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Bennett, David

One or more keywords matched the following items that are connected to Bennett, David

Item Type	Name
Concept	Gene Expression Regulation, Enzymologic
Concept	Gene Expression Profiling
Concept	Regulatory Elements, Transcriptional
Concept	Genetic Pleiotropy
Concept	Gene Regulatory Networks
Concept	Multigene Family
Concept	Genes, Tumor Suppressor
Concept	Epistasis, Genetic
Concept	Gene Expression
Concept	Amino Acid Sequence
Concept	Trinucleotide Repeat Expansion
Concept	Gene Knock-In Techniques
Concept	Genome, Human
Concept	Gene Targeting
Concept	Transcriptome
Concept	Gene Rearrangement
Concept	Polymorphism, Single Nucleotide
Concept	Quantitative Trait Loci
Concept	Gene Library
Concept	Gene Expression Regulation, Neoplastic
Concept	Sequence Homology, Amino Acid
Concept	Gene-Environment Interaction
Concept	Exome
Concept	Genetic Loci
Concept	Genome
Concept	Pseudogenes
Concept	Gene Frequency
Concept	Gene Deletion
Concept	Base Sequence
Concept	Alleles
Concept	Genes, Recessive
Concept	Gene Knockdown Techniques
Concept	Molecular Sequence Data
Concept	Gene Expression Regulation, Developmental
Concept	Gene Expression Regulation
Concept	Gene Dosage
Academic Article	GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP.
Academic Article	Novel late-onset Alzheimer disease loci variants associate with brain gene expression.
Academic Article	Sex difference in daily rhythms of clock gene expression in the aged human cerebral cortex.
Academic Article	Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease.
Academic Article	An inflection point in gene discovery efforts for neurodegenerative diseases: from syndromic diagnoses toward endophenotypes and the epigenome.
Academic Article	Genetic variation in the brain derived neurotrophic factor gene in Alzheimer's disease.
Academic Article	Variation in longevity gene KLOTHO is associated with greater cortical volumes.
Academic Article	The significance of Pin1 in the development of Alzheimer's disease.
Academic Article	24-hour rhythms of DNA methylation and their relation with rhythms of RNA expression in the human dorsolateral prefrontal cortex.
Academic Article	Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions.
Academic Article	APOE e4 and the associations of seafood and long-chain omega-3 fatty acids with cognitive decline.
Academic Article	Genome-wide chromatin state transitions associated with developmental and environmental cues.
Academic Article	REST and stress resistance in ageing and Alzheimer's disease.
Academic Article	ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.
Academic Article	The complex PrP(c)-Fyn couples human oligomeric A? with pathological tau changes in Alzheimer's disease.
Academic Article	Neuropathologic intermediate phenotypes enhance association to Alzheimer susceptibility alleles.
Academic Article	Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.
Academic Article	Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer's brain.
Academic Article	Brain erythropoietin receptor expression in Alzheimer disease and mild cognitive impairment.
Academic Article	Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes.
Academic Article	Cerebrovascular and microglial states are not altered by functional neuroinflammatory gene variant.
Academic Article	Genome-wide association study identifies 74 loci associated with educational attainment.
Academic Article	Higher brain BDNF gene expression is associated with slower cognitive decline in older adults.
Academic Article	A coding variant in CR1 interacts with APOE-e4 to influence cognitive decline.
Academic Article	Mitochondrial DNA rearrangements in aging human brain and in situ PCR of mtDNA.
Academic Article	APOE e4 increases risk for dementia in pure synucleinopathies.
Academic Article	New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.
Academic Article	The SORL1 gene and convergent neural risk for Alzheimer's disease across the human lifespan.
Academic Article	Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals.
Academic Article	Plasma Exosomal miRNAs in Persons with and without Alzheimer Disease: Altered Expression and Prospects for Biomarkers.
Academic Article	Fragile X gene expansions are not associated with dementia.
Academic Article	Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment.
Academic Article	The Role of MAPT Haplotype H2 and Isoform 1N/4R in Parkinsonism of Older Adults.
Academic Article	GSK3? Interactions with Amyloid Genes: An Autopsy Verification and Extension.
Academic Article	Genetic variants in Alzheimer disease - molecular and brain network approaches.
Academic Article	Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease.
Academic Article	Is there a link between cancer and Alzheimer disease?
Academic Article	The epigenome in Alzheimer's disease: current state and approaches for a new path to gene discovery and understanding disease mechanism.
Academic Article	Apolipoprotein E epsilon4 and incidence of Alzheimer disease in a community population of older persons.
Academic Article	Down-regulation of trkA mRNA within nucleus basalis neurons in individuals with mild cognitive impairment and Alzheimer's disease.
Academic Article	The apolipoprotein E epsilon 2 allele and decline in episodic memory.
Academic Article	Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.
Academic Article	Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory.
Academic Article	Alternative Approaches in Gene Discovery and Characterization in Alzheimer's Disease.
Academic Article	A novel Alzheimer disease locus located near the gene encoding tau protein.
Academic Article	GWAS for executive function and processing speed suggests involvement of the CADM2 gene.
Academic Article	miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo.
Academic Article	Gene expression elucidates functional impact of polygenic risk for schizophrenia.
Academic Article	Differential transcriptome expression in human nucleus accumbens as a function of loneliness.
Academic Article	Circadian alterations during early stages of Alzheimer's disease are associated with aberrant cycles of DNA methylation in BMAL1.
Academic Article	A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression.
Academic Article	A genome-wide profiling of brain DNA hydroxymethylation in Alzheimer's disease.
Academic Article	Polygenic risk scores in familial Alzheimer disease.
Academic Article	Selective lowering of synapsins induced by oligomeric a-synuclein exacerbates memory deficits.
Academic Article	Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.
