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Search Results to Nadim Hallab

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overview Adjunct Professor, Department of Immunity and Emerging Pathogen Overview: Dr. Hallab’s research involves the study of implant degradation and biologic reactivity to soluble and particulate implant debris with four areas of focus: 1) Immune reactivity to implant debris, from both an adaptive (T-cell) and innate (macrophage) perspective, 2) Implant connections (modular junctions) and implant fretting corrosion, metal release and metal-protein complex formation, 3) Peri-implant cell toxicity responses to implant degradation products such as metals, 4) Study of how material surfaces can be used to control immune and cell function such as bone deposition. Over the years his group has found different types of implant debris (ions vs particles) bind to different specific serum proteins in people with total joint replacements, these differences translate into quantifiable person- and material-specific immune responses that can be used as diagnostic measures of performance. His research has dealt with the engineering aspects of implant degradation (wear and corrosion) and innate/adaptive immune responses to implant debris. He has discovered how metal implant debris induces inflammasome danger signaling and how DTH responses to implants metal depend on both the innate and adaptive immune system. His group has been at the for front of discovery in this field of improving implant performance over the past 20 years and reported that implant metals induce person-dependent monocyte-macrophage activation, where metals such as Cobalt ions and Co-Cr-Mo alloy particles were found to consistently induced inflammasome dependent co-stimulatory molecule increases, lysosome destabilization, hypoxia type responses, and increased DTH immune responses in prospective THA cohorts. Additnionally, he has developed methods for diagnosing metal sensitivity that are being used clinically to help people with or receiving orthopedic implants. They have quantified toxicity responses of many implant metals (e.g. Al, Co, Cr, Cu, Fe, Mo Nb, Ni and Zr) to peri-implant cells. These areas are focused on the continuing mission of his lab to improve implant performance through increased knowledge of person-dependent immune-implant debris interactions. My ORCID is 0000-0001-6421-2836. My Scopus ID is 7004113864. MY NIH COMMONS name is nhallab. Education: PhD, Tulane University (Biomedical Engineering) MS, Texas A&M University (Mechanical Engineering) BS, Texas A&M University (Mechanical Engineering)

One or more keywords matched the following items that are connected to Hallab, Nadim

Item TypeName
Concept Metals, Heavy
Concept Metals
Academic Article In vitro reactivity to implant metals demonstrates a person-dependent association with both T-cell and B-cell activation.
Academic Article Effects of soluble metals on human peri-implant cells.
Academic Article Metal-on-metal bearing surfaces.
Academic Article The biology of alternative bearing surfaces in total joint arthroplasty.
Academic Article Concentration- and composition-dependent effects of metal ions on human MG-63 osteoblasts.
Academic Article Soluble ions more than particulate cobalt-alloy implant debris induce monocyte costimulatory molecule expression and release of proinflammatory cytokines critical to metal-induced lymphocyte reactivity.
Academic Article Metal degradation products: a cause for concern in metal-metal bearings?
Academic Article Th1 type lymphocyte reactivity to metals in patients with total hip arthroplasty.
Academic Article Can metal levels be used to monitor metal-on-metal hip arthroplasties?
Academic Article Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: a novel mechanism for implant debris reactivity.
Academic Article Loosening and osteolysis associated with metal-on-metal bearings: A local effect of metal hypersensitivity?
Academic Article Analysis of metal ion-induced DNA damage, apoptosis, and necrosis in human (Jurkat) T-cells demonstrates Ni2+ and V3+ are more toxic than other metals: Al3+, Be2+, Co2+, Cr3+, Cu2+, Fe3+, Mo5+, Nb5+, Zr2+.
Academic Article Hypersensitivity to metallic biomaterials: a review of leukocyte migration inhibition assays.
Academic Article A triple assay technique for the evaluation of metal-induced, delayed-type hypersensitivity responses in patients with or receiving total joint arthroplasty.
Academic Article Evaluation of metallic and polymeric biomaterial surface energy and surface roughness characteristics for directed cell adhesion.
Academic Article Metal sensitivity in patients with orthopaedic implants.
Academic Article The potential role of the osteoblast in the development of periprosthetic osteolysis: review of in vitro osteoblast responses to wear debris, corrosion products, and cytokines and growth factors.
Academic Article Lymphocyte transformation testing for quantifying metal-implant-related hypersensitivity responses.
Academic Article Early failure of metal-on-metal bearings in hip resurfacing and large-diameter total hip replacement: A consequence of excess wear.
Academic Article Metal sensitivities among TJA patients with post-operative pain: indications for multi-metal LTT testing.
Academic Article TLR4 (not TLR2) dominate cognate TLR activity associated with CoCrMo implant particles.
Academic Article Females with Unexplained Joint Pain Following Total Joint Arthroplasty Exhibit a Higher Rate and Severity of Hypersensitivity to Implant Metals Compared with Males: Implications of Sex-Based Bioreactivity Differences.
Academic Article Transition from metal-DTH resistance to susceptibility is facilitated by NLRP3 inflammasome signaling induced Th17 reactivity: Implications for orthopedic implants.
Academic Article Trunnion Corrosion in Total Hip Arthroplasty-Basic Concepts.
Academic Article Do Battlefield Injury-acquired Indwelling Metal Fragments Induce Metal Immunogenicity?
Academic Article Metal-induced delayed type hypersensitivity responses potentiate particle induced osteolysis in a sex and age dependent manner.

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