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Mikecz, Katalin
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overview My research focuses on rheumatoid arthritis (RA), a joint disease that causes chronic pain and disability. We described a new mouse model of RA 30 years ago, and fully characterized it with respect to its pathogenesis, immunology, and genetics. My group was the first to report on the non-invasive imaging of the trafficking of white blood cells in the inflamed joints of live mice (with RA-like arthritis) using two-photon microscopy. My current research interest is in the immune recognition of a cartilage molecule termed proteoglycan (or aggrecan) by lymphocytes from mice with arthritis and from RA patients. Our ultimate goals are to identify therapeutic targets and to find a cure for RA. My ORCID is 0000-0003-1506-4296 My Scopus ID is 7006756303 My NIH COMMONS name is KMIKECZ Education: MD: Medical University of Debrecen, Hungary (1982) PhD: Medical University of Debrecen & Hungarian Academy of Sciences, Budapest, Hungary (1989)
One or more keywords matched the following items that are connected to Mikecz, Katalin
Item TypeName
Concept Arthritis, Rheumatoid
Concept Arthritis, Experimental
Concept Arthritis
Academic Article Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to toll-like receptor 4 and toll-like receptor 2 ligands via soluble CD14.
Academic Article Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models.
Academic Article Cytokine-controlled RANKL and osteoprotegerin expression by human and mouse synovial fibroblasts: fibroblast-mediated pathologic bone resorption.
Academic Article Immunomodulation of proteoglycan-induced progressive polyarthritis by leflunomide.
Academic Article Cartilage proteoglycan-induced arthritis in BALB/c mice. Antibodies that recognize human and mouse cartilage proteoglycan and can cause depletion of cartilage proteoglycan with little or no synovitis.
Academic Article Proteoglycan-specific autoreactive antibodies and T-lymphocytes in experimental arthritis and human rheumatoid joint diseases.
Academic Article Proteoglycan-induced polyarthritis and spondylitis adoptively transferred to naive (nonimmunized) BALB/c mice.
Academic Article Immunity to cartilage proteoglycans in BALB/c mice with progressive polyarthritis and ankylosing spondylitis induced by injection of human cartilage proteoglycan.
Academic Article Proteoglycan-induced arthritis in BALB/c mice. Clinical features and histopathology.
Academic Article Mapping of arthritogenic/autoimmune epitopes of cartilage aggrecans in proteoglycan-induced arthritis.
Academic Article A proteoglycan (aggrecan)-specific T cell hybridoma induces arthritis in BALB/c mice.
Academic Article Anti-CD44 treatment abrogates tissue oedema and leukocyte infiltration in murine arthritis.
Academic Article Interferon-gamma but not granulocyte/macrophage colony-stimulating factor augments proteoglycan presentation by synovial cells and chondrocytes to an autopathogenic T cell hybridoma.
Academic Article Antigen-specific B cells present cartilage proteoglycan (aggrecan) to an autoreactive T cell hybridoma derived from a mouse with proteoglycan-induced arthritis.
Academic Article Presentation of cartilage proteoglycan to a T cell hybridoma derived from a mouse with proteoglycan-induced arthritis.
Academic Article The role of adhesion molecules in the development of autoimmune arthritis.
Academic Article Mediators and autopathogenic effector cells in proteoglycan-induced arthritic and clinically asymptomatic BALB/c mice.
Academic Article Migration and homing of lymphocytes to lymphoid and synovial tissues in proteoglycan-induced murine arthritis.
Academic Article Functional assessment of joint use in experimental inflammatory murine arthritis.
Academic Article CD44 expression by leucocytes in rheumatoid arthritis and modulation by specific antibody: implications for lymphocyte adhesion to endothelial cells and synoviocytes in vitro.
Academic Article Critical roles of glycosaminoglycan side chains of cartilage proteoglycan (aggrecan) in antigen recognition and presentation.
Academic Article Progressive polyarthritis induced in BALB/c mice by aggrecan from normal and osteoarthritic human cartilage.
Academic Article Modulation of hyaluronan receptor (CD44) function in vivo in a murine model of rheumatoid arthritis.
Academic Article Proteoglycan (aggrecan)-induced arthritis in BALB/c mice is a Th1-type disease regulated by Th2 cytokines.
Academic Article Identification of multiple loci linked to inflammation and autoantibody production by a genome scan of a murine model of rheumatoid arthritis.
Academic Article Complex pattern of Th1 and Th2 activation with a preferential increase of autoreactive Th1 cells in BALB/c mice with proteoglycan (aggrecan)-induced arthritis.
Academic Article A genome scan using a novel genetic cross identifies new susceptibility loci and traits in a mouse model of rheumatoid arthritis.
