Item Type | Name |
Concept
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Disease Models, Animal
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Concept
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Animals, Newborn
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Concept
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Animals
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Concept
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Models, Animal
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Concept
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Animal Rights
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Concept
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Animal Experimentation
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Concept
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Animals, Outbred Strains
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Concept
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Lameness, Animal
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Concept
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Behavior, Animal
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Concept
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Animals, Genetically Modified
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Academic Article
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Doublecortin expression in adult cat and primate cerebral cortex relates to immature neurons that develop into GABAergic subgroups.
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Academic Article
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Abnormal alpha-synuclein reduces nigral voltage-dependent anion channel 1 in sporadic and experimental Parkinson's disease.
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Academic Article
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Bioactivity of AAV2-neurturin gene therapy (CERE-120): differences between Parkinson's disease and nonhuman primate brains.
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Academic Article
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Modeling Parkinson's disease.
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Academic Article
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Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease.
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Academic Article
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?-Secretase-1 elevation in aged monkey and Alzheimer's disease human cerebral cortex occurs around the vasculature in partnership with multisystem axon terminal pathogenesis and ?-amyloid accumulation.
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Academic Article
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Knockout of p75NTR does not alter the viability of striatal neurons following a metabolic or excitotoxic injury.
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Academic Article
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Neurotrophic factor therapy for Parkinson's disease.
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Academic Article
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Future of cell and gene therapies for Parkinson's disease.
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Academic Article
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Neurturin gene therapy improves motor function and prevents death of striatal neurons in a 3-nitropropionic acid rat model of Huntington's disease.
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Academic Article
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Trophic factors for Parkinson's disease: To live or let die.
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Academic Article
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Chronic ischemic stroke model in cynomolgus monkeys: behavioral, neuroimaging and anatomical study.
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Academic Article
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Estrogen increases the number of spinophilin-immunoreactive spines in the hippocampus of young and aged female rhesus monkeys.
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Academic Article
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a-synuclein aggregation reduces nigral myocyte enhancer factor-2D in idiopathic and experimental Parkinson's disease.
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Academic Article
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The prion hypothesis of Parkinson's disease.
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Academic Article
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Neutralization of RANTES and Eotaxin Prevents the Loss of Dopaminergic Neurons in a Mouse Model of Parkinson Disease.
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Academic Article
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Cell therapy for Parkinson's disease: what next?
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Academic Article
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Striatal delivery of CERE-120, an AAV2 vector encoding human neurturin, enhances activity of the dopaminergic nigrostriatal system in aged monkeys.
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Academic Article
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Structural and functional neuroprotection in a rat model of Huntington's disease by viral gene transfer of GDNF.
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Academic Article
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Decreased alpha-synuclein expression in the aging mouse substantia nigra.
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Academic Article
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Estrogen replacement increases spinophilin-immunoreactive spine number in the prefrontal cortex of female rhesus monkeys.
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Academic Article
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Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum.
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Academic Article
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Introduction: gene therapy has gone from a pipe dream to clinical reality.
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Academic Article
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GDNF family ligands: a potential future for Parkinson's disease therapy.
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Academic Article
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Propagation of host disease to grafted neurons: accumulating evidence.
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Academic Article
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Human neural stem cell transplants improve motor function in a rat model of Huntington's disease.
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Academic Article
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PGC-1a Promoter Methylation in Parkinson's Disease.
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Academic Article
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Age-related alterations in GABA(A) receptor subunits in the nonhuman primate hippocampus.
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Academic Article
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Differential transduction following basal ganglia administration of distinct pseudotyped AAV capsid serotypes in nonhuman primates.
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Academic Article
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Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?
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Academic Article
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Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates.
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Academic Article
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In vivo gene delivery of glial cell line--derived neurotrophic factor for Parkinson's disease.
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Academic Article
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Dopaminergic transplantation for Parkinson's disease: current status and future prospects.
