecanase(s) step up: evaluating the criteria that define aggrecanase activity in osteoarthritis.
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Academic Article
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Intra-articular injection of tumor necrosis factor-alpha in the rat: an acute and reversible in vivo model of cartilage proteoglycan degradation.
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Academic Article
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Reduced incidence and severity of experimental autoimmune arthritis in mice expressing catalytically inactive A disintegrin and metalloproteinase 8 (ADAM8).
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Academic Article
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An immunoaffinity liquid chromatography-tandem mass spectrometry assay for detection of endogenous aggrecan fragments in biological fluids: Use as a biomarker for aggrecanase activity and cartilage degradation.
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Academic Article
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Chemogenetic Inhibition of Pain Neurons in a Mouse Model of Osteoarthritis.
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Academic Article
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Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification.
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Academic Article
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Therapeutic effects of an anti-ADAMTS-5 antibody on joint damage and mechanical allodynia in a murine model of osteoarthritis.
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Academic Article
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Spinal microglial activation in a murine surgical model of knee osteoarthritis.
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Academic Article
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Nerve growth factor blockade for the management of osteoarthritis pain: what can we learn from clinical trials and preclinical models?
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Academic Article
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CCL2 and CCR2 regulate pain-related behaviour and early gene expression in post-traumatic murine osteoarthritis but contribute little to chondropathy.
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Academic Article
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Can we target CCR2 to treat osteoarthritis? The trick is in the timing!
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Academic Article
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Chemokine receptor-7 (CCR7) deficiency leads to delayed development of joint damage and functional deficits in a murine model of osteoarthritis.
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Academic Article
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Combination therapy with DMARDs and biological agents in collagen-induced arthritis.
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Academic Article
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Anti-IL-12 and anti-TNF antibodies synergistically suppress the progression of murine collagen-induced arthritis.
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Academic Article
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Suppression of TNF-alpha expression, inhibition of Th1 activity, and amelioration of collagen-induced arthritis by rolipram.
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Academic Article
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DBA/1 mice expressing the human TNF-alpha transgene develop a severe, erosive arthritis: characterization of the cytokine cascade and cellular composition.
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Academic Article
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Why we should study pain in animal models of rheumatic diseases.
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Academic Article
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Visualization of Peripheral Neuron Sensitization in a Surgical Mouse Model of Osteoarthritis by In Vivo Calcium Imaging.
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Academic Article
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Peripheral Mechanisms Contributing to Osteoarthritis Pain.
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Academic Article
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An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2.
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Academic Article
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Osteoarthritis pain: What are we learning from animal models?
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Academic Article
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Nerve growth factor antibody for the treatment of osteoarthritis pain and chronic low-back pain: mechanism of action in the context of efficacy and safety.
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Academic Article
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The nociceptive innervation of the normal and osteoarthritic mouse knee.
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Academic Article
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An emerging role for Toll-like receptors at the neuroimmune interface in osteoarthritis.
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Academic Article
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The innate immune response as a mediator of osteoarthritis pain.
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Academic Article
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Microarray analyses of the dorsal root ganglia support a role for innate neuro-immune pathways in persistent pain in experimental osteoarthritis.
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Academic Article
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Targeting neurotrophic factors: Novel approaches to musculoskeletal pain.
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Academic Article
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Pain-related behaviors and abnormal cutaneous innervation in a murine model of classical Ehlers-Danlos syndrome.
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Academic Article
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The role of intra-articular neuronal CCR2 receptors in knee joint pain associated with experimental osteoarthritis in mice.
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Academic Article
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Mitochondrial calcium uniporter deletion prevents painful diabetic neuropathy by restoring mitochondrial morphology and dynamics.
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Academic Article
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Animal Models of Ehlers-Danlos Syndromes: Phenotype, Pathogenesis, and Translational Potential.
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Academic Article
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Notch signaling is activated in knee-innervating dorsal root ganglia in experimental models of osteoarthritis joint pain.
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Academic Article
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Age-Associated Changes in Knee Osteoarthritis, Pain-Related Behaviors, and Dorsal Root Ganglia Immunophenotyping of Male and Female Mice.
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Academic Article
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Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis.
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