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overview Other Appointments: Director, Section of Neurobiology Overview: Kordower is an international authority in the area of movement disorders with special expertise in pathophysiology and experimental therapeutic strategies in Parkinson’s disease, Alzheimer’s disease and Huntington’s disease — especially using nonhuman primate models. He has published landmark papers in the area of cell replacement strategies, including the first demonstration that fetal dopaminergic grafts can survive, innervate and form synapses in patients with Parkinson’s disease that was published in the New England Journal of Medicine. His recent demonstration that long-term grafts in such patients can form Lewy bodies was recently published in Nature Medicine. Kordower has published seminal studies including the lead article in Science demonstrating that gene delivery of the trophic factors GDNF and neurturin can prevent the emergence of motor symptoms and nigrostriatal degeneration in a monkey model of PD. He also was the first to demonstrate that gene delivery of trophic factors can obviate neurodegenerative processes in nonhuman primate models of Huntington’s disease and Alzheimer’s disease, with these studies being published in Nature and The Journal of Comparative Neurology, respectively. He has published numerous papers investigating the role of misfolded proteins in PD pathogenesis. These include papers in human and experimental PD on the role of alpha synuclein misfolding on Nurr1 and dopamine expression, lysosome and proteasome dysfunction, and axonal transport defects. He is a co-author on the landmark Nature paper lead by the Studer group demonstrating the structural and functional efficacy of dopaminergic human stem cells in rodent and nonhuman primate models of PD. In addition, he is collaborating with Trojanowski and Lee and recently demonstrated the ability of preformed fibrils to be transported in nonhuman primates and cause degeneration in nonhuman primates, a study that serves as the foundation of the current application. Kordower has published over 350 papers, has lectured all over the world, has been on over 20 editorial boards, and is on the SAB’s of many biotech companies and scientific organizations. He is a past councilor and past president of the American Society for Neural Transplantation, past chair for the Committee for the Use of Animals for SFN, and is a founding SAB member for the Michael J. Fox Foundation and is a past member of their Executive SAB. My Scopus ID is 7005337450. My NIH COMMONS name is JKORDOWER. Education PhD, Queens College, City University of New York MA, Queens College, City University of New York BA, Queens College, City University of New York

One or more keywords matched the following items that are connected to Kordower, Jeffrey

Item TypeName
Concept Disease Models, Animal
Concept Animals, Newborn
Concept Animals
Concept Models, Animal
Concept Animal Rights
Concept Animal Experimentation
Concept Animals, Outbred Strains
Concept Lameness, Animal
Concept Behavior, Animal
Concept Animals, Genetically Modified
Academic Article Doublecortin expression in adult cat and primate cerebral cortex relates to immature neurons that develop into GABAergic subgroups.
Academic Article Abnormal alpha-synuclein reduces nigral voltage-dependent anion channel 1 in sporadic and experimental Parkinson's disease.
Academic Article Bioactivity of AAV2-neurturin gene therapy (CERE-120): differences between Parkinson's disease and nonhuman primate brains.
Academic Article Modeling Parkinson's disease.
Academic Article Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease.
Academic Article ß-Secretase-1 elevation in aged monkey and Alzheimer's disease human cerebral cortex occurs around the vasculature in partnership with multisystem axon terminal pathogenesis and ß-amyloid accumulation.
Academic Article Neuroprotection for Parkinson's disease using viral vector-mediated delivery of GDNF.
Academic Article Knockout of p75NTR does not alter the viability of striatal neurons following a metabolic or excitotoxic injury.
Academic Article Neurotrophic factor therapy for Parkinson's disease.
Academic Article Future of cell and gene therapies for Parkinson's disease.
Academic Article Neurturin gene therapy improves motor function and prevents death of striatal neurons in a 3-nitropropionic acid rat model of Huntington's disease.
Academic Article Trophic factors for Parkinson's disease: To live or let die.
Academic Article Chronic ischemic stroke model in cynomolgus monkeys: behavioral, neuroimaging and anatomical study.
Academic Article Estrogen increases the number of spinophilin-immunoreactive spines in the hippocampus of young and aged female rhesus monkeys.
Academic Article a-synuclein aggregation reduces nigral myocyte enhancer factor-2D in idiopathic and experimental Parkinson's disease.
