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One or more keywords matched the following properties of Kordower, Jeffrey
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overview Other Appointments: Director, Section of Neurobiology Overview: Kordower is an international authority in the area of movement disorders with special expertise in pathophysiology and experimental therapeutic strategies in Parkinson’s disease, Alzheimer’s disease and Huntington’s disease — especially using nonhuman primate models. He has published landmark papers in the area of cell replacement strategies, including the first demonstration that fetal dopaminergic grafts can survive, innervate and form synapses in patients with Parkinson’s disease that was published in the New England Journal of Medicine. His recent demonstration that long-term grafts in such patients can form Lewy bodies was recently published in Nature Medicine. Kordower has published seminal studies including the lead article in Science demonstrating that gene delivery of the trophic factors GDNF and neurturin can prevent the emergence of motor symptoms and nigrostriatal degeneration in a monkey model of PD. He also was the first to demonstrate that gene delivery of trophic factors can obviate neurodegenerative processes in nonhuman primate models of Huntington’s disease and Alzheimer’s disease, with these studies being published in Nature and The Journal of Comparative Neurology, respectively. He has published numerous papers investigating the role of misfolded proteins in PD pathogenesis. These include papers in human and experimental PD on the role of alpha synuclein misfolding on Nurr1 and dopamine expression, lysosome and proteasome dysfunction, and axonal transport defects. He is a co-author on the landmark Nature paper lead by the Studer group demonstrating the structural and functional efficacy of dopaminergic human stem cells in rodent and nonhuman primate models of PD. In addition, he is collaborating with Trojanowski and Lee and recently demonstrated the ability of preformed fibrils to be transported in nonhuman primates and cause degeneration in nonhuman primates, a study that serves as the foundation of the current application. Kordower has published over 350 papers, has lectured all over the world, has been on over 20 editorial boards, and is on the SAB’s of many biotech companies and scientific organizations. He is a past councilor and past president of the American Society for Neural Transplantation, past chair for the Committee for the Use of Animals for SFN, and is a founding SAB member for the Michael J. Fox Foundation and is a past member of their Executive SAB. My Scopus ID is 7005337450. My NIH COMMONS name is JKORDOWER. Education PhD, Queens College, City University of New York MA, Queens College, City University of New York BA, Queens College, City University of New York
One or more keywords matched the following items that are connected to Kordower, Jeffrey
Item TypeName
Concept Graft Rejection
Concept Graft Survival
Concept Transplants
Academic Article Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease.
Academic Article Human neural stem cell transplants improve motor function in a rat model of Huntington's disease.
Academic Article Huntington's disease: pathological mechanisms and therapeutic strategies.
Academic Article Celebrating neural repair.
Academic Article Lewy body pathology in fetal grafts.
Academic Article Neuropathology in transplants in Parkinson's disease: implications for disease pathogenesis and the future of cell therapy.
Academic Article Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian rats.
Academic Article Extensive neuroprotection by choroid plexus transplants in excitotoxin lesioned monkeys.
Academic Article Introduction to the special ASNTR issue.
Academic Article Neonatal immune-tolerance in mice does not prevent xenograft rejection.
Academic Article Neural repair strategies for Parkinson's disease: insights from primate models.
Academic Article Survival and early differentiation of human neural stem cells transplanted in a nonhuman primate model of stroke.
Academic Article Misfolded proteins in Huntington disease fetal grafts: further evidence of cell-to-cell transfer?
Academic Article Transfer of host-derived a synuclein to grafted dopaminergic neurons in rat.
Academic Article Lewy body pathology in long-term fetal nigral transplants: is Parkinson's disease transmitted from one neural system to another?
Academic Article Fetal grafts for Parkinson's disease: Decades in the making.
Academic Article Parkinsonian monkeys with prior levodopa-induced dyskinesias followed by fetal dopamine precursor grafts do not display graft-induced dyskinesias.
Academic Article Robust graft survival and normalized dopaminergic innervation do not obligate recovery in a Parkinson disease patient.
Academic Article Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration.
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  • Transplants