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One or more keywords matched the following properties of Landay, Alan
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overview Other Appointments: The Thomas J. Coogan, Sr., MD, Chair of Immunology, Rush Medical College. Alan L. Landay, PhD, is the professor of the Department of Immunity & Emerging Pathogens and principal investigator of the Rush Immunology Specialty Laboratory, or ISL, with 35 years experience in studies of HIV immunopathogenesis. He has worked with the AIDS Clinical Trials Group since its beginning and has directed the ISL since it began. His studies on immunophenotyping and innate immunity in HIV disease have made significant contributions to this field. These early studies were carried out in a newly recognized population of hemophiliacs that were shown to develop AIDS. This work was extended with more recent publications using multi-parameter flow cytometry to define monocyte subsets and the critical role of monocytes and innate immune cell activation in HIV pathogenesis. These papers have contributed to a shift in thinking about HIV as an adaptive immune disease to one focused on innate cell driven inflammation linked to the development of immunosenescence. My Scopus ID is 14325119400. My NIH COMMONS name is ALANDAY. Research Areas: HIV/AIDS, aging. My Faculty Profile at Rush University Medical Center: https://www.rushu.rush.edu/faculty/alan-l-landay-phd My Laboratory: https://www.rushu.rush.edu/research/departmental-research/microbial-pathogens-and-immunity-research/laboratory-alan-landay-phd My NCBI Bibliography: https://www.ncbi.nlm.nih.gov/pubmed/?term=Landay+A My Scopus: https://www.scopus.com/authid/detail.uri?authorId=14325119400 Education: PhD, University of Pittsburgh Medical School BS, Penn State University
One or more keywords matched the following items that are connected to Landay, Alan
Item TypeName
Concept Immunophenotyping
Academic Article Maternal immunologic and virologic risk factors for infant human immunodeficiency virus type 1 infection: findings from the Women and Infants Transmission Study.
Academic Article Transmembrane P-glycoprotein (P-gp/P-170) in HIV infection: analysis of lymphocyte surface expression and drug-unrelated function.
Academic Article Monitoring HIV-1 treatment in immune-cell subsets with ultrasensitive fluorescence-in-situ hybridisation.
Academic Article Immunophenotypic markers and antiretroviral therapy (IMART): T cell activation and maturation help predict treatment response.
Academic Article Normal immune function of monocyte-derived dendritic cells from HIV-infected individuals: implications for immunotherapy.
Academic Article Proliferation responses to HIVp24 during antiretroviral therapy do not reflect improved immune phenotype or function.
Academic Article Interlaboratory variability of CD8 subset measurements by flow cytometry and its applications to multicenter clinical trials. NAID/NICHD Women and Infants Transmission Study Group.
Academic Article Dysregulated B-cell TLR2 expression and elevated regulatory B-cell frequency precede the diagnosis of AIDS-related non-Hodgkin lymphoma.
Academic Article Whole blood method for simultaneous detection of surface and cytoplasmic antigens by flow cytometry.
Academic Article A role for TLR signaling during B cell activation in antiretroviral-treated HIV individuals.
Academic Article Upregulation of CD4 on CD8+ T cells: CD4dimCD8bright T cells constitute an activated phenotype of CD8+ T cells.
Academic Article Phenotypic variability of lymphocyte populations in peripheral blood and lymph nodes from HIV-infected individuals and the impact of antiretroviral therapy. DATRI 003 Study Group. Division of AIDS Treatment Research Initiative.
Academic Article CD4 immunophenotyping in HIV infection.
Academic Article Assessment of interlaboratory variability of immunophenotyping. Results of the College of American Pathologists Flow Cytometry Survey.
Academic Article Determinants of CD4+ T cell recovery during suppressive antiretroviral therapy: association of immune activation, T cell maturation markers, and cellular HIV-1 DNA.
Academic Article Characterization of human invariant natural killer T subsets in health and disease using a novel invariant natural killer T cell-clonotypic monoclonal antibody, 6B11.
