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One or more keywords matched the following properties of Gaiteri, Chris
overview How do interaction networks at the levels of genes, proteins and cells support healthy cognitive function? How do semi-independent regulatory systems such as epigenetics, chromosome configuration, miRNA and transcription factors combine to support homeostasis? How do biological networks that operate on vastly different spatial and temporal scales, mesh together seamlessly? Are there collective network “signatures” of disease? How does the connectivity of a network condition its dynamics? How can we use network insights to identify key mediators of pathology? Chris Gaiteri, PhD, is interested in answering these questions, and in the context of Alzheimer’s disease uses several types of omics data to identify networks of molecules that are closely related to brain pathology. He has also used related approaches to study major depression and schizophrenia. Living in between computation and biology is a tricky place, so he’s always on the lookout for collaborators. Feel free to email and stop by and discuss how a network approach may benefit your research.
One or more keywords matched the following items that are connected to Gaiteri, Chris
Item TypeName
Concept Gene Expression Profiling
Concept Gene Regulatory Networks
Concept Gene Expression
Concept Genome, Human
Concept Transcriptome
Concept Polymorphism, Single Nucleotide
Concept Quantitative Trait Loci
Concept Base Sequence
Concept Alleles
Concept Gene Expression Regulation
Academic Article Genetic variants in Alzheimer disease - molecular and brain network approaches.
Academic Article A molecular signature of depression in the amygdala.
Academic Article Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease.
Academic Article Bayesian network reconstruction using systems genetics data: comparison of MCMC methods.
Academic Article Altered gene synchrony suggests a combined hormone-mediated dysregulated state in major depression.
Academic Article Differentially expressed genes in major depression reside on the periphery of resilient gene coexpression networks.
Academic Article Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline.
Academic Article A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer's disease.
Academic Article Gene expression and DNA methylation are extensively coordinated with MRI-based brain microstructural characteristics.
Academic Article Multi-omic Directed Networks Describe Features of Gene Regulation in Aged Brains and Expand the Set of Genes Driving Cognitive Decline.
Academic Article Seasonal plasticity of cognition and related biological measures in adults with and without Alzheimer disease: Analysis of multiple cohorts.
Academic Article Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology.
Academic Article Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models.
Academic Article Deep learning decodes the principles of differential gene expression.
Academic Article Deconvolving the contributions of cell-type heterogeneity on cortical gene expression.
Academic Article Identifying the molecular systems that influence cognitive resilience to Alzheimer's disease in genetically diverse mice.
Academic Article Cascading epigenomic analysis for identifying disease genes from the regulatory landscape of GWAS variants.
Academic Article Benchmarking of deep neural networks for predicting personal gene expression from DNA sequence highlights shortcomings.
Academic Article Robust, scalable, and informative clustering for diverse biological networks.
Academic Article Benchmarking of deep neural networks for predicting personal gene expression from DNA sequence highlights shortcomings.
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