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Search Results to Jeffrey Kordower

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overview Other Appointments: Director, Section of Neurobiology Overview: Kordower is an international authority in the area of movement disorders with special expertise in pathophysiology and experimental therapeutic strategies in Parkinson’s disease, Alzheimer’s disease and Huntington’s disease — especially using nonhuman primate models. He has published landmark papers in the area of cell replacement strategies, including the first demonstration that fetal dopaminergic grafts can survive, innervate and form synapses in patients with Parkinson’s disease that was published in the New England Journal of Medicine. His recent demonstration that long-term grafts in such patients can form Lewy bodies was recently published in Nature Medicine. Kordower has published seminal studies including the lead article in Science demonstrating that gene delivery of the trophic factors GDNF and neurturin can prevent the emergence of motor symptoms and nigrostriatal degeneration in a monkey model of PD. He also was the first to demonstrate that gene delivery of trophic factors can obviate neurodegenerative processes in nonhuman primate models of Huntington’s disease and Alzheimer’s disease, with these studies being published in Nature and The Journal of Comparative Neurology, respectively. He has published numerous papers investigating the role of misfolded proteins in PD pathogenesis. These include papers in human and experimental PD on the role of alpha synuclein misfolding on Nurr1 and dopamine expression, lysosome and proteasome dysfunction, and axonal transport defects. He is a co-author on the landmark Nature paper lead by the Studer group demonstrating the structural and functional efficacy of dopaminergic human stem cells in rodent and nonhuman primate models of PD. In addition, he is collaborating with Trojanowski and Lee and recently demonstrated the ability of preformed fibrils to be transported in nonhuman primates and cause degeneration in nonhuman primates, a study that serves as the foundation of the current application. Kordower has published over 350 papers, has lectured all over the world, has been on over 20 editorial boards, and is on the SAB’s of many biotech companies and scientific organizations. He is a past councilor and past president of the American Society for Neural Transplantation, past chair for the Committee for the Use of Animals for SFN, and is a founding SAB member for the Michael J. Fox Foundation and is a past member of their Executive SAB. My Scopus ID is 7005337450. My NIH COMMONS name is JKORDOWER. Education PhD, Queens College, City University of New York MA, Queens College, City University of New York BA, Queens College, City University of New York

One or more keywords matched the following items that are connected to Kordower, Jeffrey

Item TypeName
Concept Haplorhini
Academic Article ß-Secretase-1 elevation in aged monkey and Alzheimer's disease human cerebral cortex occurs around the vasculature in partnership with multisystem axon terminal pathogenesis and ß-amyloid accumulation.
Academic Article Chronic ischemic stroke model in cynomolgus monkeys: behavioral, neuroimaging and anatomical study.
Academic Article Estrogen increases the number of spinophilin-immunoreactive spines in the hippocampus of young and aged female rhesus monkeys.
Academic Article Striatal delivery of CERE-120, an AAV2 vector encoding human neurturin, enhances activity of the dopaminergic nigrostriatal system in aged monkeys.
Academic Article Estrogen replacement increases spinophilin-immunoreactive spine number in the prefrontal cortex of female rhesus monkeys.
Academic Article Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum.
Academic Article Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?
Academic Article Expression, bioactivity, and safety 1 year after adeno-associated viral vector type 2-mediated delivery of neurturin to the monkey nigrostriatal system support cere-120 for Parkinson's disease.
Academic Article Gene transfer of trophic factors and stem cell grafting as treatments for Parkinson's disease.
Academic Article Age-related accumulation of Marinesco bodies and lipofuscin in rhesus monkey midbrain dopamine neurons: relevance to selective neuronal vulnerability.
Academic Article Age-related changes in glial cells of dopamine midbrain subregions in rhesus monkeys.
Academic Article Age and region-specific responses of microglia, but not astrocytes, suggest a role in selective vulnerability of dopamine neurons after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in monkeys.
Academic Article The immunophilin ligand GPI-1046 does not have neuroregenerative effects in MPTP-treated monkeys.
Academic Article Long-term gonadal hormone treatment and endogenous neurogenesis in the dentate gyrus of the adult female monkey.
Academic Article Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration.
Academic Article Striatal trophic factor activity in aging monkeys with unilateral MPTP-induced parkinsonism.
Academic Article Extensive neuroprotection by choroid plexus transplants in excitotoxin lesioned monkeys.
Academic Article Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys.
Academic Article RET expression does not change with age in the substantia nigra pars compacta of rhesus monkeys.
Academic Article Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys.
Academic Article Testing NF-?B-based therapy in hemiparkinsonian monkeys.
Academic Article Effects of estrogen replacement therapy on cholinergic basal forebrain neurons and cortical cholinergic innervation in young and aged ovariectomized rhesus monkeys.
Academic Article RNA amplification of bromodeoxyuridine labeled newborn neurons in the monkey hippocampus.
Academic Article Attenuation of microglial RANTES by NEMO-binding domain peptide inhibits the infiltration of CD8(+) T cells in the nigra of hemiparkinsonian monkey.
Academic Article Parkinsonian monkeys with prior levodopa-induced dyskinesias followed by fetal dopamine precursor grafts do not display graft-induced dyskinesias.
Academic Article Cryopreservation Maintains Functionality of Human iPSC Dopamine Neurons and Rescues Parkinsonian Phenotypes In Vivo.
Academic Article Response of aged parkinsonian monkeys to in vivo gene transfer of GDNF.
Academic Article Delayed onset of progressive dystonia following subacute 3-nitropropionic acid treatment in Cebus apella monkeys.
Academic Article Low-Dose Maraviroc, an Antiretroviral Drug, Attenuates the Infiltration of T Cells into the Central Nervous System and Protects the Nigrostriatum in Hemiparkinsonian Monkeys.
Academic Article Intrastriatal alpha-synuclein fibrils in monkeys: spreading, imaging and neuropathological changes.
Academic Article Anti-a-synuclein ASO delivered to monoamine neurons prevents a-synuclein accumulation in a Parkinson's disease-like mouse model and in monkeys.
Academic Article A novel tau-based rhesus monkey model of Alzheimer's pathogenesis.
Academic Article Corrigendum to "Anti-a-synuclein ASO delivered to monoamine neurons prevents a-synuclein accumulation in a Parkinson's disease-like mouse model and in monkeys" [EBioMedicine 2020; 59:102944].

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