Academic Article Preservation of lymphocyte immunophenotype and proliferative responses in cryopreserved peripheral blood mononuclear cells from human immunodeficiency virus type 1-infected donors: implications for multicenter clinical trials. The ACTG Immunology Advanced Technology Laboratories.
Academic Article Lymphocyte phenotyping in infants: maturation of lymphocyte subpopulations and the effects of HIV infection.
Academic Article CD4+ lymphocytes in perinatal human immunodeficiency virus (HIV) infection: evidence for pregnancy-induced immune depression in uninfected and HIV-infected women.
Academic Article The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trial.
Academic Article GB virus C infection is associated with altered lymphocyte subset distribution and reduced T cell activation and proliferation in HIV-infected individuals.
Academic Article Regulatory B cell frequency correlates with markers of HIV disease progression and attenuates anti-HIV CD8? T cell function in vitro.
Academic Article Repertoire of chemokine receptor expression in the female genital tract: implications for human immunodeficiency virus transmission.
Academic Article Association of selected phenotypic markers of lymphocyte activation and differentiation with perinatal human immunodeficiency virus transmission and infant infection.
Academic Article Age-associated changes in monocyte and innate immune activation markers occur more rapidly in HIV infected women.
Academic Article CD8+ T cells that express CD4 on their surface (CD4dimCD8bright T cells) recognize an antigen-specific target, are detected in vivo, and can be productively infected by T-tropic HIV.
Academic Article Increases in T cell telomere length in HIV infection after antiretroviral combination therapy for HIV-1 infection implicate distinct population dynamics in CD4+ and CD8+ T cells.
Academic Article Procedural guidelines for performing immunophenotyping by flow cytometry.
Academic Article Characterization of IL-22 and IL-17 Expressing Leukocytes in the Cervix.
Academic Article Immune responses to abacavir in antigen-presenting cells from hypersensitive patients.
Academic Article Increased IFN-gamma production by NK and CD3+/CD56+ cells in sexually HIV-1-exposed but uninfected individuals.
Academic Article Dysfunctional natural killer cells, in vivo, are governed by HIV viremia regardless of whether the infected individual is on antiretroviral therapy.
Academic Article CD1d-restricted natural killer T cells are potent targets for human immunodeficiency virus infection.
Academic Article Evidence of a selective depletion of a CD16+ CD56+ CD8+ natural killer cell subset during HIV infection.
Academic Article Identification of a population of large granular lymphocytes obtained from the rheumatoid joint coexpressing the CD3 and CD16 antigens.
Academic Article Cellular restoration in HIV infected persons treated with abacavir and a protease inhibitor: age inversely predicts naive CD4 cell count increase.
Academic Article Immunophenotypic alterations in acute and early HIV infection.
Academic Article Interleukin-7 signalling is sufficient to phenotypically and functionally prime human CD4 naive T cells.
Academic Article Detection of T cell receptor circles (TRECs) as biomarkers for de novo T cell synthesis using a quantitative polymerase chain reaction-enzyme linked immunosorbent assay (PCR-ELISA).
Academic Article Persistence of intracellular HIV-1 mRNA correlates with HIV-1-specific immune responses in infected subjects on stable HAART.
Academic Article Vitamin D does not modulate immune-mediated bone loss during ART initiation.
Academic Article Delayed gastrointestinal-associated lymphoid tissue reconstitution in duodenum compared with rectum in HIV-infected patients initiating antiretroviral therapy.
Academic Article Innate and adaptive immune cell subsets as risk factors for coronary heart disease in two population-based cohorts.
Academic Article Natural killer cells, gamma delta T cells and classical monocytes are associated with systolic blood pressure in the multi-ethnic study of atherosclerosis (MESA).
Academic Article Nonclassical Monocytes (CD14dimCD16+) Are Associated With Carotid Intima-Media Thickness Progression for Men but Not Women: The Multi-Ethnic Study of Atherosclerosis-Brief Report.
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  • Immunophenotyping