Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.

Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron. 2008 Dec 26; 60(6):988-1009.

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subject areas

Age Factors
Aged, 80 and over
Alzheimer Disease
Amyloid beta-Peptides
Amyloid beta-Protein Precursor
Amyloid Precursor Protein Secretases
Animals
Antimetabolites
Aspartic Acid Endopeptidases
Cells, Cultured
Cerebral Cortex
Convulsants
Dactinomycin
Deoxyglucose
Disease Models, Animal
eIF-2 Kinase
Embryo, Mammalian
Enzyme Activation
Gene Expression Regulation
Glucose
Humans
Mice
Mice, Inbred C57BL
Mice, Transgenic
Neurons
Nitro Compounds
Peptide Fragments
Phosphorylation
Plaque, Amyloid
Propionates
Protein Synthesis Inhibitors
Time Factors
Transcription Factors
Transfection

authors with profiles

David A. Bennett