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overview Chair and The Francis N. and Catherine O. Bard Professor of Physiology, Department of Physiology & Biophysics, Rush Medical College, Rush University Medical Center. The research of Michael Fill, PhD, explores the local control of intracellular Ca signals mediated by the ryanodine receptor (RyR) Ca release channel in excitable cells. These control mechanisms are fundamental to many cellular phenomena and, thus, are often sites of pathological failure and potential targets for therapeutic intervention. Dr. Fill’s laboratory at Rush University is internationally recognized for its world-class RyR experimental expertise. The Ca signals generated by RyRs are known to modulate a myriad of physiological functions. Our lab details clinically significant structure-function attributes of single RyR function in health and disease, including local RyR control by Ca, closely regulatory proteins and post-translational modifications. This provides a strong mechanistic foundation for our group’s ongoing work toward developing new RyR-targeted drugs that will hopefully be applied to limit/treat diseases exacerbated or caused by hyperactive RyR Ca signaling. My Scopus ID is 7003468631. My NIH COMMONS name is MFILL2005. Research Areas: Ryanodine receptor calcium release channel, calcium signaling. My Faculty Profile at Rush University Medical Center: My Laboratory: My NCBI Bibliography: My Scopus: Education: PhD, University of Illinois at Urbana-Champaign MS, University of Illinois at Urbana-Champaign BS, University of Illinois at Urbana-Champaign

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