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One or more keywords matched the following properties of Mikecz, Katalin
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overview My research focuses on rheumatoid arthritis (RA), a joint disease that causes chronic pain and disability. We described a new mouse model of RA 30 years ago, and fully characterized it with respect to its pathogenesis, immunology, and genetics. My group was the first to report on the non-invasive imaging of the trafficking of white blood cells in the inflamed joints of live mice (with RA-like arthritis) using two-photon microscopy. My current research interest is in the immune recognition of a cartilage molecule termed proteoglycan (or aggrecan) by lymphocytes from mice with arthritis and from RA patients. Our ultimate goals are to identify therapeutic targets and to find a cure for RA. My ORCID is 0000-0003-1506-4296 My Scopus ID is 7006756303 My NIH COMMONS name is KMIKECZ Education: MD: Medical University of Debrecen, Hungary (1982) PhD: Medical University of Debrecen & Hungarian Academy of Sciences, Budapest, Hungary (1989)
One or more keywords matched the following items that are connected to Mikecz, Katalin
Item TypeName
Concept Lymphocytes
Concept Receptors, Antigen, T-Cell, alpha-beta
Concept Hybrid Cells
Concept Antigens, Differentiation, T-Lymphocyte
Concept Receptors, Antigen, T-Cell
Concept NIH 3T3 Cells
Concept Dendritic Cells
Concept T-Lymphocytes, Helper-Inducer
Concept Clone Cells
Concept Th1 Cells
Concept CD8-Positive T-Lymphocytes
Concept Endothelial Cells
Concept CHO Cells
Concept CD4-Positive T-Lymphocytes
Concept Antigen-Presenting Cells
Concept Th2 Cells
Concept B-Lymphocytes
Concept T-Lymphocyte Subsets
Concept Tumor Cells, Cultured
Concept Epitopes, T-Lymphocyte
Concept Bone Marrow Cells
Concept Myeloid Cells
Concept Th17 Cells
Concept Plasma Cells
Concept Cells, Cultured
Concept T-Lymphocytes
Academic Article Effects of soluble metals on human peri-implant cells.
Academic Article Cytokine-controlled RANKL and osteoprotegerin expression by human and mouse synovial fibroblasts: fibroblast-mediated pathologic bone resorption.
Academic Article Proteoglycan-specific autoreactive antibodies and T-lymphocytes in experimental arthritis and human rheumatoid joint diseases.
Academic Article Proteoglycan-induced polyarthritis and spondylitis adoptively transferred to naive (nonimmunized) BALB/c mice.
Academic Article Isolation of proteoglycan-specific T lymphocytes from patients with ankylosing spondylitis.
Academic Article Antigenic profiles of human, bovine and canine articular chondrocytes.
Academic Article A proteoglycan (aggrecan)-specific T cell hybridoma induces arthritis in BALB/c mice.
Academic Article Interferon-gamma but not granulocyte/macrophage colony-stimulating factor augments proteoglycan presentation by synovial cells and chondrocytes to an autopathogenic T cell hybridoma.
Academic Article Antigen-specific B cells present cartilage proteoglycan (aggrecan) to an autoreactive T cell hybridoma derived from a mouse with proteoglycan-induced arthritis.
Academic Article Presentation of cartilage proteoglycan to a T cell hybridoma derived from a mouse with proteoglycan-induced arthritis.
Academic Article The role of adhesion molecules in the development of autoimmune arthritis.
Academic Article Mediators and autopathogenic effector cells in proteoglycan-induced arthritic and clinically asymptomatic BALB/c mice.
Academic Article Migration and homing of lymphocytes to lymphoid and synovial tissues in proteoglycan-induced murine arthritis.
Academic Article Chondrocyte matrix metalloproteinase-8. Human articular chondrocytes express neutrophil collagenase.
Academic Article CD44 expression by leucocytes in rheumatoid arthritis and modulation by specific antibody: implications for lymphocyte adhesion to endothelial cells and synoviocytes in vitro.