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Academic Article
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Aging-related changes in the nigrostriatal dopamine system and the response to MPTP in nonhuman primates: diminished compensatory mechanisms as a prelude to parkinsonism.
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Academic Article
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Expression, bioactivity, and safety 1 year after adeno-associated viral vector type 2-mediated delivery of neurturin to the monkey nigrostriatal system support cere-120 for Parkinson's disease.
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Academic Article
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Enduring cortical alterations after a single in-vivo treatment of HIV-1 Tat.
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Academic Article
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Celebrating neural repair.
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Academic Article
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Gene therapy for Huntington's disease.
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Academic Article
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Gene transfer of trophic factors and stem cell grafting as treatments for Parkinson's disease.
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Academic Article
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Age-related accumulation of Marinesco bodies and lipofuscin in rhesus monkey midbrain dopamine neurons: relevance to selective neuronal vulnerability.
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Academic Article
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Age-related changes in glial cells of dopamine midbrain subregions in rhesus monkeys.
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Academic Article
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Excitotoxic and metabolic damage to the rodent striatum: role of the P75 neurotrophin receptor and glial progenitors.
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Academic Article
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AAV2-mediated delivery of human neurturin to the rat nigrostriatal system: long-term efficacy and tolerability of CERE-120 for Parkinson's disease.
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Academic Article
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Lewy body pathology in fetal grafts.
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Academic Article
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Age and region-specific responses of microglia, but not astrocytes, suggest a role in selective vulnerability of dopamine neurons after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in monkeys.
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Academic Article
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The immunophilin ligand GPI-1046 does not have neuroregenerative effects in MPTP-treated monkeys.
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Academic Article
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Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease.
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Academic Article
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GFAP knockout mice have increased levels of GDNF that protect striatal neurons from metabolic and excitotoxic insults.
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Academic Article
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Deep brain stimulation for treatment of obesity in rats.
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Academic Article
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Analysis of YFP(J16)-R6/2 reporter mice and postmortem brains reveals early pathology and increased vulnerability of callosal axons in Huntington's disease.
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Academic Article
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Long-term gonadal hormone treatment and endogenous neurogenesis in the dentate gyrus of the adult female monkey.
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Academic Article
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Gene therapy for Parkinson's disease: still a hot topic?
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Academic Article
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Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration.
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Academic Article
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Gene therapy for Parkinson's disease.
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Academic Article
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Striatal trophic factor activity in aging monkeys with unilateral MPTP-induced parkinsonism.
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Academic Article
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Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian rats.
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Academic Article
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Peripheral alpha-synuclein and Parkinson's disease.
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Academic Article
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Issues regarding gene therapy products for Parkinson's disease: the development of CERE-120 (AAV-NTN) as one reference point.
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Academic Article
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Alterations in Activity-Dependent Neuroprotective Protein in Sporadic and Experimental Parkinson's Disease.
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Academic Article
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Extensive neuroprotection by choroid plexus transplants in excitotoxin lesioned monkeys.
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Academic Article
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Proteasome inhibition and Parkinson's disease modeling.
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Academic Article
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Regulatable promoters and gene therapy for Parkinson's disease: is the only thing to fear, fear itself?
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Academic Article
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Animal rights terrorists: what every neuroscientist should know.
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Academic Article
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Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys.
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Academic Article
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RET expression does not change with age in the substantia nigra pars compacta of rhesus monkeys.
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Academic Article
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Neonatal immune-tolerance in mice does not prevent xenograft rejection.
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Academic Article
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Distribution of high affinity choline transporter immunoreactivity in the primate central nervous system.
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Academic Article
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Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease.
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Academic Article
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The role of alpha-synuclein in Parkinson's disease: insights from animal models.
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Academic Article
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Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions.
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Academic Article
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Cell transplantation and gene therapy in Parkinson's disease.
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Academic Article
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Intrastriatal CERE-120 (AAV-Neurturin) protects striatal and cortical neurons and delays motor deficits in a transgenic mouse model of Huntington's disease.
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Academic Article
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Missing pieces in the Parkinson's disease puzzle.