Academic Article The prion hypothesis of Parkinson's disease.
Academic Article Neutralization of RANTES and Eotaxin Prevents the Loss of Dopaminergic Neurons in a Mouse Model of Parkinson Disease.
Academic Article Cell therapy for Parkinson's disease: what next?
Academic Article Striatal delivery of CERE-120, an AAV2 vector encoding human neurturin, enhances activity of the dopaminergic nigrostriatal system in aged monkeys.
Academic Article Structural and functional neuroprotection in a rat model of Huntington's disease by viral gene transfer of GDNF.
Academic Article Decreased alpha-synuclein expression in the aging mouse substantia nigra.
Academic Article Etiology of Parkinson's disease: Genetics and environment revisited.
Academic Article Estrogen replacement increases spinophilin-immunoreactive spine number in the prefrontal cortex of female rhesus monkeys.
Academic Article Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum.
Academic Article Introduction: gene therapy has gone from a pipe dream to clinical reality.
Academic Article GDNF family ligands: a potential future for Parkinson's disease therapy.
Academic Article Propagation of host disease to grafted neurons: accumulating evidence.
Academic Article Human neural stem cell transplants improve motor function in a rat model of Huntington's disease.
Academic Article PGC-1a Promoter Methylation in Parkinson's Disease.
Academic Article Age-related alterations in GABA(A) receptor subunits in the nonhuman primate hippocampus.
Academic Article Differential transduction following basal ganglia administration of distinct pseudotyped AAV capsid serotypes in nonhuman primates.
Academic Article Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?
Academic Article Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates.
Academic Article In vivo gene delivery of glial cell line--derived neurotrophic factor for Parkinson's disease.
Academic Article Dopaminergic transplantation for Parkinson's disease: current status and future prospects.
Academic Article Aging-related changes in the nigrostriatal dopamine system and the response to MPTP in nonhuman primates: diminished compensatory mechanisms as a prelude to parkinsonism.
Academic Article Expression, bioactivity, and safety 1 year after adeno-associated viral vector type 2-mediated delivery of neurturin to the monkey nigrostriatal system support cere-120 for Parkinson's disease.
Academic Article Enduring cortical alterations after a single in-vivo treatment of HIV-1 Tat.
Academic Article Celebrating neural repair.
Academic Article Gene therapy for Huntington's disease.
Academic Article Gene transfer of trophic factors and stem cell grafting as treatments for Parkinson's disease.
Academic Article Age-related accumulation of Marinesco bodies and lipofuscin in rhesus monkey midbrain dopamine neurons: relevance to selective neuronal vulnerability.
Academic Article Age-related changes in glial cells of dopamine midbrain subregions in rhesus monkeys.
Academic Article Excitotoxic and metabolic damage to the rodent striatum: role of the P75 neurotrophin receptor and glial progenitors.
Academic Article AAV2-mediated delivery of human neurturin to the rat nigrostriatal system: long-term efficacy and tolerability of CERE-120 for Parkinson's disease.
Academic Article Lewy body pathology in fetal grafts.
Academic Article Age and region-specific responses of microglia, but not astrocytes, suggest a role in selective vulnerability of dopamine neurons after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in monkeys.
Academic Article The immunophilin ligand GPI-1046 does not have neuroregenerative effects in MPTP-treated monkeys.
Academic Article Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease.
Academic Article GFAP knockout mice have increased levels of GDNF that protect striatal neurons from metabolic and excitotoxic insults.
Academic Article Deep brain stimulation for treatment of obesity in rats.
Academic Article Analysis of YFP(J16)-R6/2 reporter mice and postmortem brains reveals early pathology and increased vulnerability of callosal axons in Huntington's disease.
Academic Article Long-term gonadal hormone treatment and endogenous neurogenesis in the dentate gyrus of the adult female monkey.
Academic Article Gene therapy for Parkinson's disease: still a hot topic?
Academic Article Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration.
Academic Article Gene therapy for Parkinson's disease.
Academic Article Striatal trophic factor activity in aging monkeys with unilateral MPTP-induced parkinsonism.
Academic Article Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian rats.
Academic Article Peripheral alpha-synuclein and Parkinson's disease.
