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Search Results to Nadim Hallab

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overview Adjunct Professor, Department of Immunity and Emerging Pathogen Overview: Dr. Hallab’s research involves the study of implant degradation and biologic reactivity to soluble and particulate implant debris with four areas of focus: 1) Immune reactivity to implant debris, from both an adaptive (T-cell) and innate (macrophage) perspective, 2) Implant connections (modular junctions) and implant fretting corrosion, metal release and metal-protein complex formation, 3) Peri-implant cell toxicity responses to implant degradation products such as metals, 4) Study of how material surfaces can be used to control immune and cell function such as bone deposition. Over the years his group has found different types of implant debris (ions vs particles) bind to different specific serum proteins in people with total joint replacements, these differences translate into quantifiable person- and material-specific immune responses that can be used as diagnostic measures of performance. His research has dealt with the engineering aspects of implant degradation (wear and corrosion) and innate/adaptive immune responses to implant debris. He has discovered how metal implant debris induces inflammasome danger signaling and how DTH responses to implants metal depend on both the innate and adaptive immune system. His group has been at the for front of discovery in this field of improving implant performance over the past 20 years and reported that implant metals induce person-dependent monocyte-macrophage activation, where metals such as Cobalt ions and Co-Cr-Mo alloy particles were found to consistently induced inflammasome dependent co-stimulatory molecule increases, lysosome destabilization, hypoxia type responses, and increased DTH immune responses in prospective THA cohorts. Additnionally, he has developed methods for diagnosing metal sensitivity that are being used clinically to help people with or receiving orthopedic implants. They have quantified toxicity responses of many implant metals (e.g. Al, Co, Cr, Cu, Fe, Mo Nb, Ni and Zr) to peri-implant cells. These areas are focused on the continuing mission of his lab to improve implant performance through increased knowledge of person-dependent immune-implant debris interactions. My ORCID is 0000-0001-6421-2836. My Scopus ID is 7004113864. MY NIH COMMONS name is nhallab. Education: PhD, Tulane University (Biomedical Engineering) MS, Texas A&M University (Mechanical Engineering) BS, Texas A&M University (Mechanical Engineering)

One or more keywords matched the following items that are connected to Hallab, Nadim

Item TypeName
Concept Cobalt
Academic Article Interfacial kinetics of titanium- and cobalt-based implant alloys in human serum: metal release and biofilm formation.
Academic Article Lymphocyte responses in patients with total hip arthroplasty.
Academic Article Cobalt-alloy implant debris induce HIF-1a hypoxia associated responses: a mechanism for metal-specific orthopedic implant failure.
Academic Article Fretting-corrosion behavior in hip implant modular junctions: The influence of friction energy and pH variation.
Academic Article Metal-on-metal bearing surfaces.
Academic Article Increasing both CoCrMo-alloy particle size and surface irregularity induces increased macrophage inflammasome activation in vitro potentially through lysosomal destabilization mechanisms.
Academic Article Immune responses correlate with serum-metal in metal-on-metal hip arthroplasty.
Academic Article Soluble ions more than particulate cobalt-alloy implant debris induce monocyte costimulatory molecule expression and release of proinflammatory cytokines critical to metal-induced lymphocyte reactivity.
Academic Article Effect of a second joint arthroplasty on metal ion levels after primary total hip arthroplasty.
Academic Article Ten-year outcome of serum metal ion levels after primary total hip arthroplasty: a concise follow-up of a previous report*.
Academic Article Asymptomatic prospective and retrospective cohorts with metal-on-metal hip arthroplasty indicate acquired lymphocyte reactivity varies with metal ion levels on a group basis.
Academic Article Cobalt Alloy Implant Debris Induces Inflammation and Bone Loss Primarily through Danger Signaling, Not TLR4 Activation: Implications for DAMP-ening Implant Related Inflammation.
Academic Article Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: a novel mechanism for implant debris reactivity.
Academic Article Metal release in patients who have had a primary total hip arthroplasty. A prospective, controlled, longitudinal study.
Academic Article Differential lymphocyte reactivity to serum-derived metal-protein complexes produced from cobalt-based and titanium-based implant alloy degradation.
Academic Article Orthopaedic implant related metal toxicity in terms of human lymphocyte reactivity to metal-protein complexes produced from cobalt-base and titanium-base implant alloy degradation.
Academic Article Biomaterial optimization in total disc arthroplasty.
Academic Article Calcineurin/nuclear factor of activated T cells (NFAT) signaling in cobalt-chromium-molybdenum (CoCrMo) particles-induced tumor necrosis factor-a (TNFa) secretion in MLO-Y4 osteocytes.
Academic Article Quantifying subtle but persistent peri-spine inflammation in vivo to submicron cobalt-chromium alloy particles.
Academic Article Orthopedic implant cobalt-alloy particles produce greater toxicity and inflammatory cytokines than titanium alloy and zirconium alloy-based particles in vitro, in human osteoblasts, fibroblasts, and macrophages.
Academic Article Metal sensitivities among TJA patients with post-operative pain: indications for multi-metal LTT testing.
Academic Article Cytotoxic effects of cobalt and nickel ions on osteocytes in vitro.

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  • Cobalt