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One or more keywords matched the following properties of Landay, Alan
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overview Other Appointments: The Thomas J. Coogan, Sr., MD, Chair of Immunology, Rush Medical College. Alan L. Landay, PhD, is the professor of the Department of Immunity & Emerging Pathogens and principal investigator of the Rush Immunology Specialty Laboratory, or ISL, with 35 years experience in studies of HIV immunopathogenesis. He has worked with the AIDS Clinical Trials Group since its beginning and has directed the ISL since it began. His studies on immunophenotyping and innate immunity in HIV disease have made significant contributions to this field. These early studies were carried out in a newly recognized population of hemophiliacs that were shown to develop AIDS. This work was extended with more recent publications using multi-parameter flow cytometry to define monocyte subsets and the critical role of monocytes and innate immune cell activation in HIV pathogenesis. These papers have contributed to a shift in thinking about HIV as an adaptive immune disease to one focused on innate cell driven inflammation linked to the development of immunosenescence. My Scopus ID is 14325119400. My NIH COMMONS name is ALANDAY. Research Areas: HIV/AIDS, aging. My Faculty Profile at Rush University Medical Center: https://www.rushu.rush.edu/faculty/alan-l-landay-phd My Laboratory: https://www.rushu.rush.edu/research/departmental-research/microbial-pathogens-and-immunity-research/laboratory-alan-landay-phd My NCBI Bibliography: https://www.ncbi.nlm.nih.gov/pubmed/?term=Landay+A My Scopus: https://www.scopus.com/authid/detail.uri?authorId=14325119400 Education: PhD, University of Pittsburgh Medical School BS, Penn State University
One or more keywords matched the following items that are connected to Landay, Alan
Item TypeName
Concept Cellular Senescence
Concept Aging, Premature
Concept Aging
Academic Article Viremic and Virologically Suppressed HIV Infection Increases Age-Related Changes to Monocyte Activation Equivalent to 12 and 4 Years of Aging, Respectively.
Academic Article HIV and aging: state of knowledge and areas of critical need for research. A report to the NIH Office of AIDS Research by the HIV and Aging Working Group.
Academic Article HIV infection induces age-related changes to monocytes and innate immune activation in young men that persist despite combination antiretroviral therapy.
Academic Article Using the pathogenic and nonpathogenic nonhuman primate model for studying non-AIDS comorbidities.
Academic Article Early immune senescence in HIV disease.
Academic Article T cell activation predicts carotid artery stiffness among HIV-infected women.
Academic Article The effect of aging on T-regulatory cell frequency in HIV infection.
Academic Article Age-related immune dysfunction in health and in human immunodeficiency virus (HIV) disease: association of age and HIV infection with naive CD8+ cell depletion, reduced expression of CD28 on CD8+ cells, and reduced thymic volumes.
Academic Article Biomarkers of immune dysfunction in HIV.
Academic Article HIV infection and aging of the innate immune system.
Academic Article Age-associated changes in monocyte and innate immune activation markers occur more rapidly in HIV infected women.
Academic Article Older HIV-infected patients on antiretroviral therapy have B-cell expansion and attenuated CD4 cell increases with immune activation reduction.
Academic Article T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women.
Academic Article Neurodegeneration and ageing in the HAART era.
Academic Article Cellular restoration in HIV infected persons treated with abacavir and a protease inhibitor: age inversely predicts naive CD4 cell count increase.
Academic Article Is HIV a model of accelerated or accentuated aging?
Academic Article Detection of T cell receptor circles (TRECs) as biomarkers for de novo T cell synthesis using a quantitative polymerase chain reaction-enzyme linked immunosorbent assay (PCR-ELISA).
Academic Article Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function.
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Academic Article Moderate wine consumption is associated with lower hemostatic and inflammatory risk factors over 8 years: The study of women's health across the nation (SWAN).
Academic Article Association of cognitive activity and neurocognitive function in blacks and whites with HIV.
Academic Article Loneliness in Older Black Adults with Human Immunodeficiency Virus Is Associated with Poorer Cognition.
Academic Article HIV and aging: role of the microbiome.
Academic Article Diminished antibody response to influenza vaccination is characterized by expansion of an age-associated B-cell population with low PAX5.
Academic Article Wnt signaling in bone, kidney, intestine, and adipose tissue and interorgan interaction in aging.
Academic Article Physical Functioning Among Patients Aging With Human Immunodeficiency Virus (HIV) Versus HIV Uninfected: Feasibility of Using the Short Physical Performance Battery in Clinical Care of People Living With HIV Aged 50 or Older.
Academic Article The E3 ubiquitin ligase CHIP in normal cell function and in disease conditions.
Academic Article Brief Report: Differences in Types of Myocardial Infarctions Among People Aging With HIV.
Academic Article Sex Differences in Human Immunodeficiency Virus Persistence and Reservoir Size During Aging.
Academic Article HIV and Aging in the Era of ART and COVID-19: Symposium Overview.
Academic Article Chronic HIV Infection and Aging: Application of a Geroscience-Guided Approach.
Academic Article Network Topology of Biological Aging and Geroscience-Guided Approaches to COVID-19.
Academic Article Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis.
Academic Article Can statin preventative treatment inform geroscience-guided therapeutics?
Academic Article Plasma Glycomic Markers of Accelerated Biological Aging During Chronic HIV Infection.
Academic Article Distinct Intestinal Microbial Signatures Linked to Accelerated Biological Aging in People with HIV.
Concept Cognitive Aging
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  • Aging