Academic Article Issues regarding gene therapy products for Parkinson's disease: the development of CERE-120 (AAV-NTN) as one reference point.
Academic Article Alterations in Activity-Dependent Neuroprotective Protein in Sporadic and Experimental Parkinson's Disease.
Academic Article Extensive neuroprotection by choroid plexus transplants in excitotoxin lesioned monkeys.
Academic Article Proteasome inhibition and Parkinson's disease modeling.
Academic Article Regulatable promoters and gene therapy for Parkinson's disease: is the only thing to fear, fear itself?
Academic Article Animal rights terrorists: what every neuroscientist should know.
Academic Article Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys.
Academic Article RET expression does not change with age in the substantia nigra pars compacta of rhesus monkeys.
Academic Article Behavioral and morphological comparison of two nonhuman primate models of Huntington's disease.
Academic Article Neonatal immune-tolerance in mice does not prevent xenograft rejection.
Academic Article Distribution of high affinity choline transporter immunoreactivity in the primate central nervous system.
Academic Article Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease.
Academic Article The role of alpha-synuclein in Parkinson's disease: insights from animal models.
Academic Article Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions.
Academic Article Cell transplantation and gene therapy in Parkinson's disease.
Academic Article Intrastriatal CERE-120 (AAV-Neurturin) protects striatal and cortical neurons and delays motor deficits in a transgenic mouse model of Huntington's disease.
Academic Article Missing pieces in the Parkinson's disease puzzle.
Academic Article Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys.
Academic Article Neural repair strategies for Parkinson's disease: insights from primate models.
Academic Article Testing NF-?B-based therapy in hemiparkinsonian monkeys.
Academic Article Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of Huntington's disease.
Academic Article Animal models of Huntington's disease.
Academic Article Primate models of Parkinson's disease.
Academic Article Survival and early differentiation of human neural stem cells transplanted in a nonhuman primate model of stroke.
Academic Article Trophic factors therapy in Parkinson's disease.
Academic Article Broad distribution of ataxin 1 silencing in rhesus cerebella for spinocerebellar ataxia type 1 therapy.
Academic Article Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson's disease.
Academic Article Transfer of host-derived a synuclein to grafted dopaminergic neurons in rat.
Academic Article Prenatal 3,4-methylenedioxymethamphetamine (ecstasy) alters exploratory behavior, reduces monoamine metabolism, and increases forebrain tyrosine hydroxylase fiber density of juvenile rats.
Academic Article Inhibitors of cyclooxygenase-2, but not cyclooxygenase-1 provide structural and functional protection against quinolinic acid-induced neurodegeneration.
Academic Article Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease.
Academic Article Are growth factors the answer?
Academic Article Effects of estrogen replacement therapy on cholinergic basal forebrain neurons and cortical cholinergic innervation in young and aged ovariectomized rhesus monkeys.
Academic Article The prion hypothesis of Parkinson's disease: this hot topic just got hotter.
Academic Article Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease.
Academic Article Alpha-synuclein propagation: New insights from animal models.
Academic Article Parkinson's disease and prion disease: Straining the comparison.
Academic Article RNA amplification of bromodeoxyuridine labeled newborn neurons in the monkey hippocampus.
Academic Article Injectable hydrogels providing sustained delivery of vascular endothelial growth factor are neuroprotective in a rat model of Huntington's disease.
Academic Article Properly scaled and targeted AAV2-NRTN (neurturin) to the substantia nigra is safe, effective and causes no weight loss: support for nigral targeting in Parkinson's disease.
Academic Article Regulation of cyclic AMP response element binding and hippocampal plasticity-related genes by peroxisome proliferator-activated receptor a.
Academic Article Attenuation of microglial RANTES by NEMO-binding domain peptide inhibits the infiltration of CD8(+) T cells in the nigra of hemiparkinsonian monkey.
Academic Article Parkinsonian monkeys with prior levodopa-induced dyskinesias followed by fetal dopamine precursor grafts do not display graft-induced dyskinesias.
Academic Article Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates.
Academic Article Cryopreservation Maintains Functionality of Human iPSC Dopamine Neurons and Rescues Parkinsonian Phenotypes In Vivo.
Academic Article Aging and Parkinson's disease: Different sides of the same coin?
