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One or more keywords matched the following items that are connected to Sandy, John

Item TypeName
Concept Aggrecans
Academic Article Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models.
Academic Article Aggrecanolysis in human osteoarthritis: confocal localization and biochemical characterization of ADAMTS5-hyaluronan complexes in articular cartilages.
Academic Article Biochemical identification and immunolocalizaton of aggrecan, ADAMTS5 and inter-alpha-trypsin-inhibitor in equine degenerative suspensory ligament desmitis.
Academic Article Murine tendon function is adversely affected by aggrecan accumulation due to the knockout of ADAMTS5.
Academic Article ADAMTS5 is required for biomechanically-stimulated healing of murine tendinopathy.
Academic Article Individual cartilage aggrecan macromolecules and their constituent glycosaminoglycans visualized via atomic force microscopy.
Academic Article Intact aggrecan and chondroitin sulfate-depleted aggrecan core glycoprotein inhibit axon growth in the adult rat spinal cord.
Academic Article Mature bovine articular cartilage contains abundant aggrecan that is C-terminally truncated at Ala719-Ala720, a site which is readily cleaved by m-calpain.
Academic Article Focal cerebral ischemia induces changes in both MMP-13 and aggrecan around individual neurons.
Academic Article ADAMTS5-mediated aggrecanolysis in murine epiphyseal chondrocyte cultures.
Academic Article Aggrecan expression is substantially and abnormally upregulated in Hutchinson-Gilford Progeria Syndrome dermal fibroblasts.
Academic Article Expression of aggrecan(ases) during murine preadipocyte differentiation and adipose tissue development.
Academic Article Selective and non-selective metalloproteinase inhibitors reduce IL-1-induced cartilage degradation and loss of mechanical properties.
Academic Article Image analysis of aggrecan degradation in articular cartilage with formalin-fixed samples.
Academic Article Aggrecanases and aggrecanase-generated fragments in the human intervertebral disc at early and advanced stages of disc degeneration.
Academic Article Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production.
Academic Article Aggrecanolysis and in vitro matrix degradation in the immature bovine meniscus: mechanisms and functional implications.
Academic Article Interleukin-1alpha treatment of meniscal explants stimulates the production and release of aggrecanase-generated, GAG-substituted aggrecan products and also the release of pre-formed, aggrecanase-generated G1 and m-calpain-generated G1-G2.
Academic Article Adult bone marrow stromal cell-based tissue-engineered aggrecan exhibits ultrastructure and nanomechanical properties superior to native cartilage.
Academic Article Adamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor ß1 (TGFß1) signaling.
Academic Article Deletion of ADAMTS5 does not affect aggrecan or versican degradation but promotes glucose uptake and proteoglycan synthesis in murine adipose derived stromal cells.
Academic Article A cartilage explant system for studies on aggrecan structure, biosynthesis and catabolism in discrete zones of the mammalian growth plate.
Academic Article Pathways of aggrecan processing in joint tissues. Implications for disease mechanism and monitoring.
Academic Article Inhibition of cartilage degradation and changes in physical properties induced by IL-1beta and retinoic acid using matrix metalloproteinase inhibitors.
Academic Article ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain.
Academic Article ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors.
Academic Article The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain.
Academic Article Variability in the G3 domain content of bovine aggrecan from cartilage extracts and chondrocyte cultures.
Academic Article Identification of a stromelysin cleavage site within the interglobular domain of human aggrecan. Evidence for proteolysis at this site in vivo in human articular cartilage.
Academic Article Analysis of the catabolism of aggrecan in cartilage explants by quantitation of peptides from the three globular domains.
Academic Article Catabolism of aggrecan in cartilage explants. Identification of a major cleavage site within the interglobular domain.
Academic Article Isolation and characterization of disulfide-bonded peptides from the three globular domains of aggregating cartilage proteoglycan.
Academic Article Aggrecan in bovine tendon.
Academic Article Effects of proteinase inhibitors on aggrecan catabolism in chondrocyte cultures.
Academic Article Cartilage aggrecan. Biosynthesis, degradation and osteoarthritis.
Academic Article The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis.
Academic Article [Mechanisms of degradation of argecanes in osteoarthritic cartilage].
Academic Article Chondrocyte-mediated catabolism of aggrecan: aggrecanase-dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamine.
Academic Article Chondrocyte-mediated catabolism of aggrecan: evidence for a glycosylphosphatidylinositol-linked protein in the aggrecanase response to interleukin-1 or retinoic acid.
Academic Article Mannosamine inhibits aggrecanase-mediated changes in the physical properties and biochemical composition of articular cartilage.
Academic Article The intermediates of aggrecanase-dependent cleavage of aggrecan in rat chondrosarcoma cells treated with interleukin-1.
Academic Article Chondrocyte extracellular matrix synthesis and turnover are influenced by static compression in a new alginate disk culture system.
Academic Article Intact aggrecan and fragments generated by both aggrecanse and metalloproteinase-like activities are present in the developing and adult rat spinal cord and their relative abundance is altered by injury.
Academic Article Proteoglycan core proteins and catabolic fragments present in tissues and fluids.
Academic Article Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing in vivo.
Academic Article Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage.
Academic Article A contentious issue finds some clarity: on the independent and complementary roles of aggrecanase activity and MMP activity in human joint aggrecanolysis.
Academic Article Removal of O-linked and N-linked oligosaccharides is required for optimum detection of NITEGE neoepitope on ADAMTS4-digested fetal aggrecans: implications for specific N-linked glycan-dependent aggrecanolysis at Glu373-Ala374.

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