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One or more keywords matched the following properties of Kordower, Jeffrey
overview Other Appointments: Director, Section of Neurobiology Overview: Kordower is an international authority in the area of movement disorders with special expertise in pathophysiology and experimental therapeutic strategies in Parkinson’s disease, Alzheimer’s disease and Huntington’s disease — especially using nonhuman primate models. He has published landmark papers in the area of cell replacement strategies, including the first demonstration that fetal dopaminergic grafts can survive, innervate and form synapses in patients with Parkinson’s disease that was published in the New England Journal of Medicine. His recent demonstration that long-term grafts in such patients can form Lewy bodies was recently published in Nature Medicine. Kordower has published seminal studies including the lead article in Science demonstrating that gene delivery of the trophic factors GDNF and neurturin can prevent the emergence of motor symptoms and nigrostriatal degeneration in a monkey model of PD. He also was the first to demonstrate that gene delivery of trophic factors can obviate neurodegenerative processes in nonhuman primate models of Huntington’s disease and Alzheimer’s disease, with these studies being published in Nature and The Journal of Comparative Neurology, respectively. He has published numerous papers investigating the role of misfolded proteins in PD pathogenesis. These include papers in human and experimental PD on the role of alpha synuclein misfolding on Nurr1 and dopamine expression, lysosome and proteasome dysfunction, and axonal transport defects. He is a co-author on the landmark Nature paper lead by the Studer group demonstrating the structural and functional efficacy of dopaminergic human stem cells in rodent and nonhuman primate models of PD. In addition, he is collaborating with Trojanowski and Lee and recently demonstrated the ability of preformed fibrils to be transported in nonhuman primates and cause degeneration in nonhuman primates, a study that serves as the foundation of the current application. Kordower has published over 350 papers, has lectured all over the world, has been on over 20 editorial boards, and is on the SAB’s of many biotech companies and scientific organizations. He is a past councilor and past president of the American Society for Neural Transplantation, past chair for the Committee for the Use of Animals for SFN, and is a founding SAB member for the Michael J. Fox Foundation and is a past member of their Executive SAB. My Scopus ID is 7005337450. My NIH COMMONS name is JKORDOWER. Education PhD, Queens College, City University of New York MA, Queens College, City University of New York BA, Queens College, City University of New York
One or more keywords matched the following items that are connected to Kordower, Jeffrey
Item TypeName
Concept Genes, Reporter
Concept Transgenes
Concept Gene Expression
Concept Amino Acid Sequence
Concept Gene Targeting
Concept Calcitonin Gene-Related Peptide
Concept Gene-Environment Interaction
Concept tat Gene Products, Human Immunodeficiency Virus
Concept Gene Knockdown Techniques
Concept Gene Transfer Techniques
Concept Molecular Sequence Data
Concept Gene Expression Regulation, Developmental
Concept Gene Expression Regulation
Concept Gene Dosage
Academic Article Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial.
Academic Article Doublecortin expression in adult cat and primate cerebral cortex relates to immature neurons that develop into GABAergic subgroups.
Academic Article Bioactivity of AAV2-neurturin gene therapy (CERE-120): differences between Parkinson's disease and nonhuman primate brains.
Academic Article A phase1 study of stereotactic gene delivery of AAV2-NGF for Alzheimer's disease.
Academic Article Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease.
Academic Article A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease.
Academic Article ?-Secretase-1 elevation in aged monkey and Alzheimer's disease human cerebral cortex occurs around the vasculature in partnership with multisystem axon terminal pathogenesis and ?-amyloid accumulation.
Academic Article Future of cell and gene therapies for Parkinson's disease.
Academic Article Neurturin gene therapy improves motor function and prevents death of striatal neurons in a 3-nitropropionic acid rat model of Huntington's disease.
Academic Article Gene transfer provides a practical means for safe, long-term, targeted delivery of biologically active neurotrophic factor proteins for neurodegenerative diseases.
Academic Article Structural and functional neuroprotection in a rat model of Huntington's disease by viral gene transfer of GDNF.
Academic Article Introduction: gene therapy has gone from a pipe dream to clinical reality.
Academic Article PGC-1a Promoter Methylation in Parkinson's Disease.
Academic Article Age-related alterations in GABA(A) receptor subunits in the nonhuman primate hippocampus.
Academic Article In vivo gene delivery of glial cell line--derived neurotrophic factor for Parkinson's disease.
Academic Article Expression, bioactivity, and safety 1 year after adeno-associated viral vector type 2-mediated delivery of neurturin to the monkey nigrostriatal system support cere-120 for Parkinson's disease.
Academic Article Trophic factor gene therapy for Parkinson's disease.
Academic Article Enduring cortical alterations after a single in-vivo treatment of HIV-1 Tat.
Academic Article Gene therapy for Huntington's disease.
Academic Article Gene transfer of trophic factors and stem cell grafting as treatments for Parkinson's disease.
Academic Article Differential vulnerability of neurons in Huntington's disease: the role of cell type-specific features.
Academic Article Analysis of YFP(J16)-R6/2 reporter mice and postmortem brains reveals early pathology and increased vulnerability of callosal axons in Huntington's disease.
Academic Article Gene therapy for Parkinson's disease: still a hot topic?
Academic Article Gene therapy approaches for the treatment of Parkinson's disease.
Academic Article Gene therapy for Parkinson's disease.
Academic Article Issues regarding gene therapy products for Parkinson's disease: the development of CERE-120 (AAV-NTN) as one reference point.
Academic Article Regulatable promoters and gene therapy for Parkinson's disease: is the only thing to fear, fear itself?
Academic Article RET expression does not change with age in the substantia nigra pars compacta of rhesus monkeys.
Academic Article Cell transplantation and gene therapy in Parkinson's disease.
Academic Article Intrastriatal CERE-120 (AAV-Neurturin) protects striatal and cortical neurons and delays motor deficits in a transgenic mouse model of Huntington's disease.
Academic Article Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys.
Academic Article Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of Huntington's disease.
Academic Article Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease.
Academic Article Gene delivery of neurturin to putamen and substantia nigra in Parkinson disease: A double-blind, randomized, controlled trial.
Academic Article Properly scaled and targeted AAV2-NRTN (neurturin) to the substantia nigra is safe, effective and causes no weight loss: support for nigral targeting in Parkinson's disease.
Academic Article Regulation of cyclic AMP response element binding and hippocampal plasticity-related genes by peroxisome proliferator-activated receptor a.
Academic Article Attenuation of microglial RANTES by NEMO-binding domain peptide inhibits the infiltration of CD8(+) T cells in the nigra of hemiparkinsonian monkey.
Academic Article Response of aged parkinsonian monkeys to in vivo gene transfer of GDNF.
Academic Article Parkinson's disease gene therapy: Will focused ultrasound and nanovectors be the next frontier?
Academic Article Loss of One Engrailed1 Allele Enhances Induced a-Synucleinopathy.
Academic Article Spreading of alpha-synuclein - relevant or epiphenomenon?
Academic Article Long-term post-mortem studies following neurturin gene therapy in patients with advanced Parkinson's disease.
Academic Article Anti-a-synuclein ASO delivered to monoamine neurons prevents a-synuclein accumulation in a Parkinson's disease-like mouse model and in monkeys.
Academic Article Enhanced CNS transduction from AAV.PHP.eB infusion into the cisterna magna of older adult rats compared to AAV9.
Academic Article Post-Mortem Studies of Neurturin Gene Therapy for Parkinson's Disease: Two Subjects with 10?Years CERE120 Delivery.
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