Academic Article a-Synuclein nonhuman primate models of Parkinson's disease.
Academic Article What would Dr. James Parkinson think today? parcelling out the circuitry of levodopa-induced dyskinesias.
Academic Article Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease.
Academic Article Is Axonal Degeneration a Key Early Event in Parkinson's Disease?
Academic Article Special issue on stem cells.
Academic Article In vivo evaluation of [(123)I]MNI-420: a novel single photon emission computed tomography radiotracer for imaging of adenosine 2A receptors in brain.
Academic Article Kinetic modeling and occupancy measures of the norepinephrine transporters in baboons using single photon emission computed tomography with (123)I-INER.
Academic Article Prenatal exposure to MDMA alters noradrenergic neurodevelopment in the rat.
Academic Article Response of aged parkinsonian monkeys to in vivo gene transfer of GDNF.
Academic Article Association of early experience with neurodegeneration in aged primates.
Academic Article Therapeutic approaches to target alpha-synuclein pathology.
Academic Article Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology.
Academic Article Disease Modification for Parkinson's Disease: Axonal Regeneration and Trophic Factors.
Academic Article Detecting Alpha Synuclein Seeding Activity in Formaldehyde-Fixed MSA Patient Tissue by PMCA.
Academic Article Disease Modification Through Trophic Factor Delivery.
Academic Article Chronic stress-induced gut dysfunction exacerbates Parkinson's disease phenotype and pathology in a rotenone-induced mouse model of Parkinson's disease.
Academic Article Demonstration of prion-like properties of mutant huntingtin fibrils in both in vitro and in vivo paradigms.
Academic Article Role of TLR4 in the gut-brain axis in Parkinson's disease: a translational study from men to mice.
Academic Article Parkinson's disease gene therapy: Will focused ultrasound and nanovectors be the next frontier?
Academic Article Loss of One Engrailed1 Allele Enhances Induced a-Synucleinopathy.
Academic Article Widespread Striatal Delivery of GDNF from Encapsulated Cells Prevents the Anatomical and Functional Consequences of Excitotoxicity.
Academic Article Temporal evolution of microglia and a-synuclein accumulation following foetal grafting in Parkinson's disease.
Academic Article Focused ultrasound opening of the blood-brain barrier for treatment of Parkinson's disease.
Academic Article Spreading of alpha-synuclein - relevant or epiphenomenon?
Academic Article Immunotherapy in Parkinson's disease: Current status and future directions.
Academic Article Intrastriatal alpha-synuclein fibrils in monkeys: spreading, imaging and neuropathological changes.
Academic Article Human autologous iPSC-derived dopaminergic progenitors restore motor function in Parkinson's disease models.
Academic Article Does Developmental Variability in the Number of Midbrain Dopamine Neurons Affect Individual Risk for Sporadic Parkinson's Disease?
Academic Article T cell infiltration in both human multiple system atrophy and a novel mouse model of the disease.
Academic Article Striatal Nurr1 Facilitates the Dyskinetic State and Exacerbates Levodopa-Induced Dyskinesia in a Rat Model of Parkinson's Disease.
Academic Article GDNF and Parkinson's Disease: Where Next? A Summary from a Recent Workshop.
Academic Article Anti-a-synuclein ASO delivered to monoamine neurons prevents a-synuclein accumulation in a Parkinson's disease-like mouse model and in monkeys.
Academic Article Mitomycin-C treatment during differentiation of induced pluripotent stem cell-derived dopamine neurons reduces proliferation without compromising survival or function in?vivo.
Academic Article Inflammation in Experimental Models of a-Synucleinopathies.
Academic Article Viral-based rodent and nonhuman primate models of multiple system atrophy: Fidelity to the human disease.
Academic Article GDNF signaling in subjects with minimal motor deficits and Parkinson's disease.
Academic Article A novel tau-based rhesus monkey model of Alzheimer's pathogenesis.
Academic Article Enhanced CNS transduction from AAV.PHP.eB infusion into the cisterna magna of older adult rats compared to AAV9.
Academic Article A historical review of multiple system atrophy with a critical appraisal of cellular and animal models.
Academic Article In situ proximity labeling identifies Lewy pathology molecular interactions in the human brain.

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