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Search Results to Nadim Hallab

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overview Adjunct Professor, Department of Immunity and Emerging Pathogen Overview: Dr. Hallab’s research involves the study of implant degradation and biologic reactivity to soluble and particulate implant debris with four areas of focus: 1) Immune reactivity to implant debris, from both an adaptive (T-cell) and innate (macrophage) perspective, 2) Implant connections (modular junctions) and implant fretting corrosion, metal release and metal-protein complex formation, 3) Peri-implant cell toxicity responses to implant degradation products such as metals, 4) Study of how material surfaces can be used to control immune and cell function such as bone deposition. Over the years his group has found different types of implant debris (ions vs particles) bind to different specific serum proteins in people with total joint replacements, these differences translate into quantifiable person- and material-specific immune responses that can be used as diagnostic measures of performance. His research has dealt with the engineering aspects of implant degradation (wear and corrosion) and innate/adaptive immune responses to implant debris. He has discovered how metal implant debris induces inflammasome danger signaling and how DTH responses to implants metal depend on both the innate and adaptive immune system. His group has been at the for front of discovery in this field of improving implant performance over the past 20 years and reported that implant metals induce person-dependent monocyte-macrophage activation, where metals such as Cobalt ions and Co-Cr-Mo alloy particles were found to consistently induced inflammasome dependent co-stimulatory molecule increases, lysosome destabilization, hypoxia type responses, and increased DTH immune responses in prospective THA cohorts. Additnionally, he has developed methods for diagnosing metal sensitivity that are being used clinically to help people with or receiving orthopedic implants. They have quantified toxicity responses of many implant metals (e.g. Al, Co, Cr, Cu, Fe, Mo Nb, Ni and Zr) to peri-implant cells. These areas are focused on the continuing mission of his lab to improve implant performance through increased knowledge of person-dependent immune-implant debris interactions. My ORCID is 0000-0001-6421-2836. My Scopus ID is 7004113864. MY NIH COMMONS name is nhallab. Education: PhD, Tulane University (Biomedical Engineering) MS, Texas A&M University (Mechanical Engineering) BS, Texas A&M University (Mechanical Engineering)

One or more keywords matched the following items that are connected to Hallab, Nadim

Item TypeName
Concept Orthopedic Fixation Devices
Concept Orthopedic Procedures
Concept Orthopedics
Academic Article Cobalt-alloy implant debris induce HIF-1a hypoxia associated responses: a mechanism for metal-specific orthopedic implant failure.
Academic Article The pathology of orthopedic implant failure is mediated by innate immune system cytokines.
Academic Article Biologic effects of implant debris.
Academic Article Metal degradation products: a cause for concern in metal-metal bearings?
Academic Article Evaluation and treatment of painful total hip arthroplasties with modular metal taper junctions.
Academic Article Metal sensitivity in patients with orthopaedic implants.
Academic Article Orthopaedic implant related metal toxicity in terms of human lymphocyte reactivity to metal-protein complexes produced from cobalt-base and titanium-base implant alloy degradation.
Academic Article Effects of graft rotation on initial biomechanical failure characteristics of bone-patellar tendon-bone constructs.
Academic Article The effect of spinal instrumentation particulate wear debris. an in vivo rabbit model and applied clinical study of retrieved instrumentation cases.
Academic Article Comparison of ultrasonic suture welding and traditional knot tying in a rabbit rotator cuff repair model.
Academic Article Metal sensitivity in patients with orthopedic implants.
Academic Article The multi-suture technique for rotator cuff repair: a biomechanical evaluation.
Academic Article Orthopedic implant cobalt-alloy particles produce greater toxicity and inflammatory cytokines than titanium alloy and zirconium alloy-based particles in vitro, in human osteoblasts, fibroblasts, and macrophages.
Academic Article Epidural application of spinal instrumentation particulate wear debris: a comprehensive evaluation of neurotoxicity using an in vivo animal model.
Academic Article Biologic Responses to Orthopedic Implants: Innate and Adaptive Immune Responses to Implant Debris.
Academic Article Chemokines Associated with Pathologic Responses to Orthopedic Implant Debris.
Academic Article Transition from metal-DTH resistance to susceptibility is facilitated by NLRP3 inflammasome signaling induced Th17 reactivity: Implications for orthopedic implants.
Academic Article The Inflammatory Effects of Breast Implant Particulate Shedding: Comparison With Orthopedic Implants.

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