Academic Article	Diurnal and seasonal molecular rhythms in human neocortex and their relation to Alzheimer's disease.
Academic Article	Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data.
Academic Article	Neuronal-expressed microRNA-targeted pseudogenes compete with coding genes in the human brain.
Academic Article	Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline.
Academic Article	A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants.
Academic Article	Loneliness 5 years ante-mortem is associated with disease-related differential gene expression in postmortem dorsolateral prefrontal cortex.
Academic Article	A transcriptomic atlas of aged human microglia.
Academic Article	A Common DIO2 Polymorphism and Alzheimer Disease Dementia in African and European Americans.
Academic Article	Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of?Selective Neuronal Vulnerability.
Academic Article	Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology.
Academic Article	Integrated biology approach reveals molecular and pathological interactions among Alzheimer's A?42, Tau, TREM2, and TYROBP in Drosophila models.
Academic Article	Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.
Academic Article	Genetic association of low density lipoprotein receptor and Alzheimer's disease.
Academic Article	A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer's disease.
Academic Article	Gene expression and DNA methylation are extensively coordinated with MRI-based brain microstructural characteristics.
Academic Article	The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease target.
Academic Article	Multi-omic Directed Networks Describe Features of Gene Regulation in Aged Brains and Expand the Set of Genes Driving Cognitive Decline.
Academic Article	Seasonal plasticity of cognition and related biological measures in adults with and without Alzheimer disease: Analysis of multiple cohorts.
Academic Article	Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility.
Academic Article	Candidate-based screening via gene modulation in human neurons and astrocytes implicates FERMT2 in A? and TAU proteostasis.
Academic Article	Hippocampal gene expression patterns linked to late-life physical activity oppose age and AD-related transcriptional decline.
Academic Article	Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria.
Academic Article	Brain expression of the vascular endothelial growth factor gene family in cognitive aging and alzheimer's disease.
Academic Article	Integrating Gene and Protein Expression Reveals Perturbed Functional Networks in Alzheimer's Disease.
Academic Article	TIGAR: An Improved Bayesian Tool for Transcriptomic Data Imputation Enhances Gene Mapping of Complex Traits.
Academic Article	A genome-wide association study identifies genetic loci associated with specific lobar brain volumes.
Academic Article	cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis.
Academic Article	APOE e4-specific associations of VEGF gene family expression with cognitive aging and Alzheimer's disease.
Academic Article	Rate of brain aging and APOE e4 are synergistic risk factors for Alzheimer's disease.
Academic Article	Bayesian integrative analysis of epigenomic and transcriptomic data identifies Alzheimer's disease candidate genes and networks.
Academic Article	Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation.
Academic Article	Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology.
Academic Article	Genome-wide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways.
Academic Article	Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models.
Academic Article	Deconvolving the contributions of cell-type heterogeneity on cortical gene expression.
Academic Article	Integration of postmortem amygdala expression profiling, GWAS, and functional cell culture assays: neuroticism-associated synaptic vesicle glycoprotein 2A (SV2A) gene is regulated by miR-133a and miR-218.
Academic Article	Bayesian Genome-wide TWAS Method to Leverage both cis- and trans-eQTL Information through Summary Statistics.
Academic Article	Genetic Factors of Alzheimer's Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study.
Academic Article	Single-cell transcriptomic analysis of Alzheimer's disease.
Academic Article	Genetic control of the human brain proteome.
Academic Article	Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture.
Academic Article	Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer's dementia.
Academic Article	Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer's disease.
Academic Article	Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study.
Academic Article	A Genetic Study of Cerebral Atherosclerosis Reveals Novel Associations with NTNG1 and CNOT3.
Academic Article	Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE e2 protective effect in Alzheimer disease.
Academic Article	Cascading epigenomic analysis for identifying disease genes from the regulatory landscape of GWAS variants.
Academic Article	Atlas of RNA editing events affecting protein expression in aged and Alzheimer's disease human brain tissue.
Academic Article	Integration of GWAS and brain transcriptomic analyses in a multiethnic sample of 35,245 older adults identifies DCDC2 gene as predictor of episodic memory maintenance.
Academic Article	Blood and brain transcriptome analysis reveals APOE genotype-mediated and immune-related pathways involved in Alzheimer disease.
Academic Article	Genotype-phenotype correlation of T-cell subtypes reveals senescent and cytotoxic genes in Alzheimer's disease.
Academic Article	Benchmarking of deep neural networks for predicting personal gene expression from DNA sequence highlights shortcomings.
Academic Article	A single-nucleus transcriptome-wide association study implicates novel genes in depression pathogenesis.
Academic Article	Estrogen Receptor Genes, Cognitive Decline, and Alzheimer Disease.
Academic Article	Multiple gene variants linked to Alzheimer's-type clinical dementia via GWAS are also associated with non-Alzheimer's neuropathologic entities.
Academic Article	Author Response: Estrogen Receptor Genes, Cognitive Decline, and Alzheimer Disease.
Academic Article	Differential gene expression analysis based on linear mixed model corrects false positive inflation for studying quantitative traits.
Academic Article	Benchmarking of deep neural networks for predicting personal gene expression from DNA sequence highlights shortcomings.
Academic Article	A single-nucleus transcriptome-wide association study implicates novel genes in depression pathogenesis.

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