Academic Article Modulation of hyaluronan receptor (CD44) function in vivo in a murine model of rheumatoid arthritis.
Academic Article Proteoglycan (aggrecan)-induced arthritis in BALB/c mice is a Th1-type disease regulated by Th2 cytokines.
Academic Article Complex pattern of Th1 and Th2 activation with a preferential increase of autoreactive Th1 cells in BALB/c mice with proteoglycan (aggrecan)-induced arthritis.
Academic Article Adhesion of lymphoid cells to CD44-specific substrata: the consequences of attachment depend on the ligand.
Academic Article Spontaneous thymocyte apoptosis is regulated by a mitochondrion-mediated signaling pathway.
Academic Article A triple assay technique for the evaluation of metal-induced, delayed-type hypersensitivity responses in patients with or receiving total joint arthroplasty.
Academic Article Impaired Fas signaling pathway is involved in defective T cell apoptosis in autoimmune murine arthritis.
Academic Article Differential lymphocyte reactivity to serum-derived metal-protein complexes produced from cobalt-based and titanium-based implant alloy degradation.
Academic Article Antibody-induced shedding of CD44 from adherent cells is linked to the assembly of the cytoskeleton.
Academic Article Increased resistance to collagen-induced arthritis in CD44-deficient DBA/1 mice.
Academic Article Th1 and Th2 cytokines regulate proteoglycan-specific autoantibody isotypes and arthritis.
Academic Article Hyaluronan binding properties of a CD44 chimera containing the link module of TSG-6.
Academic Article Continuous nasal administration of antigen is critical to maintain tolerance in adoptively transferred autoimmune arthritis in SCID mice.
Academic Article Cartilage-specific constitutive expression of TSG-6 protein (product of tumor necrosis factor alpha-stimulated gene 6) provides a chondroprotective, but not antiinflammatory, effect in antigen-induced arthritis.
Academic Article Role of the extracellular and cytoplasmic domains of CD44 in the rolling interaction of lymphoid cells with hyaluronan under physiologic flow.
Academic Article IL-4 potentiates activated T cell apoptosis via an IL-2-dependent mechanism.
Academic Article CD4+CD25+ immunoregulatory T cells may not be involved in controlling autoimmune arthritis.
Academic Article Differential recognition of altered peptide ligands distinguishes two functionally discordant (arthritogenic and nonarthritogenic) autoreactive T cell hybridoma clones.
Academic Article Induction of arthritis in SCID mice by T cells specific for the "shared epitope" sequence in the G3 domain of human cartilage proteoglycan.
Academic Article Disease-associated qualitative and quantitative trait loci in proteoglycan-induced arthritis and collagen-induced arthritis.
Academic Article Achievement of a synergistic adjuvant effect on arthritis induction by activation of innate immunity and forcing the immune response toward the Th1 phenotype.
Academic Article Expression of L-selectin, but not CD44, is required for early neutrophil extravasation in antigen-induced arthritis.
Academic Article Induction of arthritis in HLA-DR4-humanized and HLA-DQ8-humanized mice by human cartilage proteoglycan aggrecan but only in the presence of an appropriate (non-MHC) genetic background.
Academic Article Proteoglycan aggrecan-induced arthritis: a murine autoimmune model of rheumatoid arthritis.
Academic Article Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation.
Academic Article Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation.
Academic Article CD44, but not l-selectin, is critically involved in leucocyte migration into the skin in a murine model of allergic dermatitis.
Academic Article T-cell recognition of differentially tolerated epitopes of cartilage proteoglycan aggrecan in arthritis.
Academic Article Antigen-induced differential gene expression in lymphocytes and gene expression profile in synovium prior to the onset of arthritis.
Academic Article Inhibition of indoleamine 2,3-dioxygenase-mediated tryptophan catabolism accelerates collagen-induced arthritis in mice.
Academic Article TSG-6 regulates bone remodeling through inhibition of osteoblastogenesis and osteoclast activation.