Academic Article Vitaxin applied molecular evolution.
Academic Article Variations in susceptibility to proteoglycan-induced arthritis and spondylitis among C3H substrains of mice: evidence of genetically acquired resistance to autoimmune disease.
Academic Article Impaired Fas signaling pathway is involved in defective T cell apoptosis in autoimmune murine arthritis.
Academic Article Anti-inflammatory and chondroprotective effect of TSG-6 (tumor necrosis factor-alpha-stimulated gene-6) in murine models of experimental arthritis.
Academic Article Increased resistance to collagen-induced arthritis in CD44-deficient DBA/1 mice.
Academic Article Th1 and Th2 cytokines regulate proteoglycan-specific autoantibody isotypes and arthritis.
Academic Article Continuous nasal administration of antigen is critical to maintain tolerance in adoptively transferred autoimmune arthritis in SCID mice.
Academic Article Cartilage-specific constitutive expression of TSG-6 protein (product of tumor necrosis factor alpha-stimulated gene 6) provides a chondroprotective, but not antiinflammatory, effect in antigen-induced arthritis.
Academic Article IL-4 and IL-12 regulate proteoglycan-induced arthritis through Stat-dependent mechanisms.
Academic Article Combined autoimmune models of arthritis reveal shared and independent qualitative (binary) and quantitative trait loci.
Academic Article CD4+CD25+ immunoregulatory T cells may not be involved in controlling autoimmune arthritis.
Academic Article Sex effect on clinical and immunologic quantitative trait loci in a murine model of rheumatoid arthritis.
Academic Article Differential recognition of altered peptide ligands distinguishes two functionally discordant (arthritogenic and nonarthritogenic) autoreactive T cell hybridoma clones.
Academic Article Induction of arthritis in SCID mice by T cells specific for the "shared epitope" sequence in the G3 domain of human cartilage proteoglycan.
Academic Article Proteoglycan-induced arthritis: immune regulation, cellular mechanisms, and genetics.
Academic Article Disease-associated qualitative and quantitative trait loci in proteoglycan-induced arthritis and collagen-induced arthritis.
Academic Article Achievement of a synergistic adjuvant effect on arthritis induction by activation of innate immunity and forcing the immune response toward the Th1 phenotype.
Academic Article Expression of L-selectin, but not CD44, is required for early neutrophil extravasation in antigen-induced arthritis.
Academic Article Induction of arthritis in HLA-DR4-humanized and HLA-DQ8-humanized mice by human cartilage proteoglycan aggrecan but only in the presence of an appropriate (non-MHC) genetic background.
Academic Article Proteoglycan aggrecan-induced arthritis: a murine autoimmune model of rheumatoid arthritis.
Academic Article Enhanced neutrophil extravasation and rapid progression of proteoglycan-induced arthritis in TSG-6-knockout mice.
Academic Article A longitudinal study on an autoimmune murine model of ankylosing spondylitis.
Academic Article Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation.
Academic Article Genetic control of experimental spondylarthropathy.
Academic Article T-cell recognition of differentially tolerated epitopes of cartilage proteoglycan aggrecan in arthritis.
Academic Article Visualization and in situ analysis of leukocyte trafficking into the ankle joint in a systemic murine model of rheumatoid arthritis.
Academic Article Expression of CD44 and L-selectin in the innate immune system is required for severe joint inflammation in the proteoglycan-induced murine model of rheumatoid arthritis.
Academic Article Antigen-induced differential gene expression in lymphocytes and gene expression profile in synovium prior to the onset of arthritis.
Academic Article Inhibition of indoleamine 2,3-dioxygenase-mediated tryptophan catabolism accelerates collagen-induced arthritis in mice.
Academic Article Two loci on chromosome 15 control experimentally induced arthritis through the differential regulation of IL-6 and lymphocyte proliferation.
Academic Article Congenic strains displaying similar clinical phenotype of arthritis represent different immunologic models of inflammation.
Academic Article CD44-specific antibody treatment and CD44 deficiency exert distinct effects on leukocyte recruitment in experimental arthritis.
Academic Article BALB/c mice genetically susceptible to proteoglycan-induced arthritis and spondylitis show colony-dependent differences in disease penetrance.
Academic Article Th1/Th17 polarization and acquisition of an arthritogenic phenotype in arthritis-susceptible BALB/c, but not in MHC-matched, arthritis-resistant DBA/2 mice.
Academic Article Oral glucosamine modulates the response of the liver and lymphocytes of the mesenteric lymph nodes in a papain-induced model of joint damage and repair.
Academic Article Age-related changes in arthritis susceptibility and severity in a murine model of rheumatoid arthritis.
Academic Article The genetic background of ankylosing spondylitis.