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Academic Article
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Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys.
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Academic Article
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Neural repair strategies for Parkinson's disease: insights from primate models.
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Academic Article
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Testing NF-?B-based therapy in hemiparkinsonian monkeys.
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Academic Article
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Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of Huntington's disease.
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Academic Article
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Animal models of Huntington's disease.
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Academic Article
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Primate models of Parkinson's disease.
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Academic Article
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Survival and early differentiation of human neural stem cells transplanted in a nonhuman primate model of stroke.
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Academic Article
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Trophic factors therapy in Parkinson's disease.
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Academic Article
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Broad distribution of ataxin 1 silencing in rhesus cerebella for spinocerebellar ataxia type 1 therapy.
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Academic Article
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Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson's disease.
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Academic Article
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Transfer of host-derived a synuclein to grafted dopaminergic neurons in rat.
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Academic Article
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Prenatal 3,4-methylenedioxymethamphetamine (ecstasy) alters exploratory behavior, reduces monoamine metabolism, and increases forebrain tyrosine hydroxylase fiber density of juvenile rats.
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Academic Article
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Inhibitors of cyclooxygenase-2, but not cyclooxygenase-1 provide structural and functional protection against quinolinic acid-induced neurodegeneration.
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Academic Article
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Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease.
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Academic Article
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Are growth factors the answer?
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Academic Article
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Effects of estrogen replacement therapy on cholinergic basal forebrain neurons and cortical cholinergic innervation in young and aged ovariectomized rhesus monkeys.
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Academic Article
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The prion hypothesis of Parkinson's disease: this hot topic just got hotter.
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Academic Article
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Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease.
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Academic Article
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Alpha-synuclein propagation: New insights from animal models.
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Academic Article
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Parkinson's disease and prion disease: Straining the comparison.
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Academic Article
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RNA amplification of bromodeoxyuridine labeled newborn neurons in the monkey hippocampus.
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Academic Article
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Injectable hydrogels providing sustained delivery of vascular endothelial growth factor are neuroprotective in a rat model of Huntington's disease.
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Academic Article
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Properly scaled and targeted AAV2-NRTN (neurturin) to the substantia nigra is safe, effective and causes no weight loss: support for nigral targeting in Parkinson's disease.
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Academic Article
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Regulation of cyclic AMP response element binding and hippocampal plasticity-related genes by peroxisome proliferator-activated receptor a.
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Academic Article
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Attenuation of microglial RANTES by NEMO-binding domain peptide inhibits the infiltration of CD8(+) T cells in the nigra of hemiparkinsonian monkey.
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Academic Article
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Parkinsonian monkeys with prior levodopa-induced dyskinesias followed by fetal dopamine precursor grafts do not display graft-induced dyskinesias.
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Academic Article
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Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates.
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Academic Article
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Cryopreservation Maintains Functionality of Human iPSC Dopamine Neurons and Rescues Parkinsonian Phenotypes In?Vivo.
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Academic Article
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Aging and Parkinson's disease: Different sides of the same coin?
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Academic Article
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a-Synuclein nonhuman primate models of Parkinson's disease.
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Academic Article
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What would Dr. James Parkinson think today? parcelling out the circuitry of levodopa-induced dyskinesias.
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Academic Article
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Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease.
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Academic Article
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Is Axonal Degeneration a Key Early Event in Parkinson's Disease?
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Academic Article
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Special issue on stem cells.
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Academic Article
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In vivo evaluation of [(123)I]MNI-420: a novel single photon emission computed tomography radiotracer for imaging of adenosine 2A receptors in brain.
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Academic Article
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Kinetic modeling and occupancy measures of the norepinephrine transporters in baboons using single photon emission computed tomography with (123)I-INER.
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Academic Article
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Prenatal exposure to MDMA alters noradrenergic neurodevelopment in the rat.
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Academic Article
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Response of aged parkinsonian monkeys to in vivo gene transfer of GDNF.