Academic Article Th1/Th17 polarization and acquisition of an arthritogenic phenotype in arthritis-susceptible BALB/c, but not in MHC-matched, arthritis-resistant DBA/2 mice.
Academic Article Oral glucosamine modulates the response of the liver and lymphocytes of the mesenteric lymph nodes in a papain-induced model of joint damage and repair.
Academic Article Modulation of hyaluronan production by CD44 positive glioma cells.
Academic Article IFN-gamma regulates the requirement for IL-17 in proteoglycan-induced arthritis.
Academic Article Development of proteoglycan-induced arthritis depends on T cell-supported autoantibody production, but does not involve significant influx of T cells into the joints.
Academic Article Immunosenescence and its potential modulation: lessons from mouse models.
Academic Article Impaired activation-induced cell death promotes spontaneous arthritis in antigen (cartilage proteoglycan)-specific T cell receptor-transgenic mice.
Academic Article Proteoglycan-induced arthritis and recombinant human proteoglycan aggrecan G1 domain-induced arthritis in BALB/c mice resembling two subtypes of rheumatoid arthritis.
Academic Article TSG-6 protein, a negative regulator of inflammatory arthritis, forms a ternary complex with murine mast cell tryptases and heparin.
Academic Article Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes.
Academic Article T cell receptor (TCR) signal strength controls arthritis severity in proteoglycan-specific TCR transgenic mice.
Academic Article Suppression of dendritic cell maturation and T cell proliferation by synovial fluid myeloid cells from mice with autoimmune arthritis.
Academic Article Arthritogenic T cells drive the recovery of autoantibody-producing B cell homeostasis and the adoptive transfer of arthritis in SCID mice.
Academic Article In vivo two-photon imaging of T cell motility in joint-draining lymph nodes in a mouse model of rheumatoid arthritis.
Academic Article TSG-6 protein is crucial for the development of pulmonary hyaluronan deposition, eosinophilia, and airway hyperresponsiveness in a murine model of asthma.
Academic Article The role of citrullination of an immunodominant proteoglycan (PG) aggrecan T cell epitope in BALB/c mice with PG-induced arthritis.
Academic Article Differentially expressed epigenome modifiers, including aurora kinases A and B, in immune cells in rheumatoid arthritis in humans and mouse models.
Academic Article Of mice and men: how animal models advance our understanding of T-cell function in RA.
Academic Article Proteoglycan aggrecan conducting T cell activation and apoptosis in a murine model of rheumatoid arthritis.
Academic Article Identification of myeloid-derived suppressor cells in the synovial fluid of patients with rheumatoid arthritis: a pilot study.
Academic Article Suppression of proteoglycan-induced autoimmune arthritis by myeloid-derived suppressor cells generated in vitro from murine bone marrow.
Academic Article Rheumatoid arthritis vaccine therapies: perspectives and lessons from therapeutic ligand epitope antigen presentation system vaccines for models of rheumatoid arthritis.
Academic Article Enigma of IL-17 and Th17 Cells in Rheumatoid Arthritis and in Autoimmune Animal Models of Arthritis.
Academic Article Immune Recognition of Citrullinated Proteoglycan Aggrecan Epitopes in Mice with Proteoglycan-Induced Arthritis and in Patients with Rheumatoid Arthritis.
Academic Article Modified High-Molecular-Weight Hyaluronan Promotes Allergen-Specific Immune Tolerance.
Academic Article An epitope-specific DerG-PG70 LEAPS vaccine modulates T cell responses and suppresses arthritis progression in two related murine models of rheumatoid arthritis.
Academic Article Citrullinated Aggrecan Epitopes as Targets of Autoreactive CD4+ T Cells in Patients With Rheumatoid Arthritis.
Academic Article Amelioration of Autoimmune Arthritis in Mice Treated With the DNA Methyltransferase Inhibitor 5'-Azacytidine.
Academic Article GRB2 promotes thymocyte positive selection by facilitating THEMIS-mediated inactivation of SHP1.
Academic Article THEMIS increases TCR signaling in CD4+CD8+ thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1.
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