Academic Article IFN-gamma regulates the requirement for IL-17 in proteoglycan-induced arthritis.
Academic Article Development of proteoglycan-induced arthritis depends on T cell-supported autoantibody production, but does not involve significant influx of T cells into the joints.
Academic Article Impaired activation-induced cell death promotes spontaneous arthritis in antigen (cartilage proteoglycan)-specific T cell receptor-transgenic mice.
Academic Article Osteoarthritis-like damage of cartilage in the temporomandibular joints in mice with autoimmune inflammatory arthritis.
Academic Article Proteoglycan-induced arthritis and recombinant human proteoglycan aggrecan G1 domain-induced arthritis in BALB/c mice resembling two subtypes of rheumatoid arthritis.
Academic Article TSG-6 protein, a negative regulator of inflammatory arthritis, forms a ternary complex with murine mast cell tryptases and heparin.
Academic Article Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes.
Academic Article T cell receptor (TCR) signal strength controls arthritis severity in proteoglycan-specific TCR transgenic mice.
Academic Article Disease-promoting and -protective genomic loci on mouse chromosomes 3 and 19 control the incidence and severity of autoimmune arthritis.
Academic Article Suppression of dendritic cell maturation and T cell proliferation by synovial fluid myeloid cells from mice with autoimmune arthritis.
Academic Article Arthritogenic T cells drive the recovery of autoantibody-producing B cell homeostasis and the adoptive transfer of arthritis in SCID mice.
Academic Article In vivo two-photon imaging of T cell motility in joint-draining lymph nodes in a mouse model of rheumatoid arthritis.
Academic Article Non-MHC risk alleles in rheumatoid arthritis and in the syntenic chromosome regions of corresponding animal models.
Academic Article Genetics of rheumatoid arthritis - a comprehensive review.
Academic Article Pharmacogenetics and pharmacogenomics in rheumatology.
Academic Article The role of citrullination of an immunodominant proteoglycan (PG) aggrecan T cell epitope in BALB/c mice with PG-induced arthritis.
Academic Article Differentially expressed epigenome modifiers, including aurora kinases A and B, in immune cells in rheumatoid arthritis in humans and mouse models.
Academic Article Of mice and men: how animal models advance our understanding of T-cell function in RA.
Academic Article Epigenetics in the pathogenesis of rheumatoid arthritis.
Academic Article Proteoglycan aggrecan conducting T cell activation and apoptosis in a murine model of rheumatoid arthritis.
Academic Article Identification of myeloid-derived suppressor cells in the synovial fluid of patients with rheumatoid arthritis: a pilot study.
Academic Article Suppression of proteoglycan-induced autoimmune arthritis by myeloid-derived suppressor cells generated in vitro from murine bone marrow.
Academic Article Rheumatoid arthritis vaccine therapies: perspectives and lessons from therapeutic ligand epitope antigen presentation system vaccines for models of rheumatoid arthritis.
Academic Article Enigma of IL-17 and Th17 Cells in Rheumatoid Arthritis and in Autoimmune Animal Models of Arthritis.
Academic Article Characterization and Localization of Citrullinated Proteoglycan Aggrecan in Human Articular Cartilage.
Academic Article Immune Recognition of Citrullinated Proteoglycan Aggrecan Epitopes in Mice with Proteoglycan-Induced Arthritis and in Patients with Rheumatoid Arthritis.
Academic Article Immunoregulation of Proteoglycan-Induced Arthritis in Balb/c Mice.
Academic Article An epitope-specific DerG-PG70 LEAPS vaccine modulates T cell responses and suppresses arthritis progression in two related murine models of rheumatoid arthritis.
Academic Article Editorial: Ratiometric Optical Imaging of Subclinical Inflammation With a Thrombin-Cleavable Probe: A Future Tool for the In Vivo Visualization of Clinically Silent Synovitis?
Academic Article Citrullinated Aggrecan Epitopes as Targets of Autoreactive CD4+ T Cells in Patients With Rheumatoid Arthritis.
Academic Article Amelioration of Autoimmune Arthritis in Mice Treated With the DNA Methyltransferase Inhibitor 5'-Azacytidine.
Academic Article Regulation of autoimmune arthritis by the SHP-1 tyrosine phosphatase.
Academic Article Vaccination by Two DerG LEAPS Conjugates Incorporating Distinct Proteoglycan (PG, Aggrecan) Epitopes Provides Therapy by Different Immune Mechanisms in a Mouse Model of Rheumatoid Arthritis.
Academic Article Restoring the Balance between Pro-Inflammatory and Anti-Inflammatory Cytokines in the Treatment of Rheumatoid Arthritis: New Insights from Animal Models.
Search Criteria
  • Arthritis