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Academic Article
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Association of early experience with neurodegeneration in aged primates.
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Academic Article
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Therapeutic approaches to target alpha-synuclein pathology.
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Academic Article
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Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology.
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Academic Article
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Disease Modification for Parkinson's Disease: Axonal Regeneration and Trophic Factors.
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Academic Article
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Detecting Alpha Synuclein Seeding Activity in Formaldehyde-Fixed MSA Patient Tissue by PMCA.
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Academic Article
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Disease Modification Through Trophic Factor Delivery.
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Academic Article
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Chronic stress-induced gut dysfunction exacerbates Parkinson's disease phenotype and pathology in a rotenone-induced mouse model of Parkinson's disease.
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Academic Article
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Demonstration of prion-like properties of mutant huntingtin fibrils in both in vitro and in vivo paradigms.
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Academic Article
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Role of TLR4 in the gut-brain axis in Parkinson's disease: a translational study from men to mice.
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Academic Article
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Parkinson's disease gene therapy: Will focused ultrasound and nanovectors be the next frontier?
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Academic Article
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Loss of One Engrailed1 Allele Enhances Induced a-Synucleinopathy.
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Academic Article
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Widespread Striatal Delivery of GDNF from Encapsulated Cells Prevents the Anatomical and Functional Consequences of Excitotoxicity.
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Academic Article
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Temporal evolution of microglia and a-synuclein accumulation following foetal grafting in Parkinson's disease.
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Academic Article
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Focused ultrasound opening of the blood-brain barrier for treatment of Parkinson's disease.
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Academic Article
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Spreading of alpha-synuclein - relevant or epiphenomenon?
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Academic Article
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Immunotherapy in Parkinson's disease: Current status and future directions.
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Academic Article
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Intrastriatal alpha-synuclein fibrils in monkeys: spreading, imaging and neuropathological changes.
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Academic Article
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Human autologous iPSC-derived dopaminergic progenitors restore motor function in Parkinson's disease models.
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Academic Article
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Does Developmental Variability in the Number of Midbrain Dopamine Neurons Affect Individual Risk for Sporadic Parkinson's Disease?
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Academic Article
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T cell infiltration in both human multiple system atrophy and a novel mouse model of the disease.
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Academic Article
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Striatal Nurr1 Facilitates the Dyskinetic State and Exacerbates Levodopa-Induced Dyskinesia in a Rat Model of Parkinson's Disease.
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Academic Article
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GDNF and Parkinson's Disease: Where Next? A Summary from a Recent Workshop.
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Academic Article
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Anti-a-synuclein ASO delivered to monoamine neurons prevents a-synuclein accumulation in a Parkinson's disease-like mouse model and in monkeys.
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Academic Article
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Mitomycin-C treatment during differentiation of induced pluripotent stem cell-derived dopamine neurons reduces proliferation without compromising survival or function in?vivo.
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Academic Article
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Inflammation in Experimental Models of a-Synucleinopathies.
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Academic Article
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Viral-based rodent and nonhuman primate models of multiple system atrophy: Fidelity to the human disease.
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Academic Article
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GDNF signaling in subjects with minimal motor deficits and Parkinson's disease.
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Academic Article
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A novel tau-based rhesus monkey model of Alzheimer's pathogenesis.
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Academic Article
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Enhanced CNS transduction from AAV.PHP.eB infusion into the cisterna magna of older adult rats compared to AAV9.
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Academic Article
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A historical review of multiple system atrophy with a critical appraisal of cellular and animal models.
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Academic Article
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SeqStain is an efficient method for multiplexed, spatialomic profiling of human and murine tissues.
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Academic Article
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In situ proximity labeling identifies Lewy pathology molecular interactions in the human brain.
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Academic Article
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Stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau in cellular and mouse models of tauopathies.
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Academic Article
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Nigral-specific increase in ser31 phosphorylation compensates for tyrosine hydroxylase protein and nigrostriatal neuron loss: Implications for delaying parkinsonian signs.
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